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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 3 | Electromagnetic Analysis of Cylindrical Invisibility Cloaks and the Mirage Effect 显示文摘 | Zolla F Guenneau S Nicolet A | 2007 | Optics Letters2007，32，9： | 1 |
| 4 | Incidence and conse quence of an hepatic artery injury in patients with postchole cystectomy bile duct strictures显示文摘 | Alves A Farges O Nicolet J | 2003 | Ann Surg2003，238，： | 1 |
| 5 | Association between clinical presentation,biogroups and virulence attributes of Yersinia enterocolitica strains in human diarrhoeal disease显示文摘 | Burnens AP Frey A Nicolet J | 1996 | Epidemiol Infect1996，116，： | 1 |
| 6 | Incidence and consequence of an epatic artery injury in patients with postcholecystectomy bile duct strictures 显示文摘 | Alves A Farges O Nicolet J | 2003 | Ann Surg2003，238，： | 1 |
| 7 | Diffusion barriers in thin films显示文摘 | Nicolet M A | 1978 | Thin Solid Films1978，52，： | 1 |
| 8 | DNA sequence determinnation and biochemical analysis of the immunogenic protein P36, the lactate dehydrogenase (LDH) of Mycoplasma hyopneumoniae 显示文摘 | Haldimann A Nicolet J Frey J | 1993 | J Gen Microbiol1993，139，2： | 1 |
| 9 | Characterization of apxIV A, a new RTX determinant of Actinobacillus pleuropneumoniae显示文摘 | Schaller A Kuhnert P Nicolet J | 1999 | Microbiology1999，145，： | 1 |
| 10 | 显示文摘 | Nicolet M A Mayer J W | 1971 | Applied Physics Letter1971，18，： | 1 |
| 11 | Diffusion Phenomena in Thin Films and Microelectronic Materials显示文摘 | Kattelus H P Nicolet Marc A | 1989 | Materials Research Bulletin1989，24，4： | 1 |
| 12 | Reaction of thin metal films with SiOz substrates显示文摘 | Pretorius R HarrisJ M Nicolet M A | 1978 | Solid State E?lectron1978，21，： | 1 |
| 13 | Diffusion barriers in lay-ered contacts structures 显示文摘 | M A Nicolet M Bartur | 1981 | Vac sci Technol1981，19，3： | 1 |
| 14 | An enzyme-linked immunosorbent assay,using an EDTA-extracted antigen for serology of Haemophilus pleuropneumoniae显示文摘 | Nicolet J Krawinkler M Baurngartner A | 1981 | Am J Vet Res1981，42，： | 1 |
| 15 | Contact resistivity of Re, Pt and Ta films on n-type β-SiC: preliminary results显示文摘 | Chen J S B(a)chli A Nicolet M A | 1995 | Materials Science and Engineering1995，29，： | 1 |
| 16 | DNA sequencedetermination and biochemical lanalysis of the immunogenicprotein P36,the lactate dehydrogenase(LDH)of Mycoplasmahyopneumoniae显示文摘 | HALDIMANN A NICOLET J FREY J | 1993 | Gen Microbiol1993，139，： | 1 |
| 17 | DNA se-quence determination and biochemical analysis of the immunogenic protein P36,the lactate dehydrogenase(LDH)of Mycoplasma hyopneumoniae显示文摘 | HALDIMANN A NICOLET J FREY J | 1993 | J Gen Microbiol1993，139，2： | 1 |
| 18 | Chromosomal heterogeneity of various Mycoplasma hyopneumoniae field strains显示文摘 | Frey J Haldimann A Nicolet J | 2005 | Int J Syst Bacteriol2005，42，2： | 1 |
| 19 | Modeling of photonic crystal optical fibers with fi- nite element显示文摘 | GUENNEAU S NICOLET A ZOLLA F | 2002 | IEEE Transdction on Magnetics2002，38，2： | 1 |
| 20 | Cu/In Deposited at room temperature: morphology, Phase and Reaction显示文摘 | Chen J S Kolawa E Nicolet M A Ruiz R P | 1991 | Solar Cells1991，30，： | 1 |
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