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| 1 | Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis显示文摘 | Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang | 2016 | Chinese Medical Journal2016，，7： | 64 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | Relationship Between Grain Yield and Yield Components in Super Hybrid Rice显示文摘Chinese super hybrid rice breeding project has developed many new varieties with great yield potential. It is controversial which yield component should be emphasized in super hybrid rice production. The present study was conducted to compare super hybrid rice with common hybrid and super inbred rice and analyze contributions of yield components to grain yield of super hybrid rice under experimental conditions, and evaluate relationships between grain yield and yield components of super hybrid rice in farmer’s paddy fields. Field experiments were done in Changsha, Guidong, and Nanxian, Hunan Province, China, from 2007 to 2009. Eight super hybrid varieties, one common hybrid variety, and one super inbred variety were grown in each location and year. Rice production investigation was undertaken in high-yielding (Guidong), moderate-yielding (Nanxian), and low-yielding (Ningxiang) regions of Hunan Province, China, in 2009. Grain yield and yield components were measured in both the field experiments and rice production investigation. Super hybrid rice varieties outyielded common hybrid and super inbred varieties across three locations and years. Yield potential has been increased by 11.4% in super hybrid rice varieties compared with common and super inbred varieties. The higher yield of super hybrid varieties was attributed to improvement in panicle size. Panicles per m2 had the highest positive contribution to grain yield with the exception under yield level of 10.0 to 12.0 t ha-1, and was positively related to grain yield in farmer’s field at all of the high-, moderate-, and low-yielding regions. Our study suggests that panicle per m2 ought to be emphasized in super hybrid rice production. | HUANG Min ZOU Ying-bin JIANG Peng XIA Bing Md Ibrahim AO He-jun | 2011 | Agricultural Sciences in China2011，10，10： | 41 |
| 4 | Epidemiology of fungal infections in China显示文摘与 immunocompromised 主人的增加的数字,真菌的感染的流行病学的特征经历了世界范围的庞大的变化,在中国包括。在这份报纸,我们越过中国在真菌病上考察了存在数据总结可得到的流行病学的侧面。我们发现在中国的表面的真菌的感染的一般发生是稳定的,但是癣 capitis 的发生减少了,传播线路变化了。由对比,侵略真菌的感染的全面发生继续升起了。candidemia 的出现由除 C 以外的 Candida 种类引起了。albicans 和不平常的 Candida 种类最近在中国增加了的包括的一些。曲霉属菌引起的感染也在最近的年里宣传了,特别地与 azole 抵抗的曲霉属菌 fumigatus 的出现。cryptococcosis 的一个增加的趋势在中国被注意了,与 Cryptococcus neoformans var。grubii 圣 5 遗传型作为占优势的病原体孤立。回顾的研究建议了在中国的 Pneumocystis 肺病的流行病学的特征可能类似于在另外的发展中的国家的那些。地方性的真菌的感染例如在东北中国的 sporotrichosis,必须引起研究,诊断,并且处理警戒。当前,在中国的真菌病上的流行病学的数据可变、碎片。因此,关于在中国的真菌的感染的全国流行病学的研究是对改进国家健康的重要需要。 | Min Chen Yuan Xu Nan Hong Yali Yang Wenzhi Lei Lin Du Jingjun Zhao Xia Lei Lin Xiong Langqi Cai Hui Xu Weihua Pan Wanqing Liao | 2018 | Frontiers of Medicine2018，12，1： | 49 |
| 5 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 6 | Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line显示文摘曙光 A kinase, serine/threonine 蛋白质 kinase,是潜在的 oncogene。扩大并且在人的肿瘤的几种类型在曙光 A 的表示上被发现了,包括的食道的有鳞的房间癌(ESCC ) 。在表示曙光 A 上的房间对导致 cisplatin 的 apoptosis 更抵抗,这被表明了。然而,调停的分子的机制这些效果仍然保持大部分未知。在这份报告,我们证明在通过在人的 ESCC KYSE150 的 pEGFP-Aurora-A 的稳定的 transfection 的曙光 A 的表示上,房间显著地支持了房间增长并且禁止了 cisplatin- 或紫外导致照耀的 apoptosis。caspase-3 并且 poly 的劈开(自动数据处理核糖) 在在表示房间上的曙光 A 的聚合酶(PARP ) 实质地在 cisplatin 或紫外处理以后被减少。而且,我们发现有 siRNA 的内长的曙光 A kinase 的那 silencing 实质地提高了敏感到导致 cisplatin 或在人的 ESCC EC9706 房间的紫外导致 apoptosis。在平行,在曙光 A 的表示上 potently 起来调整了 Bcl-2 的表示。而且,由废除的 siRNA 的 Bcl-2 击倒 Aurora-A 禁止 apoptosis 上的效果。总起来说,这些数据提供证据在支持房间增长并且禁止 apoptosis 的表示上的那曙光 A,建议是的新奇机制仔细与恶意的显型和 ESCC 房间的反癌症药抵抗有关。 | Xiao Xia Wang Rong Liu Shun Qian Jin Fei Yue Fan Qi Min Zhan | 2006 | Cell Research2006，16，4： | 24 |
| 7 | A single center investigation of bare-metal or drug-eluting stent restenosis from 1633 consecutive Chinese Han ethnic patients显示文摘Background Stents are widely used in China but the clinical impression is somehow that restenosis is less common because of the lower prevalence of coronary artery disease (CAD) and associated risk factors in Chinese populations. However, no large-sample published studies are available on angiographic stent restenosis including those of bare-metal stent (BMS) or drug-eluting stent (DES) in Chinese Han ethnic population. Mothods A total of 1633 consecutive patients with CAD who had undergone coronary stenting, quantitative coronary angiography (QCA) were retrospectively studied. At the time of stent implantation and at 7 months post-stenting 675 patients had a follow-up angiography. Statistical analysis was made with the chi-square test for categorical variables, unpaired t test for continuous variables, univariate or multivariate regression for baseline and angiographic characteristics and the Kaplan-Meier method for rate of target lesion revascularization (TLR). Results Stent restenosis was defined as ≥50% diameter stenosis in the dilated segment. A total of 675 patients with 1074 lesions were subjected to angiographic follow-up for 7 months on average. Of these lesions, 448 were implanted with BMS whereas 626 lesions with DES. At 7 months, bare-metal in-stent restenosis occured in 148 lesions (33.0%), and bare metal in-segment restenosis in 155 lesions (34.6%) in contrast to drug-eluting in-stent restenosis in 48 lesions (7.7%) and drug-eluting in-segment restenosis in 73 lesions (11.7%) (P<0.001 compared with BMS respectively). Late loss in both in-stent and in segment was higher in BMS than in DES groups [(1.00±0.69) vs (0.28±0.52); (0.78±0.71) vs (0.21±0.52), P<0.001 respectively]. Angulated lesion, lesion length, pre-procedural minimal luminal diameter (MLD), and BMS were independent predictors for TLR, (P<0.01 respectively), whereas current smoker, ostial lesion, and stent overlapping, post-procedure in-stent MLD, lesion length, and stent types were independent predictors for in-segment restenosis (P<0.01 respectively). Standard coronary risk factors such as hypertension, hyperlipidemia, diabetes, and history of CAD were not associated with a higher rate of restenosis caused by BMS or DES implantation in our Chinese Han ethnic population. Conclusions Coronary stenting including BMS or DES implantation in Chinese Han ethnic patients is associated with a restenosis rate comparable to that demonstrated in previous studies from the western countries, and predictors of stent restenosis are somehow different from those in the western population. | XU Bo LI Jian-jun YANG Yue-jin MA Wei-hua CHEN Ji-lin QIAO Shu-bin QIN Xue-wen YAO Min LIU Hai-bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin | 2006 | Chinese Medical Journal2006，，7： | 23 |
| 8 | Effect of three interventional bronchoscopic methods on tracheal stenosis and the formation of granulation tissues in dogs显示文摘为繁的使成粒状纸巾的形成引起的气管的狭窄的背景治疗学的途径通常包括 electrocautery,机械膨胀,激光治疗,氩血浆凝结(APC ) ,冷冻疗法和 stent 放置。然而,在 stent 插入以后的狭窄仍然是重要限制。我们检验了三条不同途径的功效,包括机械损害的正式就职, APC 与不同力量或持续时间和冷冻疗法表现了,识别限制了使成粒状织物的形成的方法。12 特殊饲养了研究杂种狗的方法被划分成三个组。在组 1 (四条狗) 温和(过程 1;二条狗) 或中等(过程 2;二条狗) 损坏机械地被导致。(六条狗) 组 2 在不同力量或持续时间收到了 APC (过程 3:30 W, 1 amis;过程 4:30 W, 2 cm/s;过程 5:25 W, 3 cm/s ) 。(二条狗) 组 3 收到了冷冻疗法(过程 6:30 秒的二个结冰融化周期) 。揭开的自我可扩充的金属性的 stents 在所有狗被插入维持连续刺激到气管 mucosa。狗被监视因为在使用的使成粒状织物增长和方法之间的 4 个星期和关系被分析。在组 1 的结果,使成粒状织物生长与更多的严重机械损坏增加了。在组 2 的使成粒状织物的生长比在组 1 更显著,并且因为严重狭窄,在过程 3 的两条狗死了。在这个组,使成粒状织物的形成与减少的力量和持续时间减少了。在组 3,没有明显的使成粒状织物在星期 4 点被发现。从外国身体(stent ) 的结论损害和刺激是导致使成粒状组织的增生的二个重要因素。热损害例如 APC,似乎导致更大的使成粒状织物生长和软骨损坏与相比机械并且冷冻疗法损害。在有机械膨胀的联合的冷冻疗法可以是为管理使成粒状织物的形成引起的气管的狭窄的一个安全、有效的处理方法。 | ZHANG Jie WANG Ting WANG Juan PEI Ying-hua XU Min WANG Yu-ling ZHANG Xia WANG Chen | 2010 | Chinese Medical Journal2010，，5： | 23 |
| 9 | Hierarchical graphene foam-based phase change materials with enhanced thermal conductivity and shape stability for efficient solar-to-thermal energy conversion and storage显示文摘最近, graphene 泡沫(GF ) 与一三维(3D ) 互连指导模板的化学蒸汽免职(CVD ) 生产的网络被用来与提高的热电导率准备合成阶段变化材料(脉冲编码调制) 。然而, GF 的毛孔尺寸象几百测微计一样大,导致为从在到 GF 神气墙的大毛孔内的 PCM 的热转移的一个显著热电阻。在这研究,新奇 3D 层次 GF (HGF ) 被用空 graphene 网络填满 GF 的毛孔获得。HGF 然后被用来准备基于的石蜡蜡(PW ) 合成脉冲编码调制。PW/HGF 合成脉冲编码调制的热传导性分别地比 PW/GF 合成脉冲编码调制和纯 PW 的高是 87% 和 744% 。PW/HGF 合成脉冲编码调制也与在 100 次骑车比 PW/GF 合成脉冲编码调制,在阶段变化温度的可以忽略的变化,是 95% 纯 PW 的高热的精力存储密度,好热可靠性,和化学稳定性展出更好的形状稳定性。更重要地, PW/HGF 合成脉冲编码调制与高 light-to-thermal 精力变换和存储效率允许光驱动的热精力存储,显示它为在太阳能的利用和存储的应用的大潜力。 | Guoqiang Qi Jie Yang Ruiying Bao Dongyun Xia Min Cao Wei Yang Mingbo Yang Dacheng Wei | 2017 | Nano Research2017，10，3： | 18 |
| 10 | Angiographic prevalence of myocardial bridging in a defined very large number of Chinese patients with chest pain显示文摘背景:心肌内冠的动脉被称为的 epicardial 分割的肌纤维 overlying 心肌的衔接(MB ) 。MB 的可变流行与小、大的样品尺寸研究在尸体和 angiographic 系列被描述了。另外,没有类似的学习在中国人口被报导。这研究的目的是调查 MB 的 angiographic 流行在连续有从我们的中心的胸痛的 37,106 个中国病人。方法:我们进行了观察研究在经历的病人之中与 MB 评估连续案例选择冠的血管造影术,并且在很大的样品尺寸的这研究分析了 angiograhic 流行和 MB 的临床的特征。结果:在有胸痛的 37 105 个病人之中,我们以一种回顾的方式与 1011 MB 发现了 1002 个案例,并且全面流行是 2.70% 。尽管(991/1002 ) 超过 99% 病人有单个桥牌, 8 个案例被发现有超过二 MB (七与二,和一与三) 。没有动脉粥样硬化患者损害,总的来说 54.39% 案例(545/1002 ) 有 MB,并且(973/1011 )96.24% 在左前面的下降冠的动脉(男孩) 衔接定位了,主要在男孩的中间(792/1011, 78.33%) 。根据诺贝尔分类,单个桥(n=991 ) ,阻塞的 <50% 是占优势的(471/991, 47.52%) 。完全, 50%-69% 占了 34.81%(345/991 ) ,阻塞的 >70% 是 17.65%(175/991 ) 。结论:这些数据证明在有胸痛的中国病人的 angiographically 可检测的 MB 的流行类似于以前的研究的那些,与在这种很大的样品尺寸的 2.7% 流行。 | LI Jian-jun SHANG Zheng-lu YAO Min LI Jie YANG Yue-jin CHEN Ji-lin QIAO Shu-bin MA Wei-hua QIN Xue-wen LIU Hai-bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XU Bo XIA Ran GAO Run-lin | 2008 | Chinese Medical Journal2008，，5： | 17 |
| 11 | Role of plasma C-reactive protein in predicting in-stent restenosis in patients with stable angina after coronary stenting显示文摘背景血浆的角色高敏感在 in-stent 狭窄(ISR ) 的 C 反应的蛋白质(hs-CRP ) 仍然保持争论。我们在成功的冠的 stenting 以后与稳定的咽峡炎( SA )在病人在承认和后续调查了血浆 hs-CRP 水平以便为我们总结了的 ISR.Methods 澄清 hs-CRP 的预兆的价值有冠的 drug-eluting stent ( DES )的 303 个连续长期的 SA 病人 implantation.The ISR 被量的冠的分析分析( QCA )在一个平均数, 8 个月的后续,和病人作为 ISR 组( n=48 )和 non-ISR g 根据检测 ISR 被划分成二个组血浆 hs-CRP 在所有病人,在承认和 8 月的后续被检验在整个调查 period.Results QCA 继续的标准药介绍了那 48 个病人(15.8%) 在后续受不了 ISR。当血浆 hs-CRP 在在承认和后续的 non-ISR 组比那在 ISR 组是更高的时,基本临床的特征在二个组之间是类似的, P 0.001 分别地。 Multivariate 回归分析显示在承认或后续的那血浆 hs-CRP 水平能独立地预言 ISR 出现( OR=5.581 ,95% Cl 2.532-12.302 , P0.001and OR=6.299 ,95% CI 2.722-14.577 , P 0.001 ,分别地) .Conclusions 我们的数据显示那血浆 hs-CRP 水平可以独立地与冠的 DES 培植在 SA 病人在承认和后续预言 ISR ,它暗示长期的、持续全身的煽动性的回答可能涉及 ISR | XU Yan-lu LI Jian-jun XU Bo ZHU Cheng-gang YANG Yue-jin CHEN Ji-lin QIAO Shu-bin YUAN Jin-qing QIN Xue-wen MA Wei-hua YAO Min LIU Hai-bo WU Yong-jian CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin | 2011 | Chinese Medical Journal2011，，6： | 17 |
| 12 | An Empirical Study on Chinese City Network Pattern Based on Producer Services显示文摘Globalization and informatization have accelerated city networking process over the world, which makes research on city network a hot topic in the fields of urban geography and economic geography. With Chinese economic structure adjustment and city economic growth, producer services have begun to play an increasingly important role in city-region networking. This paper employs the methodology of world city network to analyze and explain the spatial development characteristics of China's urban network system based on the data of nationwide producer services enterprise network. The research result indicated that the distribution of producer services network has a positive effect on the development of Chinese city networks. City network connectivity is closely related to the significance of city in producer services development, and the former will gradually decline with the drop of the latter. Accordingly, the 64 cities can be divided into the national central cities, regional central cities, sub-regional central cities and local central cities in accordance with their position and role in the nationwide producer services network. It is concluded that high-grade cities with quality producer services dominate the pattern of Chinese city networks and there emerges three spatial agglomerations of producer services enterprises in Changjiang (Yangtze) River Delta, Zhujiang (Pearl) River Delta and Beijing-Tianjin-Tangshan Economical Region. Moreover, the distribution of different producer services industry varies from city to city, which also affects the characteristics of network development. | ZHEN Feng WANG Xia YIN Jun ZHANG Min | 2013 | Chinese Geographical Science2013，23，3： | 17 |
| 13 | Increased plasma C-reactive protein level predicts rapid progression of non-target atherosclerotic lesions in patients with stable angina after stenting显示文摘背景尽管在预言动脉粥样硬化患者损害的快速的前进的 C 反应的蛋白质(CRP ) 的角色强烈地在不稳定的冠的动脉疾病被学习了,从有稳定的咽峡炎(SA ) 的病人的数据大部分是不在的。现在的学习评估了一个中间尺寸的耐心的队与 stent 培植和后续经历了经皮的冠的干预(一种总线标准)冠的 angiography ( CAG )并且测试了高度敏感的 CRP 的那增加的血浆水平将显示的假设 de novo 非目标的快速的前进在有 SA.Methods 的中国病人的冠的动脉损害学习人口与长期的 SA 311 个连续病人包括了在起始的承认上经历了冠的 stent | XU Yan-lu LI Jian-jun XU Bo ZHU Cheng-gang YANG Yue-jin CHEN Ji-lin QIAO Shu-bing YUAN Jin-qing QIN Xue-wen MA Wei-hua YAO Min LIU Hai-bo WU Yong-jian CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin | 2011 | Chinese Medical Journal2011，，19： | 17 |
| 14 | Effect of protein kinase C alpha, caspase-3, and survivin on apoptosis of oral cancer cells induced by staurosporine显示文摘瞄准:阐明蛋白质激酶 C 高山的抑制哈(PKC 高山哈) 由口头的癌症房间线的 apoptosis 上的 staurosporine 的活动舔有鳞的房间癌(TSCCa ) 房间并且在调停澄清 survivin 和 caspase-3 的角色 apoptosis。方法:TSCCa 房间生存能力被 MTT 试金在 100 nmol/L staurosporine 治疗以后测量。Apoptotic 房间被使用阶段对比显微镜学,染色的氮蒽 orange/ethidium 溴化物,和流动血细胞计数识别。PKC 高山的水平哈并且它的潜水艇细胞的地点用西方的污点分析被调查。survivin 和 caspase-3 的表达式用免疫细胞化学被计算。结果:Staurosporine 显著地在一个剂量依赖者和时间依赖者举止禁止了 TSCCa 房间的房间生存能力。在 G2/M 阶段的显著房间累积为 6 h 和 12 h 在 100 nmol/L staurosporine 暴露以后被观察。另外, apoptosis 的百分比为 24 h 在 100 nmol/L staurosporine 治疗在控制文化以一种时间依赖者方式增加了,从 2.9% 到约 27.4% 。Staurosporine 在在 cytosolic 和导出 membrance 的 PKC 高山之间的禁止的功效显示了差别哈。在膜对 cytosol 的 PKCalpha 的内容为 24 h 在 staurosporine 暴露以后在对待乙醇的控制文化快速减少了,从 0.45 到 0.18 | Yu-xia ZHANG Shi-bin YU Jing-ping OU-YANG Dong XIA Min WANG Jin-rong LI | 2005 | Acta Pharmacologica Sinica2005，26，11： | 16 |
| 15 | What Happened in the Trans-North China Orogen in the Period 2560-1850 Ma?显示文摘Trans 北方中国造山带(TNCO ) 是东方、西方的块沿着混合了形成一个协调 NorthChina 古地台(NCC ) 的一条 Paleoproterozic continent-continentcollisional 带。最近地质,结构,有在东方块的西方的边缘下面的海洋的岩石圈的东方指导俯冲的 geochemical 和 theorogen 沿着东方块的西方的边缘是大陆人边缘或日本类型弧的同位素的数据表演,由旧海洋与西方的块被分开,。在 2550-2520 妈, deepsubduction 引起了媒介降低的外壳的部分融化,生产被侵入进形成 granitoid plutons 在的外壳的上面的层次的丰富的 granitoid 岩浆低 --tomedium 等级花岗石绿岩岩层。在 2530-2520 妈,海洋的岩石圈的俯冲引起了披风楔的部分融化,它在弧在下地壳和普遍 mafic 和次要的 felsic 火山作用在 mafic 岩浆的 plating 下面导致了,形成绿岩集合的部分。普遍 mafic 驾驶到 felsic 火山作用的扩展在造山带导致了发展 ofback 弧或 intra 弧盆。在 2520-2475 妈,俯冲引起了形成大量 tonalitic-trondhjemitic-granodioritic (TTG ) 的下地壳的进一步偏爱的融化岩浆酌。背弧盆的在这时候后面的进一步的扩展,阵发性的 granitoidmagmatism 发生了,导致 2360 妈,的炮兵阵地~ 2 250 妈 2110-21760 妈和~ 2 在造山带的 050 Magranites。当代的火山沉积的岩石在背弧 orintra 弧盆发展了。在 2150-1920 妈,造山带经历了几前紧张的事件,一条海洋的山脉的可能到期的 tosubduction,导致是的 mafic 女同性恋的炮兵阵地随后变形了到角闪岩和媒介 -- 到高压的 mafic granulites。在 1880-1820 妈,在东方、西方的块之间的海洋被俯冲完全消费,并且关门海洋导致了 continent-arc-continent 碰撞,它引起了大规模推进和等斜褶皱并且搬运了一些岩石进更低的外壳的层次或上地幔形成 granulites 或 eclogites 。山峰变态被 exhumation/uplift 跟随,导致在岩石中的不对称褶皱和 symplectic 质地的普遍开发。 | Guochun ZHAO LIU Shuwen Min SUN LI Sanzhong Simon WILDE Xiaoping XIA Jian ZHANG Yanhong HE | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 16 |
| 16 | U-Pb Zircon Dating of the Granitic Conglomerates of the Hutuo Group:Affinities to the Wutai Granitoids and Significance to the Tectonic Evolution of the Trans-North China Orogen显示文摘与在中间的最好、古典的剖面图 Trans 北方 ChinaOrogen 分割的邻近的 Fuping 和 Hengshan Complexesrepresents 联系的 Wutai 建筑群,通常划分了成东方、西方的块。Unconformably overlying Wutai andFuping 建筑群 Hutuo 组在这个区域被看作最年轻的岩石地层单位并且为解释前寒武纪的历史以及 theTrans 北方中国造山带的全面进化重要。在这个组的沉积岩的起源的知识的缺乏妨碍了 depositional 和构造意义的理解。LA-ICP-MS 被使用为花岗石的卵石获得 U-Pb 锆石年龄, Hutuo 组的最低岩石层位学的岩石,它,与结合了以前的岩石层位学, geochronological,结构、变形的数据,在沉积起源和这个区域的构造进化上提供新限制。Hutuo 的顺序从更低的底砾岩 andvolcaniclastic 岩石(Doucun 亚群) 向上组织范围,通过碎屑沉积物,板岩,白云石和云石(Dongye 亚群) ,到在顶(Guojiazhai 亚群) 的沙岩和集团企业。从在 Doucun 亚群底砾岩保存的花岗石的卵石的锆石给加权的mean~( 207 )在 2517 妈和 2566 妈之间的Pb/~( 206 ) Pb 年龄,它与为迟了的 ArcheanWutai Granitoids 的那些一样,显示卵石从 Wutai 花岗石的侵入( 2566-2515 妈)被导出。基于新数据和以前的研究,与在 Hutuo 组为 volcanics 获得的 2087 ±9 妈的火的锆石结晶化年龄结合了, Hutuo 组在在东方块的西方的边缘下面在西方的块的东方指导俯冲期间在 theWutai 弧后面发展了的subduction相关的制动火箭弧低岬盆环境被扔。这盆经历了长寿沉积并且最后在~ 1 期间关上了导致了北方中国古地台的最后的合并的 850 妈 collisional 事件。 | Jian ZHANG Guochun ZHAO LI Sanzhong Min SUN LIU Shuwen Xiaoping XIA Yanhong HE | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 15 |
| 17 | A comparison of clinical and angiographic outcomes after Excel bioabsorbable polymer versus Firebird durable polymer rapamycin-eluting stent for the treatment of coronary artery disease in a “real world” setting:six-month follow-up results显示文摘背景几临床的试用证明了 rapamycin-eluting stents 显著地在经皮的冠的干预(一种总线标准) 以后减少狭窄的风险。鲜艳的小鸟 stent 和 Excel stent (与 bioabsorbable 聚合物涂) rapamycin-eluting stents 的二种不同类型在中国被做,两个最近被州的食物药品管理局在中国为临床的使用同意了。然而,是否在在在2006年6月的每日的 practice.Methods 的 stents 的二种类型之间的安全和功效地有差别,是不清楚的, 190 个连续病人的一个总数专门与鲜艳的小鸟 stents 被对待( n=93 ,鲜艳的小鸟组)或胜过 stents ( n=97 ,胜过组)在我们的中心并且在这研究被包括。主要不利心脏的事件的频率(向,一死亡,心肌的梗塞或目标损害 revascularization 合成) ,二进制狭窄,和迟了的腔损失和 stent 血栓在二个 groups.Results 病人之间在一个六月的后续时期期间被比较,损害特征在这些组之间是可比较的。主要不利心脏的事件率在医院里并且在 6 个月是低的(2.1% 在 Excel 组织, 0% 在鲜艳的小鸟组织, P 0.05 ) 。6 月的 angiographic in-stent 狭窄率在两个组是 0% ,与联系迟了的损失(0.15 更高显著地在 PES 组织((0.14 ???????琠牨浯潢祬楳 吗?? | LIU Hai-bo XU Bo QIAO Shu-bin YANG Yue-jin MA Wei-hua QIN Xue-wen YAO Min WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XIA Ran LI Jian-jun CHEN Ji-lin GAO Run-lin | 2007 | Chinese Medical Journal2007，，7： | 15 |
| 18 | Effects of warming and clipping on plant and soil properties of an alpine meadow in the Qinghai-Tibetan Plateau, China显示文摘Climate warming and livestock grazing are known to have great influences on alpine ecosystems like those of the Qinghai-Tibetan Plateau(QTP) in China. However, it is lacking of studies on the effects of warming and grazing on plant and soil properties in these alpine ecosystems. In this study, we reported the related research from manipulative experiment in 2010–2012 in the QTP. The aim of this study was to investigate the individual and combined effects of warming and clipping on plant and soil properties in the alpine meadow ecosystem. Infrared radiators were used to simulate climate warming starting in July 2010, while clipping was performed once in October 2011 to simulate the local livestock grazing. The experiment was designed as a randomized block consisting of five replications and four treatments: control(CK), warming(W), clipping(C) and warming+clipping combination(WC). The plant and soil properties were investigated in the growing season of the alpine meadow in 2012. The results showed that W and WC treatments significantly decreased relative humidity at 20-cm height above ground as well as significantly increases air temperature at the same height, surface temperature, and soil temperature at the depth of 0–30 cm. However, the C treatment did not significantly decrease soil moisture and soil temperature at the depth of 0–60 cm. Relative to CK, vegetation height and species number increased significantly in W and WC treatment, respectively, while vegetation aboveground biomass decreased significantly in C treatment in the early growing season. However, vegetation cover, species diversity, belowground biomass and soil properties at the depth of 0–30 cm did not differ significantly in W, C and WC treatments. Soil moisture increased at the depth of 40–100 cm in W and WC treatments, while belowground biomass, soil activated carbon, organic carbon and total nitrogen increased in the 30–50 cm soil layer in W, C and WC treatments. Although the initial responses of plant and soil properties to experimental warming and clipping were slow and weak, the drought induced by the downward shift of soil moisture in the upper soil layers may induce plant belowground biomass to transfer to the deeper soil layers. This movement would modify the distributions of soil activated carbon, organic carbon and total nitrogen. However, long-term data collection is needed to further explain this interesting phenomenon. | Man Hou XU Fei PENG Quan Gang YOU Jian GUO Xia Fei TIAN Min LIU Xian XUE | 2015 | Journal of Arid Land2015，7，2： | 14 |
| 19 | CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization显示文摘Despite the diverse etiologies of drug-induced liver injury(DILI),innate immunity activation is a common feature involved in DILI progression.However,the involvement of innate immunity regulation in inflammation resolution and liver regeneration in DILI remains obscure.Herein,we identified the chemokine CCL5 as a central mediator of innate immunity regulation in the pathogenesis of DILI.First,we showed that serum and hepatic CCL5 levels are elevated in both DILI patients and an APAP-induced liver injury(AILI)mouse model.Interestingly,both nonparenchymal cells and stressed hepatocytes are cell sources of CCL5 induction in response to liver injury.Functional experiments showed that CCL5 deficiency has no effect on the early phase of AILI but promotes liver repair in the late phase mainly by promoting inflammation resolution and liver regeneration,which are associated with an increased number of hepatic M2 macrophages.Mechanistically,CCL5 can directly activate M1 polarization and impede M2 polarization through the CCR1-and CCR5-mediated activation of the MAPK and NF-κB pathways.We then showed that CCL5 inhibition mediated by either a CCL5-neutralizing antibody or the antagonist Met-CCL5 can greatly alleviate liver injury and improve survival in an AILI mouse model.Our data demonstrate CCL5 induction during DILI,identify CCL5 as a novel innate immunity regulator in macrophage polarization,and suggest that CCL5 blockage is a promising therapeutic strategy for the treatment of DILI. | Meng Li Xuehua Sun Jie Zhao Lei Xia Jichang Li Min Xu Bingrui Wang Han Guo Chang Yu Yueqiu Gao Hailong Wu Xiaoni Kong Qiang Xia | 2020 | Cellular & Molecular Immunology2020，17，7： | 13 |
| 20 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
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