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| 1 | Renal sympathetic denervation in therapy resistant hypertension-pathophysiological aspects and predictors for treatment success显示文摘Many forms of human hypertension are associated with an increased systemic sympathetic activity. Especially the renal sympathetic nervous system has been found to play a prominent role in this context. Therefore, catheterinterventional renal sympathetic denervation(RDN) has been established as a treatment for patients suffering from therapy resistant hypertension in the past decade. The initial enthusiasm for this treatment was markedly dampened by the results of the Symplicity-HTN-3 trial, although the transferability of the results into clinical practice to date appears to be questionable. In contrast to the extensive use of RDN in treating hypertensive patients within or without clinical trial settings over the past years, its effects on the complex pathophysiological mechanisms underlying therapy resistant hypertension are only partly understood and are part of ongoing research. Effects of RDN have been described on many levels in human trials: From altered systemic sympathetic activity across cardiac and metabolic alterations down to changes in renal function. Most of these changes could sustainably change long-term morbidity and mortality of the treated patients, even if blood pressure remains unchanged. Furthermore, a number of promising predictors for a successful treatment with RDN have been identified recently and further trials are ongoing. This will certainly help to improve the preselection of potential candidates for RDN and thereby optimize treatment outcomes. This review summarizes important pathophysiologic effects of renal denervation and illustrates the currently known predictors for therapy success. | Karl Fengler Karl Philipp Rommel Thomas Okon Gerhard Schuler Philipp Lurz | 2016 | World Journal of Cardiology2016，8，8： | 5 |
| 2 | Comparison of antioxidant activity of insulin, Ocimum gratissimum L., and Vernonia amygdalina L. in type 1 diabetic rat model显示文摘OBJECTIVE: Diabetes mellitus(DM) is known to be associated with increase of oxidative stress products. The direction of effect of any treatment on these products could therefore be a reliable measure of its efficacy on DM. So the aim of this study was to investigate the activity of insulin, Ocimum gratissimum L.(OG) and Vernonia amygdalina L.(VA) on oxidative stress products.METHODS: Thirty-six female Wistar rats weighing 150–200 g were randomly divided into six groups of six rats each. Thirty rats were induced for type 1 DM(DM1) with a single intraperitoneal administration of 65 mg/kg body weight of streptozotocin. Group 1 was normal control and was administered distilled water while Group 2 served as DM1 control group; Groups 3, 4, 5 and 6 were diabetic rats treated with 208 mg/kg OG(DM1 + OG), 52 mg/kg VA(DM1 + VA), 208 mg/kg OG + 52 mg/kg VA(DM1+OG +VA) and 0.16 IU insulin(DM1 + insulin) respectively. Determination of methemoglobin and sulfhemoglobin was achieved by the absorption spectrum principle. Red blood cell(RBC) catalase was assayed by continuous spectrophotometric method.RESULTS: The RBC catalase concentration was significantly decreased in the DM1 and DM1+VA groups when compared with the normal control. DM1 + OG significantly increased RBC-catalase when compared to DM1. The methemoglobin concentration was significantly reduced in the DM1, DM1 + VA, DM1 + OG + VA and DM1 + insulin groups when compared to the normal control group. The sulfhemoglobin concentration was significantly increased in the diabetic control and the diabetic treated groups when compared to the normal control. DM1 + OG reduced the sulfhemoglobin concentration when compared to DM1. The blood glucose concentration of all the diabetic groups was significantly raised compared to normal control. OG, VA and insulin significantly reduced the blood glucose concentration with the efficacy of OG and VA higher than insulin.CONCLUSION: Adverse alteration of oxidative indices were observed in type 1 DM model. Treatment with OG and insulin showed potent antioxidant activity, while the hypoglycemic efficacy of OG and VA were higher than insulin. | Uduak Akpan Okon Idorenyin Udo Umoren | 2017 | Journal of Integrative Medicine2017，15，4： | 3 |
| 3 | Lead levels in Chromolaena odorata (Compositae) along rural and urban roads in Akwa Ibom State, Nigeria显示文摘Concentrations of lead(Pb) were determined in leaf samples of \%Chromolaena adorata\% from a rural road and an urban road in Akwa Ibom State of Nigeria in relation to vehicular traffic density. Mixed results were obtained wich no trend to indict automobile exhaust fumes. Lead was not detected in rain water from these areas and leaf lead levels seemed to relate more to soil lead concentrations. There was no significant difference in mean leaf lead levels between rural and urban leaf samples and between washed and unwashed leaf samples. It was suggested that the lack of concordance between vehicular traffic density and lead levels in leaves along the highways indicates either a low level use of tetraethyl leaded petrol or, a relatively low vehicular traffic density with lead from exhaust fumes not reaching a threshold to affect levels in plants or be detected in the atmosphere. Implications of concentrations obtained in leaves to consumers when compared with international standards were discussed. | Essien D. Udosen\+1, Okon M. Udodiong\+2 (1. Department of Chemistry and Biochemistry, University of Uyo, Nigeria 2.Department of Zoology, University of Uyo, Nigeria) | 1999 | Journal of Environmental Sciences1999，11，4： | 2 |
| 4 | Daptomycin structure and mechanism of action revealed显示文摘 | Jung D Rozek A Okon M | | 0，，： | 1 |
| 5 | Plant growth - promo- ting effects of diazotrophs in the rhizosphere 显示文摘 | Dobbelaere S Vanderleyden J Okon Y | 2003 | Critical Re- views in Plant Sciences2003，22，： | 1 |
| 6 | Pulmonary manifestations in Be-hcet^ syndrome显示文摘 | Raz I Okon E Chajek-Shaul T | 1989 | Chest1989，95，3： | 1 |
| 7 | Serum androgen levels in women who have recurrent miscalviages and their correlation with markers of endometrial function 显示文摘 | Okon MA Laird SM Tuckerman EM | 1998 | Fertil Steril1998，69，4： | 1 |
| 8 | N2 fixation by Azospirillum brazilense and its incorporation into host Setaria italica 显示文摘 | Okon Y Heytler PG Hardy WF | 1983 | Appl Environ Microbiol1983，46，： | 1 |
| 9 | Does early initiation of continuous renal replacement therapy affect outcome:experience in a tertiary care center显示文摘 | Vats HS Dart RA Okon TR | | 0，，： | 1 |
| 10 | Azospirillum/Plant associations显示文摘 | | 1977 | Appl Environ Microbiol1977，33，： | 1 |
| 11 | Defining disparities in cardio- vascular disease for American Indians: trends in heart disease and stroke mortality among American Indians and whites in Montana 1991 to 2000 显示文摘 | Harwell TS Oser CS Okon NJ | 2005 | Circulation2005，112，15： | 1 |
| 12 | Development and function of Azospirillum-inoculated roots显示文摘 | Okon Y & Kapalink Y | 1986 | Plant & Soil1986，90，： | 1 |
| 13 | The influence of the hormonal replacement therapy on the amount and stability of the tear film among peri- and postmenopausal women显示文摘 | Okon A Jurowski P Gos R | 2001 | Klin Oczna2001，103，： | 1 |
| 14 | Multi-detector row CT urography in the evaluation of hematuria 显示文摘 | Joffe SA Servaes S Okon S | 2003 | Radiographics2003，23，： | 1 |
| 15 | The development of Azospirillum as a com- mercial inoculants for improving crop yields显示文摘 | Okon Y Itzigsonhn R | 1995 | Biotechnol Adv1995，13，3： | 1 |
| 16 | Chemical control of bacte rial speck of tomato and its effect on tomato yield显示文摘 | Yunis H Bashan Y Okon Y | 1980 | Hassadeh1980，60，5： | 1 |
| 17 | Involvement of the Reserve Material Poly beta-hydroxybutyrate in Azospirillum Brasilense Stress Endurance and Root Colonization 显示文摘 | Kadouri D Jurkevitch E Okon Y | 2003 | Applied and Environmental Microbiology2003，69，6： | 1 |
| 18 | Metalloproteinases and tissue inhibitor of metalloproteinase 1 ( TIMP-1 ) in endometrial flushings from pre- and post-menopausal women and from women with endometrial adenocarcinoma 显示文摘 | Laird SM Dalton CF Okon MA | 1999 | J Reprod Fertil1999，115，2： | 1 |
| 19 | Development and function of Azospirillum-inoculateroots显示文摘 | KAPULNIK Y | 1986 | Plant and Soil1986，90，： | 1 |
| 20 | Distinguishing splenosis from renal masses using ferumoxide-enhanced magnetic resonance imaging显示文摘 | Berman A J Zahalsky MP Okon SA | 2003 | Urology2003，60，50： | 1 |
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