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| 1 | 左氧氟沙星、加替沙星及莫西沙星对肺结核患者的早期及延长早期杀菌活性显示文摘目的:评估左氧氟沙星、加替沙星及莫西沙星等新氟喹诺酮类药物对肺结核患者的早期杀菌活性及延长早期杀菌活性。设计:随机开放临床试验。40例成年新诊断的涂阳肺结核患者(每组10例)分别每日单一接受异烟肼300mg,或左氧氟沙星1000mg,或加替沙星400mg,或莫西沙星400mg的7天治疗。治疗前2天及单药治疗7天期间,每日收集痰液进行定量培养。计量单药治疗开始的头2天(0-2天)及治疗后5天(2-7天)的菌量下降情况,以评估各药的早期及延长早期杀菌活性。对实验室工作人员关于病人治疗分组信息采用单盲法。结果:异烟肼的早期杀菌活性为0.67log10cfu/毫升/天,高于莫西沙星(0.33log10cfu/毫升/天)及加替沙星(0.35log10cfu/毫升/天)。与每日1000mg左氧氟沙星的早期杀菌活性(0.45log10cfu/毫升/天)相比,无统计学差异(P=0.14)。3种氟喹诺酮类药物的早期杀菌活性(0-2天)与延长早期杀菌活性(2-7天)相似。总体说来,氟喹诺酮类药物的延长早期杀菌活性高于异烟肼。结论:莫西沙星、加替沙星及高剂量左氧氟沙星,虽然略低于异烟肼,但均有良好的早期杀菌活性,并具有较高的延长早期杀菌活性。有理由对这些药物敏感的结核病人进行进一步的治疗研究。 | J. L. Johnson D. J. Hadad W. H. Boom C. L. Daley C. A. Peloquin K. D. Eisenach D. D. Jankus S. M. Debanne E. D. Charlebois E. Maciel M. Palaci R. Dietzet 马玙(译) 屠德华(校) 张立兴(审) | 2006 | 国际结核病与肺部疾病杂志2006，1，2： | 5 |
| 2 | Characteristics of corrosion scales on steel in C02 - saturated NaCl brine显示文摘 | Palacious C A Shadley J R | 1991 | Corrosion1991，47，2： | 1 |
| 3 | Role of plasma membrane transporters in muscle metabolism显示文摘 | Zorzano A Fandos C Palaci M | 2000 | Biochem J2000，349，3： | 1 |
| 4 | Role of plasma membrane transporters in muscle metabole metabolism显示文摘 | Zorzano A Fandos C Palaci M | 2000 | Biochem J2000，349，3： | 1 |
| 5 | Role of plasma membrane transporters in muscle metabolism 显示文摘 | ZORZANO A FANDOS C PALACI M | 2000 | Biochem J2000，349，3： | 1 |
| 6 | Pericardial effusion and tamponade显示文摘 | Palacious IF | 1999 | Curr Treat Option Cardiovasc1999，1，1： | 1 |
| 7 | Surgical training in selective pelvic arterial ligation or use of embolization only显示文摘 | Palacious Joraqnemadea JM | | 0，，02： | 1 |
| 8 | Evaluation of oral antiseptic rinsing before sputum collection to reduce contamination of mycobacterial cultures显示文摘 | Peres RL Palaci M Loureiro RB | | 0，，08： | 1 |
| 9 | Characteristics of corrosion scales on steel in a CO2-saturated NaC1 brine显示文摘 | Palacious C A Shadley J R | 1991 | Corrosion Science1991，47，2： | 1 |
| 10 | The 2/3 power law dependence of capillary force on normal load in nanoscopic frictions 显示文摘 | Riedo E Palaci I Boragno C | 2004 | Journal of Physical Chemistry B2004，108，： | 1 |
| 11 | The 2/3 power law dependence of capillary force on normal load in nanoscopic frictions 显示文摘 | Riedo E Palaci I Boragno C | 2004 | Journal of Physical Chemistry B2004，108，： | 1 |
| 12 | Role of plasmamebrane transporters in muscle metabolism显示文摘 | Zorzano A Fandos C Palaci M | 2000 | Biochem2000，393，3： | 1 |
| 13 | EAM-SOA Millimeter- Wave Frequency up-Converter for Radio-over-Fiber Applications显示文摘 | Palaci J Villanueva G Herrera J | 2011 | Optics Communications2011，284，1： | 1 |
| 14 | Tuberculosis and HIV infection among female inmates in Sao Paulo,Brazil:a prospective cohort study显示文摘 | Ferreira MM Ferrazoli L Palaci M | 1996 | J Acquir Immune Defic Syndr Hum Retrovirol1996，13，2： | 1 |
| 15 | Evaluation of MGIT for recovery and drug susceptibility testing of Mycobacterium tuberculosis isolates from respiratory specimens显示文摘 | Palaci M Ueki SYM Sato DN | 1996 | J Clin Microbiol1996，34，3： | 1 |
| 16 | Significant tricuspid regurgitation does not resolve after percutaneous balloon mitral valvotomy显示文摘 | Sagie A Schwanmenthal E Palacies IF | 1994 | J Thorac Cardiovasc Surg1994，108，： | 1 |
| 17 | Cytotoxic T lymphocyte antigen-4 gene polymorphisms do not confer susceptibility to autoimmune hepatitis type 1 and 2 in Brazil显示文摘 | Bittencount PL Palacious SA Cancado EL | 2003 | Am J Gastroenterol2003，98，7： | 1 |
| 18 | Transcatheter left atrial appendage occlusion with Amplatzer devices to obviate anticoagulation in patients with atrial fibrillation显示文摘 | Meier B Palacious I Windecker S | 2003 | Cather Cardiovasc Interv2003，60，： | 1 |
| 19 | Performance analysis of photonic vector modulation techniques for multi-Gb/s wireless links显示文摘 | Rakesh Sambaraju Juan Luis Corral Jesus Palaci | 2008 | Lightwave Technol2008，26，15： | 1 |
| 20 | Evaluation of oral antisep-tic rinsing before sputum collection to reduce contamination of myco-bacterial culture 显示文摘 | Peres RL Palaci M Loureiro RB | 2011 | J Clin Microbiol2011，49，8： | 1 |
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