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| 1 | Rescue associating liver partition and portal vein ligation for staged hepatectomy after portal embolization: Our experience and literature review显示文摘AIM To report a single-center experience in rescue associating liver partition and portal vein ligation for staged hepatectomy(ALPPS), after failure of previous portal embolization. We also performed a literature review.METHODS Between January 2014 and December 2015, every patient who underwent a rescue ALPPS procedure in Toulouse Rangueil University Hospital, France, was included. Every patient included had a project of major hepatectomy and a previous portal vein embolization(PVE) with insufficient future liver remnant to body weight ratio after the procedure. The ALPPS procedure was performed in two steps(ALPPS-1 and ALPPS-2), separated by an interval phase. ALPPS-2 was done within 7 to 9 d after ALPPS-1. To estimate the FLR, a computed tomography scan examination was performed 3 to 6 wk after the PVE procedure and 6 to 8 d after ALPPS-1. A transcystic stent was placed during ALPPS-1 and remained opened duringthe interval phase, in order to avoid biliary complications. Postoperative liver failure was defined using the 50-50 criteria. Postoperative complications were assessed according to the Dindo-Clavien Classification.RESULTS From January 2014 to December 2015, 7 patients underwent a rescue ALPPS procedure. Median FLR before PVE, ALPPS-1 and ALPPS-2 were respectively 263 cc(221-380), 450 cc(372-506), and 660 cc(575-776). Median FLR/BWR before PVE, ALPPS-1 and ALPPS-2 were respectively 0.4%(0.3-0.5), 0.6%(0.5-0.8), and 1%(0.8-1.2). Median volume growth of FLR was 69%(18-92) after PVE, and 45%(36-82) after ALPPS-1. The combination of PVE and ALPPS induced a growth of median initial FLR of +408 cc(254-513), leading to an increase of +149%(68-199). After ALPPS-2, 4 patients had stage Ⅰ-Ⅱ complications. Three patients had more severe complications(one stage Ⅲ, one stage Ⅳ and one death due to bowel perforation). Two patients suffered from postoperative liver failure according to the 50/50 criteria. None of our patients developed any biliary complication during the ALPPS procedure.CONCLUSION Rescue ALPPS may be an alternative after unsuccessful PVE and could allow previously unresectable patients to reach surgery. Biliary drainage seems to reduce biliary complications. | Charlotte Maulat Antoine Philis Bérénice Charriere Fatima-Zohra Mokrane Rosine Guimbaud Philippe Otal Bertrand Suc Fabrice Muscari | 2017 | World Journal of Clinical Oncology2017，8，4： | 7 |
| 2 | Hepatocellular carcinoma and non-alcoholic steatohepatitis:The state of play显示文摘Hepatocellular carcinoma(HCC) is now the fifth cancer of greatest frequency and the second leading cause of cancer related deaths worldwide. Chief amongst the risks of HCC are hepatitis B and C infection, aflatoxin B1 ingestion, alcoholism and obesity. The latter can promote non-alcoholic fatty liver disease(NAFLD), that can lead to the inflammatory form non-alcoholic steatohepatitis(NASH), and can in turn promote HCC. The mechanisms by which NASH promotes HCC are only beginning to be characterized. Here in this review, we give a summary of the recent findings that describe and associate NAFLD and NASH with the subsequent HCC progression. We will focus our discussion on clinical and genomic associations that describe new risks for NAFLD and NASH promoted HCC. In addition, we will consider novel murine models that clarify some of the mechanisms that drive NASH HCC formation. | Bérénice Charrez Liang Qiao Lionel Hebbard | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 3 | Contribution of alpha-fetoprotein in liver transplantation for hepatocellular carcinoma显示文摘Alpha-fetoprotein(AFP) is the main tumor biomarker available for the management of hepatocellular carcinoma(HCC). Although it is neither a good screening test nor an accurate diagnostic tool for HCC, it seems to be a possible prognostic marker. However, its contribution in liver transplantation for HCC has not been fully determined, although its use to predict recurrence after liver transplantation has been underlined by international societies. In an era of organ shortages, it could also have a key role in the selection of patients eligible for liver transplantation. Yet unanswered questions remain. First, the cut-off value of serum AFP above which liver transplantation should not be performed is still a subject of debate. We show that a concentration of 1000 ng/m L could be an exclusion criterion, whereas values of < 15 ng/m L indicate patients with an excellent prognosis whatever the size and number of tumors. Monitoring the dynamics of AFP could also prove useful. However, evidence is lacking regarding the values that should be used. Today, the real input of AFP seems to be its integration into new criteria to select patients eligible for a liver transplantation. These recent tools have associated AFP values with morphological criteria, thus refining pre-existing criteria, such as Milan, University of California, San Francisco, or 'up-to-seven'. We provide a review of the different criteria submitted within the past years. Finally, AFP can be used to monitor recurrence after transplantation, although there is little evidence to support this claim. Future challenges will be to draft new international guidelines to implement the use of AFP as a selection tool, and to determine a clear cut-off value above which liver transplantation should not be performed. | Bérénice Charrière Charlotte Maulat Bertrand Suc Fabrice Muscari | 2016 | World Journal of Hepatology2016，8，21： | 3 |
| 4 | The role of fructose in metabolism and cancer显示文摘 | Bérénice Charrez Liang Qiao Lionel Hebbard | 2015 | Hormone Molecular Biology and Clinical Investigation2015，，2： | 1 |
| 5 | Comparative analysis of clinical efficacy and cost between University of Wisconsin solution and histidine-tryptophan-ketoglutarate显示文摘 | Bellamy CA Nicely B Mattice B J | | 0，，03： | 1 |
| 6 | Inhibition of Pluripotency Networks by the Rb Tumor Suppressor Restricts Reprogramming and Tumorigenesis显示文摘 | Michael S. Kareta Laura L. Gorges Sana Hafeez Bérénice A. Benayoun Samuele Marro Anne-Flore Zmoos Matthew J. Cecchini Damek Spacek Luis F.Z. Batista Megan O’Brien Yi-Han Ng Cheen Euong Ang Dedeepya Vaka Steven E. Artandi Frederick A. Dick Anne Brunet Juli | 2014 | Cell Stem Cell2014，，： | 1 |
| 7 | The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man显示文摘 | Baldwin ME Catimel B Nice EC | 2001 | J Biol Chem2001，276，19： | 1 |
| 8 | Instrumental biosensors: new perspectives for the analysis of biomolecular interactions显示文摘 | Nice E C Catimel B | 1999 | BioEssays1999，21，4： | 1 |
| 9 | Instrumental biosensors:new perspectives for the analysis of biomolecular interactions显示文摘 | Nice EC Catimel B | 1999 | Bioessays1999，21，4： | 1 |
| 10 | Toxicity of cadmium-copper-nickel-zinc mixtures to larval purple sea urchins ( Strongylocentrotus purpuratus) 显示文摘 | PHILLIPS B M NICELY P A HUNT J W | 2003 | Bull Environ Contam Toxicol2003，70，： | 1 |
| 11 | Hypoglycemia and risk of death in critically ill patients 显示文摘 | NICE SUGAR Study Investigators Finfer S Liu B | 2012 | New England Journal of Medicine2012，，： | 1 |
| 12 | Role of aquapofin-4 water channel in the development and integrity of the blood-brain barrier 显示文摘 | Nice B Frigefi A Nicchia GP | 2001 | JCellSci2001，114，： | 1 |
| 13 | The post‐translational modification profile of the forkhead transcription factor FOXL2 suggests the existence of parallel processive/concerted modification pathways显示文摘 | Bérénice A.Benayoun JanaAuer SandrineCaburet Reiner A.Veitia | 2008 | Proteomics2008，，15： | 1 |
| 14 | Predicting factors for the need of extracorporeal membrane oxygenation for suicide attempts by cardiac medication:a single-center cohort study显示文摘BACKGROUND:Severe poisoning due to the overdosing of cardiac drugs can lead to cardiovascular failure.In order to decrease the mortality rate,the most severe patients should be transferred as quickly as possible to an extracorporeal membrane oxygenation(ECMO)center.However,the predictive factors showing the need for venous-arterial ECMO(VA-ECMO)had never been evaluated.METHODS:A retrospective,descriptive,and single-center cohort study.All consecutive patients admitted in the largest ICU of Reunion Island(Indian Ocean)between January 2013 and September 2018 for beta-blockers(BB),calcium channel blockers(CCB),renin-angiotensin-aldosterone system blockers,digoxin or anti-arrythmic intentional poisonings were included.ECMO implementation was the primary outcome.RESULTS:A total of 49 consecutive admissions were included.Ten patients had ECMO,39 patients did not have ECMO.Three patients in ECMO group died,while no patients in the conventional group died.The most relevant ECMO-associated factors were pulse pressure and heart rate at first medical contact and pulse pressure,heart rate,arterial lactate concentration,liver enzymes and left ventricular ejection fraction(LVEF)at ICU-admission.Only pulse pressure at first medical contact and LVEF were significant after logistic regression.CONCLUSION:A transfer to an ECMO center should be considered for a pulse pressure<35 mmHg at first medical contact or LVEF<20%on admission to ICU. | David Vandroux Thomas Aujoulat Bernard-Alex Gaüzère Bérénice Puech Bertrand Guihard Olivier Martinet | 2022 | World Journal of Emergency Medicine2022，13，4： | 1 |
| 15 | Hy- paglycemia and risk of death incritically ill patients显示文摘 | NICE -SUGAR Study Investigators Finfer S Liu B | 2012 | N Engl J Med2012，367，12： | 1 |
| 16 | Forkhead transcription factors: key players in health and disease显示文摘 | Bérénice A. Benayoun Sandrine Caburet Reiner A. Veitia | 2011 | Trends in Genetics2011，，6： | 1 |
| 17 | Impact of high-fat diet and vitamin D_3 supplementation on aortic stenosis establishment in waved-2 epidermal growth factor receptor mutant mice显示文摘Objective: The use of animal models of aortic stenosis(AS) remains essential to further elucidate its pathophysiology and to evaluate new therapeutic strategies. The waved-2 mouse AS model has been proposed;data have indicated that while aortic regurgitation(AR) is effectively induced, development of AS is rare.We aimed to evaluate the effect of high-fat diet(HFD) and vitamin D_3 supplementation in this model.Methods: HFD and subcutaneous vitamin D_3 injections were initiated at the age of 6 weeks until the age of 6(n = 16, 6-month treatment group) and 9(n = 11, 9-month treatment group) months. Twelve waved-2 mice without supplementation were used as control. Echocardiography was performed at 3, 6 and 9 months. Blood serum analysis(calcium, 1,25(OH)_2D_3 and cholesterol), histology and immunohistochemistry(CD-31, CD-68 and osteopontin) were evaluated at the end of the experiment(6 or 9 months).Results: Total cholesterol and 1,25(OH)_2D_3 were significantly increased relative to the control group. HFD and vitamin D_3 supplementation did result in improvements to the model, since AS was only detected in 6(15.3%) mice(2 in the 3 groups) and AR was developed in the remaining animals. Echocardiographic parameters, fibrosis, thickness, inflammation and valvular calcification, were not significantly different between the 6-month treatment and control groups. Similar results were also observed in the 9-month treatment group.Conclusion: These results suggest that HFD and vitamin D_3 supplementation have no effect in the waved-2 mouse model. This model essentially mimics AR and rarely AS. Further studies are needed to find a reliable animal model of AS. | Bérénice Colleville Nicolas Perzo Guillaume Avinée Ana?s Dumesnil Frederic Ziegler Paul Billoir Hélène Eltchaninoff Vincent Richard Eric Durand | 2019 | Journal of Integrative Medicine2019，17，2： | 0 |
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