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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012,18,26: | 6 |
| 2 | Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘 | Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini | 2007 | Lancet Oncology2007,,: | 2 |
| 3 | Co - amoxiclav pharmacokinetics during posttraumatic hemorrhagic shock 显示文摘 | Olivier M Veronique S Pascal I | 2001 | Critical Care Medicine2001,29,7: | 1 |
| 4 | The effect of the corrugation inclination angle on the thermo-hydraulic performance of plate heat exchangers显示文摘 | FOCKE W W ZACHARIADES J OLIVIER I | 1985 | Int J Heat and Mass Transfer1985,28,8: | 1 |
| 5 | Understanding wild-type and mutant p53 activities in human cancer:new landmarks on the way to targeted therapies显示文摘 | Goldstein I Marcel V Olivier M | 2011 | Cancer Gene Ther2011,18,1: | 1 |
| 6 | Acute infection by conjunctival route with Brucella melitensis induces IgG+ cells and IFN-gamma producing cells in peripheral and mucosal lymph nodes in sheep 显示文摘 | Suraud V Jacques I Olivier M | 2008 | Microbes Infect2008,10,1213: | 1 |
| 7 | Defects in the ubiquitin pathway induce capase- independent apoptosis blocked by Bcl - 2 显示文摘 | Otter I Olivier R | 1998 | J Biol Chem1998,273,11: | 1 |
| 8 | Does exercise therapy for chronic low-back pain require daily isokinetic reinforcement of the trunk muscle显示文摘 | Olivier N Lepretre A Caby I | 2008 | Ann Readapt Med Phys2008,51,4: | 1 |
| 9 | Understanding wild- type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies显示文摘 | Goldstein I Marcel V Olivier M | 2011 | Cancer Gene Therapy2011,18,1: | 1 |
| 10 | Numerical inves- tigation of unsteady wave phenomena for transonic airfoil flow显示文摘 | Hermes V Klioutchnikov I Olivier H | 2013 | Aerospace Science and Technology2013,25,1: | 1 |
| 11 | Seronegative spondylarthropathies:imaging of spondylitis,enthesitis and dactylitis显示文摘 | Barozzi L Olivier I De Matteis M | 1998 | Eur J Radiol1998,27,1: | 1 |
| 12 | Developmental changes of static standing balance in children显示文摘 | RIVAL C CEYTE H OLIVIER I | 2005 | Neuroscience Letters2005,376,: | 1 |
| 13 | Time - course of the effect of dietary L - tryptophan on plasma cortisol levels in rainbow trout Oncorhynchus mykiss 显示文摘 | Olivier L Vilchez I M Porringer T G | 2003 | J Experimental Biol2003,206,: | 1 |
| 14 | Postural control and atten- tional demand during adolescence 显示文摘 | Palluel E Nougier V Olivier I | 2010 | Brain Research2010,1358,: | 1 |
| 15 | The effect of the corrugation inclination angle on the thermo hydraulic performance of plate heat exchangers显示文摘 | FOCKE W W ZACHARIADES J OLIVIER I | 1985 | Heat Mass Transfer1985,8,8: | 1 |
| 16 | Analytical Propagation of Uncer- tainty in Life Cycle Assessment Using Matrix Formulation显示文摘 | Hugues I T Olivier J Louise D | 2014 | BioEner- gy Research2014,7,1: | 1 |
| 17 | Novel approach to quantitative polymerase chain reaction using real-time detection:application to the detection of gene amplification in breast cancer显示文摘 | Olivi M Helene M | 1998 | Int J Cancer1998,78,: | 1 |
| 18 | High-egieiency organic eletroluminesent devices using an organoterbium emitter 显示文摘 | Capecchi mone I Renault Olivier Moon Dae-Gyu | 2000 | Adv Mater2000,12,: | 1 |
| 19 | Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies 显示文摘 | Goldstein I Marcel V Olivier M | 2011 | Cancer Gene Ther2011,18,1: | 1 |
| 20 | Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels显示文摘 | Pennacchio I A Olivier M Hubacek JA | 2002 | Hum Mol Genet2002,11,: | 1 |