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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Role of eIF4E on epithelial-mesenchymal transition,invasion,and chemoresistance of prostate cancer cells显示文摘Dear Editor,Prostate cancer(PCa)is the most common cancer and second leading cause of cancer death for men in the United States[1].PCa with similar Gleason score has been reported to show substantial interpatient heterogeneity and differential prostate cancer-specific mortality rate[2].Such heterogeneity in PCa often results in different therapeutic responses among patients,including therapy resistance,therapeutic failure,relapse,and metastasis[3].Numerous oncogenes,such as eukaryotic translation initiation factor 4E(eIF4E),have been reported to be involved in epithelial-mesenchymal transition(EMT)and/or drug resistance in PCa[4].We previously demonstrated that eIF4E overexpression was involved in chemoresistance of triple-negative breast cancer and silencing eIF4E significantly inhibited cancer cell proliferation and sensitized cancer cells to chemotherapy in a patient-derived xenograft mouse model[5].In addition,eIF4E phosphorylation is known to stimulate the translation of matrix metalloproteinase 3(MMP3)and Snail mRNAs to promote EMT in PCa[6].Furthermore,the complexity and dynamic nature of EMT contributes to the heterogeneity of aggressive cancer cells[7].The precise role of eIF4E in EMT,invasion,and chemoresistance in PCa is still to be established with consideration of different subpopulations in order to develop precision medicine for PCa.In this work,we aimed to explore the role of eIF4E in EMT,invasion,and chemoresistance in PCa for establishing a promising new therapeutic strategy by regulating eIF4E expression using(1-aminoethyl)iminobis[Noleicylcysteinyl-1-aminoethyl)propionamide](ECO)/small interfering RNA(siRNA)nanoparticles previously developed in our lab[8-10]for PCa therapy in the context of tumor heterogeneity. | Xujie Liu Amita M Vaidya Da Sun Yan Zhang Nadia Ayat Andrew Schilb Zheng-Rong Lu | 2020 | Cancer Communications2020，40，2： | 2 |
| 3 | Pediatric asthma severity score is associated with critical care interventions显示文摘AIM To determine if a standardized asthma severity scoring system(PASS) was associated with the time spent on continuous albuterol and length of stay in the pediatric intensive care unit(PICU).METHODS This is a single center,retrospective chart review study at a major children's hospital in an urban location.To qualify for this study,participants must have been admitted to the PICU with a diagnosis of status asthmaticus.There were a total of 188 participants between the ages of two and nineteen,excluding patients receiving antibiotics for pneumonia.PASS was calculated upon PICU admission.Subjects were put into one of three categories based on PASS: ≤ 7(mild),8-11(moderate),and ≥ 12(severe).The groups were compared based on different variables,including length of continuous albuterol and PICU stay.RESULTS The age distribution across all groups was similar.The median length of continuous albuterol was longest in the severe group with a duration of 21.5 h(11.5-27.5),compared to 15(7.75-23.75) and 10(5-15) in the moderate and mild groups,respectively(P = 0.001).Thelength of stay was longest in the severe group,with a stay of 35.6 h(22-49) compared to 26.5(17-30) and 17.6(12-29) in the moderate and mild groups,respectively(P = 0.001).CONCLUSION A higher PASS is associated with a longer time on continuous albuterol,an increased likelihood to require noninvasive ventilation,and a longer stay in the ICU.This may help safely distribute asthmatics to lower and higher levels of care in the future. | Danielle K Maue Nadia Krupp Courtney M Rowan | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 2 |
| 4 | A Randomized, Double-Blind,Phase II Study of Two Doses of Pemetrexed as First- Line Chemotherapy for Advanced Breast Cancer显示文摘 | Antonio L-C Miguel M Nadia H | 2007 | Clin Canc er Res2007，13，12： | 1 |
| 5 | Fluctuations in bovine o- varian follicular fluid composition throughout the oestrous cycle 显示文摘 | NICOLAS M O NADIA G HENRY J L | 2005 | Reproduction2005，129，： | 1 |
| 6 | Sustained hippocampal ehromatin regulation in a mouse model of depression and antidepressant action 显示文摘 | Nadia M Tsankova Olivier Berton William Renthal | 2006 | Nature Neuroscience2006，9，： | 1 |
| 7 | Synthesis and anti-inflammatory activity of novel pyridazine and pyridazinone deriva- tives as non-ulcerogenic agents显示文摘 | Makarem M Saeed Nadia A Khalil Eman M | 2012 | Arch Pharm Res2012，35，12： | 1 |
| 8 | Synthesis of quinone and xanthone analogs of rhein显示文摘 | Nadia F Philippe M Martine M | 2001 | Tetrahedron2001，57，44： | 1 |
| 9 | Polyhydric alcohol liquefaction of some lignocellulosic agricultural residues显示文摘 | EI-barbary M Hassan Nadia Shukry | | 0，，1： | 1 |
| 10 | Transportation properties and association behavior of the zwitterionic drug 5-aminolevulinic acid in water显示文摘 | Nadia M Beronius P | 2004 | Euro J Pharml Sci2004，21，： | 1 |
| 11 | the expanding universe of γδT lytuphocytes : subsets, generation and function 显示文摘 | Serena M Nadia C L M Girliana G | 2008 | Current Immuno Rev2008，4，4： | 1 |
| 12 | Surface characterization of recycled tire rubber to be used in cement paste matrix显示文摘 | NADIA S PAULO J M GARRISON S | 2002 | J of Coll & Inter Sci2002，，248： | 1 |
| 13 | Lipoprotein profile in subclinical hypothyroidism:Response to levothyroxine replacement,a randomized placebo-controlled study 显示文摘 | Nadia C Ele F Fabio M | 2002 | J Clin Endocrinol Metab2002，87，4： | 1 |
| 14 | Molecular analy-sis of antimicrobial resistance in gram-negative bacteria i- solated from fish farms in Egypt显示文摘 | YOJIRO I ASHRAF M NADIA B | 2010 | J Vet Med Sci2010，72，6： | 1 |
| 15 | Iontophoretic delivery of 5aminolevlinic acid and its methyl ester using a carbopol gel as vehicle显示文摘 | NADIA M TOBIAS B KATARINA E | 2004 | J Controlled Release2004，98，1： | 1 |
| 16 | Physiological and retinoid induced proliferations of epidermis basal keratinocytes are differently controlled显示文摘 | Beboit C Manuel M Nadia M | 2002 | EMBO J2002，21，13： | 1 |
| 17 | Volatile compounds in table olives 显示文摘 | Nadia S Vincenzo M | 2008 | Food Chem2008，107，1： | 1 |
| 18 | Major proteome variations associated with cherry tomato pericarp development and ripening显示文摘 | Mireille F Christina M Nadia B | 2007 | Plant Physiology2007，143，： | 1 |
| 19 | SA13-26 :application of Plackett-Burman experimental design to evaluate culture requirements 显示文摘 | Nadia A Soliman M M Berekaa Y R Polyglutamic acid (PGA) production by Bacillus sp | 2005 | Applied Microbiology and Biotechnology2005，69，： | 1 |
| 20 | Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases显示文摘 | Mübeccel Akdis Simone Burgler Reto Crameri Thomas Eiwegger Hiroyuki Fujita Enrique Gomez Sven Klunker Norbert Meyer Liam O’Mahony Oscar Palomares Claudio Rhyner Nadia Quaked Anna Schaffartzik Willem Van De Veen Sabine Zeller Maya Zimmermann Cezmi A. Akdis | 2011 | The Journal of Allergy and Clinical Immunology2011，，3： | 1 |
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