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| 1 | Prospective study of differential diagnosis of hepatic tumors by pattern-based classification of contrast-enhanced sonography显示文摘AIM: To prospectively evaluate the usefulness of a pattern-based classification of contrast-enhanced sonographic findings for differential diagnosis of hepatic tumors. METHODS: We evaluated the enhancement pattern of the contrast-enhanced sonography images in 586 patients with 586 hepatic lesions, consisting of 383 hepatocellular carcinomas, 89 metastases, and 114 hemangiomas. After injecting a galactose-palmitic acid contrast agent, lesions were scanned by contrast- enhanced harmonic gray-scale sonography in three phases: arterial, portal, and late. The enhancement patterns of the initial 303 lesions were classified retrospectively, and multiple logistic regression analysis was used to identify enhancement patterns that allowed differentiation between hepatic tumors. We then used the pattern-based classification of enhancement we had retrospectively devised to prospectively diagnose 283 liver tumors. RESULTS: Seven enhancement patterns were found to be significant predictors of different hepatic tumors. The presence of homogeneous or heterogeneous enhancement both in the arterial and portal phase was the typical enhancement pattern for hepatocellular carcinoma, while the presence of peritumoral vessels in the arterial phase and ring enhancement or a perfusion defect in the portal phase was the typical enhancement pattern for metastases, and the presence of peripheral nodular enhancement both in the arterial and portal phase was the typical enhancement pattern forhemangioma. The sensitivity, specificity, and accuracy of prospective diagnosis based on the combinations of enhancement patterns, respectively, were 93.2%, 96.2%, and 94.0% for hepatocellular carcinoma, 87.9%, 99.6%, and 98.2% for metastasis, and 95.6%, 94.1%, and 94.3% for hemangioma. CONCLUSION: The pattern-based classification of the contrast-enhanced sonographic findings is useful for differentiating among hepatic tumors. | Kazushi Numata Tetsuo Isozaki Manabu Morimoto Kazuya Sugimori Reiko Kunisaki Toshio Morizane Katsuaki Tanaka | 2006 | World Journal of Gastroenterology2006，12，39： | 18 |
| 2 | Familial pancreatic cancer: Concept, management and issues显示文摘Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (<20%) and the familial aggregation is usually modest. However, an ethnic deviation (Ashkenazi Jewish>Caucasian) and a younger onset are common also in FPC. In European countries, 'anticipation' is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society. | Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi Shinichi Yachida Masami Suzuki Risa Usui Toru Furukawa Junji Furuse Takamitsu Sato Makoto Ueno Yoshimi Kiyozumi Susumu Hijioka Nobumasa Mizuno Takeshi Terashima Masaki Mizumoto Yuzo Kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki Furukawa Ken Kawabe Yoshiyuki Majima Toru Shimosegawa | 2017 | World Journal of Gastroenterology2017，23，6： | 5 |
| 3 | Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma显示文摘 | Shunsuke Kondo Hidenori Ojima Hitoshi Tsuda Jun Hashimoto Chigusa Morizane Masafumi Ikeda Hideki Ueno Kenji Tamura Kazuaki Shimada Yae Kanai Takuji Okusaka | 2013 | International Journal of Clinical Oncology2013，，2： | 2 |
| 4 | A phase II study of S-1 in gemcitabine-refractory metastatic pancreatic cancer显示文摘 | MORIZANE C OKUSAKA T FURUSE J | 2009 | Cancer Chemother Pharmacol2009，63，2： | 1 |
| 5 | Cathelicidin antimicrobial peptide LL-37 in psoriasis enables keratinocyte reactivity against TLR9 ligands显示文摘 | Morizane S Yamasaki K Mtihleisen B | 2012 | J Invest Dermatol2012，132，1： | 1 |
| 6 | Autologous transplantation of the internal limiting membrane for refractory macular holes 显示文摘 | Morizane Y Shiraga F Kimura S | 2014 | Am J Ophthalmol2014，157，： | 1 |
| 7 | A novel thermoelectric cooling device using Peltier modules for inducing local hypothermia of the spinal cord:The effect of local electrically controlled cooling for the treatment of spinal cord injuries in conscious rats显示文摘 | Morizane K Ogate T Morino T | | 0，，3： | 1 |
| 8 | Control of Traction and Levitation of Linear Induction Motor Driven by Power Source With Frequency Component Synchronous With the Motor Speed显示文摘 | Toshimitsu Morizane Kousuke Tsujikawa Noriyuki Kimura | 2011 | 1EEE Transactions on Magnetics2011，47，10： | 1 |
| 9 | Involvement of gran-ulysin -producing T cells in the development of superficial micro-bial folliculitis显示文摘 | 0onoT Morizane S Yamasaki 0 | 2004 | Br J Dermatol2004，150，5： | 1 |
| 10 | Randomized phase II study of gemcitabine plus S-1 versus S-1 in advanced biliary tract cancer: a Japan Clinical Oncology Group trial ( JCOG 0805 ) 显示文摘 | Morizane C Okusaka T Mizusawa J | 2013 | Cancer Sci2013，104，9： | 1 |
| 11 | X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase- 9 and cytosolic Smac/DIABLO 显示文摘 | Morizane Y Honda R Fukami K | 2005 | J Biochem2005，137，2： | 1 |
| 12 | Ossifying luteinized theco ma of the ovary显示文摘 | Morizane M Ohara N Mori T | 2008 | Arch Gynecol Obstet2008，267，3： | 1 |
| 13 | Cisplatin and etoposide as first-line chemotherapy for poorly differentiated neuroendocrine carcinoma of the hepatobiliary tract and pancreas显示文摘 | Iwasa S Morizane C Okusaka T | 2010 | Jpn J Clin Oneol2010，40，4： | 1 |
| 14 | Glycation and phosphorylation of fl-lactoglobumin by dry-heating: effect on protein structure and some properties显示文摘 | ENOMOTO H LI C P MORIZANE K | 2007 | J Agric Food Chem2007，55，6： | 1 |
| 15 | Glycation and phosphorylation of β -lactoglobulin by dry-heating: effect on protein structare and some properties显示文摘 | ENOMOTO H LI C P MORIZANE H R | 2007 | J Agric Food Chem2007，55，： | 1 |
| 16 | Phase l / II study of gem- citabine as a fixed dose rate infusion and S-1 combination therapy (FGS) in gemcitabine-refractory pancreatic cancer patients显示文摘 | Morizane C Okusaka T Ueno H | 2012 | Can- cer Chemother Pharmacol2012，69，4： | 1 |
| 17 | X-linked inhibitor of apoptosis functions as uhiquitin ligase toward matuse caspase-9 and cytosolic Smac/DIABLO显示文摘 | Morizane Y Honda R Fukamik | 2005 | Biochem(Tokyo)2005，137，2： | 1 |
| 18 | Staphylococcal cutaneous infections , invasion , evasion and aggression显示文摘 | Iwat suki K Yamasaki O Morizane S | 2006 | Dermatol Sci2006，42，3： | 1 |
| 19 | Differentiation of murine embryonic stem and induced pluripotent stem cells to renal lineage in vitro显示文摘 | Morizane R Monkawa T Itoh H | 2009 | Biochem Biophys Res Commun2009，390，4： | 1 |
| 20 | Glycation andphosphorylation of p - lactoglobulin by dry - heating : Effect onprotein structure and some properties 显示文摘 | Enomoto H Li C P Morizane K | 2007 | Journal of Agriculturaland Food Chemistry2007，55，6： | 1 |
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