| 1 | Molecular evolution,virology and spatial distribution of HCV genotypes in Pakistan:A meta-analysis显示文摘Background:Hepatitis C,caused by the Hepatitis C Virus(HCV),is the second most common form of viral hepatitis.The geographical distribution of HCV genotypes can be quite complex,making it challenging to ascertain the most prevalent genotype in a specific area.Methods:To address this,a review was conducted to determine the prevalence of HCV genotypes across various provinces and as a whole in Pakistan.The scientific literature regarding the prevalence,distribution,genotyping,and epidemiology of HCV was gathered from published articles spanning the years 1996-2020.Results:Genotype 1 accounted for 5.1%of the patients,with its predominant subtype being 1a at 4.38%.The frequencies of its other subtypes,1b and 1c,were observed to be 1.0%and 0.31%respectively.Genotype 2 had a frequency of 2.66%,with the most widely distributed subtype being 2a at 2.11%of the patients.Its other subtypes,2b and 2c,had frequencies of 0.17%and 0.36%respectively.The most prevalent genotype among all isolates was 3(65.35%),with the most frequent subtype being 3a(55.15%),followed by 3b(7.18%).The prevalence of genotypes 4,5,and 6 were scarce in Pakistan,with frequencies of 0.97%,0.08%,and 0.32%respectively.The prevalence of untypeable and mixed genotypes was 21.34%and 3.53%respectively.Estimating genotypes proves to be a productive method in assisting with the duration and selection of antiviral treatment.Different HCV genotypes can exhibit variations in their response to specific antiviral treatments.Different genotypes may have distinct natural histories,including variations in disease progression and severity.Some genotypes may lead to more rapid liver damage,while others progress more slowly.Conclusions:This information can guide screening and testing strategies,helping to identify individuals at higher risk of developing severe complications.Studying the distribution of HCV genotypes in a population can provide valuable insights into the transmission dynamics of the virus. | Arslan Habib Nadiya Habib Khalid Mahmood Anjum Riffat Iqbal Zeeshan Ashraf Muhammad Usman Taj Muhammad Asim Kanwal Javid Faezeh Idoon Saeid Dashti Cassio Rocha Medeiros Ana Pavla Almeida Diniz Gurgel Henrique Douglas Melo Coutinho | 2023 | Infectious Medicine2023，2，4： | 0 |
| 2 | Travelers'attitudes toward carpooling in Lahore:motives and constraints显示文摘Traffic congestion has become a critical issue in developing countries,as it tends to increase social costs in terms of travel cost and time,energy consumption and environmental degradation.With limited resources,reducing travel demand by influencing individuals' travel behavior can be a better long-term solution.To achieve this objective,alternate travel options need to be provided so that people can commute comfortably and economically.This study aims to identify key motives and constraints in the consideration of carpooling policy with the help of stated preference questionnaire survey that was conducted in Lahore City.The designed questionnaire includes respondents' socioeconomic demographics,and intentions and stated preferences on carpooling policy.Factor analysis was conducted on travelers' responses,and a structural model was developed for carpooling.Survey and modeling results reveal that social,environmental and economic benefits,disincentives on car use,preferential parking treatment for carpooling,and comfort and convenience attributes are significant determinants in promoting carpooling.However,people with strong belief in personal privacy,security,freedom in traveling and carpooling service constraints would have less potential to use thecarpooling service.In addition,pro-auto and pro-carpooling attitudes,marital status,profession and travel purpose for carpooling are also underlying factors.The findings implicate that to promote carpooling policy it is required to consider appropriate incentives on this service and disincentives on use of private vehicle along with modification of people's attitudes and intentions. | Muhammad Ashraf Javid Tahir Mehmood Hafiz Muhammad Asif Ahsan Ullah Vaince Mohsin Raza | 2017 | Journal of Modern Transportation2017，25，4： | 0 |
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