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| 1 | More anxious than depressed:prevalence and correlates in a 15-nation study of anxiety disorders in people with type 2 diabetes mellitus显示文摘Background Anxiety disorder, one of the highly disabling, prevalent and common mental disorders, is known to be more prevalent in persons with type 2 diabetes mellitus (T2DM) than the general population, and the comorbid presence of anxiety disorders is known to have an impact on the diabetes outcome and the quality of life. However, the information on the type of anxiety disorder and its prevalence in persons with T2DM is limited. Aims To assess the prevalence and correlates of anxiety disorder in people with type 2 diabetes in different countries. Methods People aged 18-65 years with diabetes and treated in outpatient settings were recruited in 15 countries and underwent a psychiatric interview with the Mini-International Neuropsychiatric Interview. Demographic and medical record data were collected. Results A total of 3170 people with type 2 diabetes (56.2% women;with mean (SD) duration of diabetes 10.01 (7.0) years) participated. The overall prevalence of anxiety disorders in type 2 diabetic persons was 18%;however, 2.8% of the study population had more than one type of anxiety disorder. The most prevalent anxiety disorders were generalised anxiety disorder (8.1%) and panic disorder (5.1%). Female gender, presence of diabetic complications, longer duration of diabetes and poorer glycaemic control (HbA1c levels) were significantly associated with comorbid anxiety disorder. A higher prevalence of anxiety disorders was observed in Ukraine, Saudi Arabia and Argentina with a lower prevalence in Bangladesh and India. Conclusions Our international study shows that people with type 2 diabetes have a high prevalence of anxiety disorders, especially women, those with diabetic complications, those with a longer duration of diabetes and poorer glycaemic control. Early identification and appropriate timely care of psychiatric problems of people with type 2 diabetes is warranted. | Santosh K Chaturvedi Shayanth Manche Gowda Helal Uddin Ahmed Fahad D Alosaimi Nicola Andreone Alexey Bobrov Viola Bulgari Giuseppe Carra Gianluca Castelnuovo Giovanni de Girolamo Tomasz Gondek Nikola Jovanovic Thummala Kamala Andrzej Ki Nebojsa Lalic Dusica Lecic-Tosevski Fareed Minhas Victoria Mutiso David Ndetei Golam Rabbani Suntibenchakul Somruk Sathyanarayana Srikanta Rizwan Taj Umberto Valentini Olivera Vukovic Wolfgang Wolwer Larry Cimino Arie Nouwen Cathy Lloyd Norman Sartorius | 2019 | General Psychiatry2019，32，4： | 11 |
| 2 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 3 | Absolute atomic oxygen density profiles in the discharge core of a microscale atmospheric pressure plasma jet显示文摘 | Nikolas K Karl N Stephan R | 2008 | Applied Physics Letters2008，93，13： | 1 |
| 4 | Molecular pathways:the complex roles of inflammation pathways in the development and treatment of liver cancer显示文摘 | Nikolaou K Sarris M Talianidis I | 2013 | Clin Can Res2013，19，11： | 1 |
| 5 | Diagnosing pulmonary em-bolism :new computed tomography applications 显示文摘 | Nikolaou K Thieme S Sommer W | 2010 | J Thorac Ima-ging2010，25，2： | 1 |
| 6 | Diagnostic accuracy of dual-source computed tomography in the diagnosis of coronary artery disease显示文摘 | Johnson T Nikolaou K Busch S | 2007 | Invest Radiol2007，42，10： | 1 |
| 7 | Accuracy of 64-MDCT in the diagnosis of isehemic heart disease 显示文摘 | Nikolaou K Knez A Rist C | 2006 | AJR2006，187，1： | 1 |
| 8 | Computed tomograpy and magnetic resonance imaging for nonoinvasive coronary angiography and plaque imaging:current and potential future concepts显示文摘 | Fayad ZA Fuster V Nikolaou K | 2002 | Circulation2002，106，15： | 1 |
| 9 | Application of different analytical methods for determination of volatile chlorination by-products in drinking water 显示文摘 | Anastasia D Nikolaou Themistokles D Lekkas Spyros K Golfinopoulos | 2002 | Talanta2002，56，4： | 1 |
| 10 | Ex vivo coronary atheroscle-rotic plaque characterization with multi detector row CT显示文摘 | Becker CR Nikolaou K Muders M | 2009 | Eur Radi-ol2009，13，9： | 1 |
| 11 | Dual Energy CT lung perfusion imaging--correlation with SPECT/CT显示文摘 | Thieme SF Graute V Nikolaou K | 2012 | Eur J Radiol2012，81，2： | 1 |
| 12 | Dual-source CT cardiac imaging:initial experience显示文摘 | Johnson TR Nikolaou K Wintersperger BJ | 2006 | Eur Radiol2006，16，7： | 1 |
| 13 | Diagnostic accuracy of dual-source computed tomography in the diagnosis of coronary artery disease显示文摘 | Johnson TR Nikolaou K Busch S | 2007 | Invest Radiol2007，42，10： | 1 |
| 14 | Comparison of methods for determination of volatile organic compounds in drinking water 显示文摘 | Golfinopoulos S K Lekkas T D Nikolaou A D | 2001 | Chemosphere2001，45，3： | 1 |
| 15 | Assessment of myocardial infarctions using muhidetector-row computed tomography显示文摘 | Nikolaou K Knez A Sagmeister S | 2004 | J Comput Assist Tomogr2004，28，： | 1 |
| 16 | Advances in cardiac CT imaging:64-slice scanner显示文摘 | Nikolaou K Flohr T Knez A | 2004 | Int J Cardiovasc Imaging2004，20，6： | 1 |
| 17 | Otologic manifestations of relapsing polychondritis显示文摘 | Edgar Bachor Nikolas H. Blevins Collin Karmody Thomas Kühnel | 2005 | Auris Nasus Larynx2005，，2： | 1 |
| 18 | Multidetector-row computed tomography and magnetic resonance imaging of atherosclerotic lesions in human ex vivo coronary arteries显示文摘 | Nikolaou K Becker CR Muders M | 2004 | Atherosclerosis2004，174，2： | 1 |
| 19 | Dual-source CT cardiac imaging: initial experience 显示文摘 | Johnson TRC Nikolaou K Wintersperger B J etal | 2006 | Eur Radiol2006，16，7： | 1 |
| 20 | Time-resolved CT angiography in aortic dissection显示文摘 | Meinel FG Nikolaou K Weidenhagen R | 2012 | Eur J Radiol2012，81，： | 1 |
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