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| 1 | Urgent endoscopic ultrasound-guided choledochoduodenostomy for acute obstructive suppurative cholangitis-induced sepsis显示文摘Acute obstructive suppurative cholangitis(AOSC) due to biliary lithiasis is a life-threatening condition that requires urgent biliary decompression. Although endoscopic retrograde cholangiopancreatography(ERCP) with stent placement is the current gold standard for biliary decompression, it can sometimes be difficult because of failed biliary cannulation. In this retrospective case series, we describe three cases of successful biliary drainage with recovery from septic shock after urgent endoscopic ultrasound-guided choledochoduodenostomy(EUS-CDS) was performed for AOSC due to biliary lithiasis. In all three cases, technical success in inserting the stents was achieved and the patients completely recovered from AOSC with sepsis in a few days after EUS-CDS. There were no procedure-related complications. When initial ERCP fails, EUS-CDS can be an effective life-saving endoscopic biliary decompression procedure that shortens the procedure time and prevents post-ERCP pancreatitis, particularly in patients with AOSC-induced sepsis. | Kosuke Minaga Masayuki Kitano Hajime Imai Kentaro Yamao Ken Kamata Takeshi Miyata Shunsuke Omoto Kumpei Kadosaka Tomoe Yoshikawa Masatoshi Kudo | 2016 | World Journal of Gastroenterology2016，22，16： | 18 |
| 2 | Endoscopic ultrasound-guided gallbladder drainage for acute cholecystitis: Long-term outcomes after removal of a self-expandable metal stent显示文摘AIM To assess the long-term outcomes of this procedure after removal of self-expandable metal stent(SEMS). The efficacy and safety of endoscopic ultrasoundguided gallbladder drainage(EUS-GBD) with SEMS were also assessed.METHODS Between January 2010 and April 2015, 12 patients with acute calculous cholecystitis, who were deemed unsuitable for cholecystectomy, underwent EUSGBD with a SEMS. EUS-GBD was performed under the guidance of EUS and fluoroscopy, by puncturing the gallbladder with a needle, inserting a guidewire, dilating the puncture hole, and placing a SEMS. TheSEMS was removed and/or replaced with a 7-Fr plastic pigtail stent after cholecystitis improved. The technical and clinical success rates, adverse event rate, and recurrence rate were all measured.RESULTS The rates of technical success, clinical success, and adverse events were 100%, 100%, and 0%, respectively. After cholecystitis improved, the SEMS was removed without replacement in eight patients, whereas it was replaced with a 7-Fr pigtail stent in four patients. Recurrence was seen in one patient(8.3%) who did not receive a replacement pigtail stent. The median follow-up period after EUS-GBD was 304 d(78-1492).CONCLUSION EUS-GBD with a SEMS is a possible alternative treatment for acute cholecystitis. Long-term outcomes after removal of the SEMS were excellent. Removal of the SEMS at 4-wk after SEMS placement and improvement of symptoms might avoid migration of the stent and recurrence of cholecystitis due to food impaction. | Ken Kamata Mamoru Takenaka Masayuki Kitano Shunsuke Omoto Takeshi Miyata Kosuke Minaga Kentaro Yamao Hajime Imai Toshiharu Sakurai Tomohiro Watanabe Naoshi Nishida Masatoshi Kudo | 2017 | World Journal of Gastroenterology2017，23，4： | 15 |
| 3 | Contrast-enhanced harmonic endoscopic ultrasonography for assessment of lymph node metastases in pancreatobiliary carcinoma显示文摘AIM: To assess the usefulness of contrast-enhanced harmonic endoscopic ultrasonography(CH-EUS) for lymph node metastasis in pancreatobiliary carcinoma.METHODS: All patients suspected of pancreatobiliary carcinoma with visible lymph nodes after standard EUS between June, 2009 and January, 2012 were enrolled.In the primary analysis, patients with successful EUSfine needle aspiration(FNA) were included. The lymph nodes were assessed by several standard EUS variables(short and long axis lengths, shape, edge characteristic and echogenicity), color Doppler EUS variable [central intranodal blood vessel(CIV) presence] and CH-EUS variable(heterogeneous/homogeneous enhancement patterns). The diagnostic accuracy relative to EUSFNA was calculated. In the second analysis, N-stage diagnostic accuracy of CH-EUS was compared with EUS-FNA in patients who underwent surgical resection.RESULTS: One hundred and nine patients(143 lymph nodes) fulfilled the criteria. The short axis cutoff ≥ 13 mm predicted malignancy with a sensitivity and specificity of 72% and 85%, respectively. These values were 72% and 63% for the long axis cut-off ≥ 20 mm, 62% and 75% for the round shape variable, 81% and 30% for the sharp edge variable, 66% and 61% for the hypoechogenicity variable, 70% and 72% for the CIV-absent variable, and 83% and 91% for the heterogeneous CH-EUS-enhancement variable, respectively. CH-EUS was more accurate than standard and color Doppler EUS, except the short axis cut-off. Notably, three patients excluded because of EUS-FNA failure were correctly N-staged by CH-EUS.CONCLUSION: CH-EUS complements standard and color Doppler EUS and EUS-FNA for assessment of lymph node metastases. | Takeshi Miyata Masayuki Kitano Shunsuke Omoto Kumpei Kadosaka Ken Kamata Hajime Imai Hiroki Sakamoto Naoshi Nisida Yogesh Harwani Takamichi Murakami Yoshifumi Takeyama Yasutaka Chiba Masatoshi Kudo | 2016 | World Journal of Gastroenterology2016，22，12： | 7 |
| 4 | Dermatomyositis associated with hepatocellular carcinoma in an elderly female patient with hepatitis C virus-related liver cirrhosis显示文摘有丙肝的一个 79 岁的女病人病毒相关的肝肝硬化作为与 2.0 厘米的一条直径有肝细胞癌(HCC ) 被诊断。她为 HCC 拒绝了治疗。在诊断以后的九个月,当 HCC 扩大了到 6.0 厘米的一条直径时,她开发了皮肤肌炎。她为皮肤肌炎,然后 transcatheter 经历了治疗为 HCC 的动脉的 chemoembolization。尽管皮肤肌炎的表明改善了,全部肿瘤坏死被完成,她在 HCC 的治疗以后死于肺病 2 瞬间。HCC 或长期的丙肝病毒感染可能涉及皮肤肌炎的致病。 | Nobuyuki Toshikuni Rikako Torigoe Mikio Mitsunaga Akiyoshi Omoto Koji Nakashima | 2006 | World Journal of Gastroenterology2006，12，10： | 6 |
| 5 | Expression of vascular endothelial growth factor?C and vascular endothelialgrowth factor receptor?3 in esophageal squamous cell carcinoma显示文摘 | Itaru Omoto Masataka Matsumoto Hiroshi Okumura Yasuto Uchikado Tetsuro Setoyama Yoshiaki Kita Tetsuhiro Owaki Yuko Kijima Hiroyuki Shinchi Sumiya Ishigami Shinichi Ueno Shoji Natsugoe | 2014 | Oncology Letters2014，，4： | 3 |
| 6 | Two flavone 2'-glucosides from Scutellaria baicalensis显示文摘 | Ishimaru K Nishikawa K Omoto T | 1995 | Phytochemistry1995，40，1： | 2 |
| 7 | Modified single transluminal gateway transcystic multiple drainage technique for a huge infected walled-off pancreatic necrosis: A case report显示文摘We report a successful endoscopic ultrasonographyguided drainage of a huge infected multilocular walledoff necrosis(WON) that was treated by a modified single transluminal gateway transcystic multiple drainage(SGTMD) technique. After placing a widecaliber fully covered metal stent, follow-up computed tomography revealed an undrained subcavity of WON. A large fistula that was created by the wide-caliber metal stent enabled the insertion of a forward-viewing upper endoscope directly into the main cavity, and the narrow connection route within the main cavity to the subcavity was identified with a direct view, leading to the successful drainage of the subcavity. This modified SGTMD technique appears to be useful for seeking connection routes between subcavities of WON in some cases. | Kosuke Minaga Masayuki Kitano Hajime Imai Kentaro Yamao Ken Kamata Takeshi Miyata Tomohiko Matsuda Shunsuke Omoto Kumpei Kadosaka Tomoe Yoshikawa Masatoshi Kudo | 2016 | World Journal of Gastroenterology2016，22，21： | 2 |
| 8 | Significance of platelet-derived microparticles and activated platelets in diabetic nephropathy 显示文摘 | Omoto S Nomura S Shouzu A | 1999 | Nephron1999，81，3： | 1 |
| 9 | Clinical significance of the expression of estrogen receptors alpha and beta for endocrine therapy of breast cancer显示文摘 | Zhang Z Omoto Y | 2003 | Cancer Chemother Pharmacol2003，52，1： | 1 |
| 10 | Two flavone 2' -glucosides from Scutellaria baicalensis显示文摘 | KANJI ISHIMARU KAZUTAKA NISHIKAWA TOSHITO OMOTO | 1995 | Phytochemistry1995，40，1： | 1 |
| 11 | Accurate and rapidnovel genetic diagnosis for detection of sentinel lymph nodemetastasis in breast cancer patients 显示文摘 | Iinuma H Tamura J Omoto D | 2012 | Br J Cancer2012，107，4： | 1 |
| 12 | Non-grasp Manipulation of Deformable Object by Using Pizza Handling Mechanism显示文摘 | Mitsurn Higashimori Yasutaka Omoto Makoto Kaneko | 2009 | IEEE International Conference on Robotics and Automation2009，，： | 1 |
| 13 | HIV-1 nef sup- pression by virally encoded microRNA 显示文摘 | Omoto S Ito M Tsutsumi Y | 2004 | Retroviroi- ogy2004，1，： | 1 |
| 14 | Binding ofSilurus asotus lectin to Gb3 on Raji cells causes disap-pearance of membrane-bound form of HSP70显示文摘 | Sugawara S Kawano T Omoto T | 2009 | bio-chimica et biophysica acta-general subjects2009，1790，2： | 1 |
| 15 | Activated platelet and oxidized LDL induce endothelial membrane vesiculation:clinical significance of endothelial cell-derived microparticles in patients with type 2 diabetes显示文摘 | Shouzu Akira MD Omoto Seitaro MD | 2004 | Clin App Thromb/Hemost2004，10，3： | 1 |
| 16 | Detection of monocyte-derived microparticles in patients with type Ⅱ diabetes mellitus显示文摘 | NOMURA S SHOUZU A | 2002 | Diabetologia2002，45，4： | 1 |
| 17 | Regulation of human immunodefi ciency virus 1 transcription by nef microRNA显示文摘 | Omoto S Fujii Y R | 2005 | JGen Virol2005，86，： | 1 |
| 18 | Effect of cilostazol on soluble adhesion molecules and platelet-derivad microparticle in patients with diabetes显示文摘 | SHOSAKU NOMURA AKIRASHOUZU SEITARO OMOTO | | 0，，03： | 1 |
| 19 | Regulation of human immunodeficiency virusl transcription by nef microRNA显示文摘 | Omoto S Fujii Y R | | 0，，03： | 1 |
| 20 | Prospective, Randomized Study of the Efficacy of Systemic Cyclosporine in High-Risk Corneal Transplantation显示文摘 | Jun Shimazaki Seika Den Masahiro Omoto Yoshiyuki Satake Shigeto Shimmura Kazuo Tsubota | 2011 | American Journal of Ophthalmology2011，，1： | 1 |
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