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| 1 | Association of CagA and VacA presence with ulcer and non-ulcer dyspepsia in a Turkish population显示文摘AIM: The mostly known genotypic virulence features, of H. pyloriare cytotoxin associated gene A (ragA) and Vacuolating cytotoxin gene A (VacA). We investigated the association of these major virulence factors with ulcer and non-ulcer dyspepsia in our region.METHODS: One hundred and forty two dyspeptic patients were studied (average age 44.8±15.9 years, range 15-87years, 64 males and 78 females). Antral and corpus biopsies were taken for detecting and genotyping of H. pylori. 107patients who were H. pylori positive by histological assessment were divided into three groups according to endoscopic findings: Duodenal ulcer (DU), gastric ulcer (GU)and non-ulcer dyspepsia (NUD). The polymerase chain reaction (PCR) was used to detect CagA and VacA genes of H.pylori using specific primers.RESULTS: H.pyloriwas isolated from 75.4 % (107/142) of the patients. Of the 107 patients, 66 (61.7 %) were cagApositive and 82 (76.6 %) were Vacl-positive. CagA gene was positively associated with DU and GU (P<0.01, P<0.02),but not with NUD (P>0.05). Although VacA positivity in ulcer patients was higher than that in NUD group, the difference was not statistically significant (P>0.05).CONCLUSION: There is a significantly positive association between CagA genes and DU and GU. The presence of VacA is not a predictive marker for DU, GU, and NUD in our patients. | Kantarceken Bulent Aladag Murat Atik Esin Koksal Fatih Harputluoglu MMMurat Harputluoglu Hakan Karincaoglu Melih Ares Mehmet Yildirim Bulent Hilmioglu Fatih | 2003 | World Journal of Gastroenterology2003，9，7： | 8 |
| 2 | Fascioliasis presenting as colon cancer liver metastasis on 18Ffluorodeoxyglucose positron emission tomography/computed tomography: A case report显示文摘BACKGROUND Fascioliasis is caused by watercress and similar freshwater plants or drinking water or beverages contaminated with metacercariae. Fascioliasis can radiologically mimic many primary or metastatic liver tumors. Herein, we aimed to present the treatment process of a patient with fascioliasis mimicking colon cancer liver metastasis. CASE SUMMARY A 35-year-old woman who underwent right hemicolectomy due to cecum cancer was referred to our clinic for management of colon cancer liver metastasis. Both computed tomography and 18F-fluorodeoxyglucose positron emission tomography revealed several tumoral lesions localized in the right lobe of the liver. After a 6-course FOLFOX (folinic acid, fluorouracil, oxaliplatin) and bevacizumab regimen, the hypermetabolic state on both liver and abdominal lymph nodes continued, and chemotherapy was extended to a 12-course regimen. The patient was referred to our institute when the liver lesions were detected to be larger on dynamic liver magnetic resonance imaging 6 weeks after completion of chemotherapy. Right hepatectomy was performed, and histopathological examination was compatible with fascioliasis. Fasciola hepatica IgG enzyme-linked immunosorbent assay was positive. The patient was administered two doses of triclabendazole (10 mg/kg/dose) 24 h apart. During the follow-up period, dilatation was detected in the common bile duct, and Fasciola parasites were extracted from the common bile duct by endoscopic retrograde cholangiopancreatography (ERCP). Triclabendazole was administered to the patient after ERCP. CONCLUSION Parasitic diseases, such as those caused by Fasciola hepatica, should be kept in mind in the differential diagnosis of primary or metastatic liver tumors, such as colorectal cancer liver metastasis, in patients living in endemic areas. | Sami Akbulut Egemen Ozdemir Emine Samdanci Selver Unsal Murat Harputluoglu Sezai Yilmaz | 2019 | World Journal of Hepatology2019，11，8： | 1 |
| 3 | The Relationship of Heart Rate Variability with Severity and Prognosis of Cirrhosis显示文摘 | Fehmi Ates Ergun Topal Feridun Kosar Melih Karincaoglu Bulent Yildirim Yuksel Aksoy Murat Aladag Murat M. M. Harputluoglu Ulvi Demirel Hakan Alan Fatih Hilmioglu | 2006 | Digestive Diseases and Sciences2006，，9： | 1 |
| 4 | Gastric Tissue Oxidative Changes in Portal Hypertension and Cirrhosis显示文摘 | Yuksel Seckin Murat M. M. Harputluoglu Kadir Batcioglu Melih Karincaoglu Bulent Yildirim Ramazan I. Oner Burcin Uyumlu Nurettin Aydogdu Fatih Hilmioglu | 2007 | Digestive Diseases and Sciences2007，，5： | 1 |
| 5 | Autoimmune hepatitis and liver transplantation:Indications,and recurrent and de novo autoimmune hepatitis显示文摘Autoimmune hepatitis is a chronic inflammatory disease of the liver that is characterized by circulating autoantibodies and elevated serum globulin levels.Liver transplantation may be required for patients with acute liver failure,decompensated cirrhosis,and hepatocellular carcinoma.Recurrence is defined as development of the same disease in the allograft following liver transplantation.Autoimmune hepatitis recurs in 36%-68%of the recipients 5 years after liver transplantation.De novo autoimmune hepatitis is the development of autoimmune hepatitis like clinical and laboratory characteristics in patients who had undergone liver transplantation for causes other than autoimmune hepatitis.Diagnostic work up for recurrent and de novo autoimmune hepatitis is similar to the diagnosis of the original disease,and it is usually difficult.Predniso(lo)ne with or without azathioprine is the main treatment for recurrent and de novo autoimmune hepatitis.Early diagnosis and treatment are vital for patient prognosis because de novo autoimmune hepatitis and recurrent autoimmune hepatitis cause graft loss and result in subsequent retransplantation if medical treatment fails. | Murat Harputluoglu Ali Riza Caliskan Sami Akbulut | 2022 | World Journal of Transplantation2022，12，3： | 0 |
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