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| 1 | Effects of creep feeding and supplemental glutamine or glutamine plus glutamate (Aminogut) on pre- and post-weaning growth performance and intestinal health of piglets显示文摘Background: Creep feeding is used to stimulate piglet post-weaning feed consumption.L-Glutamine(GLN) is an important source of fuel for intestinal epithelial cells.The objective of this study was to determine the impact of creep feeding and adding GLN or AminoGut(AG;containing glutamine + glutamate) to pre-and post-weaning diets on pig performance and intestinal health.Litters(N = 120) were allotted to four treatments during 14–21 d of lactation: 1) No creep feed(NC,n = 45);2) creep fed control diet(CFCD,n = 45);3) creep fed 1% GLN(CFGLN,n = 15);4) creep fed.88% AG(CFAG,n = 15).After weaning,the NC and CFCD groups were sub-divided into three groups(n = 15 each),receiving either a control nursery diet(NC-CD,CFCD-CD) or a diet supplemented with either GLN(NC-GLN,CFCD-GLN) or with AG(NC-AG,CFCD-AG).Litters that were creep fed with diets containing GLN or AG also were supplemented with those amino acids in the nursery diets(CFGLN-GLN,CFAG-AG).Glutamine was added at 1% in all three post-weaning diet phases and AG was added at.88% in phase 1 and 2 and at.66% in phase 3.Results: Feed conversion(feed/gain) showed means among treatment means close to significance(P = 0.056) and Tukey's test for pairwise mean comparisons showed that Pigs in the CFGLN-GLN group had the best feed conversion(feed/gain) in the first three-week period post-weaning,exceeding(P = 0.044) controls(CFCD-CD) by 34%.The NC-AG group had(P = 0.02) the greatest feed intake in the last three week of the study,exceeding controls(CFCD-CD) by 12%.CFGLN-GLN,CFCD-GLN and sow reared(SR) pigs had the greatest(P = 0.049) villi height exceeding the CFCD-AG group by 18%,20% and 19% respectively.The CFAG-AG group had the deepest(P = 0.001) crypts among all treatments.CFGLN-GLN,CFCD-GLN and SR groups had the greatest(P = 0.001) number of cells proliferating(PCNA) exceeding those in the NC-CD group by 43%,54% and 63% respectively.Sow reared pigs showed the greatest(P = 0.001) intestinal absorption capacity for xylose and mannitol.Conclusion: Supplementation of creep feed and nursery diets with GLN and/or AminoGut in the first three week improved feed conversion possibly due to improved intestinal health. | Rafael A Cabrera James L Usry Consuelo Arrellano Eduardo T Nogueira Marianne Kutschenko Adam J Moeser Jack Odle | 2013 | Journal of Animal Science and Biotechnology2013，4，3： | 17 |
| 2 | Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets显示文摘AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet model.METHODS: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus infected.After one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber analyses.RESULTS: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P < 0.05).Three days post-infection,marked diarrhea and weight loss were accompanied by sharp reductions in villus height(59%) and lactase activity(91%) and increased crypt depth(21%) in infected compared with non-infected pigs(P < 0.05).Malnutrition also increased crypt depth(21%) compared to full-fed piglets.Villus:crypt ratio was reduced(67%) with viral infection.There was a trend for reduction in transepithelial electrical resistance with rotavirus infection and malnutrition(P = 0.1).3H-mannitol flux was significantly increased(50%;P < 0.001) in rotavirus-infected piglets compared to non-infected piglets,but there was no effect of nutritional status.Furthermore,rotavirus infection reduced localization of the tight junction protein,occludin,in the cell membrane and increased localization in the cytosol.CONCLUSION: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. | Sheila K Jacobi Adam J Moeser Anthony T Blikslager J Marc Rhoads Benjamin A Corl Robert J Harrell Jack Odle | 2013 | World Journal of Gastroenterology2013，19，31： | 4 |
| 3 | Influence of birth order, birth weight, colostrum and serum immunoglobulin G on neonatal piglet survival显示文摘Background: Intake of colostrum after birth is essential to stimulate intestinal growth and function, and to provide systemic immunological protection via absorption of Immunoglobulin G (IgG). The birth order and weight of 745 piglets (from 75 litters) were recorded during a one-week period of farrowing. Only pigs weighing greater than 0.68 kg birth weight were chosen for the trial. Sow colostrum was collected during parturition, and piglets were bled between 48 and 72 hours post-birth. Piglet serum IgG and colostral IgG concentrations were determined by radial immunodiffusion. Results: Sow parity had a significant (P < 0.001) effect on sow colostral IgG concentration, being 5% higher in multiparous females. Sow colostral IgG concentration explained 6% and piglet birth order accounted for another 4% of the variation observed in piglet serum IgG concentration (P < 0.05); however, birth weight had no detectable effect. Piglet serum IgG concentration had both a linear (P < 0.05) and quadratic effect (P < 0.05) on % survival. Piglets with 1,000 mg/dl serum IgG or less (n=24) had a 67% survival; whereas, piglets with IgG concentrations between 2250 to 2500 mg/dl (n=247) had a 91% survival. Birth order had no detectable effect on survival, but birth weight had a positive linear effect (P < 0.05). Piglets weighing 0.9 kg (n = 107) at birth had a 68% survival rate, and those weighing 1.6 kg (n = 158) had an 89% survival. Conclusion: We found that the combination of sow colostrum IgG concentration and birth order can account for 10% of the variation of piglet serum IgG concentration and that piglets with less than 1,000 mg/dl IgG serum concentration and weight of 0.9 kg at birth had low survival rate when compared to their larger siblings. The effective management of colostrum uptake in neonatal piglets in the first 24 hrs post-birth may potentially improve survival from birth to weaning. | Rafael A Cabrera Xi Lin Joy M Campbell Adam J Moeser Jack Odle | 2013 | Journal of Animal Science and Biotechnology2013，4，2： | 2 |
| 4 | Comparison of the chloride channel activator lubiprostone and the oral laxative Polyethylene Glycol 3350 on mucosal barrier repair in ischemic-injured porcine intestine显示文摘AIM: To investigate the effects of lubiprostone and Polyethylene Glycol 3350 (PEG) on mucosal barrier repair in ischemic-injured porcine intestine. METHODS: Ileum from 6 piglets (approximately 15 kg body weight) was subjected to ischemic conditions by occluding the local mesenteric circulation for 45 min in vivo. Ileal tissues from each pig were then harvested and mounted in Ussing chambers and bathed in oxygenated Ringer's solution in vitro. Intestinal barrier function was assessed by measuring transepithelial electrical resistance (TER) and mucosal-to-serosal fluxes of 3H-mannitol and 14C-inulin. Statistical analyses of data collected over a 120-min time course included 2-way ANOVA for the effects of time and treatment on indices of barrier function. RESULTS: Application of 1 μmol/L lubiprostone to the mucosal surface of ischemic-injured ileum in vitro induced significant elevations in TER compared to non-treated tissue. Lubiprostone also reduced mucosal-to-serosal fluxes of 3H-mannitol and 14C-inulin. Alternatively,application of a polyethylene laxative (PEG,20 mmol/L) to the mucosal surface of ischemic tissues significantly increased flux of 3H-mannitol and 14C-inulin. CONCLUSION: This experiment demonstrates that lubiprostone stimulates recovery of barrier function in ischemic intestinal tissues whereas the PEG laxative had deleterious effects on mucosal repair. These results suggest that,unlike osmotic laxatives,lubiprostone stimulates repair of the injured intestinal barrier. | Adam J Moeser Prashant K Nighot Birgit Roerig Ryuji Ueno Anthony T Blikslager | 2008 | World Journal of Gastroenterology2008，14，39： | 2 |
| 5 | Restoration of barrier function in injured intestinal mucosa 显示文摘 | Blikslager AT Moeser AJ Gookin JL | 2007 | Physiol Rev2007，87，2： | 1 |
| 6 | Complexation of europium and uranium by humic acids analyzed by capillary electrophoresis- inductively coupled plasma mass spectrometry显示文摘 | Moeser C Kautenburger R Beck H P | 2012 | Electrophoresis2012，33，910： | 1 |
| 7 | Restoration of barrier function in injured intestinal mucosa 显示文摘 | Blikslager A T Moeser A J Gookin J L | 2007 | Physiol Rev2007，87，2： | 1 |
| 8 | Initial dynamics of supercontinuum generation in highly nonlinear photonic crystal fiber 显示文摘 | MOESER J T WOLCHOVER N A KNIGHT J C | 2007 | Opt Lett2007，32，8： | 1 |
| 9 | Twenty years after Hines, Hungerford, and Tomera: A new metaanalysis of psychosocial determinants of pro-environmental behaviour显示文摘 | Bamberg S G Moeser | 2007 | Journal of Environmental Psychology2007，27，1： | 1 |
| 10 | CRF induces intestinal epithe- lial barrier injury via the release of mast cell proteases and TNF-a 显示文摘 | Overman EL Rivier JE Moeser AJ | 2012 | PLoS One2012，7，39： | 1 |
| 11 | Water-based magnetic fluids as extractants for synthetic organic compounds显示文摘 | Geoffrey D Moeser Kaitlin A Roach William H Green | 2002 | Ind Eng Chem Res2002，41，： | 1 |
| 12 | Long term effects of spray-dried plasma in nursery diets on intestinal immune response to subsequent stress显示文摘 | Moeser A J. Campbell J. Crenshaw | | 0，，2： | 1 |
| 13 | 营养调控胃肠道屏障显示文摘肠黏膜是保护肠腔的一道重要的防御屏障。因此,肠道屏障的完整性对于猪的健康具有极其重要的作用。在养猪生产过程中,许多传染源和应激因子伴随着一系列的连锁免疫反应破坏肠道屏障,从而增加了疾病的发生机会。所以,研究保护猪肠黏膜屏障功能的策略是必须的。 | Adam Moeser | 2012 | 饲料工业2012，33，4： | 1 |
| 14 | Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig显示文摘 | MOESER A J KLOK V C RYAN K A | 2007 | Am J Physiol Gastrointest Liver Physiol2007，292，1： | 1 |
| 15 | Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig显示文摘 | Moeser A J Vander Klok C Ryan K A | 2007 | Am J Physiol-Gastr L2007，292，1： | 1 |
| 16 | Restoration of barrier function in injured intestinal mucosa 显示文摘 | Blikslager AT Moeser AJ Gookin JL | 2007 | Physiol Rev2007，87，2： | 1 |
| 17 | Gas- trointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs 显示文摘 | MOESER A J RYAN K A NIGHOT P K | 2007 | American Journal of Physiology : Gastroin- testinal and Liver Physiology2007，293，2： | 1 |
| 18 | CRF induces intestinal epithelial barrier injury via the re- lease of mast cell proteases and TNF-alpha 显示文摘 | OVERMAN E L RIVIER J E MOESER A J | 2012 | PLoS One2012，7，39： | 1 |
| 19 | Nutritional value for swine of extruded corn and corn fractions obtained after dry milling 显示文摘 | Muley N S van Heugten E Moeser A J | 2007 | J Anim Sci2007，85，： | 1 |
| 20 | Restoration of barrier function in injured intestinal mucosa显示文摘 | Blikslager A T Moeser A J Gookin J L | 2007 | Physiol Rev2007，87，2： | 1 |
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