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| 1 | Inflammatory bowel disease in an underdeveloped region of Northeastern Brazil显示文摘AIM: To evaluate the demographic characteristics and clinical phenotypes of inflammatory bowel disease(IBD) in a geographic area in Northeastern Brazil.METHODS: This retrospective study was conducted at the Hospital of the Federal University of Piauí in Northeastern Brazil. Demographic characteristics and clinical phenotypes of IBD were analyzed in relation to the time of diagnostic confirmation, which was defined as the date of disease onset. Data were collected between January 2011 and December 2012 and included all census patients 18 years of age or older during that period for whom there was diagnostic confirmation of Crohn's disease(CD), ulcerative colitis(UC), or unclassified colitis according to the Montreal criteria. We also analyzed the period of time between the onset of clinical manifestations and the diagnosis of IBD(delay in the diagnosis). Statistical analyses included means and standard deviations for numeric variables and the Pearson χ2 adherence test for nominal variables. The annual index occurrence and overall prevalence of IBD at our institution were also calculated, with P values < 0.05 indicating statistical significance. This study was approved by the Institutional Ethics and Research Committee.RESULTS: A total of 252 patients with IBD were included, including 152(60.3%) UC patients and 100(39.7%) CD patients. The clinical and demographic characteristics of all patients with IBD showed a female to male ratio of 1.3:1.0 and a mean age of35.2(SD = 14.5) years. In addition, the majority of patients were miscegenated(171, 67.9%), had received higher education(157, 62.4%), lived in urban areas(217, 86.1%), and were under the age of 40 years(97, 62.5%). For patients with CD, according to the Montreal classification, the predominant features present from the onset of disease were an age between 17 and 40 years(A2); colonic disease location(L2); and nonstricturing, nonfistulizing disease behavior(B1). However, approximately one-quarter of all CD patients demonstrated perineal involvement. We also observed considerable delay in the diagnosis of IBD throughout the entire study period(mean = 35.5 mo). In addition, the annual index occurrence rose from 0.08 to 1.53 cases/105 inhabitants/year during the study period, and the prevalence rate was 12.8 cases/105 inhabitants in 2012. Over the last two decades, there was a noted increase in the frequency of IBD in the study area.CONCLUSION: In this study, there was a predominance of patients with UC, young people under 40 years of age, individuals with racial miscegenation, and low annual incomes. | José Miguel Luz Parente Claudio Saddy Rodrigues Coy Viriato Campelo Mírian Perpétua Palha Dias Parente Leonardo Araújo Costa Renata Mendes da Silva Celso Stephan José Murilo Robilotta Zeitune | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 2 | Fourteen short tandem repeat loci Y chromo- some haplotypes:genetic analysis in populations from north- ern Brazil显示文摘 | PALHA T RIBEIRO-RODRIGUES E RIBE1RO-DOS-SAN- TOS A | 2012 | Forensic Sci Int Genet2012，6，3： | 1 |
| 3 | Mucosal lymphocyte subsets and HLA-DR antigen expression in paediatric Helieobacter pylori-associated gastritis 显示文摘 | Lopes AI Victorino RM Palha AM | 2006 | Clin Exp Immunol2006，145，1： | 1 |
| 4 | The impact of wave energy farms in the shoreline wave climate: Portuguese pilot zone case study using Pelamis energy wave devices 显示文摘 | Palha A Mendes L Fortes C J | 2010 | Renewable Energy2010，35，1： | 1 |
| 5 | The impact of wave energy farms in the shoreline wave climate: Portuguese pilot zone case study using Pelamis ener- gy wave devices显示文摘 | Palha A Mendes L Fortes C J | 2010 | Renewable Energy2010，35，1： | 1 |
| 6 | Transthyretin regu-lates thyroid hormone levels in the choroid plexus,but not in the brainparenchyma:study in a transthyretin-null mouse model显示文摘 | Palha J A Fernandes R de-Escobar G M | 2000 | Endocri-nology2000，141，9： | 1 |
| 7 | The impact of wave energy farms in the shoreline wave climate: Portuguese pilot zone ease study using Pelamis Energy wave devices 显示文摘 | Palha A Mendes L Fortes C J | 2010 | Renewable Energy2010，35，1： | 1 |
| 8 | Transthyretin as a thyroid hormone carrier: Function revisited 显示文摘 | Palha J A | 2002 | Clin Chem Lab Med2002，40，12： | 1 |
| 9 | Autoimmune gastritis presenting as iron deficiency anemia in childhood显示文摘AIM: To characterize clinical, laboratorial, and histological profile of pediatric autoimmune gastritis in the setting of unexplained iron deficiency anemia investigation.METHODS: A descriptive, observational study including pediatric patients with a diagnosis of autoimmune gastritis(positive parietal cell antibody and gastric corpus atrophy) established in a 6 year period(2006-2011) in the setting of refractory iron deficiency anemia(refractoriness to oral iron therapy for at least 6 mo and requirement for intravenous iron therapy) investigation, after exclusion of other potentially contributing causes of anemia. Helicobacter pylori(H. pylori) infection and anti-secretory therapy were also excluded. Data were retrospectively collected from clinical files, including: demographic data(age, gender, and ethnic background), past medical history, gastrointestinal symptoms, familial history, laboratorial evaluation(Hb, serum ferritin, serum gastrin, pepsinogen Ⅰ/ pepsinogen Ⅱ, B12 vitamin, intrinsic factor autoantibodies, thyroid autoantibodies, and anti-transglutaminase antibodies), and endoscopic and histological findings(HE, Periodic Acid-Schiff/Alcian blue, gastrin, chromogranin A and immunochemistry analysis for CD3, CD20 and CD68). Descriptive statistical analysis was performed(mean, median, and standard deviation).RESULTS: We report a case-series concerning 3 girls and 2 boys with a mean age of 13.6 ± 2.8 years(3 Caucasian and 2 African). One girl had type Ⅰ diabetes. Familial history was positive in 4/5 cases, respectively for autoimmune thyroiditis(2/5), sarcoidosis(1/5) and multiple myeloma(1/5). Laboratorial evaluation on admission included: Hb: 9.5 ± 0.7 g/d L; serum ferritin: 4.0 ± 0.9 ng/m L; serum gastrin: 393 ± 286 pg/m L; low pepsinogen Ⅰ/ pepsinogen Ⅱ ratio in 1/5 patients; normal vitamin B12 levels(analyzed in 3 patients). Endoscopy findings included: duodenal nodularity(2/5) and gastric fold softening(2/5), and histological evaluation showed corpus atrophic gastritis with lymphocytic infiltration(5/5), patchy oxyntic gland mononuclear cell infiltration(5/5), intestinal and/or pseudo-pyloric metaplasia in corpus mucosa(4/5), and enterochromaffin cell hyperplasia(4/5). Immunochemistry for gastrin on corpus biopsies was negative in all cases. Duodenal histology was normal. All biopsies were negative for H. pylori(Giemsa staining and cultural examination). CONCLUSION: We highlight autoimmune gastritis as a diagnosis to be considered when investigating refractory iron deficiency anemia in children, particularly in the setting of a personal/familial history of autoimmune disease, as well as the diagnostic contribution of a careful immunohistological evaluation. | Cristina Gon?alves Maria Emília Oliveira Ana M Palha Anabela Ferr?o Anabela Morais Ana Isabel Lopes | 2014 | World Journal of Gastroenterology2014，20，42： | 1 |
| 10 | Helicobacter pylori genotypes in children from a population at high gastric cancer risk: no association with gastroduodenal histopathology显示文摘 | Costa Lopes AI Palha A Monteriro L Olcastro M Pelerito A Fernandes A | 2006 | Am J Gastroenterol2006，101，9： | 1 |
| 11 | Antibiotic-resistant Helicobacter Pylori stains in portuguese,children显示文摘 | Lopes A I Oleastro M Palha A | 2005 | Pediatr Infect Dis J2005，24，5： | 1 |
| 12 | S182 protein in Alzheimer's disease neuritic plaque显示文摘 | Wisniewski T Palha JA Ghiso J | 1995 | Lancet1995，3，： | 1 |
| 13 | Thyroid hormone distribution in the mouse brain : The role of transthyretin 显示文摘 | Palha JA Nissanov J Femandes R | 2002 | Neuroscience2002，113，2： | 1 |
| 14 | A study of the sexuality of opiate addicts显示文摘 | Palha AP Esteves M | 2002 | J Sex Marital Ther2002，28，： | 1 |
| 15 | Antibiotic-resistant Helicobacter pylori strains in PortugueSe Children显示文摘 | Lopes AI Oleastro M Palha A | | 0，，： | 1 |
| 16 | Fourteen short tandem repeat loci Y chromosome haplotypes: Genetic analysis in populations from northern Brazil 显示文摘 | Palha T Ribeiro-Rodrigues E Ribeiro-dos-Santos A Santos S | 2012 | Forensic Sci Int2012，6，3： | 1 |
| 17 | A study of the sexuality of opiate addicts 显示文摘 | Palha AP Esteves M | 2002 | J Sex Marital Ther2002，28，5： | 1 |
| 18 | The impact of wave energy farms in the shoreline wave climate:portuguese pilot zone case study using Pelamis energy wave devices显示文摘 | PALHA A MENDES L FORTES C J | 2010 | Renewable Energy2010，35，1： | 1 |
| 19 | Temporal trends in areas at risk for concomitant tuberculosis in a hyperendemic municipality in the Amazon region of Brazil显示文摘Background Although preventable and curable,tuberculosis(TB)still occurs in poor or developing countries,mainly in metropolitan regions of larger cities.The disease is a serious public health problem,and is directly linked to social issues.We analyzed temporal trend variations in areas at risk for concomitant TB,and characterized the clinical and epidemiological profiles of cases in a hyperendemic municipality in the Amazon region of Brazil.Methods This ecological study was performed in the municipality of Manaus,in northern Brazil.The population comprised cases with concomitant pulmonary and extrapulmonary TB,registered on the Notifiable Diseases Information System(SINAN),between January 1,2009 and December 31,2018.For risk cluster detection,spatial and spatiotemporal scanning statistical techniques were used.The Spatial Variation in Temporal Trends(SVTT)approach was used to detect and infer clusters for significantly different time trends.Results Between 2009 and 2018,873 concomitant TB cases were registered in Manaus.By using purely spatial scanning statistics,we identified two risk clusters.The relative risk(RR)of the clusters was 2.21(95%confidence interval[CI]:1.57–2.88;P=0.0031)and 2.03(95%CI:1.58–2.58;P=0.0029).Using space-time scanning,we identified a risk cluster with an RR of 3.57(95%CI:2.84–4.41;P=0.014),between 2017 and 2018.For SVTT analyses,three clusters with spatial variations were detected in the significant temporal trends:SVTT 1(P=0.042),SVTT 2(P=0.046)and SVTT 3(P=0.036).Conclusions In Brazil,several TB-determining factors such as race/color,gender,low educational level and low income overlap in needy urban areas and communities,demonstrating that it is unlikely to reach the goals,agreed and launched with the END TB Strategy within the deadlines of international agreements,if there is no reduction in existing inequities determinants and risk of illness in the country. | Alexandre Tadashi Inomata Bruce Thais Zamboni Berra Felipe Lima dos Santos Yan Mathias Alves Ludmilla Leidianne Limirio Souza Antônio Carlos Vieira Ramos Luiz Henrique Arroyo Juliane de Almeida Crispim Ione Carvalho Pinto Pedro Fredemir Palha Aline Aparecida Monroe Mellina Yamamura Regina Célia Fiorati Ana Carolina Scarpel Moncaio Dulce Maria de Oliveira Gomes Ricardo Alexandre Arcêncio | 2020 | Infectious Diseases of Poverty2020，9，4： | 0 |
| 20 | 有关于城市的19个欲望显示文摘本期品色专辑将为您讲述15个都市欲望中的关键词,并通过4位名家与4位摄影师共同解读,呈现当下的种种欲望,通过他们的分享,都市这一欲望的巨型容器被再一次诠释. | 保罗·安德鲁 沈黎晖 克里希那穆提 鲍昆 Navid Baraty(图) Rui Palha(图) Andrew Lucas(图) 杨泳梁(图) | 2013 | 摄影之友2013，0，5： | 0 |
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