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19篇 您的检索式：作者名="Oidtmann"

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		题名	作者	年代	出处	被引量
	1	Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth显示文摘AIM: Standard immunosuppression after organ transplantation stimulates tumor growth. Sirolimus has a strong antiproliferative and a tumor inhibiting effect. The purpose is to assess the effect on tumor growth of the immunosuppressive compounds sirolimus and tacrolimus alone and in combination on cells of human hepatocellular carcinoma.METHODS: We used the human cell lines SK-Hep 1 and Hep 3B derived from hepatocellular carcinoma. Proliferation analyses after treatment with sirolimus, tacrolimus, or the combination of both were performed. FACS analyses were done to reveal cell cycle changes and apoptotic cell death. The expression of apoptosis-related proteins was estimated by Western blots.RESULTS: Sirolimus alone or combined with tacrolimus inhibited the growth of both cell lines after 5 d by up to 35% in SK-Hep 1 cells, and by up to 68% in Hep 3B cells at 25 ng/mL. Tacrolimus alone stimulated the growth by 12% after 5 ng/mL and by 25% after 25 ng/mL in Hep 3B cells. We found an increase of apoptotic Hep 3B cells from 6 to 16%, and a G1-arrest in SK-Hep 1 cells with an increase of cells from 61 to 82%, when sirolimus and tacrolimus were combined. Bcl-2 was down-regulated in Hep 3B, but not in SK-Hep 1 cells after combined treatment.CONCLUSION: Sirolimus appears to inhibit the growth of hepatocellular carcinoma cells alone and in combination with tacrolimus. Sirolimus seems to inhibit the growth stimulation of tacrolimus.	Guido Schumacher Marijke Oidtmann Anne Rueggeberg Dietmar Jacob Sven Jonas Jan M. Langrehr Ruth Neuhaus Marcus Bahra Peter Neuhaus	2005	World Journal of Gastroenterology2005，11，10：	14
	2	Model for ranking freshwater fish farms according to their risk of infection and illustration for viral haemorrhagic septicaemia显示文摘	Birgit C. Oidtmann Fiona M. Pearce Mark A. Thrush Edmund J. Peeler Chiara Ceolin Katharina D.C. St?rk Manuela Dalla Pozza Ana Afonso Nicolas Diserens R. Allan Reese Angus Cameron	2014	Preventive Veterinary Medicine2014，，：	1
	3	Identification of cDNAs from Japanese pufferfish ( Fugu rubripes ) and Atlantic salmon ( Salmo salar ) coding for homologues to tetrapod prion proteins显示文摘	Birgit Oidtmann Dietrich Simon Nikola Holtkamp Rudolf Hoffmann Michael Baier	2003	FEBS Letters2003，，1：	1
	4	Identification of cDNAs fromapanese pufferfish;(Fugu rubripes) and Atlantic salmon (Salmon salar) coding for homologous to tetrapod prion proteins 显示文摘	Oidtmann B Simon D Holtkamp N	2003	FEBS Letters2003，538，：	1
	5	Sirolimus inhibits growth of human hepatoma cells in contrast to tacrolimus which promotes cell growth 显示文摘	SCHUMACHER G OIDTMANN M BAHRA M	2002	Transplant Proceeding2002，34，5：	1
	6	Disparate evolution of prion protein domains and the distinct origin of Doppel-and prion-related loci revealed by fish-to-mammal comparisons显示文摘	Rivera-Milla E Oidtmann B Panagiotidis C H	2006	FASEB J2006，20，2：	1
	7	Detection of Aphanomy-ces astaci in North American crayfish by polymerase chain reac-tion显示文摘	Oidtmann B Geiger S Stebauer P	2006	Dis Aquat Org2006，72，：	1
	8	An improved isolationmethod for the cultivation of the crayfish plague fungus,Aphano-myces astaci显示文摘	Oidtmann B Schmid I Rogers D	1999	Freshw Crayfish1999，12，：	1
	9	Sirolimus inhibits growth of human hepatoma cells in contrast to tacrolimus which promotes cell growth显示文摘	Schumacher G Oidtmann M Rosewicz S		0，，05：	1
	10	Identification of cDNAs from Japanese pufferfish (Fugu rubripes)and Atlantic salmon (Salmo salar) coding for homologues to tetrapod prion proteins 显示文摘	Oidtmann B Simon D Holtkamp N at al	2003	FEBS Left2003，538，：	1
	11	Disparate evolution of prion protein domains and the distinct origin of Doppel- and priori-related loci revealed by fish-to-mammal comparisons 显示文摘	Rivera-Milla E Oidtmann B Panagiotidis CH at al	2006	FASEB J2006，20，：	1
	12	Sirolimus inhibits growth of human hepatoma cells in contrast to tacrolimus which promotes cell growth 显示文摘	SCHUMACHER G OIDTMANN M ROSEWICZ S	2002	Transplant Proc2002，34，5：	1
	13	identification of cDNAs from Japanese pufferfish (Fugu rubripes) and Atlantic salmon (Salmo salar) coding for homologues to tetrapod prion proteins 显示文摘	Oidtmann B Simon D Holtkamp N at al	2003	FEBS Lett2003，538，：	1
	14	Identification of cDNAs from Japanese pufferfish (Fugu rubripes) and Atlantic salmon (Salmo salar) coding for homologous to tetrapod prion proteins 显示文摘	Simon D Holtkamp N	2003	FEBS Letters2003，538，：	1
	15	Ranking freshwater fish farms for the risk of pathogen introduction and spread 显示文摘	Oidtmann B C Crane C N Thrush M A	2011	Prev Veter Med2011，102，4：	1
	16	Disparate evolution of prion protein domains and the distinct origin of Doppel and prion-related loci revealed by fish-to-mammal comparisons显示文摘	Rivera-Milla E Oidtmann B Panagiotidis CH	2006	FASEB J2006，20，：	1
	17	Sirolimus inhibits growth of human hepatoma cells in contrast to tacrolimus which promotes cell growth显示文摘	G Schumacher M Oidtmann S Rosewicz J.M Langrehr S Jonas A.R Mueller A Rueggeberg R Neuhaus M Bahra D Jacob H Gerlach P Neuhaus	2002	Transplantation Proceedings2002，，5：	1
	18	Ranking freshwater fish farms for the risk of pathogen introduction and spread显示文摘	Oidtmann BC Crane CN Thrush MA		0，，04：	1
	19	Preparation and comparative release characteristics of three anthocyanin encpsulation systems显示文摘	OIDTMANN J SCHANTZ M MADER K		0，，：	1

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