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| 1 | Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention显示文摘Carcinoma of the stomach is still the second most common cause of cancer death worldwide, although the incidence and mortality have fallen dramatically over the last 50 years in many regions. The incidence of gastric cancer varies in different parts of the world and among various ethnic groups. Despite advances in diagnosis and treatment, the 5-year survival rate of stomach cancer is only 20 per cent. Stomach cancer can be classified into intestinal and diffuse types based on epidemiological and clinicopathological features. The etiology of gastric cancer is multifactorial and includes both dietary and nondietary factors. The major diet-related risk factors implicated in stomach cancer development include high content of nitrates and high salt intake. Accumulating evidence has implicated the role of Helicobacter pylori (H. pylori) infection in the pathogenesis of gastric cancer. The development of gastric cancer is a complex, multistep process involving multiple genetic and epigenetic alterations of oncogenes, tumor suppressor genes, DNA repair genes, cell cycle regulators, and signaling molecules. A plausible program for gastric cancer prevention involves intake of a balanced diet containing fruits and vegetables, improved sanitationand hygiene, screening and treatment of H. pylori infection, and follow-up of precancerous lesions. The fact that diet plays an important role in the etiology of gastric cancer offers scope for nutritional chemoprevention. Animal models have been extensively used to analyze the stepwise evolution of gastric carcinogenesis and to test dietary chemopreventive agents. Development of multitargeted preventive and therapeutic strategies for gastric cancer is a major challenge for the future. | Siddavaram Nagini | 2012 | World Journal of Gastrointestinal Oncology2012，4，7： | 87 |
| 2 | Intrinsic apoptosis and NF-κB signaling are potential molecular targets for chemoprevention by black tea polyphenols in HepG2 cells in vitro and in a rat hepatocarcinogenesis model in vivo显示文摘 | R. Senthil Murugan R. Vidya Priyadarsini K. Ramalingam Y. Hara D. Karunagaran S. Nagini | 2010 | Food and Chemical Toxicology2010，，11： | 2 |
| 3 | Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer显示文摘 | K. Kavitha J. Kowshik T. Kranthi Kiran Kishore Abdul Basit Baba S. Nagini | 2013 | BBA - General Subjects2013，，10： | 2 |
| 4 | Prevention of 4-nitroquinoline 1-oxideinduced rat tongue carcinogenesis by garlic显示文摘 | Balasenthil Seetharaman Ramachandran Chinnamanoor R Nagini Siddavaram | 2001 | Fitoterapia2001，72，5： | 1 |
| 5 | Altered cytokeratin expression during chemoprevention of experimental hamster buccal pouch carcinogenesis by garlic显示文摘 | Balasenthil S Rao KS Nagini S | 2002 | J Oral Pathol Med2002，31，3： | 1 |
| 6 | Tomato and garlic by gavage modulate 7,12-dimethylbenz anthracene-induced genotoxicity and oxidative stress in mice显示文摘 | Bhuvaneswaril V Velmuruganl B Nagini S | 2004 | Braz J Med Biol Res2004，37，7： | 1 |
| 7 | Ethanolic neem (Azadirachta indica) leaf extract induces apoptosis in the hamster buccal pouch carcinogenesis model by modulation of Bcl-2, Bim, caspase 8 and caspase3显示文摘 | Subapriya R Bhuvaneswari V Nagini S | 2005 | Asian Pac J Cancer Prey2005，6，4： | 1 |
| 8 | Chapter seven-neem limonoids as anticancer agents:modulation of cancer hallmarks and oncogenic signaling显示文摘 | Nagini S | 2014 | The Enzymes2014，36，： | 1 |
| 9 | Altered cytokeratin expression during chemoprevention of experimental hamster buccal pouch carcinogenesis by garlic 显示文摘 | Balasenthil S Rao KS Nagini S | 2002 | J Oral Pathol Med2002，31，3： | 1 |
| 10 | Cancer chemoprevention by garlic and its organosulfur compounds-panacea or promise 显示文摘 | Nagini S | 2008 | Anticancer Agents Med Chem2008，8，3： | 1 |
| 11 | Altered cytokeratin expression during chemoprevention of experimental hamster buccal pouch carcinogenesis by garlic显示文摘 | Balasenthil S Rao KS Nagini S | 2002 | J Oral Pathol Med2002，31，3： | 1 |
| 12 | Of humans and ham- sters: a comparative evaluation of carcinogen activation, DNA damage, cell proliferation, apoptosis, invasion, and angiogenesis in oral cancer patients and hamster buccal pouch carcinomas显示文摘 | Nagini S Letchoumy PV A T | 2009 | Oral Oncology2009，5，6： | 1 |
| 13 | Antiperoxidative effects of lycopene during N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis显示文摘 | Velmurugan B Bhuvaneswari V Nagini S | 2002 | Fitoterapia2002，73，78： | 1 |
| 14 | Altered cytokeratin expression during chemoprevention of experimental hamster buccal pouch carcinogenesis by garlic显示文摘 | Balasenthil S Rao KS Nagini S | 2002 | J Oral Pathol Med2002，31，3： | 1 |
| 15 | Protective effect of S-allylcysteine and lycopene in combination against N-methyl-N'-nitro-N-nitrosoguanidine-induced genotoxicity显示文摘 | Velmurugan B Santhiya ST Nagini S | 2004 | Pol J Pharmncol2004，56，2： | 1 |
| 16 | Effect of S-allycysteine on oxidant-antioxidant status during N-methyl-N′-nitroN-nitrosoguanidine and saturated sodium chloride-induced gastric carcinogenesis in Wistar rats 显示文摘 | Velmurugan B Bhuvaneswari V Nagini S | 2003 | Asia PacJ Clin Nutr2003，12，4： | 1 |
| 17 | Expression of PCNA, cytokeratin, Bcl-2 and p53 during chemoprevention of hamster buccal pouch carcinogenesis by ethanolic neem (Azadirachta indica) leaf extract显示文摘 | Subapriya R Kumarguparan R Nagini S | 2006 | Clin Biochem2006，39，： | 1 |
| 18 | Prevention of 4-nitroquinoline 1-oxide-induced rat tongue car-cinogenesis by garlic显示文摘 | BALASENTHIL S RAMACHANDRAN C R NAGINI S | 2001 | Fitoterapia2001，72，： | 1 |
| 19 | Chemoprevention of rat mammary carcinogenesis by Azadirachta indica leaf fractions: Modulation of hormone status, xenobiotic-metabolizing enzymes, oxidative stress, cell proliferation and apoptosis显示文摘 | G. Vinothini P. Manikandan R. Anandan S. Nagini | 2009 | Food and Chemical Toxicology2009，，8： | 1 |
| 20 | Modulatory effects of garlic and neem leaf extracts on N-methyl-N′-nitro-N-nitrosoguanidine(MNNG)-induced oxidative stress in Wistar rats显示文摘 | Arivazhagan S Balasenthil S Nagini S | 2000 | Cell Biochem Funct2000，18，1： | 1 |
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