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| 1 | Safety and efficacy of sofosbuvir/velpatasvir/voxilaprevir in postliver transplant patients with previous direct-acting antiviral failure:Six case reports显示文摘BACKGROUND Direct-acting antiviral(DAA)therapy regimens are highly effective at eliminating hepatitis C virus(HCV)infection but rates of sustained virologic response(SVR)are lower in patients with decompensated cirrhosis or hepatocellular carcinoma.Since many of these patients will be referred for liver transplant,they will require retreatment after transplantation.Sofosbuvir/velpatasvir/voxilaprevir(SOF/VEL/VOX)is recommended by guidelines as the preferred regimen to treat HCV in DAA-experienced patients following liver transplant however there is limited data.CASE SUMMARY We present the cases of six liver transplant recipients who had previous treatment failure with sofosbuvir-based DAA therapy prior to transplantation and who then received SOF/VEL/VOX after transplant.CONCLUSION This case series demonstrate the real-world efficacy and safety of SOF/VEL/VOX in the post liver transplant setting.Treatment was successful with all patients achieving SVR,it was well tolerated,and there were minimal drug-drug interactions with their immunosuppressants. | Cory Higley Christine C Hsu Coleman Smith Sandeep Nadella Alexander T.Lalos | 2020 | World Journal of Hepatology2020，12，12： | 2 |
| 2 | Transglutaminase 2 interacts with syndecan-4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells 显示文摘 | NADELLA V WANG Z JOHNSON T S | 2015 | Biochim Biophys Acta2015，1853，1： | 1 |
| 3 | Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra显示文摘 | Nadella R Voutilainen MH Saarma M | 2014 | J Neuroinflammation2014，11，： | 1 |
| 4 | Pharmacobiologically based scheduling of capecitabine and docetaxel results in antitumor activity in resistant human malignancies显示文摘 | Nadella P Shapiro C Otterson GA | 2002 | J Clin Oncol2002，20，11： | 1 |
| 5 | The relative sensitivity of sperm,eggs and embryos to copper in the blue mussel(Mytilus trossulus)显示文摘 | Fitzpatrick J L Nadella S Bucking C | 2008 | Comp Biochem Physiol C Toxicology Pharmacol2008，147，： | 1 |
| 6 | Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration显示文摘Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's disease.The human cerebral dopamine neurotrophic factor(h CDNF)has recently emerged as a strong candidate for Parkinson's disease therapy.This study shows that h CDNF expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral alterations.Three independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDNF gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDNF in vitro.Their injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDNF in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and striatum.Compared with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDNF transfection.An increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite levels.Partial reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were achieved.Brain-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic effects.These findings support the potential of nanoparticle-mediated h CDNF gene delivery to develop a disease-modifying treatment against Parkinson's disease.The Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization No.162-15)on June 9,2019. | Manuel A.Fernandez-Parrilla David Reyes-Corona Yazmin M.Flores-Martinez Rasajna Nadella Michael J.Bannon Lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claudia Luna-Herrera Jose Ayala-Davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila Porfirio Nava Daniel Martinez-Fong | 2022 | Neural Regeneration Research2022，17，4： | 1 |
| 7 | Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model显示文摘 | Settle M Gordon MD Nadella M Dankort D Muller W Jacobs JR | | 0，，13： | 1 |
| 8 | Dynamic analysis and damping of composite structure embedded with viscoelastic layers 显示文摘 | Rao M D Echempati R Nadella S | 1997 | Compos Part B: Eng1997，28，3： | 1 |
| 9 | Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancerbone metastases显示文摘 | DENG X TANNEHILL S H NADELLA M V | 2007 | Clin Exp Metastasis2007，24，2： | 1 |
| 10 | Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastases显示文摘 | Deng X Tannehill-Gregg SH Nadella MV | 2007 | Clin Exp Metastasis2007，24，2： | 1 |
| 11 | Macrosegregation in direct-chillcasting of aluminium alloys 显示文摘 | Nadella R Eskin D G Du Q | 2008 | Progress in Materials Science2008，53，3： | 1 |
| 12 | Expression of tumor in-vasion factors determines systemic engraftment and induction of hu-moral hypercalcemia in a mouse model of adult T-cell leukemia显示文摘 | Parrula C Zimmerman B Nadella P | 2009 | Vet Pathol2009，46，5： | 1 |
| 13 | Identifieation of new molecular entities ( NMEs ) as potential leads against tuberculosis from open source compound repository显示文摘 | Kotapalli S S Nallam S S Nadella L | 2015 | PLoS One2015，10，01： | 1 |
| 14 | Zoledronic acid decreased osteolysis but not bone metastasis in a nude mouse model of canine prostate cancer with mixed bone lesions 显示文摘 | Thudi NK Martin CK Nadella MV | 2008 | Prostate2008，68，10： | 1 |
| 15 | Parathyroid hormone - related protein and ezrin are up - regulated in human lung cancer bone metastases 显示文摘 | Deng X Tannehill -Gregg S H Nadella M V | 2007 | Clinical and Experimental Metastasis2007，24，2： | 1 |
| 16 | Effect of differ ent grain structures on centerline macrosegregation during direct- chill casting显示文摘 | ESKIN D G NADELLA R KATGERMAN L | 2008 | Acta Materialia2008，56，6： | 1 |
| 17 | Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastases显示文摘 | Tannehill-Gregg SH Nadella MV | 2007 | Clin Exp Metastasis2007，24，2： | 1 |
| 18 | Toxicity of dissolved Cu,Zn,Ni and Cd to developing embryos of the blue mussel(Mytilus trossolus)and the protective effect of dissolved organic carbon显示文摘 | Nadella S R Fitzpatrick J L Franklin N | 2009 | Comparative Biochemistry and Physiology C2009，149，34： | 1 |
| 19 | A phase I trial of herceptin and interleukin-12 in patients with HER2-overerpressing malignancies显示文摘 | Parihar R Nadella P Jensen R | 2001 | J Clin Oncol2001，20，： | 1 |
| 20 | Toxicity of dissovled Cu, Zn, Ni and Cd to developing embryos of the blue mussel (Mytilus trossolus) and the protec- tive effect of dissolved organic carbon 显示文摘 | Nadella S R Fizpatrick J L Franklin N | 2009 | Comparative Biochemistry and Physiology Part C2009，149，3： | 1 |
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