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| 1 | Therapy with stem cells in inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD) affects a part of the young population and has a strong impact upon quality of life. The underlying etiology is not known, and the existing treatments are not curative. Furthermore, a significant percentage of patients are refractory to therapy. In recent years there have been great advances in our knowledge of stem cells and their therapeutic applications. In this context, autologous hematopoietic stem cell transplantation(HSCT) has been used in application to severe refractory Crohn's disease(CD), with encouraging results. Allogenic HSCT would correct the genetic defects of the immune system, but is currently not accepted for the treatment of IBD because of its considerable risks. Mesenchymal stem cells(MSCs) have immune regulatory and regenerative properties, and low immunogenicity(both autologous and allogenic MSCs). Based on these properties, MSCs have been used via the systemic route in IBD with promising results, though it is still too soon to draw firm conclusions. Their local administration in perianal CD is the field where most progress has been made in recent years, with encouraging results. The next few years will be decisive for defining the role of such therapy in the management of IBD. | María del Pilar Martínez-Montiel Gonzalo Jesús Gómez-Gómez Ana Isabel Flores | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 2 | Stem cell therapy in inflammatory bowel disease: A promising therapeutic strategy?显示文摘Inflammatory bowel diseases are inflammatory, chronic and progressive diseases of the intestinal tract for which no curative treatment is available. Research in other fields with stem cells of different sources and with immunoregulatory cells(regulatory T-lymphocytes and dendritic T-cells) opens up new expectations for their use in these diseases. The goal for stem cell-based therapy is to provide a permanent cure. To achieve this, it will be necessary to obtain a cellular product, original or genetically modified, that has a high migration capacity and homes into the intestine, has high survival after transplantation, regulates the immune reaction while not being visible to the patient's immune system, and repairs the injured tissue. | Ana I Flores Gonzalo J Gómez-Gómez ángeles Masedo-González M Pilar Martínez-Montiel | 2015 | World Journal of Stem Cells2015，7，2： | 7 |
| 3 | Current stage in inflammatory bowel disease: What is next?显示文摘In recent years,the incidence of inflammatory bowel disease(IBD) has been on the rise,extending to countries where it was infrequent in the past. As a result,the gap between high and low incidence countries is decreasing. The disease,therefore,has an important economic impact on the healthcare system. Advances in recent years in pharmacogenetics and clinical pharmacology have allowed for the development of treatment strategies adjusted to the patient profile. Concurrently,new drugs aimed at inflammatory targets have been developed that may expand future treatment options. This review examines advances in the optimization of existing drug treatments and the development of novel treatment options for IBD. | Gonzalo Jesús Gómez-Gómez ángeles Masedo Carmen Yela Maria del Pilar Martínez-Montiel Begona Casís | 2015 | World Journal of Gastroenterology2015，21，40： | 6 |
| 4 | Diabetic gastroenteropathy:An underdiagnosed complication显示文摘This article is an extensive review that provides an update on the pathophysiology,symptoms,diagnosis,and treatment of diabetic gastroenteropathy.There is no reported prevalence,but it has been described that patients with type 1 diabetes have a cumulative incidence at 10 years of 5.2%,and type 2 patients,1%.Also,in the group of type 1 diabetes,it has been observed that women are more likely to present this condition(5.8%vs 3.5%).Many factors are associate with its development(e.g.,hyperglycemia,vagal dysfunction,loss of expression of neural nitric oxide synthase in the myenteric plexus,alterations in the Cajal interstitial cell network,and oxidative stress).Gastrointestinal discomfort could be perceived 70% higher in diabetic patients,describing that 25%of diabetic patients experience gastrointestinal symptoms.Diabetic enteropathy could affect any portion of the gastrointestinal tract,but esophageal alterations were described in more than 60% of diabetic patients,also 60% of them present constipation,and 20%,diarrhea.Gastric emptying scintigraphy is useful to evaluate gastroparesis,therefore,gastric retention of more than 60%at 2 h has a sensitivity of 100% and specificity of 20% for diagnosis;however,other studies such as breath tests,with a sensitivity of 89% and a specificity of 80%,or the endoscopic capsule contribute to the diagnosis.There is no cure;however,management must be multidisciplinary,focused on slowing the progression of diabetic gastroenteropathy,reducing symptoms,and restoring function;that includes nutritional recommendation,maintain glucose levels kept below 180 mg/dL,use of prokinetics,anti-emetics;nowadays,it has been special interest in surgical treatment,such as pyloroplasty,also gastric electrical stimulation appears to be another alternative. | Marcio JoséConcepción Zavaleta Jhean Gabriel Gonzáles Yovera Diego Martín Moreno Marreros Luciana del Pilar Rafael Robles Kely Roxana Palomino Taype Karen Nohelly Soto Gálvez Luis Fernando Arriola Torres Julia Cristina Coronado Arroyo Luis Alberto Concepción Urteaga | 2021 | World Journal of Diabetes2021，12，6： | 4 |
| 5 | Dissolving polymer microneedle patches for influenza vaccina- tion显示文摘 | Sullivan S P Koutsonanos D G del Pilar Martin M | 2010 | Nat Med2010，16，8： | 1 |
| 6 | Proteolysis and formation of volatile compounds in cheese manufactured with a hacteriocin-producing adjunct culture显示文摘 | Abdelghani O Pilar G | 2001 | Jouranl of Dairy Research2001，，68： | 1 |
| 7 | Epoxides,cyclic sulfites,and sulfate from natural pentacyclic triterpenoids:theoretical calculations and chemical transformation显示文摘 | Pilar E L Enrique M | 2003 | Journal of Organic Chemistry2003，68，： | 1 |
| 8 | Identification of Candida albicans exposed surface proteins in vivo by a rapid proteomic approach 显示文摘 | Maria L H Pilar X E Montserrat M G | 2010 | Proteomics2010，73，7： | 1 |
| 9 | Culture of human hepatocytes from small surgical liver biopsies. Biochemical characterization and comparison with in vivo显示文摘 | M. José Gómez-Lechón Pilar López Teresa Donato Angel Montoya Amparo Larrauri Patricia Giménez Ramón Trullenque Ricardo Fabra José V. Castell | 1990 | In Vitro Cellular & Developmental Biology1990，，1： | 1 |
| 10 | Sunflower protein films incorporated with clove essential oil have potential application for the preservation of fish patties显示文摘 | Pablo R. Salgado M. Elvira López-Caballero M. Carmen Gómez-Guillén Adriana N. Mauri M. Pilar Montero | 2013 | Food Hydrocolloids2013，，1： | 1 |
| 11 | Catalytic performance for CO 2 conversion to methanol of gallium-promoted copper-based catalysts: influence of metallic precursors显示文摘 | Jamil Toyir Pilar Ram??rez de la Piscina José Luis G Fierro Narc??s Homs | 2001 | Applied Catalysis B Environmental2001，，4： | 1 |
| 12 | Genetic variability related to serum uric acid concentration and risk of Parkinson’s disease显示文摘 | Isabel González‐Aramburu Pascual Sánchez‐Juan Silvia Jesús Ana Gorostidi Eduardo Fernández‐Juan Fátima Carrillo María Sierra Pilar Gómez‐Garre María T. Cáceres‐Redondo José Berciano Javier Ruiz‐Martínez Onofre Combarros Pablo Mir Jon Infante | 2013 | Mov Disord2013，，： | 1 |
| 13 | Catalytic performance for CO2 conversion methanol of gallium-promoted copper-based catalysts: influence of metallic precursors 显示文摘 | Jamil T Pilar Ramirez de la Piscina Jose Luis G Fierro | 2001 | Applied Catalysis2001，，： | 1 |
| 14 | UV and MS identification of urolithins and nasutins, the bioavailable metabolites of ellagitannins and ellagic acid in different mammals 显示文摘 | Rocio G B Pilar T Hideyuki I | 2011 | J Agric Food Chem2011，59，： | 1 |
| 15 | The effect of financial constraints, absorptive capacity and complementarities on the adoption of multiple process technologies显示文摘 | JAIME G PILAR V | 2009 | Research Policy2009，，38： | 1 |
| 16 | Antimicrobial activity of reuterin in combination with nisin against food-borne pathogens显示文摘 | JUAN L A JAVIER F PILAR G | 2004 | International Journal of Food Microbiology2004，95，2： | 1 |
| 17 | Narcea—an unknown,ancient cultivated rose variety from northern Spain显示文摘The present work reports the discovery and the complete characterisation of an ancient cultivated rose variety found growing in a private garden in the southwest of the Principality of Asturias(northern Spain).The variety is here given the name Narcea.The majority of roses currently cultivated belong to the so-called group of‘Modern Roses’,all of which were obtained after 1867 via artificial crosses and improvement programmes.All are destined for ornamental use.Until the 19th century,the great majority of the many ancient cultivated roses in Europe were used in perfumery and cosmetics,or had medicinal uses.Rosa damascena and Rosa centifollia are still grown and used by the French and Bulgarian perfume industries.The Asturian Massif of the Cantabrian Mountain Range provides a natural habitat for some 75%of the wild members of the genus Rosa,but until now there was no evidence that this area was home to ancient cultivated roses.A complete botanical description is here provided for a discovered ancient rose.It is also characterised according to a series of sequence tagged microsatellite sites,and its agronomic features are reported.In addition,a histological description(optical and scanning electronic microscope studies)of the petals is offered,along with an analysis of the volatile compounds present in these organs as determined by solid phase microextraction and gas chromatography-mass spectroscopy.The results reveal the uniqueness of this ancient type of rose and suggest it may be of interest to the perfume industry. | María-Carmen Martínez José-Luis Santiago Susana Boso Pilar Gago InmaculadaÁlvarez-Acero María-Estela De Vega Miguel Martínez-Bartolomé RafaelÁlvarez-Nogal Pilar Molíst Matteo Caser Valentina Scariot Daniel Gómez-García | 2020 | Horticulture Research2020，7，1： | 1 |
| 18 | Metabolism of oak leaf ellagitannins and urolitbin production in beef cattle 显示文摘 | Rocia G B Pilar T Rocio G V | 2012 | J Agric Food Chem2012，86，： | 1 |
| 19 | Effects of intravenous albumin in patients with cirrhosis and episodic hepatic encephalopathy: A randomized double-blind study显示文摘 | Macarena Simón-Talero Rita García-Martínez Maria Torrens Salvador Augustin Susana Gómez Gustavo Pereira Mónica Guevara Pere Ginés Germán Soriano Eva Román Jordi Sánchez-Delgado Roser Ferrer Juan C. Nieto Pilar Sunyé Inma Fuentes Rafael Esteban Juan Córdob | 2013 | Journal of Hepatology2013，，6： | 1 |
| 20 | Congenital and acquired anomalies of the portal venous systerm显示文摘 | Carmen G Maria V Pilar M | 2002 | Radiographics2002，22，1： | 1 |
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