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| 1 | Novel mechanisms in functional dyspepsia显示文摘机能性消化不良(FD ) 是多重病原的机制涉及的高度流行却异构的混乱。尽管有许多研究,调查了各种各样的 pathophysiologic 机制,与 FD 联系的内在的随便小径仍然保持阴暗。与 FD 联系的当前建议的 pathophysiologic 机制包括基因危险性,推迟以及加速胃的倒空的、内脏的超敏性到酸或机械膨胀,损害胃的住所,反常底的的局面的收缩,反常 antro 十二指肠的活动性,急性、长期的感染,和精神分析社会 comorbidity。位于 FD 下面的畸形的更大的理解可以导致改进管理。这篇社论的目的是在机能性消化不良提供当前的 pathophysiologic 概念的批评概述。 | Rok Son Choung Nicholas J Talley | 2006 | World Journal of Gastroenterology2006，12，5： | 25 |
| 2 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 3 | Irritable bowel syndrome显示文摘 | Alexander C Ford Nicholas J Talley | 2012 | BMJ (sep )2012，，041： | 4 |
| 4 | Factor analysis identifies subgroups of constipation显示文摘AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction.METHODS:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport questionnaire.One hundred of these patients had colonic transit measured scintigraphically.Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology.Cluster analysis was used to determine whether indi-vidual patients naturally group into distinct subtypes.RESULTS:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors.Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool frequency.The majority of patients with these characteristics also reported regular laxative use.CONCLUSION:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated population.However,clear stratification into clinically identifiable groups remains imprecise. | Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J Talley Ian J Cook | 2011 | World Journal of Gastroenterology2011，17，11： | 3 |
| 5 | Acid and non-acid reflux in patients refractory to proton pump inhibitor therapy:Is gastroparesis a factor?显示文摘AIM:To determine whether an increased number and duration of non-acid reflux events as measured using the multichannel intraluminal impedance pH(MII-pH)is linked to gastroparesis(GP).METHODS:A case control study was conducted in which 42 patients undergoing clinical evaluation for continued symptoms of gastroesophageal reflux disease(both typical and atypical symptoms)despite acid suppression therapy.MII-pH technology was used over 24 h to detect reflux episodes and record patients’symptoms.Parameters evaluated in patients with documented GP and controls without GP by scintigraphy included total,upright,and supine number of acid and non-acid reflux episodes(pH<4 and pH>4,respectively),the duration of acid and non-acid reflux in a 24-h period,and the number of reflux episodes lasting longer than 5 min.RESULTS:No statistical difference was seen between the patients with GP and controls with respect to the total number or duration of acid reflux events,total number and duration of non-acid reflux events or the duration of longest reflux episodes.The number of nonacid reflux episodes with a pH>7 was higher in subjects with GP than in controls.In addition,acid reflux episodes were more prolonged(lasting longer than 5min)in the GP patients than in controls;however,these values did not reach statistical significance.Thirty-five patients had recorded symptoms during the 24 h study and of the 35 subjects,only 9%(n=3)had a positive symptom association probability(SAP)for acid/non-acid reflux and 91%had a negative SAP.CONCLUSION:The evaluation of patients with a documented history of GP did not show an association between GP and more frequent episodes of non-acid reflux based on MII-pH testing. | Anna Tavakkoli Bisma A Sayed Nicholas J Talley Baharak Moshiree | 2013 | World Journal of Gastroenterology2013，19，37： | 2 |
| 6 | Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis显示文摘 | Guy D Eslick Lynette L.-Y Lim Julie E Byles Harry H-X Xia Nicholas J Talley | 1999 | The American Journal of Gastroenterology1999，，： | 2 |
| 7 | GI symptoms in diabetes mellitus are associated with both poor glycemic control and diabetic complications显示文摘 | Peter Bytzer Nicholas J Talley Johann Hammer Lisa J Young Michael P Jones Michael Horowitz | 2002 | The American Journal of Gastroenterology2002，，3： | 2 |
| 8 | Predictors of health care seeking for irritable bowel syndrome and nonulcer dyspepsia: A critical review of the literature on symptom and psychosocial factors显示文摘 | Natasha A Koloski Nicholas J Talley Philip M Boyce | 2001 | The American Journal of Gastroenterology2001，，5： | 2 |
| 9 | The importance of clinicopathological correlation in the diagnosis of inflammatory conditions of the colon: histological patterns with clinical implications显示文摘 | Herschel A Carpenter Nicholas J Talley | 2000 | The American Journal of Gastroenterology2000，，4： | 1 |
| 10 | Overlapping upper and lower gastrointestinal symptoms in irritable bowel syndrome patients with constipation or diarrhea显示文摘 | Nicholas J Talley Eslie Helen Dennis V.Ann Schettler-Duncan Brian E Lacy Kevin W Olden Michael D Crowell | 2003 | The American Journal of Gastroenterology2003，，11： | 1 |
| 11 | An update of the Cochrane systematic review of Helicobacter pylori eradication therapy in nonulcer dyspepsia: resolving the discrepancy between systematic reviews显示文摘 | Paul Moayyedi Jon Deeks Nicholas J Talley Brendan Delaney David Forman | 2003 | The American Journal of Gastroenterology2003，，12： | 1 |
| 12 | A randomized controlled trial of cognitive behavior therapy, relaxation training, and routine clinical care for the irritable bowel syndrome显示文摘 | Philip M Boyce Nicholas J Talley Belinda Balaam Natasha A Koloski George Truman | 2003 | The American Journal of Gastroenterology2003，，10： | 1 |
| 13 | Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis显示文摘 | Guy D Eslick Lynette L.-Y Lim Julie E Byles Harry H-X Xia Nicholas J Talley | 1999 | The American Journal of Gastroenterology1999，，9： | 1 |
| 14 | Impact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life显示文摘 | Nicholas J Talley Lisa Young Peter Bytzer Johann Hammer Melanie Leemon Michael Jones Michael Horowitz | 2001 | The American Journal of Gastroenterology2001，，1： | 1 |
| 15 | Impact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life显示文摘 | Nicholas J Talley Lisa Young Peter Bytzer Johann Hammer Melanie Leemon Michael Jones Michael Horowitz | 2001 | The American Journal of Gastroenterology2001，，1： | 1 |
| 16 | Initial validation of a diagnostic questionnaire for gastroesophageal reflux disease显示文摘 | Michael J Shaw Nicholas J Talley Timothy J Beebe Todd Rockwood Rolf Carlsson Susan Adlis A.Mark Fendrick Roger Jones John Dent Peter Bytzer | 2001 | The American Journal of Gastroenterology2001，，： | 1 |
| 17 | Prevalence of colonic neoplasia and advanced lesions in the normal population: a prospective population-based colonoscopy study显示文摘 | Anna M Forsberg Lars Kjellstr? m Lars Agré us Anna Nixon Andreasson Henry Nyhlin Nicholas J Talley Erik Bj? rck | 2012 | Scandinavian Journal of Gastroenterology2012，，2： | 1 |
| 18 | Diagnostic and therapeutic strategies in the irritable bowel syndrome显示文摘 | Nicholas J Talley | 2004 | Minerva Med2004，95，5： | 1 |
| 19 | A randomized controlled trial of cognitive behavior therapy, relaxation training, and routine clinical care for the irritable bowel syndrome显示文摘 | Philip M Boyce Nicholas J Talley Belinda Balaam Natasha A Koloski George Truman | 2003 | The American Journal of Gastroenterology2003，，10： | 1 |
| 20 | Apoptosis in gastric epithelium induced by helicobacter pylori infection: implications in gastric carcinogenesis显示文摘 | Harry Hua-Xiang Xia Nicholas J Talley | 2001 | The American Journal of Gastroenterology2001，，1： | 1 |
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