|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Late Glacial glacier-climate modeling in two valleys on the eastern slope of Samdainkangsang Peak, Nyaiqentanggulha Mountains显示文摘Well-preserved Late Glacial moraines in the Barenduo and Yuqiongqu valleys on the eastern slope of the Samdainkangsang Peak present an opportunity to reconstruct glacier extents and examine the character of the climate during the Late Glacial stage in the Nyaiqentanggulha Mountains.This study employs a coupled mass-balance and ice-flow model to reconstruct the glacier extents in the two valleys and assess the magnitudes of temperature and precipitation change during the Late Glacial period.Model results indicate that during the Late Glacial,the Barenduo valley contained an ice volume of 1.67×10~8m^3,with the equilibrium-line altitude(ELA)being^5500 m asl;and the Yuqiongqu valley had an ice volume of 5.56×10~8 m^3,with the ELA being^5470 m asl.A climate scenario,temperature depression of 2.6-2.8℃and 60-70%,percent of modern(1981-2010)precipitation,can sustain both of the Late Glacial glacier extents in the two valleys.A 50%increase or decrease from modern precipitation would have been coupled with the respective Late Glacial temperature depressions of 1.6 and 3.0℃in the Barenduo valley,and 2.1 and 2.8℃in the Yuqiongqu valley. | XU XiangKe DONG GuoCheng PAN BaoLin HU Gang BI WeiLi LIU JinHua YI ChaoLu | 2017 | Science China Earth Sciences2017，60，1： | 3 |
| 2 | Spatial homogenization of soil-surface pollen assemblages improves the reliability of pollen-climate calibration-set显示文摘To make a reliable reconstruction of past climate from soil-surface modern pollen,it is necessary to reduce the sources of error.In this paper,pollen percentages of the sub-continental scale modern pollen-climate dataset from China and Mongolia(with 68%soil-surface samples)are homogenized at various spatial scales.A tailored calibration-set is then applied to lake sediment-surface pollen assemblages from north-central China to evaluate their predictive power.Results indicate that spatial homogenization of modern pollen percentages can increase the proportion of inertia explained by climatic variables in CCA and improve the model performance of leave-one-out cross-validation using WA-PLS.Soil-surface pollen assemblages can thus be employed into a calibration-set for reliable climate estimation and they perform better when the calibration-set has been locally homogenized.Small-scale(e.g.,radii 2,5,or 10 km)homogenization reduces the local noise in soil-surface pollen assemblages and improves the cross-validated performance,while broader scale homogenization(more than 20 km radius)blurs the pollen-climate relationship.Lake sediment-surface pollen assemblages from close to the shore could contain pollen grains transported by rivers or from the shore vegetation and thus fail to represent regional climate well like the assemblages from the central part and deep-water area of lake. | Fang TIAN Xianyong CAO Ran ZHANG Qinghai XU Wei DING Xingqi LIU Baolin PAN Jianhui CHEN | 2020 | Science China Earth Sciences2020，63，11： | 1 |
| 3 | Suppressor of fused and Spop regulate the stability,processing and function of Gli2 and Gli3 full-length activators but not their repressors显示文摘 | Chengbing Wang Yong Pan Baolin Wang | | 0，，12： | 1 |
| 4 | Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response显示文摘Endothelial-to-mesenchymal transition(EndoMT),the process wherein endothelial cells lose endothelial identity and adopt mesenchymal-like phenotypes,constitutes a critical contributor to cardiac fibrosis.The phenotypic plasticity of endothelial cells can be intricately shaped by alteration of metabolic pathways,but how endothelial cells adjust cellular metabolism to drive EndoMT is incompletely understood.Here,we identified 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFKFB3)as a critical driver of EndoMT via triggering abnormal glycolysis and compromising mitochondrial respiration.Pharmacological suppression of PFKFB3 with salvianolic acid C(SAC),a phenolic compound derived from Salvia miltiorrhiza,attenuates EndoMT and fibrotic response.PFKFB3-haplodeficiency recapitulates the anti-EndoMT effect of SAC while PFKFB3-overexpression augments the magnitude of EndoMT and exacerbates cardiac fibrosis.Mechanistically,PFKFB3-driven glycolysis compromises cytoplasmic nicotinamide adenine dinucleotide phosphate(reduced form,NADPH)production via hijacking glucose flux from pentose phosphate pathway.Efflux of mitochondrial NADPH through isocitrate/α-ketoglutarate shuttle replenishes cytoplasmic NADPH pool but meanwhile impairs mitochondrial respiration by hampering mitochondrial iron-sulfur cluster biosynthesis.SAC disrupts PFKFB3 stability by accelerating its degradation and thus maintains metabolic homeostasis in endothelial cells,underlying its anti-EndoMT effects.These findings for the first time identify the critical role of PFKFB3 in triggering EndoMT by driving abnormal glycolysis in endothelial cells,and also highlight the therapeutic potential for pharmacological intervention of PFKFB3(with SAC or other PFKFB3 inhibitors)to combat EndoMT-associated fibrotic responses via metabolic regulation. | Hao Zeng Ting Pan Meiling Zhan Renaguli Hailiwu Baolin Liu Hua Yang Ping Li | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 1 |
| 5 | Holocene lake-level changes of Ling go Co in central Tibet显示文摘 | Pan Baolin Yi Chaolu Jiang Tao Dong Guocheng Hu Gang Jin Yao | | 0，，： | 1 |
| 6 | Antibacterial conductive self-healable supramolecular hydrogel dressing for infected motional wound healing显示文摘Wounds on stretchable parts of the human body cause prolonged suffering and involve more severe healing processes than wounds on stationary parts. However, they have received insufficient attention compared with other types of chronic wounds. In this study, a novel supramolecular gelatin(GT) hydrogel composed of GT-graft-aniline tetramer and quaternized chitosan was presented. The hydrogel was crosslinked by monoaldehyde β-cyclodextrin via host-guest interaction and dynamic Schiff base and was free from permanent covalent bonds, heavy metals, and oxidants. Given its dynamic feature, the hydrogel exhibited flexibility, self-healing, and tissue adhesiveness and well adapted to motion wounds. Moreover, the hydrogel was bioactive with conductivity, antioxidant property, hemostatic effect, antibacterial, and photothermal effect(the killing ratio for methicillinresistant Staphylococcus aureus(MRSA) was higher than 99.8% after 5 min of near-infrared irradiation) and exhibited ondemand removability. In the full-thickness MRSA-infected motional wound healing experiment, this novel hydrogel exhibited a significantly enhanced wound healing efficacy with a fast wound closure ratio(about 99.0% for 14 days), mild inflammatory response, high level of collagen deposition, and enhanced re-epithelialization by downregulating interleukin-6 and CD68 and upregulating vascular endothelial growth factor. The results indicated that this hydrogel has great potential in wound healing and skin tissue engineering and serves as an inspiration for the design of supramolecular biomaterials. | Rui Yu Zhenlong Li Guoying Pan Baolin Guo | 2022 | Science China Chemistry2022，65，11： | 0 |
| 7 | A Gas Kinetic Scheme for the Simulation of Compressible Multicomponent Flows显示文摘In this paper,a gas kinetic scheme for the compressible multicomponent flows is presented by making use of two-species BGK model in[A.D.Kotelnikov and D.C.Montgomery,A Kinetic Method for Computing Inhomogeneous Fluid Behavior,J.Comput.Phys.134(1997)364-388].Different from the conventional BGK model,the collisions between different species are taken into consideration.Based on the Chapman-Enskog expansion,the corresponding macroscopic equations are derived from this two-species model.Because of the relaxation terms in the governing equations,the method of operator splitting is applied.In the hyperbolic part,the integral solutions of the BGK equations are used to construct the numerical fluxes at the cell interface in the framework of finite volume method.Numerical tests are presented in this paper to validate the current approach for the compressible multicomponent flows.The theoretical analysis on the spurious oscillations at the interface is also presented. | Liang Pan Guiping Zhao Baolin Tian Shuanghu Wang | 2013 | Communications in Computational Physics2013，14，10： | 0 |
| 8 | Galerkin-based quasi-smooth manifold element(QSME)method for anisotropic heat conduction problems in composites with complex geometry显示文摘The accurate and efficient analysis of anisotropic heat conduction problems in complex composites is crucial for structural design and performance evaluation. Traditional numerical methods, such as the finite element method(FEM), often face a trade-off between calculation accuracy and efficiency. In this paper, we propose a quasi-smooth manifold element(QSME) method to address this challenge, and provide the accurate and efficient analysis of two-dimensional(2D) anisotropic heat conduction problems in composites with complex geometry. The QSME approach achieves high calculation precision by a high-order local approximation that ensures the first-order derivative continuity.The results demonstrate that the QSME method is robust and stable, offering both high accuracy and efficiency in the heat conduction analysis. With the same degrees of freedom(DOFs), the QSME method can achieve at least an order of magnitude higher calculation accuracy than the traditional FEM. Additionally, under the same level of calculation error, the QSME method requires 10 times fewer DOFs than the traditional FEM. The versatility of the proposed QSME method extends beyond anisotropic heat conduction problems in complex composites. The proposed QSME method can also be applied to other problems, including fluid flows, mechanical analyses, and other multi-field coupled problems, providing accurate and efficient numerical simulations. | Pan WANG Xiangcheng HAN Weibin WEN Baolin WANG Jun LIANG | 2024 | Applied Mathematics and Mechanics(English Edition)2024，45，1： | 0 |
| 9 | A novel carbon cycle process assisted by Ni/La_(2)O_(3) catalyst for enhanced thermochemical CO_(2) splitting显示文摘Thermochemical two-step CO_(2) splitting is a potential approach that fixes the sustainable resource into transportable liquid fuels.However,the harsh CO_(2) splitting conditions,the limited oxygen release kinetics and capacity of metal oxides block further promoted the CO yield and solar-to-fuel energy efficiency.Here,we propose a different carbon cycle assisted by Ni/La_(2)O_(3) via coupling methane decomposition with thermochemical CO_(2) splitting,replacing conventional metal oxides cycle.Superior performance was demonstrated with methane conversion reached around 94%with almost pure H_(2) generation.Encouragingly,CO_(2) conversion of 98%and CO yield of 6.9 mmol g^(-1) derived from CO_(2) were achieved,with peak CO evolution rate(402 mL min^(-1) g^(-1))of orders of magnitude higher than that in metal oxide process and outstanding thermodynamic solar-to-fuel energy efficiency(55.5%vs.18.5%).This was relevant to the synergistic activation of La_(2)O_(3) and Ni for CO_(2) in carbon cycle,thus improving CO_(2) splitting reaction with carbon species. | Yu Kang Yujia Han Cong Wei Kuo Liu Ming Tian Chuande Huang Chaojie Wang Jian Lin Baolin Hou Xiaoli Pan Yang Su Lin Li Riguang Zhang Yong Hao Xiaodong Wang | 2021 | Journal of Energy Chemistry2021，30，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员