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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Exploring the Transcriptome Landscape of Pomegranate Fruit Peel for Natural Product Biosynthetic Gene and SSR Marker Discovery显示文摘Pomegranate fruit peel is rich in bioactive plant natural products,such as hydrolyzable tannins and anthocyanins.Despite their documented roles in human nutrition and fruit quality,genes involved in natural product biosynthesis have not been cloned from pomegranate and very little sequence information is available on pomegranate in the public domain.Shotgun transcriptome sequencing of pomegranate fruit peel cDNA was performed using RNA-Seq on the Illumina Genome Analyzer platform.Over 100 million raw sequence reads were obtained and assembled into 9,839 transcriptome assemblies (TAs) (>200 bp).Candidate genes for hydrolyzable tannin,anthocyanin,flavonoid,terpenoid and fatty acid biosynthesis and/or regulation were identified.Three lipid transfer proteins were obtained that may contribute to the previously reported IgE reactivity of pomegranate fruit extracts.In addition,115 SSR markers were identified from the pomegranate fruit peel transcriptome and primers were designed for 77 SSR markers.The pomegranate fruit peel transcriptome set provides a valuable platform for natural product biosynthetic gene and SSR marker discovery in pomegranate.This work also demonstrates that next-generation transcriptome sequencing is an economical and effective approach for investigating natural product biosynthesis,identifying genes controlling important agronomic traits,and discovering molecular markers in non-model specialty crop species. | Nadia Nicole Ono Monica Therese Britton Joseph Nathaniel Fass Charles Meyer Nicolet Dawei Lin Li Tian | 2011 | Journal of Integrative Plant Biology2011，53，10： | 12 |
| 3 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 4 | Single nucleotide polymorphism genotyping in polyploid wheat with the Illumina GoldenGate assay显示文摘 | Eduard Akhunov Charles Nicolet Jan Dvorak | 2009 | Theor Appl Genet2009，119，3： | 1 |
| 5 | Electromagnetic Analysis of Cylindrical Invisibility Cloaks and the Mirage Effect 显示文摘 | Zolla F Guenneau S Nicolet A | 2007 | Optics Letters2007，32，9： | 1 |
| 6 | Empiric antibiotic therapy in children with community-acquired pneumonia显示文摘 | Zhang L Lovatel R Nicolete D | 2008 | Indian Pediatr2008，45，7： | 1 |
| 7 | Incidence and conse quence of an hepatic artery injury in patients with postchole cystectomy bile duct strictures显示文摘 | Alves A Farges O Nicolet J | 2003 | Ann Surg2003，238，： | 1 |
| 8 | Animal mycoplasmoses: a general introduction显示文摘 | Nicolet J | 1996 | Rev Sic Tech1996，15，4： | 1 |
| 9 | The Translation Machinery and 70 kd Heat Shock Protein Cooperate in Protein Synthesis显示文摘 | NELSON RJ ZIEGELHOFFER T NICOLET C | 1992 | Cell1992，71，： | 1 |
| 10 | Detection of Mycoplasma hyopneumonia by air sampling with a nested PCR assay显示文摘 | Sark K D Nicolet J Frey J | 1998 | Appl Environ Micrdaiol1998，64，2： | 1 |
| 11 | Some antigenic properties of Haemophilus parasuis and a proposal for serological classification显示文摘 | Morozumi T Nicolet J | 1986 | J Clin Mi- crobiol1986，23，6： | 1 |
| 12 | Taxonomy and serological identification of Actinobacillus pleuropletanoniae显示文摘 | Nicolet J | 1988 | Can Vet J1988，29，： | 1 |
| 13 | Association between clinical presentation,biogroups and virulence attributes of Yersinia enterocolitica strains in human diarrhoeal disease显示文摘 | Burnens AP Frey A Nicolet J | 1996 | Epidemiol Infect1996，116，： | 1 |
| 14 | The translation machinery and 70 kD heat shock protein cooperate in protein synthesis显示文摘 | Nelson R J Ziegelhoffer T Nicolet C | 1992 | Cell1992，71，1： | 1 |
| 15 | Crystal structure of biotin synthase, an S - adenosylmethionine - dependent radical enzyme 显示文摘 | BERKOVITCH F NICOLET Y WAN J T | 2004 | Science2004，303，5654： | 1 |
| 16 | Detection of Mycoplasma hyopneumoniae by air sampling with a nestd PCR assay显示文摘 | Stark DA Nicolet J | | 0，，02： | 1 |
| 17 | Incidence and consequence of an epatic artery injury in patients with postcholecystectomy bile duct strictures 显示文摘 | Alves A Farges O Nicolet J | 2003 | Ann Surg2003，238，： | 1 |
| 18 | Some antigenic properties of Haemphi- lus parasuis and a proposal for serological classifieationE显示文摘 | Moorzumi T Nicolet J | 1986 | J Clin Microbiol1986，23，： | 1 |
| 19 | Detection of Mycoplasma hyopneumoniae by air sampling with a nested PCR assay 显示文摘 | KATHARINA D C NICOLET J FREY J | 1998 | Applied and Environmental Microbiology1998，2，： | 1 |
| 20 | High-order modeling of hydraulic power plant in islanded power network显示文摘 | Nicolet C Greiveldinger B Herou J J | 2007 | IEEE Transactions on Power Systems2007，22，： | 1 |
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