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| 1 | Cytoreductive surgery and intraperitoneal chemotherapy for colorectal peritoneal metastases显示文摘AIM:To systematically review the available evidence regarding cytoreductive surgery(CRS) and intraperitoneal chemotherapy(IPC) for colorectal peritoneal metastases(CPM).METHODS:An electronic literature search was carried out to identify publications reporting oncological outcome data(overall survival and/or disease free survival and/or recurrence rates)following CRS and IPC for treatment of CPM.Studies reporting outcomes following CRS and IPC for cancer subtypes other than colorectal were only included if data were reported independently for colorectal cancer-associated cases;in addition studies reporting outcomes for peritoneal carcinomatosis of appendiceal origin were excluded.RESULTS:Twenty seven studies,published between1999 and 2013 with a combined population of 2838patients met the predefined inclusion criteria.Included studies comprised 21 case series,5 case-control studies and 1 randomised controlled trial.Four studies provided comparative oncological outcome data for patients undergoing CRS in combination with IPC vs systemic chemotherapy alone.The primary indication for treatment was CPM in 96%of cases(2714/2838)and recurrent CPM(rCPM)in the remaining 4%(124/2838).In the majority of included studies(20/27)CRS was combined with hyperthermic intraperitoneal chemotherapy(HIPEC).In 3 studies HIPEC was used in combination with early post-operative intraperitoneal chemotherapy(EPIC),and 2 studies used EPIC only,following CRS.Two studies evaluated comparative outcomes with CRS+HIPEC vs CRS+EPIC for treatment of CPM.The delivery of IPC was performed using an'open'or'closed'abdomen approach in the included studies.CONCLUSION:The available evidence presented in this review indicates that enhanced survival times can be achieved for CPM after combined treatment with CRS and IPC. | Reza Mirnezami Brendan J Moran Kate Harvey Tom Cecil Kandiah Chandrakumaran Norman Carr Faheez Mohamed Alexander H Mirnezami | 2014 | World Journal of Gastroenterology2014，20，38： | 6 |
| 2 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 3 | Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifesta- tions that impacts on health across the lifespan显示文摘 | Teede H Deeks A Moran L | 2010 | BMC Med2010，30，8： | 1 |
| 4 | The natural history of self- harm from adolescence to young adulthood:a population-based cohort study显示文摘 | Moran P Coffey C Romaniuk H | 2012 | The Lancet2012，379，9812： | 1 |
| 5 | Basic theory of induction logging and application to study of two- coil sounders 显示文摘 | Moran J H Kunz K S | 1962 | Geophysics1962，27，6： | 1 |
| 6 | Vagal afferent and efferent contributions to the inhibition of food intake by cholecystokinin 显示文摘 | Moran T H Baldessarini A R Salorio C F | 1997 | Am Physiol1997，272，4： | 1 |
| 7 | Early- and long-term out- come data of patients with pseudomyx- oma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperi- toneal chemotherapy 显示文摘 | Chua T C Moran B J Sugarbaker P H | 2012 | J Clin On- col2012，30，20： | 1 |
| 8 | Polycystic ovary syndrome:a complexcondition with psychological,reproductive and metabolic manifestations that impacts on health across the lifespan显示文摘 | Teede H Deeks A Moran L | | 0，，： | 1 |
| 9 | Angio-immunoblastic Lymphadenopathy with dysproteinaemia显示文摘 | Frizzera G Moran EM Rappaport H | 1974 | Lancet1974，1，7866： | 1 |
| 10 | Tissue Doppler imaging in hypertrophic cardiomyopathy:impact of intraventricular obstruction on longitudinal left ventricular function显示文摘 | Cardim N Turres D Morans H | 2002 | Rev Port Cardiol2002，21，3： | 1 |
| 11 | Leaf Area Index Estimates Using Remotely Sensed Data and BRDF Models in a Semiarid Region显示文摘 | Qi J Kerr Y H Moran M S | 2000 | Remote Sensing of Environment2000，73，： | 1 |
| 12 | Polycystic ovary syndrome:a biopsychosocial understanding in young women to improve knowledge and treatment options显示文摘 | Moran L Gibson-Helm M Teede H | 2010 | J Psychosom Obstet Gynaecol2010，31，1： | 1 |
| 13 | Polycystic ovary syn- drome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan显示文摘 | Teede H Deeks A Moran L | 2010 | BMC Medicine2010，8，1： | 1 |
| 14 | Coagulation:its effect on organic matter显示文摘 | Dennett K E Amirtharaja H A Moran T F | 1996 | Journal American Water Works Association1996，88，4： | 1 |
| 15 | Theoretical Analysis of Pressure Phenomena Associated with the Wireline Formation Tester 显示文摘 | Moran J H | 1962 | SPE1771962，，： | 1 |
| 16 | Differentiation of glucose toxicity from betacell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line显示文摘 | Moran A Zhang H J Olson L K | 1997 | J Clin Invest1997，99，： | 1 |
| 17 | Evaluation of the parameters needed to describe the overall growth,the chemical growth,and the growth of feathers and breast muscles of broilers显示文摘 | Gous R M Moran E T Stilborn H R | 1999 | Poultry Science1999，78，： | 1 |
| 18 | Mapping Surface-Energy Balance Components by Combining Landsat Thematic Mapper and Ground-Based Meteorological Data显示文摘 | MORAN M S JACKSON R D RAYMOND L H | 1989 | Remote Sensing of Environment1989，30，1： | 1 |
| 19 | Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphoeytes 显示文摘 | Moran ST Cariappa A Liu H | 2007 | J Immunol2007，179，1： | 1 |
| 20 | Dynamic performance of an air cushion vehicle in a marine environment 显示文摘 | Fein J A Magnuson A H Moran D D | 1975 | Journal of Hydronautics1975，9，1： | 1 |
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