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		题名	作者	年代	出处	被引量
	1	3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors显示文摘Dengue is a severe mosquito-borne viral infection causing half a million deaths annually.Dengue virus NS2B/NS3 protease is a validated target for anti-dengue drug design. A series of hitherto unreported 3,5-bis(arylidene)-4-piperidones analogues 4a–4j were synthesized and screened in silico against DENV2 NS2B/NS3 protease to elucidate their binding mechanism and orientation around the active sites. Results were validated through an in vitro DENV2 NS2B/NS3 protease assay using a fluorogenic Boc-Gly-Arg-Arg-AMC substrate. Nitro derivatives of 3,5-bis(arylidene)-4-piperidones(4e and 4j) emerged as promising lead molecules for novel protease inhibitors with an IC50 of 15.22 and16.23 mmol/L, respectively, compared to the standard, panduratin A, having IC50 of 57.28 mmol/L.	Hasnah Osman Nor Hashima Idris Ezatul Ezleen Kamarulzaman Habibah A.Wahab Mohd.Zaheen Hassan	2017	Acta Pharmaceutica Sinica B2017，7，4：	0

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