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| 1 | Obesity in kidney disease:A heavyweight opponen显示文摘Obesity is an important worldwide challenge that must be faced in most developed and developing countries because of unhealthy nutritional habits.The consequences of obesity and being overweight are observed in different organs,but the kidney is one of the most affected.Excess adipose tissue causes hemodynamic alterations in the kidney that can result in renal disease.However,obesity is also commonly associated with other comorbidities such as chronic inflammation,hypertension and diabetes.This association of several aggravating factors is still a matter of concern in clinical and basic research because the pathophysiologic mechanisms surrounding chronic kidney disease development in obese patients remain unclear.This review will discuss the consequences of obesity in the context of renal injury. | Raphael Jose Ferreira Felizardo Marina Burgos da Silva Cristhiane Favero Aguiar Niels Olsen Saraiva Camara | 2014 | World Journal of Nephrology2014，3，3： | 7 |
| 2 | Effects of landscape composition and wetland fragmentation on frog and toad abundance and species richness in Iowa and Wisconsin,USA显示文摘 | Knutson MG Sauer JR Olsen DA Mossman MJ Hemesath LM Lannoo MJ | 1999 | Conservation Biology1999，13，： | 1 |
| 3 | Old game, new players: Linking classical theories to new trends in transplant immunology显示文摘The evolutionary emergence of an efficient immune system has a fundamental role in our survival against pathogenic attacks. Nevertheless, this same protective mechanism may also establish a negative consequence in the setting of disorders such as autoimmunity and transplant rejection. In light of the latter, although research has long uncovered main concepts of allogeneic recognition, immune rejection is still the main obstacle to long-term graft survival. Therefore, in order to define effective therapies that prolong graft viability, it is essential that we understand the underlying mediators and mechanisms that participate in transplant rejection. This multifaceted process is characterized by diverse cellular and humoral participants with innate and adaptive functions that can determine the type of rejection or promote graft acceptance. Although a number of mediators of graft recognition have been described in traditional immunology, recent studies indicate that defining rigid roles for certain immune cells and factors may be more complicated than originally conceived. Current research has also targeted specific cells and drugs that regulate immune activation and induce tolerance. This review will give a broad view of the most recent understanding of the allogeneic inflammatory/tolerogenic response and current insights into cellular and drug therapies that modulate immune activation that may prove to be useful in the induction of tolerance in the clinical setting. | Marina Burgos da Silva Flavia Franco da Cunha Fernanda Fernandes Terra Niels Olsen Saraiva Camara | 2017 | World Journal of Transplantation2017，7，1： | 1 |
| 4 | Quantification of HER2autoantibodies in the amplification phenomenon of HER2 in breastcancer 显示文摘 | Lauterlein JJ Petersen ER Olsen DA | 2011 | Clin Chem Lab Med2011，49，5： | 1 |
| 5 | Prognostic impact ofplacenta growth factor and vascular endothelial growth factor A inpatients with breast cancer 显示文摘 | Maae E Olsen DA Steffensen KD | 2012 | Breast Cancer Res Treat2012，133，1： | 1 |
| 6 | Colorectal cancer screening: Clinical guidelines and rationale显示文摘 | SJ Winawer RH Fletcher L Miller F Godlee MH Stolar CD Mulrow SH Woolf SN Glick TG Ganiats JH Bond L Rosen JG Zapka SJ Olsen FM Giardiello JE Sisk R Van Antwerp C Brown-Davis DA Marciniak RJ Mayer | 1997 | Gastroenterology1997，，2： | 1 |
| 7 | The high concentration of Arg213--Gly extracellular superoxide dismutase (EC-SOD) in plasma is caused by a reduction of both heparin and collagen affinities 显示文摘 | Ptersen SV Olsen DA Kenney JM | 2005 | Biochem J2005，385，2： | 1 |
| 8 | Furin proteolytically processes the heparin binding region of extracellular superoxide dismutase 显示文摘 | Bowler RP Nicks M Olsen DA | 2002 | J Biol Chem2002，277，16： | 1 |
| 9 | Serial measurements of serum PDGF-AA,PDGF-BB,FGF2,and VEGF in multiresistant ovarian cancer patients treated with bevacizumab显示文摘 | Madsen GV Steffensen KD Olsen DA | 2012 | J Ovarian Res2012，，： | 1 |
| 10 | Carcinomatous encephalitis: CT and MR findings显示文摘 | Olsen WL Winkler ML Ross DA | 1987 | AJNR Am J Neuroradiol1987，8，3： | 1 |
| 11 | A role for alphal lbetal integrin in the human periodontal ligament 显示文摘 | Barczyk MM Olsen LH da Franca P | 2009 | J Dent Res2009，88，7： | 1 |
| 12 | Colorectal cancer screening: Clinical guidelines and rationale显示文摘 | SJ Winawer RH Fletcher L Miller F Godlee MH Stolar CD Mulrow SH Woolf SN Glick TG Ganiats JH Bond L Rosen JG Zapka SJ Olsen FM Giardiello JE Sisk R Van Antwerp C Brown-Davis DA Marciniak RJ Mayer | 1997 | Gastroenterology1997，，2： | 1 |
| 13 | Prognostic im- pact of placenta growth factor and vascular endothelial growth factor A in patients with breast'cancer 显示文摘 | Maae E Olsen DA Steffensen KD | 2012 | Breast Cancer Res Treat2012，133，1： | 1 |
| 14 | The proteome of central and peripheral retina with progression of agerelated macular degeneration 显示文摘 | Ethen CM Reilly C Feng X Olsen TW Ferrington DA | 2006 | Invest Ophthalmol Vis Sci2006，47，6： | 1 |
| 15 | Prognostic impact of pla- centa growth factor and vascular endothelial growth factor A in pa- tients with breast cancer 显示文摘 | Maae E Olsen DA Steffensen KD | 2012 | Breast Cancer Res Treat2012，133，1： | 1 |
| 16 | Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase显示文摘 | Bowler RP Nicks M Olsen DA | 2002 | J Biol Chem2002，277，16： | 1 |
| 17 | Aver- sive parenting in China: associations with child physical and relational aggression 显示文摘 | Nelson DA Hart CH Yang C Olsen JA Jin S | 2006 | Child Development2006，，1： | 1 |
| 18 | Prognostic impact of placenta growth factor and vascular endothelial growth factor A in patients with breast cancer 显示文摘 | Maae E Olsen DA Steffensen KD | 2012 | Breast Cancer Res Treat2012，33，： | 1 |
| 19 | Serial measurements of serum PDGF-AA, PDGF-BB, FGF2, and VEGF in multiresistant o- varian cancer patients treated with bevaeizumab显示文摘 | Madsen CV Steffensan KD Olsen DA | 2012 | J Ovarian Res2012，5，1： | 1 |
| 20 | Phylogeographic studies in plants: problems and prospects显示文摘 | Schaal BA Hayworth DA Olsen KM Rauscher JT Smith WA | 1998 | Mol Ecol1998，7，4： | 1 |
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