|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a phosphatidylinositol 3-kinase- dependent mechanism显示文摘 | Benomar Y Naour N Aubourg A | 2006 | Endocrinology2006，147，5： | 1 |
| 3 | Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a PI 3-kinase dependent显示文摘 | Benomar Y Naour N Aubourgl A | 2006 | Endocrinology2006，147，5： | 1 |
| 4 | Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer显示文摘 | le NAOUR F MISEK D E KRAUSE M C | 2001 | Clin Cancer Res2001，7，11： | 1 |
| 5 | Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a phosphatidylinositnl 3-kinase-dependent mechanism显示文摘 | BENOMAR Y NAOUR N AUBOURGL A | 2006 | Endocrinology2006，147，5： | 1 |
| 6 | Insulin and leptin induce Glut4 plasma membrane translocationand glucose uptake in a human neuronal cell line by a PI3-Kinase dependent显示文摘 | Benomar Y Naour N Aubourgl A | 2006 | Endocrinology2006，23，： | 1 |
| 7 | Behaviour of Zr,Hf,Nb,Ta and Pa on Macroporous Anion Exchanger in Chloride-fluoride Media显示文摘 | TRUBERT D GUZMAN FM NAOUR CL | 1998 | Analytical Chimica Acta1998，374，： | 1 |
| 8 | Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer显示文摘 | Le Naour F Misek DE Krause MC | 2001 | Clin Cancer Res2001，7，11： | 1 |
| 9 | Identification of plasma membrane autoantigens in autoimmune hepatitis type Ⅰ using aproteomics tool显示文摘 | Tahiri F Le Naour F Huguet S | | 0，，03： | 1 |
| 10 | Identification of tumor- associated antigens using proteomics显示文摘 | Naour FL Brichory F Beretta L | 2002 | Technol Cancer Res Treat2002，1，4： | 1 |
| 11 | Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neurona cell line by a PI3-kinase dependent 显示文摘 | Benomar Y Naour N Aubourgl A | 2006 | Endocrinology2006，147，5： | 1 |
| 12 | Preferential reduction of very low density lipoprotein-1 particle number by fenofibrate in type IIB hyperlipidemia: consequences for lipid accumulation in human monocyte-derived macrophages显示文摘 | Milosavljevic D Griglio S Naour GL | 2001 | Atherosclerosis2001，155，： | 1 |
| 13 | EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells显示文摘 | Charrin S Le Naour F Labas V | 2003 | Biochem J2003，373，2： | 1 |
| 14 | Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a phosphatidylinositol 3-kinase-dependent mechanism显示文摘 | Benomar Y Naour N Aubourg A | 2006 | Endocrinology2006，147，5： | 1 |
| 15 | Cathepsius in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation显示文摘 | Naour N Rouauh C Fellahi S | 2010 | J Clin Endocrinol Metab2010，95，4： | 1 |
| 16 | Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer显示文摘 | Misek DE Krause MC | 2001 | Clin Cancer Res2001，7，11： | 1 |
| 17 | Integrated genomic and proteomic analysis of signaling pathways in dendritic cell differentiation and maturation显示文摘 | Richards J Le Naour F Hanash S | 2002 | Ann N Y Acad Sci2002，975，： | 1 |
| 18 | Protcomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer显示文摘 | Le Naour F Misek D E Krause M C | 2001 | Clin Cancer Res2001，7，11： | 1 |
| 19 | Spectroscopic and slectrochemical studies of U(IV) - hexachlo-ro complexes in hydrophobic room-temperature ionic liquids and 显示文摘 | Nikitenko S I Cannes C Le Naour C | 2005 | Inorganic Chemitry2005，44，25： | 1 |
| 20 | Profiling of the tetraspanin web of human colon cancer cells显示文摘 | Le Naour F Andre M Greco C | 2006 | Mol Cell Proteomics2006，5，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员