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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | 辅助生殖的妊娠结局显示文摘研究目的研究人类辅助生殖(AHR)的围生期结局,明确出生结局和AHR需要进一步研究的领域,为优化产科处理和辅助生殖技术的咨询工作提供指南。研究结果文章比较了各种AHR技术的围生期结局,并与自然受孕者进行比较,有助于临床医师更好理解AHR相关的产科并发症、不良围生期结局、多胎妊娠、先天性结构畸形、染色体异常、基因印记疾病。证据来源使用合适的词汇和关键字(辅助生殖、辅助生殖技术、促排卵、胞浆内单精子显微注射、胚胎移植、体外授精)检索MEDLINE和Cochrane图书馆2005年1月至2012年12月的文献。研究结果并不只限系统综述、随机对照试验/对照临床试验和观察性研究,所有的2005年1月至2012年12月英语研究都包括在内,还包括根据书目查找的文章。定期更新检索,纳入了2013年8月之前的指南。灰色(未发表)的文献是通过查询卫生技术评估和卫生技术评估相关机构、临床实践指南的集合,临床试验登记处,以及国家和国际医疗专业团体而获得的。价值本文的的证据等级根据加拿大预防保健专责小组报告的标准评定(表1)。 | Nanette Okun Sony Sierra 李炎燚 | 2014 | 中国产前诊断杂志(电子版)2014，，2： | 3 |
| 3 | Toll-like receptor signaling in neural plasticity and disease显示文摘 | Eitan Okun Kathleen J. Griffioen Mark P. Mattson | 2011 | Trends in Neurosciences2011，，5： | 2 |
| 4 | Resistance exercise decreases the need for insulin in overweight women with gestational diabetes mellitus显示文摘 | Gabrielle N Brankston B.F Mitchell Edmond A Ryan Nanette B Okun | 2004 | American Journal of Obstetrics and Gynecology2004，，1： | 2 |
| 5 | Differential diagnosis in patients with suspected bile acid synthesis defects显示文摘AIM: To investigate the clinical presentations associated with bile acid synthesis defects and to describe identification of individual disorders and diagnostic pitfalls. METHODS: We describe semiquantitative determination of 16 urinary bile acid metabolites by electrospray ionization-tandem mass spectrometry. Sample preparation was performed by solid-phase extraction. The total analysis time was 2 min per sample. We determined bile acid metabolites in 363 patients with suspected defects in bile acid metabolism. RESULTS: Abnormal bile acid metabolites were found in 36 patients. Two patients had bile acid synthesis defects but presented with atypical presentations. In 2 other patients who were later shown to be affected by biliary atresia and cystic fibrosis the profile of bile acid metabolites was initially suggestive of a bile acid synthesis defect. Three adult patients suffered from cerebrotendinous xanthomatosis. Nineteen patients had peroxisomal disorders, and 10 patients had cholestatic hepatopathy of other cause. CONCLUSION: Screening for urinary cholanoids should be done in every infant with cholestatic hepatopathy as well as in children with progressive neurological disease to provide specific therapy. | Dorothea Haas Hongying Gan-Schreier Claus-Dieter Langhans Tilman Rohrer Guido Engelmann Maura Heverin David W Russell Peter T Clayton Georg F Hoffmann Jürgen G Okun | 2012 | World Journal of Gastroenterology2012，18，10： | 2 |
| 6 | Cognitive declines after unilateral deep brain stimulation surgery in Parkinson's disease: a controlled study using reliable change, part II 显示文摘 | MikJos A Zahodne L Okun MS | 2010 | Clin Neuropsychol2010，24，2： | 1 |
| 7 | Risk and protective factors for suicidal behavior in abused African American women显示文摘 | Kaslow N J Thompson MP Okun A | 2002 | J Consult Clin Psycho12002，70，： | 1 |
| 8 | Histochemical differentiation peroxidase-mediated from tyrosinase-mediates formation in mammalian tissue显示文摘 | Okun M R Edelstein M L Hamada O N G | 1970 | Hisochemie1970，23，： | 1 |
| 9 | Antibiotics for Bacterial Vaginosis or Trichomonas in Pregnancy:A Systematic Review显示文摘 | Okun N Gronau KA Hannah ME | 2005 | Obstet & Gynecol2005，105，4： | 1 |
| 10 | Depression associated with Parkinson's disease: Clinical features and treatment显示文摘 | Okun MS Watts RL | 2002 | Neurology2002，，： | 1 |
| 11 | Toll - like receptors in ischemia - reperfusion injury显示文摘 | Arumugam TV Okun E Tang SC | 2009 | Shock2009，32，1： | 1 |
| 12 | Sleep disruption during pregnancy: how does it influence serum cytokines?显示文摘 | Okun ML Coussons-Read ME | 2007 | J Reprod Immunol2007，73，2： | 1 |
| 13 | Antibiotics for bacterial vaginalis in preg- nancy显示文摘 | Okun N Gronau KA Hannah MF | 2005 | Obstet Gynecol2005，105，： | 1 |
| 14 | Supervised locally linear embeddlng显示文摘 | RIDDER D D KOUROPTEVA O OKUN O | 2003 | Lecture Notes in Computer Sci ence2003，34，10： | 1 |
| 15 | Depressionsymptoms in movement disorders: comparing Parkinson's disease,dystonia, and essential tremor 显示文摘 | Miller KM Okun MS Fernandez HF | 2007 | Mov Disord2007，22，： | 1 |
| 16 | Psyehosoeial stress increases inflammatory markers and alters cytokine production across pregnancy显示文摘 | COUSSONS-READ M E OKUN M L NETTLLES C D | 2007 | Brain Behavior and Immunity2007，21，3： | 1 |
| 17 | Preferential inhibition by a novel Na^+/Ca^2+ channel blocker NS27 of severe to mild hypoxic injury in rat cerebral cortical slices:a possible involvement of a highly voltage-dependent blockade of Ca^2+ channel显示文摘 | OKUN N ITOH Y ULCAI Y | 2000 | J Pharmacol Exp Ther2000，293，3： | 1 |
| 18 | Prenatal stress alters cytokine levels in a manner that may endanger human pregnancy显示文摘 | Coussons R M E Okun Michele L M A | 2005 | American Psychosomatic Society Volum2005，67，4： | 1 |
| 19 | Antibiotics for bacterialvaginosis or trichomonas vaginalis in pregnancy: a systematicreview显示文摘 | Okun N Gronau KA Hannah ME | 2005 | Obstet Gynecol2005，105，4： | 1 |
| 20 | Babinski's clinical differentiation of organic paralysis from hysterical paralysis:effect on US neurology显示文摘 | Okun MS Koehler PJ | 2004 | Arch Neurol2004，61，5： | 1 |
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