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| 1 | A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy显示文摘anti-CTLA-4 抗体由阻止 B7-CTLA-4 相互作用接近否定发信号引起肿瘤拒绝,这被假定。在比临床上有效的 dosing 完成的血浆层次更加高的集中,令人惊讶地, anti-CTLA-4 抗体 Ipilimumab 不由 CTLA-4 也不 CTLA-4 绑定堵住任何一 B7 trans-endocytosis 到使不能调动或联系房间的 B7。因而, Ipilimumab 不从人性化的任何一个 CTLA4 基因在树枝状的房间(DC ) 上增加 B7 (Ctla4 h/h ) 或人的 CD34 + 茎重新组成房间的 NSG 老鼠。在 Ctla4 高效地表示人和老鼠 CTLA4 基因,绑在人的 anti-CTLA-4 抗体然而并非老鼠 CTLA-4 的 h/m 老鼠导致 Treg 弄空和 Fc 受体依赖者肿瘤拒绝。堵住的抗体 L3D10 比得上在引起肿瘤拒绝的非阻塞的 Ipilimumab。显著地,输在人类化期间堵住活动的 L3D10 子孙在导致 Treg 弄空和肿瘤拒绝仍然保持充分能干。有效地在淋巴的器官堵住 CD4 T 细胞激活和 de novo CD8 T 细胞 priming 的 Anti-B7 抗体否定地不影响 Ipilimumab 的 immunotherapeutic 效果。因此,临床上有效的 anti-CTLA-4 mAb 由独立于检查点封锁的机制引起肿瘤拒绝但是依赖于主人 Fc 受体。我们为 CTLA-4 检查点的一个重评价的数据电话封锁假设并且为安全、有效的 anti-CTLA-4 mAbs 的下一代提供新卓见。 | Xuexiang Du Fei Tang Mingyue Liu Juanjuan Su Yan Zhang Wei Wu Martin Devenport Christopher A Lazarski Peng Zhang Xu Wang Peiying Ye Changyu Wang Eugene Hwang Tinghui Zhu Ting Xu Pan Zheng Yang Liu | 2018 | Cell Research2018，28，4： | 25 |
| 2 | Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique显示文摘Many viruses can cause respiratory diseases in humans.Although great advances have been achieved in methods of diagnosis,it remains challenging to identify pathogens in unexplained pneumonia(UP) cases.In this study,we applied next-generation sequencing(NGS) technology and a metagenomic approach to detect and characterize respiratory viruses in UP cases from Guizhou Province,China.A total of 33 oropharyngeal swabs were obtained from hospitalized UP patients and subjected to NGS.An unbiased metagenomic analysis pipeline identified 13 virus species in 16 samples.Human rhinovirus C was the virus most frequently detected and was identified in seven samples.Human measles virus,adenovirus B 55 and coxsackievirus A10 were also identified.Metagenomic sequencing also provided virus genomic sequences,which enabled genotype characterization and phylogenetic analysis.For cases of multiple infection,metagenomic sequencing afforded information regarding the quantity of each virus in the sample,which could be used to evaluate each viruses' role in the disease.Our study highlights the potential of metagenomic sequencing for pathogen identification in UP cases. | Xiaohui Zou Guangpeng Tang Xiang Zhao Yan Huang Tao Chen Mingyu Lei Wenbing Chen Lei Yang Wenfei Zhu Li Zhuang Jing Yang Zhaomin Feng Dayan Wang Dingming Wang Yuelong Shu | 2017 | Science China(Life Sciences)2017，60，3： | 14 |
| 3 | Magnetoresistance enhancement and temperature stability of magnetoresistance in La_(1-x)(Sr_(1-y)Na_y)_xMnO_3显示文摘A series of the samples La_(1-x)(Sr_(1-y)Na_y)_xMnO_3(y=0.0,0.2,0.4,0.6,0.8,1.0) were prepared by the solid-state reaction method.Magnetoresistance enhancement and temperature stability of magnetoresistance in the system La_(1-x)(Sr_(1-y)Na_y)_xMnO_3 with unchanged Mn^(3+)/Mn^(4+) ratio through the doping of both monovalent and divalent elements at A site were studied through the measurements of X-ray diffraction(XRD) patterns,resistivity-temperature(ρ-T) curves and magnetoresistance-temperature(MR-T) curves.The results indicate that with the increase of Na doping amount,the peak value of MR increases,and it increases from 12.4% for y=0.2 to 50.6% for y=1.0 in the magnetic field B=0.8 T;ρ-T curves exhibit the double-peak phenomenon,which comes from the competition between the resistivity of surface phase and that of body phase;for the sample of y=0.8,MR increases slowly from 8.3% to 9.4% in the temperature range from 259 to 179 K,and MR is so stable in such a wide temperature range,which provides reference for the research on the temperature stability of MR. | Wang, Guiying Yan, Guoqing Yang, Jie Wang, Wenqi Tang, Yonggang Song, Qixiang Zhang, Mingyu Peng, Zhensheng | 2012 | Rare Metals2012，31，4： | 13 |
| 4 | Resveratrol suppresses bone cancer pain in rats by attenuating inflammatory responses through the AMPK/Drp1 signaling显示文摘Bone cancer pain(BCP)is induced by primary bone cancer and secondary bone metastasis.During BCP pathogenesis,activated spinal astrocytes release proinflammatory cytokines,which participate in pain information transmission.In this study,we found that BCP rats showed disruption of trabecular bone structure,mechanical allodynia,and spinal inflammation.Moreover,reduced adenosine monophosphate-activated protein kinase(AMPK)activity,increased mitochondrial fission-associated protein Drp1 GTPase activity accompanied by the dysfunction of mitochondrial function,and abnormal BAX and Bcl-2 expression were found in the spinal cord of BCP rats.Notably,these alterations are reversed by resveratrol(Res)administration.Cell experiment results demonstrated that Res promotes mitochondrial function by activating AMPK,decreasing Drp1 activity,and inhibiting tumor necrosis factor-cα-induced mitochondrial membrane potential reduction.Taken together,these results indicate that Res suppresses BCP in rats by attenuation of the inflammatory responses through the AMPK/Drp1 signaling pathway. | Miaomiao Hao Qiong Tang Banghua Wang Yisheng Li Jieqiong Ding Mingyue Li Min Xie Haili Zhu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，3： | 8 |
| 5 | Low-field magnetoresistance of (1-x)La_(0.6)Dy_(0.1)Sr_(0.3)MnO_3/0.5x (Sb_2O_3) composite system under different sintering temperatures of matrix显示文摘A series of (1-x)La0.6Dy0.1Sr0.3MnO3/0.5x(Sb2O3)(x=0.15) samples were prepared by the solid-state reaction method, and the influence of sintering temperature of the matrix on low-field magnetoresistance of (1-x)La0.6Dy0.1Sr0.3MnO3/0.5x (Sb2O3) was studied through the measurements of X-ray diffraction (XRD) patterns, scanning electron microscope (SEM) image, resistivity-temperature (ρ-T) curves, and magnetoresistance-temperature (MR-T) curves. The results indicate that for the samples with low sintering temperature of the matrix, lowfield magnetoresistance effect appears on the whole temperature range and can be explained by grain boundary effect; for the sample with high sintering temperature of the matrix, intrinsic magnetoresistance peak appears on the high-temperature range, low-field magnetore-sistance effect appears on low temperature range, and the magnetoresistance in the magnetic field of 0.2 T and on the comparatively large temperature range between 280 K and 225 K hardly changes with temperature and remains at 4.8%, which can be explained by the competition between the intrinsic magnetoresistance induced by double-exchange function inside grains and the tunneling magnetoresis-tance (TMR) induced by grain boundary effect. The temperature stability of magnetoresistance is beneficial to the practical applications of MR. | Yang, Jie Yan, Guoqing Wang, Guiying Tang, Yonggang Song, Qixiang Zhang, Mingyu Peng, Zhensheng | 2012 | Rare Metals2012，31，3： | 7 |
| 6 | Uncoupling therapeutic from effects for safer and effective CTLA4 humanized mice immunotherapy-related adverse anti-CTLA-4 antibodies in显示文摘 | Xuexiang Du Mingyue Liu Juanjuan Su Peng Zhang Fei Tang Peiying Ye Martin Devenport Xu Wang Yan Zhang Yang Liu Pan Zheng | 2018 | Cell Research2018，28，4： | 6 |
| 7 | Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy显示文摘It remains unclear why the clinically used anti-CTLA-4 antibodies, popularly called checkpoint inhibitors, have severe immunotherapy-related adverse effects (irAEs) and yet suboptimal cancer immunotherapeutic effects (CITE). Here we report that while irAE-prone Ipilimumab and TremeIgG1 rapidly direct cell surface CTLA-4 for lysosomal degradation, the non-irAE-prone antibodies we generated, HL12 or HL32, dissociate from CTLA-4 after endocytosis and allow CTLA-4 recycling to cell surface by the LRBA-dependent mechanism. Disrupting CTLA-4 recycling results in robust CTLA-4 downregulation by all anti-CTLA-4 antibodies and confers toxicity to a non-irAE-prone anti-CTLA-4 mAb. Conversely, increasing the pH sensitivity of TremeIgG1 by introducing designed tyrosine-to-histidine mutations prevents antibody-triggered lysosomal CTLA-4 downregulation and dramatically attenuates irAE. Surprisingly, by avoiding CTLA-4 downregulation and due to their increased bioavailability, pH-sensitive anti-CTLA-4 antibodies are more effective in intratumor regulatory T-cell depletion and rejection of large established tumors. Our data establish a new paradigm for cancer research that allows for abrogating irAE while increasing CITE of anti-CTLA-4 antibodies. | Yan Zhang Xuexiang Du Mingyue Liu Fei Tang Peng Zhang Chunxia Ai James K. Fields Eric J. Sundberg Olga S. Latinovic Martin Devenport Pan Zheng Yang Liu | 2019 | Cell Research2019，29，8： | 6 |
| 8 | Effects of alkalinity on interaction between EPS and hydroxy-aluminum with different speciation in wastewater sludge conditioning with aluminum based inorganic polymer flocculant显示文摘Extracellular polymeric substances(EPS)form a stable gel-like structure to combine with water molecules through steric hindrance,making the mechanical dewatering of wastewater sludge considerably difficult.Coagulation/flocculation has been widely applied in improving the sludge dewatering performance,while sludge properties(organic fraction and solution chemistry conditions)are highly changeable and have important effects on sludge flocculation process.In this work,the alkalinity effects on sludge conditioning with hydroxy-aluminum were comprehensively investigated,and the interaction mechanisms between EPS and hydroxy-aluminum with different speciation were unraveled.The results showed that the effectiveness of hydroxy-aluminum conditioning gradually deteriorated with increase in alkalinity.Meanwhile,the polymeric hydroxy-aluminum(Al 13)and highly polymerized hydroxy-aluminum(Al 30)were hydrolysed and converted into amorphous aluminum hydroxide(Al(OH)3),which changed the flocculation mechanism from charge neutralization and complexing adsorption to hydrogen bond interaction.Additionally,both Al 13 and Al 30 showed higher binding capacity for proteins and polysaccharides in EPS than monomeric aluminum and Al(OH)3.Al 13 and Al 30 coagulation changed the secondary structure of proteins in EPS,which caused a gelation reaction to increase molecular hydrophobicity of proteins and consequently sludge dewaterability.This study provided a guidance for optimizing the hydroxy-aluminum flocculation conditioning of sludge with high solution alkalinity. | Weijun Zhang Mingyue Tang Dandan Li Peng Yang Shiwei Xu Dongsheng Wang | 2021 | Journal of Environmental Sciences2021，33，2： | 5 |
| 9 | Emerging Variants of B.1.617 Lineage Identified Among Returning Chinese Employees Working in India—Chongqing Municipality,China,April 2021显示文摘On April 22 and 23,2021,3 confirmed COVID-19 cases in passengers on an arriving airplane from Nepal were reported by Chongqing Public Health Medical Center.Preliminary epidemiological investigation revealed these 3 patients,males aged 20-30 years,were coworkers of a cellphone company that has a manufacturing base in Noida,India,where they worked with their Indian colleagues since late 2019. | Sheng Ye Yongjun Zhang Xiang Zhao Zhen Yu Yang Song Zhangping Tan Yun Tang Shuang Chen Mingyue Wang Hua Ling | 2021 | China CDC weekly2021，3，19： | 4 |
| 10 | Multi-modal anti-counterfeiting and encryption enabled through silicon-based materials featuring pH-responsive fluorescence and room-temperature phosphorescence显示文摘Nano Research volume 13,pages1614–1619(2020)Cite this article 236 Accesses Metrics details Abstract Optical silicon(Si)-based materials are highly attractive due to their widespread applications ranging from electronics to biomedicine.It is worth noting that while extensive efforts have been devoted to developing fluorescent Si-based structures,there currently exist no examples of Si-based materials featuring phosphorescence emission,severely limiting Si-based wide-ranging optical applications.To address this critical issue,we herein introduce a kind of Si-based material,in which metal-organic frameworks(MOFs)are in-situ growing on the surface of Si nanoparticles(SiNPs)assisted by microwave irradiation.Of particular significance,the resultant materials,i.e.,MOFs-encapsulated SiNPs(MOFs@SiNPs)could exhibit pH-responsive fluorescence,whose maximum emission wavelength is red-shifted from 442 to 592 nm when the pH increases from 2 to 13.More importantly,distinct room-temperature phosphorescence(maximum emission wavelength:505 nm)could be observed in this system,with long lifetime of 215 ms.Taking advantages of above-mentioned unique optical properties,the MOFs@SiNPs are further employed as high-quality anti-counterfeiting inks for advanced encryption.In comparison to conventional fluorescence anti-counterfeiting techniques(static fluorescence outputs are generally used,thus being easily duplicated and leading to counterfeiting risk),pH-responsive fluorescence and room-temperature phosphorescence of the resultant MOFs@SiNPs-based ink could offer advanced multi-modal security,which is therefore capable of realizing higher-level information security against counterfeiting. | Jinhua Wang Bin Song Jiali Tang Guyue Hu Jingyang Wang Mingyue Cui Yao He | 2020 | Nano Research2020，13，6： | 3 |
| 11 | Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes显示文摘Severe fever with thrombocytopenia syndrome virus(SFTSV),the causative agent of a febrile human disease,was first identified from central and eastern provinces in China,and later in Japan and South Korea.Hubei Province is one of the major SFTS epidemic areas in the central part of China.This study reported the isolation of 11 new SFTSV strains from patients in Hubei Province collected in 2017.Extensive phylogenetic analyses were conducted based on the complete coding sequences of SFTSV segments including the new strains.It was suggested that five different SFTSV genotypes were circulating in Hubei,and 15 reassortment patterns and migration pathways correlated with each genotype were identified,which was more than previously recognized.Hubei Province was more involved in the evolutionary events of SFTSV than that previously thought in which the evolutionary events of SFTSV were reported to be independent from those in other epidemic regions.Further divergence of SFTSV strains was suggested by pairwise comparison of SFTSV sequences from each genotype and sequence identity normalized to representative strain in genotype C1.Subsequently,amino acid variations specific for genotype(s),strain(s),or cluster(s)were inspected,which may be related to differential biological activity of SFTSV strains/genotypes.In conclusion,we analyzed the current status of SFTSV phylogeny in Hubei Province and discussed the possible events correlated to SFTSV evolution.It provided an in-depth insight into SFTSV evolution,raising concerns for the use of proper SFTSV strains in future studies. | Xiaoli Wu Mingyue Li Yanfang Zhang Boyun Liang Junming Shi Yaohui Fang Zhengyuan Su Mengmeng Li Wenjing Zhang Ling Xu Jun Wang Qiaoli Wu Shuang Tang Hualin Wang Tao Zhang Cheng Peng Xin Zheng Fei Deng Shu Shen | 2021 | Virologica Sinica2021，36，2： | 2 |
| 12 | Plowing-Extrusion Processes and Performance of Functional Surface Structures of Copper Current Collectors for Lithium-Ion Batteries显示文摘Most copper current collectors for commercial lithium-ion batteries(LIBs)are smooth copper foils,which cannot form a stable and effective combination with electrode slurry.They are likely to deform or fall off after long-term operation,resulting in a sharp decline in battery performance.What is worse is that this condition inevitably causes internal short circuits and thus brings about security risks.In this study,a process route of fabricating the functional surface structures on the surface of a copper collector for LIBs by twice-crisscross micro-plowing(TCMP)is proposed,which provides a new idea and an efficient method to solve the above problems from the perspective of manufacturing.The finite element simulation of TCMP combined with the cutting force test and morphological characterization is conducted to verify the forming mechanism of the surface structures on a copper sheet and its relationship with the processing parameters.The influence of several key processing parameters on the surface characteristics of the copper sheet is comprehensively explored.A series of functions is tested to obtain the optimal parameters for performance improvement of the current collector.Results show that the structured copper sheet with the cutting distance of 250μm,cutting depth of 80μm,and cutting crossing angle of 90°enables the best surface features of the current collector;the contact angle reaches 0°,the slurry retention rate is up to 89.2%,and the friction coefficient reaches 0.074.The battery using the as-prepared structured copper sheet as the current collector produces a specific capacity of 318.6 mAh/g after 50 cycles at a current density of 0.2 C,which is 132.7%higher than the one based on a smooth surface.The capacity reversibility of the sample with the new current collector is much better than that of the traditional samples,yielding a lower impedance. | Chun Wang Wei Yuan Yu Chen Bote Zhao Yong Tang Shiwei Zhang Xinrui Ding Jun He Songmao Chen Baoyou Pan Mingyue Chen | 2022 | Nanomanufacturing and Metrology2022，5，4： | 2 |
| 13 | Systematic dissection of disease resistance to southern corn rust by bulked-segregant and transcriptome analysis显示文摘Southern corn rust(SCR) is a destructive maize disease caused by Puccinia polysora Underw. To investigate the mechanism of SCR resistance in maize, a highly resistant inbred line, L119 A, and a highly susceptible line, Lx9801, were subjected to gene mapping and transcriptome analysis. Bulked-segregant analysis coupled with whole-genome sequencing revealed several quantitative trait loci(QTL) on chromosomes 1, 6, 8, and 10. A set of 25 genes, including two coiled-coil nucleotide-binding site leucine-rich repeat(CC-NBS-LRR) genes, were identified as candidate genes for a major-effect QTL on chromosome 10. To investigate the mechanism of SCR resistance in L119 A, RNA-seq of P. polysorainoculated and non-inoculated plants of L119 A and Lx9801 was performed. Unexpectedly, the number of differentially expressed genes in inoculated versus non-inoculated L119 A plants was about 10 times that of Lx9801, with only 29 common genes identified in both lines, suggesting extensive gene expression changes in the highly resistant but not in the susceptible line. Based on the transcriptome analysis, one of the CC-NBS-LRR candidate genes was confirmed to be upregulated in L119 A relative to Lx9801 independently of P. polysora inoculation. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses indicated that transcription factors, as well as genes involved in defense responses and metabolic processes, were dominantly enriched, with the phenylpropanoid biosynthesis pathway most specifically activated. Consistently, accumulation of phenylpropanoid-derived lignin, especially S lignin, was drastically increased in L119 A after P. polysora inoculation, but remained unchanged in Lx9801, suggesting a critical role of lignin in SCR resistance. A regulatory network of defense activation and metabolic change in SCR-resistant maize upon P. polysora infection is described. | Xiaohuan Mu Zhuangzhuang Dai Zhanyong Guo Hui Zhang Jianping Yang Xinke Gan Jiankun Li Zonghua Liu Jihua Tang Mingyue Gou | 2022 | The Crop Journal2022，10，2： | 1 |
| 14 | 显示文摘 | WANG Guiying a b YAN Guoqing a b YANG Jie a b WANG Wenqi a b TANG Yonggang a b SONG Qixiang a b ZHANG Mingyu a b and PENG Zhensheng a c a Anhui Key Laboratory of Spintronic and Nanometric Materials(Cultivating Base) Suzhou 234000 China b School of Mechani | 2012 | Rare Metals2012，，04： | 1 |
| 15 | The thaumasite form of sulfate attack in concrete of Yongan Dam显示文摘 | HU Mingyu LONG Fumei TANG Mingshu | 2006 | Cement & Concrete Composites2006，36，10： | 1 |
| 16 | Synthesis of Lightweight Spherical Forsterite Aggregates and Research on Their Application in Mgo Based Castables显示文摘Magnesite fine powder, natural silica powder,light-burned magnesia fine powder, silica fume and middle grade magnesia fine powder were used as the starting materials,and silica sol as binder to get high purity lightweight spherical forsterite aggregates. The mixture was granulated on a disc pelletizer and then calcined at 1 400 ℃ for 3h. The synthesized spherical forsterite aggregates were added in Mg O based castables with MgO-SiO_2-H_2O binding system to replace equaldensity high purity common forsterite aggregates. Effect of spherical forsterite aggregates addition on properties of MgO based castables was investigated. The results show that: compared with common aggregates,lightweight spherical forsterite aggregates can improve castables 'flow ability and decrease water addition; addition of spherical aggregates has little effect on cold strength of castables; with the increase of spherical aggregate addition,shrinkage of specimens after drying and heating at intermediate temperatures decreases,but the expansion of specimens after heating at high temperatures increases,bulk density decreases and apparent porosity increases,and thermal conductivity declines. | MENG Qingxin ZHOU Ningsheng TANG Mingyu AN Yalun | 2018 | China's Refractories2018，27，4： | 1 |
| 17 | Reaction of Oncomelania Hupensis to the Allelopathic Triterpene Sapogenin from Nerium Indicum显示文摘 | Wanpeng Tang Xinyi Hu Mingyu Wu Wanxian Wang Qixiang Sun Xudong Zhang Zheng Long Jun Wu | 2010 | Journal of Life Sciences2010，4，4： | 1 |
| 18 | Direct electrochemistry and enzymatic activity of hemoglobin in positively charged colloid Au nanoparticles and hemoglobin layer-by-layer self-assembly films显示文摘Alternate adsorption of positively charged colloid-Au nanoparticles (nano-Au⊕) and negatively charged hemoglobin (Hb) on L-cysteine (L-cys) modified gold electrode resulted in the assembly of {Hb/nano-Au⊕}n layer-by-layer films/L-cys modified gold electrode. The nano-Au⊕ was characterized by transmission electron micrograph (TEM) and microelectrophoresis. The modified electrode interface morphology was characterized by electrochemical impedance spectroscopy (EIS), atomic force mi- croscopy (AFM), cyclic voltammograms (CV) and chronoamperometry. Direct electron transfer between hemoglobin and gold electrodes was studied, and the apparent Michaelis-Menten constant ( km app) of the modified electrode was evaluated to be 0.10 mmol·L?1. Moreover, the higher activity of proteins in the nano-Au⊕ films could be retained compared with the electropolymerization membrane, since the pro- teins in nano-Au⊕ films retained their near-native structure. Direct electron transfer between hemoglo- bin and electrode and electrochemically catalyzed reduction of hydrogen peroxide on a modified elec- trode was studied, and the linear range was from 2.1×10-8 to 1.2 ×10?3 mol·L-1 (r = 0.994) with a detection limit of 1.1×10-8 mol·L-1 H2O2. | YUAN Ruo CAO ShuRui CHAI YaQin GAO FengXian ZHAO Qing TANG MingYu TONG ZhongQiang XIE Yi | 2007 | Science China Chemistry2007，50，5： | 1 |
| 19 | Graphene‐based solid‐phase extraction disk for fast separation and preconcentration of trace polycyclic aromatic hydrocarbons from environmental water samples显示文摘 | Zonghua Wang Qiang Han Jianfei Xia Linhua Xia Mingyu Ding Jie Tang | 2013 | J Sep Science2013，，11： | 1 |
| 20 | The thaumasite form of sulfate attack in concrete of Yongan Dam显示文摘 | HU MINGYU LONG FUMEI TANG MINGSHU | 2006 | Cement and Concrete Composites2006，36，： | 1 |
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