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| 1 | Cyclophosphamide-induced reproductive toxicity: Beneficial effects of Helichrysum odoratissimum(Asteraceae) in male Wistar rats显示文摘Objective: Cyclophosphamide(CP) is commonly used to treat some cancers, but its clinical efficacy is also linked with testicular toxicity. We investigated the effects of aqueous extract(AE) and methanolic extract(ME) of Helichrysum odoratissimum for reducing CP-induced reproductive toxicity in male rats.Methods: In addition to a normal control(group 1), drugs or vehicles were administered orally to seven groups(n = 5) of rats that had already received 4-weeks of pre-treatment with CP(5 mg/[kgád], per oral administration);group 2 received CP + distilled water(10 m L/[kgád]);group 3 received CP + 5% tween 80(10 m L/[kgád]);group 4 received CP + clomiphene citrate(0.25 mg/[kgád]);groups 5 and 6 received CP + AE(50 and 100 mg/[kgád]) and groups 7 and 8 received CP + ME(50 and 100 mg/[kgád]). Animals were sacrificed on day 15, and body and sexual organ weights, sperm characteristics, testosterone level and testicular histology were evaluated.Results: The CP-treated group showed a significant reduction(P < 0.001) in the body and seminal vesicle weights, testosterone level, sperm count, sperm motility and sperm viability, but elevated(P < 0.001)sperm morphological abnormalities and testicular structure alterations, compared to the control group.Interestingly, these detrimental effects of CP were reversed by treatment with H. odoratissimum extracts.For instance, both extracts and all doses of H. odoratissimum significantly increased the sperm count(P < 0.001), sperm motility(AE, 50 mg/kg, P < 0.05;ME, 50 and 100 mg/kg, P < 0.05) and sperm viability(AE, 50 mg/kg, P < 0.001;ME, 50 and 100 mg/kg, P < 0.001) compared to the CP group. H. odoratissimum also improved plasmatic and intratesticular testosterone levels and prevented histological alterations of the testes.Conclusion: H. odoratissimum might be considered as an alternative drug to alleviate/prevent reproductive damage in cancer patients receiving CP chemotherapy. | Pierre Watcho Ismaelle Rosine Mpeck Patrick Brice Deeh Defo Modeste Wankeu-Nya Esther Ngadjui Georges Romeo Bonsou Fozin Pierre Kamtchouing Albert Kamanyi | 2019 | Journal of Integrative Medicine2019，17，5： | 3 |
| 2 | Effects of Ficus asperifolia on normal rat estrus cyclicity显示文摘Objective:To evaluate Ficus asperifolia(Moraceae)(F.asperifolia)effecting on regular estrus cycle of Wistar rats.Methods:Air-dried fruits of F.asperifolia were extracted using water.Prior to the test,vaginal smear was monitored daily for a 3-week period to select females with normal(regular)estrous cycle.Those with regular estrus cycle weighing between 150-170 g were randomized into three sets of 15 animals each.Each set was then divided into three groups:Group 1(control)was orally administered with distilled water(10 mL/kg body weight)once a day for 1 week starting from the proestrus stage.Groups 2 and 3 were respectively treated with 100and 500 mg/kg body weight of the plant aqueous extract.The two other sets of 15 animals each were similarly treated as the first set for 3 weeks and 6 weeks respectively.Estrus cycle pattern was monitored before and during plant extract application whereas lipid profile,ovary,uterus and liver growth indices were determined at the end of each treatment.Results:F.asperifolia did not disrupt(0%)the order of appearance of normal estrus cycle stages,namely,proestrus,estrus,metestrus and diestrus.Short-term treatment(1 week duration)exhibited high frequency of appearance of proestrus and estrus stages while mid-(3 weeks)and long-term(6 weeks)treatments revealed constancy in the frequency of all stages irrespective to animal groups.The plasma and organ lipid profile,as well as ovary,uterus and liver growth remained unchanged when compared to distilled water-treated animals.Following long-term administration of plant extract(6 weeks),no adverse effect was noticed.Conclusions:Our data partially support the use of F.asperifolia in common medicine. | Esther Ngadjui Pierre Watcho Telesphore Benoit Nguelefack Albert Kamanyi | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，1： | 3 |
| 3 | Prenylated flavanoids and a dihydro-4-phenylcoumarin from Dorstenia poinsettifolia 显示文摘 | Ngadjui B T Kapche G W F Tamboue H | 1999 | Phytochemistry1999，51，1： | 1 |
| 4 | Cytotoxicity and modes of action of four naturally occuring benzophenones: 2,2′,5,6′-Tetrahydroxybenzophenone, guttiferone E, isogarcinol and isoxanthochymol显示文摘 | Victor Kuete Patricia D. Tchakam Benjamin Wiench Bathelemy Ngameni Hippolyte K. Wabo Michel F. Tala Marlyse L. Moungang Bonaventure T. Ngadjui Tetsuya Murayama Thomas Efferth | 2013 | Phytomedicine2013，，6： | 1 |
| 5 | Evaluation of In Vitro Uterotonic Activities of Fruit Extracts of Ficus asperifolia in Rats显示文摘 | Pierre Watcho Esther Ngadjui Pepin Alango Nkeng-Efouet Telesphore Beno?t Nguelefack Albert Kamanyi | 2011 | Evidence-Based Complementary and Alternative Medicine2011，，： | 1 |
| 6 | Antioxidant activity of prenylated flavonoids from the West African medicinal plant Dorstenia mannii显示文摘 | Ngadjui B T Simeon K F | 2003 | Journal of Ethnopharmacology2003，87，1： | 1 |
| 7 | Homoisoflavonoids and stilbenes from the bulbs of Scilla nervosa sabsp, rigidifolia 显示文摘 | Silayo A Ngadjui B T Abegaz B M | 1999 | Phytochemistry1999，52，： | 1 |
| 8 | Quinolone and earbazole alkaloids from Clausena anis ats显示文摘 | Ngadjui B T Ayafor J F Sondengam B L | 1989 | Phytochemistry1989，28，5： | 1 |
| 9 | Prenylated anthronoid antioxidants from the stem bark of Harungana madagascariensis显示文摘 | Simeon F. Kouam Bonaventure T. Ngadjui Karsten Krohn Pascal Wafo Asma Ajaz M. Iqbal Choudhary | 2005 | Phytochemistry2005，，10： | 1 |
| 10 | Prenylated Flavones and Phenylpropanoid Derivatives from Roots of Dorstenia Psilurus 显示文摘 | NGADJUI B T DONGO E HAPPI E N | 1998 | Phytochemistry1998，48，4： | 1 |
| 11 | Limonoids from Clausena anisata 显示文摘 | Ngadjui BT Ayafor JF Sondengam BL | 1989 | J Nat Prod1989，52，4： | 1 |
| 12 | Homoisoflavonoids and stilbenes from the bulbs of Scilla nervosa subsp, rigidfolia 显示文摘 | Silayo A Ngadjui B T Abegaz B M | 1999 | Phytochemistry1999，52，： | 1 |
| 13 | Prenylated coumarins from the leaves of Clausena anisata 显示文摘 | NGADJUI B T AYAFOR J F SONDENGAM B L | 1989 | Journal of Natural Products1989，52，2： | 1 |
| 14 | Cytotoxic triterpene and sesquiterpene lactones from Elephantopus moUis and induction of apoptosis in neuroblastoma Cells 显示文摘 | Tabopda TK Liu J Ngadjui BT | 2007 | Planta med2007，73，： | 1 |
| 15 | Prenylated coumarins from the leaves of CIauaena anisata 显示文摘 | NGADJUI B T AYAFOR J F SONDENGAM B L | 1989 | Journal of Natural Products1989，52，2： | 1 |
| 16 | Prenylated chalcones and flavones from the leaves of Dorstenia Kameruniana显示文摘 | Abegaz B Ngadjui B Dongo E | | 0，，04： | 1 |
| 17 | Prenylated flavanoids and a dihydro-4-phenylcoumarin from Dorstenia poinsettifolia 显示文摘 | NGADJUI B T KAPCHE G W F TAMBOISE H | 1999 | Phytochemistry1999，51，1： | 1 |
| 18 | Oxidized palm oil impairs reproductive functions and architectures in female rats显示文摘Objective:To evaluate the effects of three oxidized palm oil diets(OPD)on female rat reproductive function.Methods:Forty-four female Wistar rats presenting five consecutive and regular estrous cycles were divided into 4 groups.The rats were fed with:a standard diet,70%of standard diet+30%oxidized palm oil diet(OPD1),OPD1+5 g of boiled yolk egg(OPD2)and OPD1+10%sucrose(OPD3)for 125 days,respectively.During the feeding period,morphometric,estrous cycle,sexual behavior,gestation,biochemical and histomorphometric parameters were evaluated.Results:All OPDs significantly increased abdominal circumference,body mass index and Lee index coupled to an irregularity and lengthening of the estrous cycle.They significantly decreased appetite and consumption behaviours,quantic pregnancy index,fertility rate,implantation sites and index,serum progesterone and high-density lipoprotein levels,increased pre-implantation losses,anti-implantation activities,serum estradiol,triglycerides,total and low-density lipoprotein-cholesterol levels,and impaired brain and ovaries oxidative status.Histomorphometric examinations revealed increases in the number of atresic and primary follicles and decreases in secondary,tertiary,Degraaf,total and corpus luteum follicles in ovaries coupled to a neurodegeneration of hypothalamic anteroventral periventricular neurons in the OPD groups compared to the standard diet group.Conclusions:The three OPDs induce obesity and impair the female reproductive function,especially OPD2 and OPD3.These findings contribute to a better understanding of the adverse effects of palm oil bleaching on the reproductive function in female rats,which could be useful in the management of women with obesity-related sexual dysfunction. | Wankeu-Nya Modeste Kengne Inès T Ateba Benjamin S Bend Fortune E Djeumeni Ornela N HathoDominique T Ngadjui E Moundipa Paul F Massoma DieudonnéL Dongmo Alain B Watcho Pierre | 2023 | Asian pacific Journal of Reproduction2023，12，4： | 0 |
| 19 | Flavonol Glycoside from Psorospermum androsaemifofium显示文摘 | Poumale, Poumale Herve Martiat Krebs, Hans Christoph Amadou, Dawe Shiono, Yoshihito Guedem, Alphonsine Nkapwa1 Komguem, Justin Ngadjui, Bonaventure Tchaleu Randrianasolo, RivoarisonI | 2011 | Chinese Journal of Chemistry2011，29，1： | 0 |
| 20 | Aframomum melegueta prevents the ejaculatory complications of propylthiouracil-induced hypothyroidism in sexually experienced male rats: Evidence from intravaginal and fictive ejaculations显示文摘Objective: Hypothyroidism has been claimed to generate sexual dysfunctions such as ejaculatory disorders. Aframomum melegueta is an aphrodisiac plant with pro-ejaculatory properties. We investigated the protective effects of aqueous extract(AE) and methanolic extract(ME) of A. melegueta on the ejaculatory function of hypothyroid male rats.Methods: Forty sexually experienced male rats were partitioned into 8 groups(5 rats per group) and treated for 28 d as follows: Group 1, Control;Group 2, propylthiouracil(PTU, 10 mg/kg)+ distilled water(DW,10 m L/kg);Group 3, PTU + 5% Tween 80(10 m L/kg);Group 4, PTU + bromocriptine(6 mg/kg);Group 5,PTU + AE(20 mg/kg);Group 6, PTU + AE(100 mg/kg);Group 7, PTU + ME(20 mg/kg), and Group 8,PTU + ME(100 mg/kg). On days 0, 7, 14 and 28 of treatment, each male rat was paired with primed receptive female for measurement of ejaculatory latency time(ELT) and post-ejaculatory interval(PEI) for1.5 h. On day 29, each male rat was urethane-anesthetized and the spinal cord was transected.Thereafter, following urethral/penile stimulations and intravenous injection of dopamine, contractions of the bulbospongiosus muscles and the intraseminal pressure were registered. After these recordings,blood was collected through the catheterization of abdominal artery and plasma was used for thyroidstimulating hormone(TSH), prolactin and testosterone assays.Results: PTU-induced hypothyroidism was characterized by a significant elevation(P < 0.001) of plasmatic TSH and prolactin levels, but a decline(P < 0.001) in plasmatic testosterone, compared to untreated group. ELT, PEI, contractions of the bulbospongiosus muscles and the intraseminal pressure were also altered by PTU treatment. On the contrary, A. melegueta extracts elevated testosterone(AE, 100 mg/kg,P < 0.01;ME, 100 mg/kg, P < 0.05) and decreased prolactin(AE, 100 mg/kg, P < 0.05;ME, 20 mg/kg,P < 0.05) levels, compared to corresponding controls. With regard to DW + PTU group, prolactin concentration was lowered(P < 0.05) in rats administered with bromocriptine. Treatment with A. melegueta extracts significantly prevented the lengthening of ELT(P < 0.05) and PEI(P < 0.001). Hypothyroid state also altered the fictive ejaculation by increasing the latency and decreasing the number and frequency of bulbospongiosus muscle contractions. There was also a decrease in the intraseminal pressure. These alterations were significantly(P < 0.05) alleviated in plant extract-treated groups.Conclusion: This study highlighted the ejaculatory disturbance of hypothyroidism in male rats and its prevention with A. melegueta extracts. | Francois Xavier Kemka Nguimatio Patrick Brice Deeh Defo Modeste Wankeu-Nya Esther Ngadjui Albert Kamanyi Pierre Kamtchouing Pierre Watcho | 2019 | Journal of Integrative Medicine2019，17，5： | 0 |
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