5篇
您的检索式：作者名="Neha Mittal"
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| 1 | Mechanisms of temozolomide resistance in glioblastoma-a comprehensive review显示文摘Glioblastoma(GBM)is the most common primary malignant brain tumor in adults and has an exceedingly low median overall survival of only 15 months.Current standard-of-care for GBM consists of gross total surgical resection followed by radiation with concurrent and adjuvant chemotherapy.Temozolomide(TMZ)is the first-choice chemotherapeutic agent in GBM;however,the development of resistance to TMZ often becomes the limiting factor in effective treatment.While O6-methylguanine-DNA methyltransferase repair activity and uniquely resistant populations of glioma stem cells are the most well-known contributors to TMZ resistance,many other molecular mechanisms have come to light in recent years.Key emerging mechanisms include the involvement of other DNA repair systems,aberrant signaling pathways,autophagy,epigenetic modifications,microRNAs,and extracellular vesicle production.This review aims to provide a comprehensive overview of the clinically relevant molecular mechanisms and their extensive interconnections to better inform efforts to combat TMZ resistance. | Neha Singh Alexandra Miner Lauren Hennis Sandeep Mittal | 2021 | Cancer Drug Resistance2021，4，1： | 4 |
| 2 | Urban transport crisis in India 显示文摘 | John Pucher Nisha Korattyswaropam Neha Mittal Neenu Ittyerah | 2005 | Transport Policy2005，12，3： | 1 |
| 3 | Urban Transport Crisis in India显示文摘 | John Pucher Nisha Korattyswaropam Neha Mittal Neenu Ittyerah | 2005 | Transport Policy2005，12，3： | 1 |
| 4 | Phosphorous pentoxide mediated synthesis of 5-HMF in ionic liquid at low temperature显示文摘 | Devalina Ray Neha Mittal Wook-Jin Chung | 2011 | Carbohydrate Research2011，，14： | 1 |
| 5 | Population genetic structure and diversity of high value vulnerable medicinal plant Acorus calamus in India using RAPD and chloroplast microsatellite markers显示文摘Acorus calamus is a highly valued medicinal plant with global distribution used in several drugs of health care systems. We evaluated the genetic diversity and population structure of 50 populations of A. calamus from different geographical regions in India through RAPD and chloroplast microsatellite markers. From the total screened 82 RAPD primers and 18 cpSSR primers, 10 RAPD and nine cpSSRs were found polymorphic. The selected 10 RAPD primers produced a total of 96 reproducible bands, out of which 65 were polymorphic (67.70%). Whereas, the selected nine cpSSR markers produced 26 alleles and all of them were polymorphic. The mean genetic diversity (H T ) among populations using RAPD (H T = 0.263) and cpSSR (H T = 0.530) markers was higher in comparison to the mean genetic diversity within populations. Mean coefficient of gene differentiation (G ST ) between the populations was also high for both RAPD (G ST = 0.830) and cpSSR markers (G ST = 0.735), whereas the estimated gene flow was very low for RAPD (Nm = 0.102) and for cpSSR (Nm = 0.179). AMOVA analysis revealed that more genetic variation resided among the populations than within populations. Significant differences (p < 0.001) were observed between the populations and individuals within the populations. Cluster analysis of RAPD and cpSSR data using UPGMA algorithm based on Nei's genetic similarity matrix placed the 50 populations into two main clusters. The implication of the results of this study in devising strategy for conservation of A. calamus is discussed. | H. S. Ginwal Neha Mittal Arvind Tomar V. K. Varshney | 2011 | Journal of Forestry Research2011，22，3： | 0 |
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