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| 1 | 乙型肝炎病毒基因型和血清亚型在我国部分地区的分布及其特点显示文摘目的 研究乙型肝炎病毒 (hepatitisBvirus ,HBV)基因型和血清亚型的分布特点及其基因的相关性。方法 湖南、广西、河南和河北 4省 (区 ) 2 5个县 (市 ) 2 80例慢性HBV携带者 ,应用聚合酶链反应 (PCR)扩增和脱氧核糖核酸 (DNA)序列分析 ,确定HBV基因型和血清亚型。结果 HBV基因型B、C和D均有分布 ,分别占 2 9.3%、6 7.9%和 2 .9% ,其中B和C为优势基因型。adr、adw2、ayr、ayw1、ayw2和ayw3等 6种血清亚型均有分布 ,其中adr和adw2为优势血清亚型 ,分别占6 4.3%和 31.4%。基因型B与adw2血清亚型 ,基因型C与adr血清亚型有非常密切的基因相关性。 2 80例HBV携带者表面抗原基因序列每 10 0个核苷酸的平均置换频数为 2 .94。基因型B(adw2血清亚型 )毒株核苷酸置换频数为 5 .6 3(5 .48) ,而基因型C(adr血清亚型 )仅为 1.6 (1.5 1)。结论 HBV基因型和血清亚型的分布均有明显的地区性 ;基因型B及相对应的adw2血清亚型毒株的基因可变性明显高于基因型C及相应的adr血清亚型。 | 夏国良 Omana V Nainan 贾志远 刘洪斌 罗述斌 李荣成 曹慧霖 刘崇柏 HaroldS Margolis | 2001 | 中华流行病学杂志2001，22，5： | 131 |
| 2 | Te prevalence of epatitis C virus infection in te united states,1988 troug 1994显示文摘 | ruszzon D Nainan D V | 1999 | N Engl J Med1999，341，8： | 1 |
| 3 | The prevalence of hepatitis C virus infection in the united states,1988 through 1994显示文摘 | Alter MJ Kruszzon D Nainan DV et a1 | 1999 | N Engl J Med1999，341，8： | 1 |
| 4 | End-point limiting-dilution real-time PCR assay for evaluation of hepatitis C virus quasispecies in serum: Performance under optimal and suboptimal conditions显示文摘 | Sumathi Ramachandran Guo-liang Xia Lilia M. Ganova-Raeva Omana V. Nainan Yury Khudyakov | 2008 | Journal of Virological Methods2008，，2： | 1 |
| 5 | The prevalence of hepatitis C virus infection in the United States,1988 through 1994显示文摘 | Kruszzon D Nainan QV | 1999 | N Engl J med1999，34，8： | 1 |
| 6 | Hepatitis a molecular epidemiology in the United States, 199671997: sources of infection and implications of vaccination policy 显示文摘 | Nainan OV Armstrong GL Han XH | 2005 | J Infect Dis2005，191，： | 1 |
| 7 | Hepatitis a molecular epidemiology in the United States, 1996 - 1997: sources of infection and implications of vaccination policy 显示文摘 | Nainan OV Armstrong GL Han XH | 2005 | J Infect Dis2005，191，6： | 1 |
| 8 | The prevalence of hepatitis C virus infection in the United States,1988 through 1994显示文摘 | Alter MJ Kruszon-Moran D Nainan OV | 1999 | N Engl J Med1999，341，8： | 1 |
| 9 | Genetic variation of hepatitis B surface antigen coding region among infants with chronic hepatitis B virus infection显示文摘 | Nainan OV Khristova ML Byun K | | 0，，： | 1 |
| 10 | Prevalence of hepatitis C virus infection in the United States,1988- 1994 显示文摘 | Alter MJ Kruszon-Moran D Nainan OV | 1999 | N Engl J Med1999，341，： | 1 |
| 11 | Prevalence of hepatitis C virus infection in the United States, 1988 - 1994 显示文摘 | Alter MJ Kruszon MD Nainan OV | 1999 | N Engl J Med1999，341，： | 1 |
| 12 | Sequence-specfic,single-primer amplification and detection of PCR products for identification of hepatitis viruses显示文摘 | Nainan OV Cromeans TL Margolis HS | 1996 | J Viro Methods1996，61，12： | 1 |
| 13 | Diagnosis of hepatitis A virus infection:A molecular approach显示文摘 | Nainan O V Xia G L Vaughan G Margolis H S | 2006 | Clin Microbiol Rev2006，19，1： | 1 |
| 14 | Genetic variation of hepatitis B surface antigen coding region among infants with chronic hepatitis B virus infection 显示文摘 | Nainan OV Khristova ML Byun K | 2002 | J Med Virol2002，68，3： | 1 |
| 15 | Fine Structural Observation on the Oogenesis and Vitellogenesis in Chinese Soft-shelled Turtle, Pelodiseus sinensis显示文摘Here we described the ovarian follicle using electron microscopy to examine the vitellogenesis pathway and the special function exerted by follicular cell during growing stage.Through the observation of vitellogenesis under the electron microscope,we found some of the mitochondria(Mt)transform into the yolk granulae gradually.So in this stage,the pathway of vitellolgenesis is | Hei Nainan Bian Xunguang Liu Yi Yang Ping Chen Qiusheng | 2012 | 畜牧与兽医2012，44，S1： | 1 |
| 16 | Switch from a CNI-to a be-latacept-based immunosuppressive regimen in kidney transplant recip-ients is safe and results in better renal function:12 month results from a phaseⅡstudy显示文摘 | Rostaing L Nainan G Rial MD | 2010 | Am J Transplant2010，10，4： | 1 |
| 17 | Immunomorphologic Studies of Antigen Identified by a Monoclonal Antibody Associated with Experimental Non-A, Non-B Hepatitis in Chimpanzees显示文摘 | KRAWCZYNSKI K BRADLEY D W SHIMIZU Y HUMPHEREY C D NAINAN O V MARGOLIS H S MAYNARD J E | 1985 | Hepatology1985，，： | 1 |
| 18 | The role of riparian corridors in maintaining regional biodiversity显示文摘 | Nainan R J Decamps H Pollock M | 1993 | Ecological Applications1993，21，： | 1 |
| 19 | Selective transmission of hepatitis C virus genotypes and quasispecies in humans and experimentally infected chimpanzees 显示文摘 | Nainan OV Lu I Gao FX | 2006 | J Gen Virol2006，87，1： | 1 |
| 20 | Diagnosis of hepatitis A virus: A molecular approach 显示文摘 | Nainan O V Xia G L Vaughan G | 2006 | Clin Microbiol Rev2006，19，1： | 1 |
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