|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Application of three-dimensional culture systems to study mammalian spermatogenesis, with an emphasis on the rhesus monkey (Macaca mulatta)显示文摘 | Mahmoud Huleihel Seyedmehdi Nourashrafeddin Tony M Plant | 2015 | Asian Journal of Andrology2015，17，6： | 6 |
| 2 | Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a progressive disease of increasing public health concern.In western populations the disease has an estimated prevalence of 20%-40%,rising to 70%-90% in obese and type Ⅱ diabetic individuals.Simplistically,NAFLD is the macroscopic accumulation of lipid in the liver,and is viewed as the hepatic manifestation of the metabolic syndrome.However,the molecular mechanisms mediating both the initial development of steatosis and its progression through non-alcoholic steatohepatitis to debilitating and potentially fatal fibrosis and cirrhosis are only partially understood.Despite increased research in this field,the development of non-invasive clinical diagnostic tools and the discovery of novel therapeutic targets has been frustratingly slow.We note that,to date,NAFLD research has been dominated by in vivo experiments in animal models and human clinical studies.Systems biology tools and novel computational simulation techniques allow the study of large-scale metabolic networks and the impact of their dysregulation on health.Here we review current systems biology tools and discuss the benefits to their application to the study of NAFLD.We propose that a systems approach utilising novel in silico modelling and simulation techniques is key to a more comprehensive,better targeted NAFLD research strategy.Such an approach will accelerate the progress of research and vital translation into clinic. | Ciarán P Fisher Andrzej M Kierzek Nick J Plant J Bernadette Moore | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 3 | Bactericidal oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes and Salmonella enterica 显示文摘 | Friedman M Henika PR activities of plant essential Mandrell RE | 2002 | J Food Prot2002，65，10： | 1 |
| 4 | Architectural correlates of exploitation efficiency显示文摘 | Fitter A H Stickland T R Harvey M L etaL Architectural analysis of plant root systems 1 | 1991 | New Phytol1991，118，： | 1 |
| 5 | Evaluation of methods forthe simultaneous analysis of cations and anions using HPLCwith charged aerosol detection and a zwitterionic stationaryphase显示文摘 | Crafts C Bailey B Plante M | 2009 | J Chromatogr Sci2009，47，7： | 1 |
| 6 | AIDS-related experience, knowledge, attitudes and beliefs amongst nurses in area with a high rate of HIV infection显示文摘 | Plant M L Foster J | 1993 | Journal of Advanced Nursing1993，18，： | 1 |
| 7 | Ovarian thecoma associated with a large quantity of ascites and elevated serum CA125 and CA15-3显示文摘 | RENAUD M C PLANTE M ROY M | 2002 | J Obstet Gynaecol Can:JOGC2002，24，12： | 1 |
| 8 | The relationship of asthma therapy and Churg-Strauss syndrome: NIH workshop summary re- port 显示文摘 | Weller PF Plant M Taggart V | 2001 | J Allergy clin immunol2001，108，2： | 1 |
| 9 | Reactive Oxygen Species Released by Activated Neutrophils, But Not by Deficient Spermatozoa, Are Sufficient to Affect Normal Sperm Motility 显示文摘 | PLANTE M DE LAMIRANDE E GAGNON C | 1994 | Fertil Steril1994，62，2： | 1 |
| 10 | Sequence data suggests big liver and spleen disease virus (BLSV) is genetically related to hepatitis E virus 显示文摘 | Payne C J Ellis T M Plant S L | 1999 | Veterinary Microbiology1999，68，： | 1 |
| 11 | Vaginal radical hysterectomy versus abdominal radical hysterectomy in the treatment of early-stage cervical cancer显示文摘 | Roy M Plante M Renaud MC | 1996 | Gynecol Oncol1996，62，3： | 1 |
| 12 | Combined laparoscopic and vaginal radical surgery in cervical cancer 显示文摘 | Renaud M C Plante M Roy M | 2000 | Gynecol Oncol2000，79，59： | 1 |
| 13 | Intranasat Immunization with gonoeoecal outer membrane preparations reduces the duration of vaginal colonization of mice by Neisseria gonorrhoeae 显示文摘 | Plante M Jerse A Hamel J | 2000 | Infect Dis2000，82，3： | 1 |
| 14 | The detection of the big liver and spleen agent in infected tissues via intravenous chick embryo inoculation 显示文摘 | Payne C J Plant S L Ellis T M | 1993 | Avian Pathology1993，22，： | 1 |
| 15 | Ex vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing glia:effects on rubrospinal tract regeneration, lesion size and functional recovery after implantation in the injured rat spinal cord显示文摘 | Ruitenberg M J Plant GW Hamers FP | 2003 | Neurosci2003，23，18： | 1 |
| 16 | Evolution in fertility-preserving options for early-stage cervical cancer: radical trachelectomy, simple trachelectomy, neoadjuvant chemotherapy显示文摘 | Plante M | 2013 | Int J Gynecol Cancer2013，23，6： | 1 |
| 17 | Phase Ⅰ and pharmacologic study of intermittent twice-daily oral therapy with capecitabine in patients with advanced and/or metastatic cancer显示文摘 | Mackean M Planting A Twelves C | 1998 | J Clin Oncol1998，16，9： | 1 |
| 18 | Fertility preservation in the management of gynecologic cancers显示文摘 | Plante M | 2000 | Curr Opin Oncol2000，12，5： | 1 |
| 19 | Fundamental application study of lignin on plastics 显示文摘 | PLANTE P PIGEON M FOY C | 1999 | Cement and Concrete Research1999，19，4： | 1 |
| 20 | Early responses of the left ventricle to pressure overload in Wistar rats显示文摘 | Roussel E Gaudreau M Plante E | 2008 | Life Sci2008，82，56： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员