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| 1 | Antithrombin in the treatment of burn trauma显示文摘Antithrombin(AT) is a natural anticoagulant with antiinflammatory properties that has demonstrated value in sepsis, disseminated intravascular coagulation and in burn and inhalation injury. With high doses, AT maydecrease blood loss during eschar excision, reducing blood transfusion requirements. There are no human randomized, placebo-controlled studies, which have tested the true benefit of this agent in these conditions. Two main forms of AT are either plasma-derived AT(ph AT) and recombinant AT(rh AT). Major ovine studies in burn and smoke inhalation injury have utilized rh AT. There have been no studies which have either translated the basic rh AT research in burn trauma, or determined the tolerance and pharmacokinetics of rh AT concentrate infusions in burn patients. Advantages of rh AT infusions are no risk of blood borne diseases and lower cost. However, the majority of human burn patient studies have been conducted utilizing ph AT. Recent Japanese clinical trials have started using ph AT in abdominal sepsis successfully. This review examines the properties of both ph AT and rh AT, and analyzes studies in which they have been utilized. We believe that it is time to embark on a randomized placebo-controlled multi-center trial to establish the role of AT in both civilian and military patients with burn trauma. | Areta Kowal-Vern Bruce A Orkin | 2016 | World Journal of Critical Care Medicine2016，5，1： | 4 |
| 2 | 小肠梗阻保守治疗与手术治疗的比较 | Williams S.B. Greenspon J. Young H.A. Orkin B.A. 陈云茹 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，11： | 2 |
| 3 | A molecular roadmap for induced multi-lineage transdifferentiation of fibroblasts by chemical combinations显示文摘 | Xiaoping Han Hao Yu Daosheng Huang Yang Xu Assieh Saadatpour Xia Li Lengmei Wang Jie Yu Luca Pinello Shujing Lai Mengmeng Jiang Xueying Tian Fen Zhang Yanhong Cen Yuko Fujiwara Wei Zhu Bin Zhou Tianhua Zhou Hongwei Ouyang Jianan Wang Guo-Cheng Yuan Shumin Duan Smart H Orkin Guoji Guo | 2017 | Cell Research2017，27，3： | 2 |
| 4 | Report and recommendations of the panel to assess the investment in research on gene therapy 显示文摘 | Orkin S Motulsky A | 1995 | Bethesda (MD) ' National Institute of Health1995，，： | 1 |
| 5 | Hematopoiesis and stem cells:plasticity versus developmental heterogeneity显示文摘 | Orkin SH Zon LI | 2002 | Nat Immunol2002，3，4： | 1 |
| 6 | Excellent outcome using selective criteria for rectocele repair显示文摘 | Murthy VK Orkin BA Smith LE | 1996 | Dis Colon Rectum1996，39，4： | 1 |
| 7 | The relationship of the position of crown margins to gingival health 显示文摘 | Orkin DA Reddy J Bradshaw D | 1987 | J Prost t Dent1987，57，： | 1 |
| 8 | Hematopoiesis and stem cel s:plasticity versus developmental heterogeneity显示文摘 | Orkin SH Zon LI | | 0，，04： | 1 |
| 9 | In vitro differentiation of murine embryonic stem cells显示文摘 | ORKIN S H | 1996 | J Clin Invest1996，97，3： | 1 |
| 10 | Abnormal RNA prcessing due to the exon mutation of the βE-globin gene显示文摘 | OrKin SH KazazianJr HH Antonarakis SE | 1982 | Nature1982，300，5894： | 1 |
| 11 | Hematopoiesis and stem cells:plasticity versus developmental heterogeneity显示文摘 | Orkin S H Zon L I | 2002 | Nat Immunol2002，3，： | 1 |
| 12 | Hemorrhoids: what the dermatologist should know显示文摘 | Orkin BA Schwartz AM Orkin M | 1999 | J Am Acad Dermatol1999，41，3： | 1 |
| 13 | Sofosbuvir plus riba- virin for treatment of hepatitis C virus in patients co-in- fected with HIV (PHOTON-2) : a multicentre, open-label, non-randomised, phase 3 study显示文摘 | Molina JM Orkin C Iser DM | 2015 | Lancet2015，385，9973： | 1 |
| 14 | Functional synergy and physical interaction of the Krtippel transcription factor GATA-1 with the Kriippel family proteins SPI and EKLF显示文摘 | MERIKA M ORKIN S | 1995 | Mol Cell Biol1995，15，： | 1 |
| 15 | Computer analysis of postanesthetic deaths 显示文摘 | Marx GF Mateo CV Orkin LR | 1973 | Anesthesiology1973，39，1： | 1 |
| 16 | In vitro differentiation of murine embryonic stem cells:new approaches to old problems显示文摘 | Weiss MJ Orkin SH | 1996 | Clin Invest1996，97，： | 1 |
| 17 | Absense of blood formation in mice lacking the T cell leukaemia oncoprotein tali/SCL 显示文摘 | SHIVDASANI R MAYER E ORKIN S | 1995 | Nature1995，373，： | 1 |
| 18 | Networking erythropoiesis显示文摘 | Kerenyi MA Orkin SH | 2010 | J Exp Med2010，207，12： | 1 |
| 19 | Platelet-derived growth factor A china:gene structure,chromosomal location,and basis for alternative mRNA splicing显示文摘 | Bonthron DT Morton CC Orkin SH | 1988 | Proc Natl Acad Sci USA1988，85，5： | 1 |
| 20 | Boosting your bottom line with yield management 显示文摘 | Orkin E B | 1988 | Comell Hotel and Restaurant Aclministration Quarterly1988，28，4： | 1 |
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