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| 1 | Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections显示文摘Antibiotic-associated diarrhea(AAD) and Clostridum difficile infections(CDI) have been well studied for adult cases, but not as well in the pediatric population. Whether the disease process or response to treatments differs between pediatric and adult patients is an important clinical concern when following global guidelines based largely on adult patients. A systematic review of the literature using databases Pub Med(June 3, 1978-2015) was conducted to compare AAD and CDI in pediatric and adult populations and determine significant differences and similarities that might impact clinical decisions. In general, pediatric AAD and CDI have a more rapid onset of symptoms, a shorter duration of disease and fewer CDI complications(required surgeries and extended hospitalizations) than in adults. Children experience more community-associated CDI and are associated with smaller outbreaks than adult cases of CDI. The ribotype NAP1/027/BI is more common in adults than children. Children and adults share some similar risk factors, but adults have more complex risk factor profiles associated with more co-morbidities, types of disruptive factors and a wider range of exposures to C. difficile in the healthcare environment. The treatment of pediatric and adult AAD is similar(discontinuing or switching the inciting antibiotic), but other treatment strategies for AAD have not been established. Pediatric CDI responds better to metronidazole, while adult CDI responds better to vancomycin. Recurrent CDI is not commonly reported for children. Prevention for both pediatric and adult AAD and CDI relies upon integrated infection control programs, antibiotic stewardship and may include the use of adjunctive probiotics. Clinical presentation of pediatric AAD and CDI are different than adult AAD and CDI symptoms. These differences should be taken into account when rating severity of disease and prescribing antibiotics. | Lynne Vernice Mc Farland Metehan Ozen Ener Cagri Dinleyici Shan Goh | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 2 | Clinical outcomes of 25-gauge vitrectomy surgery for vitreoretinal diseases: comparison of vitrectomy alone and phaco-vitrectomy显示文摘AIM: To compare the clinical outcomes of combined25-gauge pars plana vitrectomy(PPV) and phacoemulsification/posterior chamber intraocular lens(PC-IOL) implantation with vitrectomy alone surgery in patients with various vitreoretinal diseases.METHODS: A total of 306 eyes(145 with PPV alone and 161 with phaco-vitrectomy) were enrolled in this retrospective analysis. The surgical approach was 25-gauge PPV combined with phacoemulsification and PC-IOL implantation at the same time in eyes in phaco-vitrectomy group and only PPV in eyes in vitrectomy alone surgery group. The main outcome measures were postoperative clinical outcomes included anterior chamber inflammation, changes in intraocular pressure(IOP) and best corrected visual acuity(BCVA).RESULTS: The most common postoperative complication was anterior chamber reaction which has higher incidence in phaco-vitrectomy group(P <0.001).The mean postoperative 1^(st) day IOP of vitrectomy alone group was significantly lower than that of phaco-vitrectomy group(16.3 ±5.8 mm Hg vs 17.8 ±8.1 mm Hg,respectively, P =0.02). Hypotony(IOP(8 mm Hg) was not different between groups in the postoperative 1^(st) day(P >0.05). The mean preoperative visual acuity was not different between groups(1.6±0.9 log MAR vs 1.8±0.9 log MAR,respectively, P >0.05). However, the mean visual acuity was decreased in vitrectomy alone group at the final visit compared to phaco-vitrectomy group(1.2 ±0.8 log MAR,0.9±0.7 log MAR, respectively P <0.05).CONCLUSION: Twenty-five gauge PPV combined with phacoemulsification surgery is a safe and efficient procedure, which can be preferred in phacic patients with a variety of vitreoretinal diseases compared to vitrectomy alone. Despite improved outcomes, this approach is not free of limitations as anterior chamber complications especially with combined surgery. | Mucella Arikan Yorgun Yasin Toklu Melek Mutlu Umut Ozen | 2016 | International Journal of Ophthalmology(English edition)2016，9，8： | 10 |
| 3 | An overlap syndrome involving autoimmune hepatitis and systemic lupus erythematosus in childhood显示文摘We report a 12 years old female patient with an overlap syndrome involving autoimmune hepatitis (AIH) and systemic lupus erythematosus (SLE). The patient presented with jaundice, hepatosplenomegaly, malaise, polyarthralgia, arthritis and butterfly rash on the face. Laboratory tests revealed severe liver dysfunction, Coombs positive hemolytic anemia and a positive ANA/anti-dsDNA test. Renal biopsy showed class IIA kidney disease, while liver biopsy showed chronic hepatitis with severe in? ammatory activity. The patient satisfi ed the international criteria for both SLE and AIH. Clinical symptoms and laboratory findings of SLE improved with high dose treatment with corticosteroids and azathioprine, however, remission of the liver disease could not be achieved. Repeat biopsy of the liver after three years of therapy revealed ongoing chronic hepatitis with high level of in? ammatory activity. The present case indicates that children with liver dysfunction and SLE should be investigated for AIH. There is much diagnostic and therapeutic dilemma in patients with AIH-SLE overlap syndrome. | Yusuf Usta Figen Gurakan Zuhal Akcoren Seza Ozen | 2007 | World Journal of Gastroenterology2007，13，19： | 7 |
| 4 | Comparison of non-cycloplegic photorefraction,cycloplegic photorefraction and cycloplegic retinoscopy in children显示文摘AIM: To compare the results of noncycloplegic photorefraction, cycloplegic photorefraction and cycloplegic refraction in preschool and non-verbal children.METHODS: One hundred and ninety-six eyes of 98children(50 females, 48 males) were included in the study. Firstly, non-cycloplegic photorefraction was achieved with Plusoptix A09; secondly, cycloplegic photorefraction was carried out with Plusoptix A09 after10 min cyclopentolate. Finally, 30 min after instillation of twice cyclopentolate, cycloplegic refraction was obtained with autorefraction and/or standard retinoscopy. Spheric equivalent, spheric power, cylindric power and cylindrical axis measurements were statistically compared.RESULTS: The mean age was 28.8±18.5mo(range12-72mo). The differences in spherical equivalent, spheric power and cylindrical power measured by the three methods were found statistically significant(P <0.05).The spherical equivalent and spheric power measured by cycloplegic photorefraction were statistically higher than the measurements of the other methods(P <0.05). The cylindrical power measured by cycloplegic refraction was statistically lower than the measurements of the photorefraction methods(P <0.05). There was no significant difference in cylindrical axis measurements between three methods(P >0.05).CONCLUSION: For the determination of refractive errors in children, the Plusoptix A09 measurements give incorrect results after instillation of cyclopentolate.Additionally, the cylindrical power measured by Plusoptix A09 with or without cycloplegia is higher. However, the non-cycloplegic Plusoptix A09 measures spheric equivalent and spheric power similar to cycloplegic refraction measurements in preschool and non-verbal children. | Ozdemir Ozdemir Zuhal Ozen Tunay Ikbal Seza Petricli Damla Ergintürk Acar Muhammet Kazim Erol | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 6 |
| 5 | Coronary artery bypass grafting in the octogenarians: should we intervene, or leave them be?显示文摘ObjectiveCoronary 动脉绕过 grafting (CABG ) 逐渐地在老人口正在增加。我们试图在 80 的年龄和 older.MethodsBetween 2002年1月和2011年12月在病人与长期的幸存一起调查风险因素和 CABG 的结果,在 80 的年龄的 101 个连续病人的一个总数并且更旧在我们的医院里经历了 CABG 的人,在学习被包括。病人被跟随,长期的幸存是病人的 estimated.ResultsThe 平均数年龄是 82.98 ±2.27 年。(63.4%) 64 是男性,(36.6%) 37 是女性。紧急情况外科,持续时间心肺绕过,特别护理单位(ICU ) 停留, inotropic 支持,大动脉的汽球跳动申请,红血球输送的数量和新鲜冻结的血浆输送和通风时期是的 intra 在在医院里死了的病人显著地更高。持续时间心肺绕过(CPB ) 被发现是死亡的一个独立预言者(或:1.18, 95% CI 1.01 − 1.38, P = 0.034 ) 。在里面医院死亡是 16.8% 。Kaplan-Meier 分析在一年揭示了 91.3% 的幸存比率, 82.9% 在三年并且 69.0% 在五 years.ConclusionsPatients 在 80 岁时并且更旧 CABG 过程的候选人能正在牢记他们可以有一个更长的通风时期和特别护理单位停留。这个年龄组的病态和死亡在一个可接受的范围以内被考虑。最小化 CPB 的途径,或离开泵外科的选择,可以是一个预防方法降低死亡的发生。因此, CABG 可以与令人满意的幸存比率在这个年龄组被执行。 | Anil Ozen Ertekin Utku Unal Murat Songur Sinan Sabit Kocabeyoglu Onur Hanedan Metin Yilmaz Basak Soran Turkcan Ferit Cicekcioglu Sadi Kaplan Cemal Levent Birincioglu | 2015 | Journal of Geriatric Cardiology2015，12，2： | 5 |
| 6 | Effect of Helicobacter pylori eradication on serum ghrelin and obestatin levels显示文摘AIM: To investigate changes in serum ghrelin and obestatin levels before and after Helicobacter pylori (H. pylori ) eradication. METHODS: A total of 92 patients presenting with symptoms of dyspepsia were enrolled in the study. Upper endoscopy was performed on all patients and used to diagnose H. pylori infection according to the presence of characteristic histopathological findings; seventy patients were diagnosed with H. pylori infection and the remaining 22 non-infected patients were classified as healthy controls. H. pylori eradication was accomplished by administering the classical triple therapy drug regimen, consisting of lansoprazole 30 mg bid , amoxicillin 1 g bid , and clarithromycin 500 mg tid for 14 d. The eradication of H. pylori was assessed with C14-urea breath test, which was performed at eight weeks after treatment. Levels of serum active ghrelin and obestatin were assessed at beginning of the study (prior to treatment) and after eight weeks. The levels were comparatively analyzed between the H. pylori negative control group, the H. pylori eradicated group, and the H. pylori non-eradicated group. RESULTS: A total of 92 patients, 50 females and 42 males with a mean age of 38.2 ± 11.9 years (range: 19-64), were analyzed. H. pylori eradication success was achieved in 74.3% (52/70) of H. pylori positive patients. The initial levels of ghrelin in the H. pylori positive and control cases were 63.6 ± 19.8 pg/mL and 65.1 ± 19.2 pg/mL (P=0.78), respectively, and initial obestatin levels were 771±427 pg/mL and 830 ± 296 pg/mL (P=0.19), respectively. The difference between the initial levels and the week 8 levels of ghrelin and obestatin in the control group was insignificant [4.5% (P=0.30) and -0.9% (P=0.65), respectively]. The difference between the initial and week 8 levels of ghrelin and obestatin in the H. pylori non-eradicated group were also insignificant [0.9% (P=0.64) and 5.3% (P=0.32), respectively]. The H. pylori eradicated group had a greater change in obestatin levels when compared to the control and the non-eradicated groups (148 ± 381 pg/mL vs -12±138 pg/mL and -72.8±203 pg/mL, respectively, P=0.015), while decreases in ghrelin levels were insignificant (-7.2 pg/mL vs -1.4 pg/mL and -1.9 pg/mL, respectively, P=0.52). The ghrelin/obestatin ratio for the initial and week 8 levels changed significantly in only the H. pylori eradicated group (0.11 vs 0.08, respectively, P=0.015). For overweight patients (as designated by body mass index), we observed significant increases in obestatin levels in the eradicated group as compared to non-eradicated group (201 ± 458 pg/mL vs -5 ± 81 pg/mL, respectively, P=0.02). In the H. pylori-eradicated group, the levels did not differ between the sexes for ghrelin (-6.3 ± 26.9 pg/mL vs -8.0 ± 24.0 pg/mL, respectively, P=0.97) or obestatin (210 ± 390 pg/mL vs 96 ± 372 pg/mL, respectively, P=0.23).CONCLUSION: Serum levels of ghrelin decreased while obestatin levels increased in H. pylori eradicated subjects, especially in overweight and male patients. | Celal Ulasoglu Banu Isbilen Levent Doganay Filiz Ozen Safak Kiziltas Ilyas Tuncer | 2013 | World Journal of Gastroenterology2013，19，15： | 5 |
| 7 | 年龄相关性黄斑变性的脉络膜厚度评价(英文)显示文摘目的:通过光学相干断层扫描(optical coherence tomography,OCT;RTVue 100-2;V 5.1,Optovue,Fremont,CA,USA)测量比较非新生血管性与新生血管性年龄相关性黄斑变性(age-related macular degeneration,AMD)黄斑中心凹下脉络膜厚度(subfoveal choroidal thickness,SFCT),并分析脉络膜厚度(choroidal thickness,CT)对AMD新血管形成的影响。方法:本研究为回顾性、横断面研究。以单侧眼患有新生血管性AMD且对侧眼患有非新生血管性AMD的24例患者(48眼)作为研究组,选取年龄与眼轴长度相匹配的40例健康眼作为对照组。非新生血管性AMD亚组研究对象是黄斑区有玻璃疣和/或色素变化眼,而新生血管性AMD亚组研究对象是由于脉络膜新生血管而致视网膜下或视网膜内有渗出液和/或脂性渗出眼。运用OCT垂直测量外侧高反射线(视网膜色素上皮层)到脉络膜巩膜交界面间的距离。选取7个不同点进行脉络膜厚度测量,测量区域为距黄斑中心凹颞侧和鼻侧1500μm范围,测量间距为500μm。测量结果在亚组间进行统计学对比研究。结果:研究组患者平均年龄为72.4±8.97(60~82)岁,对照组受试者平均年龄为71.2±8.8(58~81)岁。新生血管性AMD组中平均SFCT明显大于非新生血管性AMD组的厚度(P<0.05)。非新生血管性AMD组中,平均SFCT与平均鼻、颞侧脉络膜厚度比较,差异无统计学意义(P>0.05);而新生血管性AMD组中,平均SFCT与平均鼻、颞侧脉络膜厚度比较,差异有统计学意义(P<0.05)。结论:运用OCT对脉络膜厚度进行测量,有助于理解AMD的病理生理机制。然而,仍需要大型前瞻性研究来探求新生血管性AMD中SFCT增厚的原因。 | Erkan Unsal Kadir Eltutar Ozen Ayranci Osmanbasoglu Sibel Zιrtιloglu Osman Kιzιlay Hulya Gungel | 2014 | 国际眼科杂志2014，14，9： | 4 |
| 8 | Genetics and epigenetics of liver cancer显示文摘 | Cigdem Ozen Gokhan Yildiz Alper Tunga Dagcan Dilek Cevik Aysegul Ors Umur Keles Hande Topel Mehmet Ozturk | 2013 | New BIOTECHNOLOGY2013，，4： | 3 |
| 9 | A new international classification of childhood vasculitis显示文摘 | Michael J. Dillon Seza Ozen | 2006 | Pediatric Nephrology2006，，9： | 2 |
| 10 | Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric patients with suspected gastroesophageal reflux显示文摘AIM To evaluate the agreement of multichannel intraluminal impedance-p H monitoring(MII-p HM) and gastroesophageal reflux scintigraphy(GES) for the diagnosis of gastroesophageal reflux disease. METHODS Seventy-five consecutive patients with suspectedgastroesophageal reflux disease(GERD) underwent 24-h combined MII-p HM recording and one hour radionuclide scintigraphy during the course of the MIIpH M study. Catheters with 6 impedance channels and 1 p H sensor were placed transnasally. Impedance and p H data analysis were performed automatically and manually. For impedance monitoring, reflux was defined as a retrograde 50% drop in impedance, starting distally and propagating retrogradely to at least the next two more proximal measuring channels. Reflux index(RI, percentage of the entire record that esophageal p H is < 4.0) greater than 4.2% for p HM and number of refluxes more than 50 for 24 h for MII were accepted as positive test results. At scintigraphy, 240 frames of 15 seconds duration were acquired in the supine position. Gastroesophageal reflux was defined as at least one reflux episode in the esophagus. After scintigraphic evaluation, impedance-pH recordings and scintigraphic images were evaluated together and agreement between tests were evaluated with Cohen's kappa.RESULTS Sufficient data was obtained from 60(80%) patients(34 male, 56.7%) with a mean age of 8.7 ± 3.7 years(range: 2.5-17.3 years; median: 8.5 years). Chronic cough, nausea, regurgitation and vomiting were the most frequent symptoms. The mean time for recording of MII-pH M was 22.8 ± 2.4 h(range: 16-30 h; median: 22.7 h). At least one test was positive in 57(95%) patients. According to diagnostic criteria, GERD was diagnosed in 34(57.7%), 44(73.3%), 47(78.3%) and 51(85%) patients by means of p HM, MII, GES and MII-p HM, respectively. The observed percentage agreements/κ values for GES and p HM, GES and MII, GES and MII-p HM, and MII and p HM are 48.3%/-0.118; 61.7%/-0.042; 73.3%/0.116 and 60%/0.147, respectively. There was no or slight agreement between GES and p HM alone, MII alone or MII-p HM. p H monitoring alone missed 17 patients compared to combined MII-p HM. The addition of MII to pH monitoring increased the diagnosis rate by 50%.CONCLUSION No or slight agreement was found among p H monitoring, MII monitoring, MII-pH monitoring and GES for the diagnosis of gastroesophageal reflux disease. | Nuray Uslu Kizilkan Murat Fani Bozkurt Inci Nur Saltik Temizel Hülya Demir Aysel Yüce Biray Caner Hasan Ozen | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 11 | Numerical investigation of seismic performance of high modulus columns under earthquake loading显示文摘This paper presents the result of two-dimensional fi nite element modeling studies in order to investigate the seismic behavior of high modulus columns in liquefi able soil. Particular attention was paid to the shear stress reduction mechanism of the high modulus columns and the shear strain distribution between soil and columns during earthquake motion. Numerical analyses were performed using a nonlinear elasto-plastic model in Plaxis 2016. The reliability of the numerical simulations was verifi ed through the results of a centrifuge test model designed to investigate the contribution of high modulus columns in liquefaction mitigation. The capability of numerical simulations was assessed primarily through comparison of predicted acceleration-time histories, pore water pressures, and displacements with the measured counterparts. The results of the numerical analysis showed that the presence of the columns did not reduce seismic shear stresses in the soil when compared to the unimproved soil condition and pure shear behavior between soil and column did not develop as expected in the current design methodology. | Selcuk Demir Pelin Ozener | 2019 | Earthquake Engineering and Engineering Vibration2019，18，4： | 2 |
| 12 | The neuroprotective effect of dexmedetomidine in the hippocampus of rabbits after subarachnoid hemorrhage显示文摘 | Murat Cosar Olcay Eser Huseyin Fidan Onder Sahin Sadik Buyukbas Yuksel Ela Murat Yagmurca Oguz A. Ozen | 2009 | Surgical Neurology2009，，1： | 2 |
| 13 | Detection of adulteration of extra-virgin olive oil by chemometric analysis of mid-infrared spectral data显示文摘 | Gozde Gurdeniz Banu Ozen | 2009 | Food Chemistry2009，，2： | 2 |
| 14 | Effects of diode laser photocoagulation treatment on ocular biometric parameters in premature infants with retinopathy of prematurity显示文摘AIM:To investigate the effects of diode laser treatment on ocular biometric parameters in premature infants with retinopathy of prematurity(ROP).METHODS:Premature infants who received diode laser treatment for ROP(n=68)and premature infants with spontaneous regressed ROP without treatment(n=50)were performed longitudinal ocular biometric measurements including anterior chamber depth,lens thickness and axial length as follows:1 d prior to laser treatment,and 3,6,9,and 12 mo after the laser treatment.RESULTS:The mean birth weight,gestational age and initial examination time values were 936.53±302.07 g,26.66±2.42 wk,36.26±2.73 wk in the treatment group and 959.78±260.08 g,27.28±2.10 wk,36.56±2.54 wk in the control group.There was no statistically significant difference in these demographic characteristics of the groups.Anterior chamber depth,lens thickness and axial length demonstrated statistically significant linear increases during the study period in the two groups(P<0.001 for each).There were no statistically significant differences between the two groups in terms of anterior chamber depth after laser treatment.Measurements of the lens thickness at 9 th and 12 th months(9 th month 3.70±0.22 vs 3.60±0.21 mm,P=0.017;12 th month 3.81±0.21 vs 3.69±0.22 mm,P=0.002)and the axial length at 12 th month(19.35±0.79 vs 19.13±0.54 mm,P=0.031)after laser treatment were statistically higher in the treatment group.CONCLUSION:Diode laser retinal photocoagulation treatment in premature infants seems to increase the lens thickness and axial length. | Damla Erginturk Acar Ugur Acar Zuhal Ozen Tunay Aysegul Arman Anil Barak | 2021 | International Journal of Ophthalmology(English edition)2021，14，2： | 2 |
| 15 | 土耳其文版低视力生活质量量表的效度和信度研究(英文)显示文摘目的:把低视力相关的生活质量(LVQOL)文书改编为土耳其文,并评估其效度和信度。方法:这项研究是在387位参加安卡拉大学医学院,低视力康复中心的患者中进行的。使用Spearman相关系数,Cronbachα系数和验证性因素分析(CFA)进行统计分析。结果:根据CFA结果,在'调节能力'维的条目,因为有低于0.40的因子负荷故被排除在调查问卷之外。根据Cronbachα系数,对量表的信度进行了评估。'远视力,移动和光感'维的信度是α=0.863;'调节能力'维是α=0.694;'读和精细工作'α=0.791,'日常生活能力'α=0.770。因此,这些结果表明,用量表来衡量低视力患者的视力相关的生活质量是可靠的。对维之间的相关性也进行了分析,'调节能力'和'读和精细工作'之间的相关性被认为是最低的(rs=0.336,P<0.01),而'读和精细工作'与'日常生活能力'之间的相关性被发现是最强的。此外,'调节能力'仅与'远视力,移动和光感'表现最强的相关性。结论:删除第二个维中最后一个条目后,对LVQOL所有维的土耳其文改编已被证明是可靠的,有效的,适合在土耳其的低视力患者中使用。 | Aysun Idil Mehmet Ozen Nazli Atak Atilla Elhan Selcen Pehlivan | 2011 | 国际眼科杂志2011，11，11： | 2 |
| 16 | Highly Personalized Information Delivery to Mobile Clients显示文摘 | Ozen B Kilic O Altinel M | 2004 | Wireless Networks2004，10，6： | 1 |
| 17 | Widespread deregulation of microRNA expression in human prostate cancer显示文摘 | Ozen M Creighton C J Ozdemir M Ittmann M | 2008 | Oncogene2008，27，12： | 1 |
| 18 | Primary osteosarcoma of the heart: experience of an unusual case显示文摘 | Karagoz Ozen DS Ozturk MA Selcukbiricik F | 2013 | Case Rep Oncol2013，6，1： | 1 |
| 19 | EULA R/PReS endorsed con- sensus critena for the classification of childhood vasculitldes 显示文摘 | Ozen S Ruperto N Dillon MI | 2006 | Ann Rheum DIS2006，65，7： | 1 |
| 20 | EULAR/PReS endorsed consensus criteria for the classification of childhood vasculitides显示文摘 | Ozen S Ruperto N Dillon MJ | 2006 | Ann Rheum Dis2006，65，7： | 1 |
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