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| 1 | Regulator of myeloid differentiation and function:The secret life of Ikaros显示文摘Ikaros (also known as Lyf-1) was initially described as a lymphoid-specific transcription factor.Although Ikaros has been shown to regulate hematopoietic stem cell renewal,as well as the development and function of cells from multiple hematopoietic lineages,including the myeloid lineage,Ikaros has primarily been studied in context of lymphoid development and malignancy.This review focuses on the role of Ikaros in myeloid cells.We address the importance of post-transcriptional regulation of Ikaros function;the emerging role of Ikaros in myeloid malignancy;Ikaros as a regulator of myeloid differentiation and function;and the selective expression of Ikaros isoform-x in cells with myeloid potential.We highlight the challenges of dissecting Ikaros function in lineage commitment decisions among lymphoidmyeloid progenitors that have emerged as a major myeloid differentiation pathway in recent studies,which leads to reconstruction of the traditional map of murine and human hematopoiesis. | Olivia L Francis Jonathon L Payne Kimberly J Payne | 2011 | World Journal of Biological Chemistry2011，2，6： | 4 |
| 2 | FOLFIRI regimen in metastatic pancreatic adenocarcinoma resistant to gemcitabine and platinum-salts显示文摘AIM: To evaluate the efficacy and safety of the FOLFIRI regimen in patients with metastatic pancreatic adenocarcinoma (PAC) after the failure of gemcitabine and platinum salts. METHODS: All consecutive patients with histologically confirmed, metastatic PAC and World Health Organiza-tion performance status (PS) ≤ 2 received FOLFIRI-1 [irinotecan 180 mg/m2 on day 1 and leucovorin 400 mg/m2 followed by 5-fluorouracil (5-FU) 400 mg/m2 bolus, then 5-FU 2400 mg/m2 as a 46-h infusion, biweekly] or FOLFIRI-3 (irinotecan 100 mg/m2 on day 1 and leucovorin 400 mg/m2, then 5-FU 2400 mg/m2 as a 46-h infusion and irinotecan 100 mg/m2 repeated on day 3, biweekly) after failure of gemcitabine and platinum-based chemotherapies as a systematic policy in two institutions between January 2005 and May 2010. Tumor response, time to progression (TTP), overall survival rate (OS) and grade 3-4 toxicities were retrospectively studied. Subgroup analyses were performed to search for prognostic factors. RESULTS: Sixty-three patients (52.4% male, median age 59 years) were analyzed. Among them, 42.9% were PS 0, 38.1% were PS 1 and 19.0% were PS 2. Fifty one patients (81.0%) had liver metastases. Before the FOLFIRI regimen, patients had received 1 line (n = 19), 2 lines (n = 39) or 3 lines (n = 5) of chemotherapy. Median TTP obtained with the line before FOLFIRI was 3.9 mo (95% CI: 3.4-5.3 mo). A total of 480 cycles was completed (median: 6 cycles, range: 1-51 cycles). The main reason for discontinuing FOLFIRI was tumor progression (90.3%). Tumor control was achieved in 25 patients (39.7%) (partial response: n = 5, stable disease: n = 20) with FOLFIRI. Median TTP was 3.0 mo (95% CI: 2.1-3.9 mo) and median OS was 6.6 mo (95% CI: 5.3-8.1 mo). Dose adaptation was required in 36 patients (57.1%). Fifteen patients (23.8%) had grade 3-4 toxicities, mainly hematological (n = 11) or digestive (n = 4). Febrile neutropenia occurred in 3 patients. There was no toxic death. PS 2 was significantly associated with poor TTP [hazard ratio (HR): 16.036, P < 0.0001] and OS (HR: 4.003, P = 0.004). CONCLUSION: The FOLFIRI regimen had an acceptable toxicity and an interesting efficacy in our study, limited to patients in good condition (PS 0-1). | Cindy Neuzillet Olivia Hentic Benot Rousseau Vinciane Rebours Léla Bengrine-Lefèvre Franck Bonnetain Philippe Lévy Eric Raymond Philippe Ruszniewski Christophe Louvet Pascal Hammel | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 3 | Natural History of Intraductal Papillary Mucinous Tumors of the Pancreas: Actuarial Risk of Malignancy显示文摘 | Philippe Lévy Vincent Jouannaud Dermot O’Toole Anne Couvelard Marie Pierre Vullierme Laurent Palazzo Alain Aubert Philippe Ponsot Alain Sauvanet Frédérique Maire Olivia Hentic Pascal Hammel Philippe Ruszniewski | 2006 | Clinical Gastroenterology and Hepatology2006，，4： | 2 |
| 4 | The long term risk of malignancy in patients with branch duct intraductal papillary mucinous neoplasms of the pancreas显示文摘 | Wafaa Khannoussi Marie Pierre Vullierme Vinciane Rebours Frédérique Maire Olivia Hentic Alain Aubert Alain Sauvanet Safi Dokmak Anne Couvelard Pascal Hammel Philippe Ruszniewski Philippe Lévy | 2012 | Pancreatology2012，，3： | 1 |
| 5 | Modulating Estrogen Receptor-related Receptor-α Activity Inhibits Cell Proliferation 显示文摘 | Stephanie B Olivia L Violaine T | 2009 | Journal of Biological Chemistry2009，284，23： | 1 |
| 6 | The line of sight jitter of the huble space telescope显示文摘 | PIERRE Y OLIVIA L JOHN L H | 1993 | SPIE1993，1945，： | 1 |
| 7 | Hergl gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells显示文摘 | Elena L Leonardo G Olivia C | 2004 | Cancer Res2004，64，： | 1 |
| 8 | Measuring consciousness in severely damaged brains显示文摘 | Olivia G Haibo D Steven L | 2014 | Annu Rev Neuroi2014，37，： | 1 |
| 9 | Caco-2 cell ferritin formation predicts nonradiolabeled food iron availability in an in vitro digestion/Caco-2 cell culture model 显示文摘 | GLAHN R P OLIVIA A L ANDREW Y | 1998 | J Nutr1998，128，9： | 1 |
| 10 | Is adjuvant therapy with streptozotocin and 5-fluorouracil useful after resection of liver metastases from digestive endocrine tumors?显示文摘 | Frédérique Maire Pascal Hammel Reza Kianmanesh Olivia Hentic Anne Couvelard Vinciane Rebours Magaly Zappa Eric Raymond Alain Sauvanet Christophe Louvet Philippe Lévy Jacques Belghiti Philippe Ruszniewski | 2009 | Surgery2009，，1： | 1 |
| 11 | Mendelson, et al Advance in the medical management of osteoporosis 显示文摘 | Stephen L Kates Olivia S Kates Daniel A | 2007 | Care Injured2007，383，： | 1 |
| 12 | A retarded integral inequality and its applications显示文摘 | OLIVIA L P | 2003 | J Math Anal App12003，285，： | 1 |
| 13 | Synthesis of red-emitting,small particle size luminescent oxides using an op- timize combustion process显示文摘 | Shea L E McKittrick J Olivia | 1996 | Journal of the American Ceramic Society1996，79，12： | 1 |
| 14 | Evaluation of an-timicrobial coatings for cloth media filtra-tion : Case study 显示文摘 | OLIVIA M V LLOYD J JEANNIE L | 2007 | Journal of Environmental Engineeringf2007，133，1： | 1 |
| 15 | The heat treatment and the gelation are strong determinants of the kinetics of milk proteins digestion and of the peripheral availability of amino acids显示文摘 | FLORENCE B OLIVIA M YANN L G | 2013 | Food Chemistry2013，136，34： | 1 |
| 16 | Comparison of susceptibility to antimicrobials of bacterial isolates from companion animals in a veterinary diagnostic laboratory in Canada between 2 time points 10 years apart显示文摘 | Simon A Dominique P Olivia L | 2006 | Can Vet J2006，47，8： | 1 |
| 17 | Immunoglobulin G4 Immunostaining of Gastric, Duodenal, or Colonic Biopsies Is Not Helpful for the Diagnosis of Autoimmune Pancreatitis显示文摘 | Vinciane Rebours Yann Le Baleur Dominique Cazals–Hatem Carmen Stefanescu Olivia Hentic Frédérique Maire Yoram Bouhnik Pierre Bedossa Pascal Hammel Philippe Ruszniewski Philippe Lévy Anne Couvelard | 2012 | Clinical Gastroenterology and Hepatology2012，，1： | 1 |
| 18 | Assessing vulnerability to panic:a systematic review of psychological and physiological responses to biological challenges as prospective predictors of panic attacks and panic disorder显示文摘Background Cognitive-behavioural theories of panic disorder posit that panic attacks arise from a positive feedback loop between arousal-related bodily sensations and perceived threat.In a recently develope computational model formalising these theories of pani attacks,it was observed that the response to a simulate perturbation to arousal provided a strong indicator of vulnerability to panic attacks and panic disorder.In this/review,we evaluate whether this observation is borne o in the empirical literature that has examined responses biological challenge(eg,C02 inhalation)and their relatio to subsequent panic attacks and panic disorder.Method We searched PubMed,Web of Science and PsycINFO using keywords denoting provocation agents(eg,sodium lactate)and procedures(eg,infusion)combined with keywords relevant to panic disorder(eg,panic).Articles were eligible if they used response to a biologic challenge paradigm to prospectively predict panic attac or panic disorder.Results We identified four eligible studies.Pooled effect sizes suggest that there is biological challenge response a moderate prospective association with subsequent pani attacks,but no prospective relationship with panic disorde Conclusions These findings provide support for the prediction derived from cognitive-behavioural theories an some preliminary evidence that response to a biological challenge may have clinical utility as a marker of vulnerab to panic attacks pending further research and developme Trial registration number 135908. | Donald J Robinaugh Meredith J Ward Emma R Toner Mackenzie L Brown Olivia M Losiewicz Eric Bui Scott P Orr | 2019 | General Psychiatry2019，32，6： | 1 |
| 19 | Line-of-sight jitter of the Hubble Space Telescope显示文摘 | Pierre Y Olivia L John L H | 1993 | SPIE1993，1945，： | 1 |
| 20 | Modulating Estrogen receptor-related receptor-or activity inhibits cell proliferation 显示文摘 | Stephanie B Olivia L Violaine T | 2009 | J Biol Chem2009，284，23： | 1 |
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