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| 1 | 全球动脉粥样硬化血栓形成门诊患者中心血管危险因素的患病率、认知和治疗显示文摘Context: Atherothrombosis is the leading cause of cardiovascular morbidity and mortality around the globe. To date, no single international database has characterized the atherosclerosis risk factor profile or treatment intensity of individuals with atherothrombosis. Objective: To determine whether atherosclerosis risk factor prevalence and treatment would demonstrate comparable patterns in many countries around the world. Design, Setting, and Participants: The Reduction of Atherothrombosis for Continued Health(REACH) Registry collected data on atherosclerosis risk factors and treatment. A total of 67 888 patients aged 45 years or older from 5473 physician practices in 44 countries had either established arterial disease(coronary artery disease[CAD], n=40 258; cerebrovascular disease, n=18843; peripheral arterial disease, n=8273) or 3 or more risk factors for atherothrombosis(n=12 389) between 2003 and 2004. Main Outcome Measures: Baseline prevalence of atherosclerosis risk factors, medication use, and degree of risk factor control. Results: Atherothrombotic patients throughout the world had similar risk factor profiles: a high proportion with hypertension(81.8% ), hypercholesterolemia(72.4% ), and diabetes(44.3% ). The prevalence of overweight(39.8% ), obesity(26.6% ), and morbid obesity(3.6% ) were similar in most geographic locales, but was highest in North America(overweight: 37.1% , obese: 36.5% , and morbidly obese: 5.8% ; P< .001 vs other regions). Patients were generally undertreated with statins(69.4% overall; range: 56.4% for cerebrovascular disease to 76.2% for CAD), antiplatelet agents(78.6% overall; range: 53.9% for ≥ 3 risk factors to 85.6% for CAD), and other evidence-based risk reduction therapies. Current tobacco use in patients with established vascular disease was substantial(14.4% ). Undertreated hypertension(50.0% with elevated blood pressure at baseline), undiagnosed hyperglycemia(4.9% ), and impaired fasting glucose(36.5% in those not known to be diabetic) were common. Among those with symptomatic atherothrombosis, 15.9% had symptomatic polyvascular disease. Conclusion: This large, international, contemporary database shows that classic cardiovascular risk factors are consistent and common but are largely undertreated and undercontrolled in many regions of the world. | Bhatt D.L Gabriel Steg P Magnus Ohman E. 黄浙勇 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，5： | 5 |
| 2 | Antithrombotic therapy dur ing percutaneous coronary intervention: the Seventh ACCP Conference on Antithromhotic and Thrombolytic Therapy显示文摘 | Popma JJ Berger P Ohman EM | 2004 | Chest2004，126，3： | 1 |
| 3 | Identification of the antigenic epltopes in staphylococcal enterotoxins A and E and design of a superantigen for human cancer therapy显示文摘 | Sjoberg A Wallen - Ohman M Antonsson P | 2003 | Mol Biol2003，333，5： | 1 |
| 4 | Platelet function during extended prasugrel and clopidogrel therapy for patients with acs treated without revascularization: the trilogy acs platelet function substudy 显示文摘 | GURBEL P A ERLINGE D OHMAN E M | 2012 | JAMA2012，308，17： | 1 |
| 5 | A chemical micro analysis system for the measurement of pressure,flow rate,temperature,conductivity,UV-absorption and fluorescence显示文摘 | NORLIN P OHMAN O EKSTROM B | 1998 | Sensors and Actuators B1998，49，： | 1 |
| 6 | Survival outcomes 1 year after reperfusion therapy with either alteplase or reteplase for acute myocardial infarction: results from the global utilization of streptokinase and t-PA for occluded coronary arteries (GUSTO) Ⅲ Trial 显示文摘 | Topoi E J Ohman E M Armstrong P W | 2000 | Circulation2000，102，： | 1 |
| 7 | Antithrombotic thera- py during percutaneous coronary intervention:the Seventh ACCP Conference on Antithrombotic and Thrombolytic Ther- apy 显示文摘 | Popma JJ Berger P Ohman EM | 2005 | Chest2005，14，2： | 1 |
| 8 | Antithrombotic therapy during percutaneous coronary intervention:the seventh ACCP conference on antithrombotic and thrombolytic therapy显示文摘 | Popma JJ Beryer P Ohman EM | | 0，，3： | 1 |
| 9 | An irritable bowel syndrome subtype defined by species -specific alterations in faecal mlcrebiota显示文摘 | Jeffey I B O' Toole P W Ohman L | 2012 | Gut2012，61，7： | 1 |
| 10 | Monocyte chemoattractant protein-1 deficien cy protects against visceral fat-induced atherosclerosis 显示文摘 | OHMAN M K WRIGHT A P WICKENHEISER K J | 2010 | Arterioscler Thromb Vase Biol2010，30，： | 1 |
| 11 | Cardiac troponin T levels for risk stratification in acute myocardial ischemia显示文摘 | Ohman E M Armstrong P W Christenson R H etal | 1996 | N Engl J Med1996，335，： | 1 |
| 12 | Value for money and the rule of law: the performance audit in Sweden 显示文摘 | Grfinlund A Svardsten F Ohman P | 2011 | Interna- tional Journal of Public Sector Management2011，24，2： | 1 |
| 13 | Determination of flavonoids in citrus juices by micro-HPLC-ESI/MS显示文摘 | Dugo P Presti M L Ohman M Fazio A Dugo G Mondello L | 2005 | J Sep Sci2005，28，： | 1 |
| 14 | Phosphoproteomics Combined with Quantitative 14-3-3-affinity Capture Identifies SIRT1 and RAI as Novel Regulators of Cytosolic Double-stranded RNA Recognition Pathway 显示文摘 | Ohman T $6 derholm S Hintsanen P | 2014 | Mol Cell Proteomics2014，13，10： | 1 |
| 15 | Westerberg Offshore Windmills and the Effects of Electromagnetic Fields on Fish显示文摘 | OHMAN M C HAKAN P S | 2007 | Ambio2007，36，8： | 1 |
| 16 | Hepatic glucocortlcoid receptor antagonism is sufficient to reduce elevated hepatic glucoseoutput andimprovaglucose control in animal models of type 2 diabetes 显示文摘 | Jacobson P B Von Geldem T W Ohman L | 2005 | J Pharmacol Exp Ther2005，314，1： | 1 |
| 17 | Antithrombotic therapy during percutaneous coronary intervention:the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy显示文摘 | Popma JJ Berger P Ohman EM | 2004 | Chest2004，126，3： | 1 |
| 18 | Antithrombotic therapy during percutaneous coronary intervention:the seventh ACCP conference on antithrombotic and thrombolytic therapy显示文摘 | BERGER P OHMAN EM | 2004 | CHEST2004，126，： | 1 |
| 19 | Toxic algae and fish mortality in a brackish-water lake in AI- and, SW Finland 显示文摘 | LINDHOLM T OHMAN P KURKI-HELASMO K | 1999 | Hydrobiologia1999，397，： | 1 |
| 20 | Cardiac troponilevels for risk stratification in acute myocardial ischemia 显示文摘 | Ohman E M Armstrong P W Christenson R H | 1996 | N En Med1996，335，： | 1 |
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