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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | High prevalence of methicillin resistant Staphylococcus aureusin pigs显示文摘 | De Neeling A J Van den Broek M J M Spalburg E C | 2007 | Vet Microbiol2007，122，： | 1 |
| 3 | Behavior of class- level landscape metrics across gradients of class aggregation andarea显示文摘 | NEEL M C MCGARIGAL K CUSHMAN S A | 2004 | Landscape Ecology2004，19，： | 1 |
| 4 | Fractional diffusion and reflective boundary condition显示文摘 | KREPYSHEVA N PIETRO L D NEEL M C | 2006 | Physica A2006，368，： | 1 |
| 5 | Parsimony in landscape metrics : Strength, universality, and consistency显示文摘 | Cushman S A McGarigal K Neel M C | 2008 | Ecological Indicators2008，8，5： | 1 |
| 6 | Patterns of allozyme diversity in the threatened plant Erigeron pariskii (Asteraeeae) 显示文摘 | Neel M C Ellstrand N C | 2001 | American Journal of Botany2001，88，5： | 1 |
| 7 | High prevalence of methicillin-resistant Staphylococcus aureus in pigs 显示文摘 | DE NEELING A J VAN DEN BROEK M J M SPALBURG E C | 2007 | Vet Microbiol2007，122，34： | 1 |
| 8 | Behavior of class - level landscape metrics across radients of class aggregation and area 显示文摘 | Neel M C McGarigal K | 2004 | Landscape Ecology2004，19，： | 1 |
| 9 | Photoconversion of YFP into a CFP-like species during aoceptor photobleaching FRET experiements显示文摘 | Valentin G Verheggen C Piolot T Neel H Coppey-Moisan M Bertrand E | | 0，，： | 1 |
| 10 | Near Shannon limit performance of low density parity cheek codes 显示文摘 | Mackay D J C Neel R M | 1996 | Electronic Letters1996，32，18： | 1 |
| 11 | Neuronal PTP1B regulates body weight,adiposity and leptin action显示文摘 | Bence K K Delibegovic M Xue B Gorgun C Z Hotamisligil G S Neel B G | 2006 | Nat Med2006，12，： | 1 |
| 12 | Collagen - Emerging collagen based therapies hit the patient显示文摘 | Ensanya A Neel A Bozec L Jonathan C Omaer S Vivek M Richard D Jung K | 2013 | Advanced Drug Delivery Reviews2013，65，4： | 1 |
| 13 | Parsimony in landscape metrics: strength, universality, and consistency显示文摘 | CUSHMAN S A McGARIGAL K NEEL M C | 2008 | Ecological Indicators2008，8，5： | 1 |
| 14 | A global quantitative synthesis of local and landscape effects on wild bee pollinators in agroecosystems显示文摘 | Kennedy C M Lonsdorf E Neel M C | 2013 | Ecology Letters2013，16，5： | 1 |
| 15 | Neuronal PTP1B regulates body weight,adiposity and leptin action显示文摘 | Bence K K Delibegovic M Xue B Gorgun C Z Hotamisligil G S Neel B G | 2006 | Nat Med2006，12，： | 1 |
| 16 | High prevalence of methicillin resistant Staphyloceccus aureus in pigs显示文摘 | De Neeling A J Van Den Broek M J Spalburg E C | 2007 | Vet Microbiol2007，122，： | 1 |
| 17 | High prevalence of methicillin resistantStaphylococcus aureus in pigs 显示文摘 | DE NEELING A J VAN DEN BROEK M J M SPAL-BURG E C | 2007 | Vet Microbiol2007，122，34： | 1 |
| 18 | Therapeutic drug monitoring of old and newer anti-epilepticdrugs 显示文摘 | NEELS H M SIERENS A C NAELAERTS K | 2004 | Clin Chem Lab Med2004，4201，： | 1 |
| 19 | Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta显示文摘 | Prockop D J Fitzpatrick L A Koo W W Gordon P L Neel M Sussman M Orchard P Marx J C Pyeritz R E Brenner M K | 1999 | Nature Med1999，5，： | 1 |
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