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| 1 | Treatment with NADPH oxidase inhibitor apocynin alleviates diabetic neuropathic pain in rats显示文摘Increased reactive oxygen species by the activation of NADPH oxidase(NOX) contributes to the development of diabetic complications.Apocynin,a NOX inhibitor,increases sciatic nerve conductance and blood flow in diabetic rats.We investigated potential protective effect of apocynin in rat diabetic neuropathy and its precise mechanism of action at molecular level.Rat models of streptozotocin-induced diabetes were treated with apocynin(30 and 100 mg/kg per day,intragastrically) for 4 weeks.Mechanical hyperalgesia and allodynia were determined weekly using analgesimeter and dynamic plantar aesthesiometer.Western blot analysis and histochemistry/immunohistochemistry were performed in the lumbar spinal cord and sciatic nerve respectively.Streptozotocin injection reduced pain threshold in analgesimeter,but not in aesthesiometer.Apocynin treatment increased pain threshold dose-dependently.Western blot analysis showed an increase in catalase and NOX-p47 phox protein expression in the spinal cord.However,protein expressions of neuronal and inducible nitric oxide synthase(n NOS,i NOS),superoxide dismutase,glutathion peroxidase,nitrotyrosine,tumor necrosis factor-α,interleukin-6,interleukin-1β,aldose reductase,cyclooxygenase-2 or MAC-1(marker for increased microgliosis) in the spinal cord remained unchanged.Western blot analysis results also demonstrated that apocynin decreased NOX-p47 phox expression at both doses and catalase expression at 100 mg/kg per day.Histochemistry of diabetic sciatic nerve revealed marked degeneration.n NOS and i NOS immunoreactivities were increased,while S-100 immunoreactivity(Schwann cell marker) was decreased in sciatic nerve.Apocynin treatment reversed these changes dose-dependently.In conclusion,decreased pain threshold of diabetic rats was accompanied by increased NOX and catalase expression in the spinal cord and increased degeneration in the sciatic nerve characterized by increased NOS expression and Schwann cell loss.Apocynin treatment attenuates neuropathic pain by decelerating the increased oxidative stress-mediated pathogenesis in diabetic rats. | Murat Olukman Aytül onal Fatma Gül celenk Yigit Uyankgil Türker cavusoglu Neslihan Düzenli Sibel ülker | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 2 | One-year experience in the retinopathy of prematurity: frequency and risk factors, short-term results and follow-up显示文摘· AIM: As a result of the increase in premature births and the advances in neonatal intensive care, retinopathy of prematurity (ROP) remains one of the most important causes of childhood blindness worldwide. The main factors in the development of ROP are gestational age, birth weight and oxygen therapy. ROP continues to gain importance due to the increasing survival rates of more immature babies. · METHODS: Between January 2007 and October 2008, 203 premature infants treated at the Neonatal Intensive Care Unit (NNICU) were prospectively enrolled and the relationship between known risk factors and the occurance of ROP was studied. · RESULTS: ROP in various stages developed in 86 cases (42.4%). Statistically significant correlations were found between the development of ROP and birth weight (P < 0.0001) gestational age (P <0.0001), oxygen treatment and its duration (P <0.0001 and P =0.002), mechanical ventilation (MV) and its duration (P =0,0001 and P =0.0001), apnea(P = 0.001), intraventricular hemorrhage (IVH) (P =0.046), sepsis (P =0.0001), use of erythropoietin (EPO) (P =0.003), the number of blood transfusions and frequency (P =0.0001 and P =0.0001), surfactant application (P =0.0001), the presence of patent ductus arteriosus (PDA) (P =0.001) or bronchopu- lmonary dysplasia (BPD) (P =0.0001). No significant correlations were found between the occurance of ROP and maternal pre-eclampsia (P =0.293), multiple pregnancy (P = 0.218), or hyperbilirubinemia (P =0.494). Severity of ROP was related significantly with birth weight (P =0.0001), but no significant correlation between severity of ROP and gestational age was present. · CONCLUSION: Early description and reduction of the risk factors related with the occurance of ROP with the help of routine screening programs may warrant the prevention of visual loss, however early ophthalmic diagnosis and treatment are still mandatory to provide better visual rehabilitation. · | Sariaydin Mehmet Atlihan Fusun Calkavur Sebnem Olukman Ozgur Ercan Gulten Ozturk Arif Taylan Kaya Kilic Fatma Gokaslan Filiz Altinyaprak Derya Malatyali Rana | 2011 | International Journal of Ophthalmology(English edition)2011，4，6： | 2 |
| 3 | Apocynin restores endo- thelial dysfunction in streptozotocin diabetic rats through regulation of nitric oxide synthase and NADPH oxidase expressions 显示文摘 | Olukman M Orhan CE Celenk FG | 2010 | J Diabetes Complications2010，24，6： | 1 |
| 4 | Pulmonary involvement in childhood brucellosis: a case report 显示文摘 | Olukman O | 2008 | Vector Borne Zoonotie Dis2008，8，2： | 1 |
| 5 | Urotensin II receptor antagonism confers vasoprotective effects in diabetes associated atherosclerosis: studies in humans and in a mouse model of diabetes显示文摘 | A. M. D. Watson M. Olukman C. Koulis Y. Tu D. Samijono D. Yuen C. Lee D. J. Behm M. E. Cooper K. A. M. Jandeleit-Dahm A. C. Calkin T. J. Allen | 2013 | Diabetologia2013，，5： | 1 |
| 6 | Apocynin restores endothelial dysfunction in streptozotocin diabetic rats through regulation of nitric oxide synthase and NADPH oxidase expressions显示文摘 | Olukman M Orhan CE Celenk FG | 2010 | Diabetes Complications2010，24，6： | 1 |
| 7 | Reversal of doxorubicin-induced vascular dysfunction by resveratrol in rat thoracic aorta: Is there a possible role of nitric oxide synthase inhibition? 显示文摘 | Olukman M Can C Erol A | 2009 | Anadolu Kardiyol Derg2009，9，4： | 1 |
| 8 | Urotensin II receptor an- tagonism confers vasoprotective effects in diabetes associated ather- osclerosis : studies in humans and in a mouse model of diabetes 显示文摘 | Watson AM Olukman M Koulis C | 2013 | Diabetologia2013，56，5： | 1 |
| 9 | Apocynin restores endo- thelial dysfunction in streptozotocin diabetic rats through regulation of nitric oxide synthase and NADPH oxidase expressions显示文摘 | Olukman M Orhan CE Celenk FG | 2010 | J Di- abetes Complieations2010，24，6： | 1 |
| 10 | Genetic factors that influence short-term neurodevelopmental outcome in term hypoxic-ischaemic en- cephalopathic neonates显示文摘 | Calkavur S Akisu M Olukman O | 2011 | Int Med Res2011，39，5： | 1 |
| 11 | Comparison of oral and intravenous Ibuprofen for medical closure of patent ductus arteriosus:which one is better?显示文摘 | Olukman O Calkavur S Ercan G | 2012 | Congenit Heart Dis2012，7，6： | 1 |
| 12 | Pulmonary involvement in childhood brucellosis:a case report显示文摘 | OLUKMAN O | 2008 | Vector Borne Zoonotic Dis2008，8，2： | 1 |
| 13 | Apocynin restores en- dothelial dysfunction in streptozotocin iabetic rats through regulation of nitric oxide synthase and NADPH oxidase expressions 显示文摘 | Olukman M Orhan CE Celenk FG | 2010 | J Di- abetes Complications2010，24，6： | 1 |
| 14 | UrotensinⅡreceptor antagonism confers vasoprotective effects in diabetes associated atherosclerosis:studies in humans and in a mouse model of diabetes显示文摘 | Watson AM Olukman M Koulis C | 2013 | Diabetologia2013，56，5： | 1 |
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