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| 1 | Non-steroidal anti-inflammatory drugs and statins in relation to colorectal cancer risk显示文摘AIM:To investigate the association between individual or combined use of non-steroidal anti-inflammatory drugs(NSAIDs) or statins and colorectal cancer risk.METHODS:In a population-based case-control study in women,we examined the association between NSAIDs and statin use and the risk of colorectal cancers.We further investigated whether the use of statins modifies the protective effect of NSAIDs.Female cases(n = 669) of colorectal cancer aged 50-74 years were identified from a statewide registry in Wisconsin during 1999-2001.Community control women(n = 1375) were randomly selected from lists of licensed drivers and Medicare beneficiaries.Medication use and risk factor information were gathered during a structured telephone interview.A multivariable logistic regression model was used to calculate odds ratio(OR) and 95% conf idence interval(CI) .RESULTS:Overall,NSAIDs users had a 30% reduction in risk of colorectal cancer(95% CI:0.56-0.88) .Statin use was not associated with colorectal cancer risk(OR = 1.17,95% CI:0.74-1.85) ,regardless of structural type(lipophilic or hydrophilic) ,duration of use,or recency.There was no evidence of an interaction between NSAIDs and statins and colorectal cancer risk(P-interaction = 0.28) .CONCLUSION:Although our results confirm the inverse association between NSAIDs use and colorectal cancer risk,they do not support a risk reduction in statin users,or an interaction effect of combined NSAIDs and statin use. | Mazyar Shadman Polly A Newcomb John M Hampton Karen J Wernli Amy Trentham-Dietz | 2009 | World Journal of Gastroenterology2009，15，19： | 5 |
| 2 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 3 | Compressibility effect on instability growth rates显示文摘 | Newcomb W A | 1983 | Phys Fluids1983，26，： | 2 |
| 4 | Narrow-band waveguide filters显示文摘 | Willitums A E Newcomb R W | 1972 | IEEE Tans Microwave Theory Tech1972，23，6： | 1 |
| 5 | Physicalactivity and survival after diagnosis of invasive breast cancer显示文摘 | Holick CN Newcomb PA Trentham-Dietz A | 2008 | Cancer Epidemiol Biomarkers Prev2008，17，2： | 1 |
| 6 | Compressibility effect on instability growth rates显示文摘 | Newcomb W A | 1983 | Phys Fluids1983，26，： | 1 |
| 7 | The metabolism of a city:the case of Hong Kong显示文摘 | Newcombe K Kalina J D Aston A R | 1978 | AMBIO1978，，7： | 1 |
| 8 | Breast feeding practices in relation to endometrial cancer risk,USA显示文摘 | Newcomb PA Trentham-Dietz A | 2000 | Cancer Cancer Causes Control2000，11，7： | 1 |
| 9 | Effect modification by population dietary folate on theassociation between MTHFR genotype,homocysteine,and st-roke risk : a meta-analysis of genetic studies and randomisedtrials显示文摘 | Michael V Holmes Paul Newcombe Jaroslav A Hubacek | 2011 | The Lancet2011，378，9791： | 1 |
| 10 | Cellulase, clostfidia, and ethanol 显示文摘 | Demain A L Newcomb M Wu J H D | 2005 | Microbiol Mol Biol R2005，69，： | 1 |
| 11 | Weightchange and risk of postmenopausal breast cancer(United States)显示文摘 | Trentham-Dietz A Newcomb PA Egan KM | 2000 | Cancer Causes Control2000，11，： | 1 |
| 12 | Improved function from progressive strengthening interventions after total knee arthroplasty:a randomized clinical trial with an imbedded prospective cohort显示文摘 | Petterson SC Mizner RL Stevens JE Raisis L Bodenstab A Newcomb W Snyder-Mackler L | 2009 | Arthritis and rheumatism2009，61，2： | 1 |
| 13 | Adenylat e energycharge measurement in soils显示文摘 | Brookes P C Newcombe A D Jenkinson D S | 1987 | Soil Biol Biochem1987，19，2： | 1 |
| 14 | The metabolism of a city:the case of Hong Kong显示文摘 | Newcombe K Kalina J D Aston A R | 1978 | AMBIO1978，7，： | 1 |
| 15 | Cellulase, clostridia, and ethanol显示文摘 | Demain A L Newcomb M Wu J H D | 2005 | Microbiol Mol Biol R2005，，69： | 1 |
| 16 | Cor triatriatum:Presentation,diagnosis and long-term surgical results显示文摘 | Alphonso N Norgaard M A Newcomb A | 2005 | Ann Thorac Surg2005，80，5： | 1 |
| 17 | Young children's use of features to reorient is more than just associative:Further evidence against a modular view of spatial processing显示文摘 | Newcombe N.S Ratliff K.R Shallcross W.L Twyman A | | 0，，： | 1 |
| 18 | Nuclear Fears and Concerns among College-students:A Cross-national-study of Attitudes显示文摘 | Rabow J Hernandez A Newcomb M D | 1990 | Political Psychology1990，11，4： | 1 |
| 19 | Internal mammary node drainage and its role in sentinel lymph node biopsy: the ini- tial ALMANAC experience显示文摘 | Mansel R E Goyal A Newcombe R G | 2004 | Clin Breast Cancer2004，5，4： | 1 |
| 20 | Analyses of expressed sequence tags from apple显示文摘 | Newcomb R D Crowhurst R N Gleave A P | 2006 | Plant Physiol2006，141，： | 1 |
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