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| 1 | Task-related functional magnetic resonance imaging-based neuronavigation for the treatment of depression by individualized repetitive transcranial magnetic stimulation of the visual cortex显示文摘To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder(MDD),we performed a sham-controlled,double-blind,randomized,three-arm VC rTMS treatment study in 74 MDD patients.Neuronavigated rTMS(10 Hz,90%of resting motor threshold,1,600 pulses over20 min twice per day)was performed over the VC for five days.Clinical outcome was measured by Hamilton Depression Rating Scale(HAMD-24)at days 0,1,3,5 and after terminating rTMS,with follow-up at four weeks.MRI was measured at days 0 and5.The individualized group exhibited the greatest change in HAMD-24 scores after VC rTMS for 5 days(F=5.53,P=0.005),which were maintained during follow-up period(F=4.22,P=0.016).All patients reported good tolerance.Changes in VC taskrelated functional MRI correlated with symptomatic reduction in the individualized group.Treatment reduced the initially abnormal increase in resting state functional connectivity from the VC to the pre/subgenual anterior cingulate cortex at day 5,especially in the individualized group.We demonstrated therapeutic potential and good tolerance of VC rTMS in MDD patients,indicated by biomarkers of f MRI measurement. | Zhijun Zhang Hongxing Zhang Chun-Ming Xie Meng Zhang Yachen Shi Ruize Song Xiang Lu Haisan Zhang Kun Li Bi Wang Yongfeng Yang Xianrui Li Jianli Zhu Yang Zhao Ti-Fei Yuan Georg Northoff | 2021 | Science China(Life Sciences)2021，64，1： | 8 |
| 2 | White Matter Deficits Underlying the Impaired Consciousness Level in Patients with Disorders of Consciousness显示文摘In this study, we aimed to(1) identify white matter(WM) deficits underlying the consciousness level in patients with disorders of consciousness(DOCs) using diffusion tensor imaging(DTI), and(2) evaluate the relationship between DTI metrics and clinical measures of the consciousness level in DOC patients. With a cohort of 8 comatose, 8 unresponsive wakefulness syndrome/vegetative state, and 14 minimally conscious state patients and 25 patient controls, we performed group comparisons of the DTI metrics in 48 core WM regions of interest(ROIs), and examined the clinical relevance using correlation analysis. We identified multiple abnormal WM ROIs in DOC patients compared with normal controls, and the DTI metrics in these ROIs were significantly correlated with clinical measures of the consciousness level. Therefore, our findings suggested that multiple WM tracts are involved in the impaired consciousness levels in DOC patients and demonstrated the clinical relevance of DTI for DOC patients. | Xuehai Wu Jiaying Zhang Zaixu Cui Weijun Tang Chunhong Shao Jin Hu Jianhong Zhu Yao Zhao Lu Lu Gang Chen Georg Northoff Gaolang Gong Ying Mao Yong He | 2018 | Neuroscience Bulletin2018，34，4： | 8 |
| 3 | Self-referential processing in our brain—A meta-analysis of imaging studies on the self显示文摘 | Georg Northoff Alexander Heinzel Moritz de Greck Felix Bermpohl Henrik Dobrowolny Jaak Panksepp | 2005 | Neuroimage2005，，1： | 3 |
| 4 | Growth control of cultured microglia 显示文摘 | Ganter S Northoff H IVlannel D | 1992 | J lburosci Res1992，33，： | 1 |
| 5 | immunologic mediators as parameters of the reaction to strenuous exercise 显示文摘 | Northoff H Berg A | 1991 | Int J sports Med1991，，： | 1 |
| 6 | The cytokine response to strenuous exercise显示文摘 | Weinstock C | 1994 | Int J Sports1994，15，： | 1 |
| 7 | Understanding the self:a cultural neuro science approach显示文摘 | Han Shi-hui Northoff G | 2009 | Progress in Brain Research2009，178，10： | 1 |
| 8 | Effects of single-pulse trans-cranial magnetic stimulation(TMS) on functional brain activity:a combined event-related TMS and evoked potential study显示文摘 | Thut G Northoff G Ives JR | 2003 | Clinical Neurophysiology2003，114，11： | 1 |
| 9 | Immunologic Mediators as Parameters of the Reaction to Strenuous Exercise 显示文摘 | NORTHOFF H BERG A | 1991 | Int J Sports Med1991，1，： | 1 |
| 10 | Rest-stimulus interaction in the brain: a review 显示文摘 | NORTHOFF G QIN P NAKAO T | 2010 | Trendc Neurosci2010，33，6： | 1 |
| 11 | How do we modulate our emotions? Parametric fMRI reveals cortical midline structures as regions specifically involved in the processing of emotional valences显示文摘 | Alexander Heinzel Felix Bermpohl Robert Niese Andrea Pfennig Alvaro Pascual-Leone Gottfried Schlaug Georg Northoff | | Cognitive Brain Research0，，： | 1 |
| 12 | Cortical midline structures and the self显示文摘 | Georg Northoff Felix Bermpohl | | Trends in Cognitive Sciences0，，： | 1 |
| 13 | Immunologic mediators as parameters of the reaction to strenuous exercise显示文摘 | Northoff H Berg A | 1991 | Int J Sports Med1991，12，： | 1 |
| 14 | Increase of serum creatine phosphokinase I catatonia :an investigation in 32 acute catatonic patients显示文摘 | Northoff G Wenke J Pflug B | 1996 | Psychol Med1996，26，3： | 1 |
| 15 | Culture-sensitive neural substrates of human cognition:A transcultural neuroimaging approach显示文摘 | Han S Northoff G | | 0，，： | 1 |
| 16 | Free radicals and oxidative stress in exercise--immunological aspects显示文摘 | Niess AM Dickhuth HH Northoff H | 1999 | Exerc Immunol Rev1999，，5： | 1 |
| 17 | Increas of serum creatine phosphokinase I catatonia:an investigation in 32 acute catatonic patients显示文摘 | Northoff G Wenke J Pflug B | 1996 | Psychol Med1996，26，3： | 1 |
| 18 | Self-referential process- ing in our brain-A meta-analysis of imaging studies on the self 显示文摘 | Northoff G Heinzel A de Greck M | 2006 | NeuroImage2006，31，： | 1 |
| 19 | NMDA hypofunction in the posterior cingulate as a model for schizophrenia: an exploratory ketamine administration study in fMRI显示文摘 | Northoff G Richter A Bermpohl F | 2005 | Schizophr Res2005，72，23： | 1 |
| 20 | Immunologic mediators as parameters of the reaction to strenuous exercise 显示文摘 | Northoff H Berg A | 1991 | Int J Sports Med1991，12，1： | 1 |
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