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| 1 | Developing a bacteriophage cocktail for biocontrol of potato bacterial wilt显示文摘Bacterial wilt is a devastating disease of potato and can cause an 80% production loss. To control wilt using bacteriophage therapy, we isolated and characterized twelve lytic bacteriophages from different water sources in Kenya and China. Based on the lytic curves of the phages with the pathogen Ralstonia solanacearum, one optimal bacteriophage cocktail, P1, containing six phage isolations was formulated and used for studying wilt prevention and treatment efficiency in potato plants growing in pots. The preliminary tests showed that the phage cocktail was very effective in preventing potato bacterial wilt by injection of the phages into the plants or decontamination of sterilized soil spiked with R. solanacearum. Eighty percent of potato plants could be protected from the bacterial wilt(caused by R. solanacearum reference strain GIM1.74 and field isolates), and the P1 cocktail could kill 98% of live bacteria spiked in the sterilized soil at one week after spraying.However, the treatment efficiencies of P1 depended on the timing of application of the phages, the susceptibility of the plants to the bacterial wilt, as well as the virulence of the bacteria infected,suggesting that it is important to apply the phage therapy as soon as possible once there are early signs of the bacterial wilt. These results provide the basis for the development of bacteriophagebased biocontrol of potato bacterial wilt as an alternative to the use of antibiotics. | Cuihua Wei Junli Liu Alice Nyarnbura Maina Francis B Mwaura Junping Yu Chenghui Yan Ruofang Zhang Hongping Wei | 2017 | Virologica Sinica2017，32，6： | 8 |
| 2 | The impact of differential expression of extracellular matrix metalloproteinase inducer,matrix metalloproteinase-2,tissue inhibitor of matrix metalloproteinase-2 and PDGF-AA on the chronicity of venous leg ulcers显示文摘 | Mwaura B Mahendran B Hynes N | 2006 | Eur J Vasc Endovasc Surg2006，31，3： | 1 |
| 3 | The impact of differential expression of extracellular matrix metalloproteinase inducer, matrix metalloproteinase-2, tissue inhibitor of matrix metalloproteinase-2 and PDGF-AA on the chronicity of venous leg ulcers 显示文摘 | Mwaura B Mahendran B Hynes N | 2006 | Eur J Vasc Endovasc Surg2006，31，3： | 1 |
| 4 | Cyanobacterial blooms and the presence of cyanotoxins in small high altitude tropical headwater reservoirs in Kenya显示文摘 | Mwaura F Koyo A Zech B | 2003 | J Water Health2003，2，： | 1 |
| 5 | The impact of differen- tial expression of extraceUular matrix metalloproteinase inducer, matrix metaUoproteinase-2, tissue inhibitor of matrix metallopro- teinase-2 and PDGF-AA on the ehronicity of venous leg ulcers 显示文摘 | Mwaura B Mahendran B Hynes N | 2006 | EurJ Vasc Endovasc Surg2006，31，3： | 1 |
| 6 | Spectral broadening in nanocystalline TiO2 solar cells based on poly (P-phenylene ethynylene) and polythiophene sensitizers显示文摘 | Jeremian K Mwaura Zhao X Y | 2006 | Chem Mater2006，18，： | 1 |
| 7 | In vitro screening of endophytic Fusarium oxysporum against banana nematode (Helicotylenchus multicinctus)显示文摘 | Mwaura P Kahangi E M Losenge T | | 0，，： | 1 |
| 8 | Cross-linked hyperbranched arylamine polymers as hole-transporting materials for polymer LEDs 显示文摘 | Paul G K Mwaura J Argun A A | 2006 | Macromolecules2006，39，23： | 1 |
| 9 | Cyanobacterial blooms and the presence of cyanotoxins in small high altitude tropical headwater reservoirs in Kenya显示文摘 | MWAURA F KOYO A O ZECH B | 2004 | J Water Health2004，2，1： | 1 |
| 10 | Spanner显示文摘 | James C. Corbett Jeffrey Dean Michael Epstein Andrew Fikes Christopher Frost J. J. Furman Sanjay Ghemawat Andrey Gubarev Christopher Heiser Peter Hochschild Wilson Hsieh Sebastian Kanthak Eugene Kogan Hongyi Li Alexander Lloyd Sergey Melnik David Mwaura D | 2013 | ACM Transactions on Computer Systems (TOCS)2013，，3： | 1 |
| 11 | The impact of differential expression of extracellular matrix metalloproteinase inducer,matrix metalloproteinase-2, tissue inhibitor of matrix metalloproteinase-2 and PDGF-AA on the chronicity of venous leg ulcers 显示文摘 | Mwaura B Mahendran B Hynes N | 2006 | Eur J Vase Endovasc Surg2006，31，3： | 1 |
| 12 | 显示文摘 | Paul G K Mwaura J Argun A A | 2006 | Macromolecules2006，39，： | 1 |
| 13 | 显示文摘 | MWAURA J K THOMSEN D L Phelu - Bobin T | 2000 | J A Chem Soc2000，122，： | 1 |
| 14 | The impact of differential expression of extracellular matrix metalloproteinase inducer,matrix metalloproteinase-2,tissue inhibitor of matrix metalloproteinase-2,and PDGF-AA on the chronicity of venous leg ulcers显示文摘 | Mwaura B Mahendran B Hynes N | 2006 | Eur J Vasc Endovasc Surg2006，31，3： | 1 |
| 15 | Spray Processable Hybrid 3,4-Propylenedioxythiophene:Phenylene Electrochromic Polymers显示文摘 | Galand E M Mwaura J K Argun A A | 2006 | Macromolecules2006，39，： | 1 |
| 16 | Luminescent Rare-Earth Multilayer Chelates from Segmented Poly(uethane ureas)显示文摘 | MWAURA J K THOMSEN D H PHLU-BOLIN T | 2000 | J Am Chem Sco2000，122，： | 1 |
| 17 | Cross-Listing and Valuation Effects" Evidence From Nairobi Securities Exchange显示文摘 | Kennedy Munyua Waweru Ganesh P. Pokhariyal Muroki F. Mwaura | 2012 | Journal of Modern Accounting and Auditing2012，8，9： | 0 |
| 18 | K-Hyperparameter Tuning in High-Dimensional Space Clustering:Solving Smooth Elbow Challenges Using an Ensemble Based Technique of a Self-Adapting Autoencoder and Internal Validation Indexes显示文摘k-means is a popular clustering algorithm because of its simplicity and scalability to handle large datasets.However,one of its setbacks is the challenge of identifying the correct k-hyperparameter value.Tuning this value correctly is critical for building effective k-means models.The use of the traditional elbow method to help identify this value has a long-standing literature.However,when using this method with certain datasets,smooth curves may appear,making it challenging to identify the k-value due to its unclear nature.On the other hand,various internal validation indexes,which are proposed as a solution to this issue,may be inconsistent.Although various techniques for solving smooth elbow challenges exist,k-hyperparameter tuning in high-dimensional spaces still remains intractable and an open research issue.In this paper,we have first reviewed the existing techniques for solving smooth elbow challenges.The identified research gaps are then utilized in the development of the new technique.The new technique,referred to as the ensemble-based technique of a self-adapting autoencoder and internal validation indexes,is then validated in high-dimensional space clustering.The optimal k-value,tuned by this technique using a voting scheme,is a trade-off between the number of clusters visualized in the autoencoder’s latent space,k-value from the ensemble internal validation index score and one that generates a value of 0 or close to 0 on the derivative f″′(k)(1+f′(k)^(2))−3 f″(k)^(2)f″((k)2f′(k),at the elbow.Experimental results based on the Cochran’s Q test,ANOVA,and McNemar’s score indicate a relatively good performance of the newly developed technique in k-hyperparameter tuning. | Rufus Gikera Jonathan Mwaura Elizaphan Muuro Shadrack Mambo | 2023 | Journal on Artificial Intelligence2023，5，1： | 0 |
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