| 5 | Statins in acute neurologic disease:which one,which dose,when to start,and when not to stop显示文摘Statins could have physiologic properties that may benefit patients that have been diagnosed with various acute neurological diseases.This review aims tosummarize the literature pertaining to stain use in acute neurological disease such as subarachnoid hemorrhage,intracerebral hemorrhage(ICH),cerebral ischemia(CI),traumatic brain injury,status epilepticus and meningitis.The authors reviewed published abstracts and manuscripts pertaining to experimental and clinical trials relevant to statins in acute neurological disease.Although acute statin therapy in the setting of subarachnoid hemorrhage might reduce delayed cerebral ischemia and mortality,it should not be considered standard care at this time.Acute statins therapy has not demonstrated anybenefit yet following an ICH or CI.Acute statin withdrawal may worsen outcome in acute CI.Observational and case-control studies suggest that pretreatment with statin at time of onset may be associated with better outcomes.Even though preclinical studies have shown statins to have beneficial effects,there has been no clinical evidence.In conclusion,current published studies have not shown that acute statin therapy has any benefical effects in acute neurologic diseases and therefore further large randomized clinical trials are needed. | Bong-Su Kang Gene Sung May Kim-Tenser Nerses Sanossian | 2016 | Neuroimmunology and Neuroinflammation2016，3，1： | 0 |
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