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| 1 | Osteoarthritis:pathogenic signaling pathways and therapeutic targets显示文摘Osteoarthritis(OA)is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide.OA was believed to be caused by the wearing and tearing of articular cartilage,but it is now more commonly referred to as a chronic whole-joint disorder that is initiated with biochemical and cellular alterations in the synovial joint tissues,which leads to the histological and structural changes of the joint and ends up with the whole tissue dysfunction.Currently,there is no cure for OA,partly due to a lack of comprehensive understanding of the pathological mechanism of the initiation and progression of the disease.Therefore,a better understanding of pathological signaling pathways and key molecules involved in OA pathogenesis is crucial for therapeutic target design and drug development.In this review,we first summarize the epidemiology of OA,including its prevalence,incidence and burdens,and OA risk factors.We then focus on the roles and regulation of the pathological signaling pathways,such as Wnt/β-catenin,NF-κB,focal adhesion,HIFs,TGFβ/ΒΜP and FGF signaling pathways,and key regulators AMPK,mTOR,and RUNX2 in the onset and development of OA.In addition,the roles of factors associated with OA,including MMPs,ADAMTS/ADAMs,and PRG4,are discussed in detail.Finally,we provide updates on the current clinical therapies and clinical trials of biological treatments and drugs for OA.Research advances in basic knowledge of articular cartilage biology and OA pathogenesis will have a significant impact and translational value in developing OA therapeutic strategies. | Qing Yao Xiaohao Wu Chu Tao Weiyuan Gong Mingjue Chen Minghao Qu Yiming Zhong Tailin He Sheng Chen Guozhi Xiao | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 11 |
| 2 | Clinical effect of traditional Chinese spinal orthopedic manipulation in treatment of chondromalacia patellae显示文摘OBJECTIVE: To evaluate the clinical effect of traditional Chinese spinal orthopedic manipulation(TCSOM) in treating chondromalacia patellae(CP).METHODS: Sixty cases of CP patients were randomly assigned to a TCSOM group and a Celecoxib group according to the random number table method. All patients in the TCSOM group were treated with a maximum of 10 spinal manipulations and rehabilitation training of quadriceps femoris. The symptoms before and after treatment were assessed with visual analog scale(VAS) and Kujala functional knee scoring system(KFKSS). A symptom improvement rate(SIR) was implemented in order to evaluate the effects of the treatments.RESULTS: The symptoms of 16 patients in the TC-SOM group quickly resolved after the first spinal manipulation and 8 cases were significantly improved. The VAS scores in the TCSOM group after 4weeks of treatment were significantly lower than those in the Celecoxib group. The KFKSS scores in the TCSOM group after 4 weeks of treatment were significantly higher than those in the Celecoxib group. Side effects of the treatment were not reported. Symptom improvement rate based on the VAS in the TCSOM group indicated more significant improvements than the Celecoxib group.CONCLUSION: TCSOM has greater efficacy than Celecoxib capsules for relief of the symptoms of CP. | Qu Liuxin Xing Liyang Wanda Norman Li Mingju Guo Yi Gao Song Li Ping | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 9 |
| 3 | Trends of Overweight and Obesity in Yi People between 1996 and 2007:An Yi Migrant Study显示文摘Objective To evaluate trends of overweight and obesity prevalence between 1996 and 2007 in Yi farmers and Yi migrants.Methods An Yi migrant study was conducted in Liangshan Yi Autonomous Prefecture,Sichuan Province,China from 1996 to 2007.Data were collected with identical methods,including standardized questionnaire and body measurements.Results Age‐ and sex‐specific body mass index (BMI) significantly increased from 20.02 in 1996 to 22.36 in 2007,among Yi farmers,which was significantly different from those among Yi migrants (23.67 in 2007 and 20.90 in 1996) (P<0.05).Prevalence of obesity rose from 1.21 % in 1996 to 4.55 % in 2007 (OR=1.15,P<0.001) in Yi migrants,while that in Yi farmers from none in 1996 to 0.12 % in 2007 (P>0.05).Prevalence of overweight rose significantly to 26.24 %in 2007 from 17.24 % in 1996 (OR=1.06,P<0.001) in Yi migrants,while that in Yi farmers from 1.29 % in 1996 to 4.45 % in 2007 (OR=1.14,P<0.001).Yi migrants appeared to have a 5.52‐fold higher risk ondeveloping overweight and obesity than Yi farmers have.Conclusion The Yi migrants had a steeper increase of overweight with year and consequently caused more obesity.Change in lifestyle may contribute most likely to higher prevalence of overweight and obesity in Yi migrants. | SHAN GuangLiang WEI DaYing WANG ChunXiu ZHANG JianHua Wang Bin MA MingJu PAN Li YU Tao XUE Fang WU ZhengLai | 2011 | Biomedical and Environmental Sciences2011，24，5： | 9 |
| 4 | Constitutive model for methane desorption and diffusion based on pore structure differences between soft and hard coal显示文摘This paper aims to improve the accuracy and applicability of gas diffusion mathematical models from coal particles. Firstly, a new constitutive model for gas diffusion from coal particles with tri-disperse pore structure is constructed by considering the difference in characteristics between soft coal and hard coal.The analytical solution is then derived, that is, the quantitative relationship between gas diffusion rate(Qt/Q_∞) and diffusion time(t), The pore structure parameters of soft coal and hard coal from Juji coal mine are determined. Gas diffusion rules are numerically calculated and investigated by physical simulation methods. Lastly, the applicability of this model is verified. The results show that the homogeneous model only applies to the gas diffusion process of hard coal during the initial 10 min. The calculation results from this model and the physical experimental results of soft coal and hard coal are nearly identical during the initial 30 min. | Liu Yanwei Wang Dandan Hao Fuchang Liu Mingju Mitri Hani S. | 2017 | International Journal of Mining Science and Technology2017，27，6： | 8 |
| 5 | Shape-free finite element method:The plane hybrid stress-function (HS-F) element method for anisotropic materials显示文摘The sensitivity problem to mesh distortion and the low accuracy problem of the stress solutions are two inherent difficulties in the finite element method.By applying the fundamental analytical solutions (in global Cartesian coordinates) to the Airy stress function of the anisotropic materials,8-and 12-node plane quadrilateral hybrid stress-function (HS-F) elements are successfully developed based on the principle of the minimum complementary energy.Numerical results show that the present new elements exhibit much better and more robust performance in both displacement and stress solutions than those obtained from other models.They can still perform very well even when the element shapes degenerate into a triangle and a concave quadrangle.It is also demonstrated that the proposed construction procedure is an effective way for developing shape-free finite element models which can completely overcome the sensitivity problem to mesh distortion and can produce highly accurate stress solutions. | CEN Song FU XiangRong ZHOU GuoHua ZHOU MingJue LI ChenFeng | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，4： | 7 |
| 6 | Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc显示文摘Intervertebral disc(IVD) degeneration(IVDD) is the main cause of low back pain with major social and economic burdens;however, its underlying molecular mechanisms remain poorly defined. Here we show that the focal adhesion protein Kindlin-2 is highly expressed in the nucleus pulposus(NP), but not in the anulus fibrosus and the cartilaginous endplates, in the IVD tissues. Expression of Kindlin-2 is drastically decreased in NP cells in aged mice and severe IVDD patients. Inducible deletion of Kindlin-2 in NP cells in adult mice causes spontaneous and striking IVDD-like phenotypes in lumbar IVDs and largely accelerates progression of coccygeal IVDD in the presence of abnormal mechanical stress. Kindlin-2 loss activates Nlrp3 inflammasome and stimulates expression of IL-1β in NP cells, which in turn downregulates Kindlin-2. This vicious cycle promotes extracellular matrix(ECM) catabolism and NP cell apoptosis. Furthermore, abnormal mechanical stress reduces expression of Kindlin-2, which exacerbates Nlrp3 inflammasome activation, cell apoptosis, and ECM catabolism in NP cells caused by Kindlin-2 deficiency. In vivo blocking Nlrp3 inflammasome activation prevents IVDD progression induced by Kindlin-2 loss and abnormal mechanical stress. Of translational significance, adeno-associated virus-mediated overexpression of Kindlin-2 inhibits ECM catabolism and cell apoptosis in primary human NP cells in vitro and alleviates coccygeal IVDD progression caused by mechanical stress in rat. Collectively, we establish critical roles of Kindlin-2 in inhibiting Nlrp3 inflammasome activation and maintaining integrity of the IVD homeostasis and define a novel target for the prevention and treatment of IVDD. | Sheng Chen Xiaohao Wu Yumei Lai Di Chen Xiaochun Bai Sheng Liu Yongchao Wu Mingjue Chen Yuxiao Lai Huiling Cao Zengwu Shao Guozhi Xiao | 2022 | Bone Research2022，10，1： | 6 |
| 7 | Determination of indices and critical values of gas parameters of the first gas outburst in a coal seam of the Xieqiao Mine显示文摘Based on the important role in mine safety played by parameters of the first gas outburst, we propose a method of combining historic data, theoretical analysis and experimental research for the purpose of critical values of gas parameters of the first gas outburst in a coal seam of the Xieqiao Mine. According to a characteristic analysis and a summary of the rules of coal and gas outbursts in the No.8 coal seam of a Huainan mine, we have investigated their effect on coal and gas outbursts in terms such as ground stress, gas, and coal structure. We have selected gas parameters and determined the critical values of each of the following indices: gas content as 7.7 m 3 /t, tectonic coal as 0.8 m thick, the absolute gas emission as 2 m 3 /min, the rate of change as 0.7 m 3 /min, the gas desorption index of a drilling chip K 1 as 0.26 mL/(g min 1/2 ) and the values of desorption indexes 4h 2 as 200 Pa. From a verification of the production, the results indicate that application of each index and their critical values significantly improve the level of safety in the production process, relieve the burden upon the mine, save much labor and bring clear economic benefits. | Ou Jianchun Liu Mingju Zhang Chunru Liu Yanwei Wei Jianping | 2012 | International Journal of Mining Science and Technology2012，22，1： | 4 |
| 8 | Differently sized cuckoos pose different threats to hosts显示文摘Hole-nesting tits Parus spp.have been classified as'unsuitable'hosts for cuckoo parasitism because cuckoos cannot enter a cavity if the entrance is too small.However,Chinese tits could re-ject alien eggs and egg ejection rate increased with the local diversity of parasitic cuckoo species.Antiparasitic behavior among Chinese tits may have evolved due to greater size variation among sympatric cuckoo species.This raises the question of whether differently sized parasitic cuckoos pose different threats to Chinese tits.A green-backed tit Parus monticolus population that is sym-patric with Asian emerald cuckoo Chrysococcyx maculatus(eme-cuckoo,small-sized parasite)and common cuckoo Cuculus canorus(com-cuckoo,large-sized parasite),and a cinereous tit P.cinereus population that is only sympatric with com-cuckoo were chosen as study organisms.We observed behavioral response and recorded alarm calls of the 2 tit species to eme-cuckoo,com-cuckoo,chipmunk Tamias sibiricus(a nest predator)and dove Streptopelia orientalis(a harm-less control),and subsequently played back alarm calls to conspecific incubating females.In dummy experiments,both tit species performed intense response behavior to chipmunk,but rarely responded strongly to the 3 avian species.In playback experiments,both tit species responded strongly to conspecific chipmunk alarm calls,but rarely responded to dove alarm calls.The inten-sity of response of incubating female green-backed tits to eme-cuckoo and com-cuckoo alarm calls were similar to that of chipmunk alarm calls,while the intensity to eme-cuckoo alarm calls was higher than the intensity to dove alarm calls which was similar to that of com-cuckoo alarm calls.In contrast,few female cinereous tits responded to eme-cuckoo and com-cuckoo alarm calls.These findings indicated that the threat level of eme-cuckoo was slightly greater than that of com-cuckoo for sympatric green-backed tits,but not for allopatric cinereous tits. | Jiangping YU Mingju E Wei SUN Wei LIANG Haitao WANG Anders Pape MΦLLER | 2020 | Current Zoology2020，66，3： | 4 |
| 9 | Some Classes of Disconnected Antimagic Graphs and Their Joins显示文摘A labeling of a graph G is a bijection from E(G) to the set {1,2,…,|E (G)| }.A labeling is antimagic if for any distinct vertices x and y,the sum of the labels on edges incident to x is different from the sum of the labels on edges incident to y.We say that a graph is antimagic if it has an antimagic labeling.Hartsfield and Ringel conjectured in 1990 that every graph other than 2 K is antimagic.In this paper,we show that the antimagic conjecture is false for the case of disconnected graphs.Furthermore,we find some classes of disconnected graphs that are antimagic and some classes of graphs whose complement are disconnected are antimagic. | WANG Tao LIU Mingju LI Deming | 2012 | Wuhan University Journal of Natural Sciences2012，17，3： | 3 |
| 10 | Heteropolyanion-based ionic hybrid solid: A green bulk-type catalyst for hydroxylation of benzene with hydrogen peroxide显示文摘 | Yan Leng Jun Wang Dunru Zhu Lei Shen Pingping Zhao Mingjue Zhang | 2011 | Chemical Engineering Journal2011，，2： | 2 |
| 11 | ROUGH OPERATORS AND COMMUTATORS ON HOMOGENEOUS WEIGHTED HERZ SPACES显示文摘The authors establish the boundedness on homogeneous weighted Herz spaces for a large class of rough grals and the rough R. Fefferman singular integral operators and the rough Ricci-Stein oscillatory singular integrals and the corresponding commutators are considered. | Jiang Yinsheng and Liu Mingju (Xinjiang University , China) | 2002 | Approximation Theory and Its Applications2002，18，1： | 2 |
| 12 | A dicationic ionic liquid-modified phosphotungstate hybrid catalyst for the heterogeneous oxidation of alcohols with H_2O_2显示文摘An ionic hybrid catalyst 1,1'-(butane-1,4-diyl)-bis(3-methylimidazolium) phosphotungstate(abbreviated [Dmim] 1.5 PW) has been prepared by anion-exchange of the divalent ionic liquid(IL) 1,1'-(butane-1,4-diyl)-bis(3-methylimidazolium) di(bromide) with the Keggin phosphotungstic acid H 3 PW 12 O 40,and characterized by IR,1 H NMR,13 C NMR,ESI-MS,TG,SEM,XRD,BET surface area measurements,elemental analysis,and melting point.The hybrid material was evaluated as a catalyst for the oxidation of alcohols with aqueous hydrogen peroxide under various conditions.The catalytic performance of [Dmim] 1.5 PW was also compared with related catalysts bearing other cations or anions.The new hybrid [Dmim] 1.5 PW proved to be an efficient liquid-solid heterogeneous catalyst for H2O2-based oxidation of alcohols,with the advantages of high conversion and selectivity,easy recovery,and quite good reusability. | LENG Yan ZHAO PingPing ZHANG MingJue CHEN GuoJian WANG Jun | 2012 | Science China Chemistry2012，55，9： | 2 |
| 13 | Microstructure and wear resistance of TaC reinforced Ni-based coating by laser cladding 显示文摘 | Chao Mingju Wang Wenli Liang Erjun | 2008 | Surface and Coatings Technology2008，202，10： | 1 |
| 14 | Microstructure and wear resistance of TaC reinforced Ni-based coating by laser cladding 显示文摘 | CHAO MINGJU WANG WENLI LIANG ERJUN | 2008 | Surface and Coatings Technology2008，，202： | 1 |
| 15 | Investigation on the microstructure and cracking susceptibility of laser-clad V2O5/NiCrBSiC alloy coatings 显示文摘 | Wang Dongsheng Liang Erjun Chao Mingju | 2008 | Surf Coat Techn2008，202，： | 1 |
| 16 | Dependence of the high-density holographic recording parameters of photopolymer on sample thickness显示文摘 | Huang Mingju Yao Hawen Chen Zhongyu | 2002 | Optik2002，113，5： | 1 |
| 17 | Development of an Oriental-style dairy product coagulated by microcapsules containing probiotics and filtrates from fermented rice显示文摘 | Su Lieh Chi Lin Chin Wen Chen Mingju | 2007 | lnt J Dairy Technol2007，60，1： | 1 |
| 18 | Textured BaTi2O5 ceramic synthesized by laser rapid solidification method and its dielectric properties显示文摘 | Junji Zhang Jumei Yu Mingju Chao Erjun Liang Mingyu Li Dechuan Li | 2012 | Journal of Materials Science2012，，3： | 1 |
| 19 | Superoxide-like Cu/GO single-atom catalysts nanozyme with high specificity and activity for removing superoxide free radicals显示文摘Although nanozyme has become an emerging area of research attracting extensive attention recently,the activity and specificity of currently reported nanozymes are generally lower than those of natural enzymes.Developing highly active and specific nanozymes is therefore extremely necessary and also remains a great challenge.Superoxide dismutase(SOD)catalyzes the disproportionation of cytotoxic O_(2)·^(−)into hydrogen peroxide and oxygen,and plays an important role in reducing human oxidative stress.In this work,we prepare Cu single-atom catalysts(Cu/GO SACs,GO=graphene oxide)through a simple and low-cost strategy at room temperature using Cu foam and graphene oxide.Cu/GO SACs can maintain excellent catalytic activity under harsh environment.Compared with the natural enzyme,SOD-like Cu/GO SAC nanozyme has higher catalytic activity and meanwhile,it does not possess the common properties of other mimic enzymes often existing in nanomaterials.Based on the excellent SOD-like enzyme activity of Cu/GO SACs,it successfully eliminates the active oxygen in cigarette smoke.This work not only provides a new idea for the design and synthesis of nanozymes with excellent SOD mimetic properties,but also is promising in the treatment of lung injury and inflammatory diseases related to free radical production. | Mingju Lu Jialu Wang Guoyuan Ren Fengjuan Qin Zhiqiang Zhao Kai Li Wenxing Chen Yuqing Lin | 2022 | Nano Research2022，15，10： | 1 |
| 20 | Optical setup and analysis of photopolymer high-density digital holographic storage 显示文摘 | Mingju Huang Zhongyu Chen Fuxi Gan | 2002 | Opt Eng 41(9)2002，，： | 1 |
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