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| 1 | Characteristics of non-erosive gastroesophageal reflux disease refractory to proton pump inhibitor therapy显示文摘AIM:To investigate whether potent acid inhibition is effective in non-erosive reflux disease (NERD) refractory to standard rabeprazole (RPZ) treatment. METHODS:We treated 10 Japanese patients with NERD resistant to standard dosages of RPZ:10 mg or 20 mg od,20 mg bid,or 10 mg qid for 14 d. All patients completed a frequency scale for symptoms of gastroesophageal reflux disease questionnaire frequency scale for the symptoms of GERD (FSSG); and underwent 24 h pH monitoring on day 14. RESULTS:With increased dosages and frequency of administration of RPZ,median intragastric pH significantly increased,and FSSG scores significantly decreased. With RPZ 10 mg qid,potent acid inhibition was attained throughout 24 h. However,five subjects were refractory to RPZ 10 mg qid,although the median intragastric pH in these subjects (6.6,range:6.2-7.1) was similar to that in the remaining five responsive subjects (6.5,range:5.3-7.3). With baseline RPZ 10 mg od,FSSG scores in responsive patients improved by > 30%,whereas there was no significant decrease in the resistant group. CONCLUSION:NERD patients whose FSSG score fails to decrease by > 30% after treatment with RPZ 10 mg od for 14 d are refractory to higher dosage. | Mitsushige Sugimoto Masafumi Nishino Chise Kodaira Mihoko Yamade Takahiro Uotani Mutsuhiro Ikuma Kazuo Umemura Takahisa Furuta | 2011 | World Journal of Gastroenterology2011，17，14： | 10 |
| 2 | The effects of focused and unfocused written corrective feedback in an English as a foreign language context显示文摘 | Rod Ellis Younghee Sheen Mihoko Murakami Hide Takashima | 2008 | System2008，，3： | 3 |
| 3 | Efficacy of Tailored Helicobacter pylori Eradication Treatment Based on Clarithromycin Susceptibility and Maintenance of Acid Secretion显示文摘 | Mitsushige Sugimoto Takahiro Uotani Shu Sahara Hitomi Ichikawa Mihoko Yamade Ken Sugimoto Takahisa Furuta | 2014 | Helicobacter2014，，4： | 3 |
| 4 | Ability of Rabeprazole to Prevent Gastric Mucosal Damage From Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype显示文摘 | Takahiro Uotani Mitsushige Sugimoto Masafumi Nishino Chise Kodaira Mihoko Yamade Shu Sahara Takanori Yamada Satoshi Osawa Ken Sugimoto Tatsuo Tanaka Kazuo Umemura Hiroshi Watanabe Hiroaki Miyajima Takahisa Furuta | 2012 | Clinical Gastroenterology and Hepatology2012，，8： | 2 |
| 5 | Tuberous sclerosis patient with neuroendocrine carcinoma of the esophagogastric junction:A case report显示文摘BACKGROUND Tuberous sclerosis complex(TSC)is a rare inherited disease with non-cancerous tumor growths in the skin,brain,kidneys,heart,and lungs.The co-occurrence of neuroendocrine neoplasm(NEN)with TSC is even rarer.There have been few reports on the relationship between TSC and neuroendocrine tumors(NETs),and fewer on the relationship between TSC and neuroendocrine carcinoma(NEC),a subtype of NEN.This is the first reported case of NEC occurring at the esophagogastric junction in a patient with TSC.CASE SUMMARY A 46-year-old woman visiting our hospital for the treatment of TSC was admitted to the emergency department with tarry stools and dizziness.Computed tomography scans revealed thickness of the gastric cardia,multiple metastatic lesions of the liver,and enlarged lymph nodes near the lesser curvature of the stomach.Esophagogastroduodenoscopy revealed a type 3 tumor located from the esophagogastric junction to the fundus,and the pathological diagnosis by biopsy was NEC.The patient was treated with seven courses of cisplatin+irinotecan,followed by eight courses of ramucirumab+nab-paclitaxel,one course of nivolumab,and two courses of S-1+oxaliplatin.Twenty-three months after the first treatment,the patient died because of disease progression and deterioration of the general condition.CONCLUSION This case of NEC occurring in a patient with TSC indicates a difference in the occurrence of NETs and NECs. | Natsuki Ishida Takahiro Miyazu Satoshi Tamura Satoshi Suzuki Shinya Tani Mihoko Yamade Moriya Iwaizumi Satoshi Osawa Yasushi Hamaya Kazuya Shinmura Haruhiko Sugimura Katsutoshi Miura Takahisa Furuta Ken Sugimoto | 2020 | World Journal of Gastroenterology2020，26，45： | 2 |
| 6 | Association Between Serum Uric Acid and Development of Type 2 Diabetes显示文摘 | Kodama Satoru Saito Kazumi Yachi Yoko Asumi Mihoko Sugawara Ayumi Totsuka Kumiko Saito Aki Sone Hirohito | 2009 | Diabetes Care2009，，： | 2 |
| 7 | The effects of focused and unfocused written corrective feedback in an English as a foreign language context显示文摘 | Rod Ellis Younghee Sheen Mihoko Murakami Hide Takashima | 2008 | System2008，，3： | 1 |
| 8 | Health effects of fluoride pollution caused by coal burning 显示文摘 | Mitsuru Ando Mihoko Tadano Shoji Yamamoto | 2001 | The Science of the Total Environment2001，271，2001： | 1 |
| 9 | Sitafloxacin‐based third‐line rescue regimens for H elicobacter pylori infection in J apan显示文摘 | Takahisa Furuta Mitsushige Sugimoto Chise Kodaira Masafumi Nishino Mihoko Yamade Takahiro Uotani Shu Sahara Hitomi Ichikawa Takanori Yamada Satoshi Osawa Ken Sugimoto Hiroshi Watanabe Kazuo Umemura | 2014 | J Gastroenterol Hepatol2014，，3： | 1 |
| 10 | Molecular characterization of the flavonoid biosynthesis of Verbena hybrida and the functional analysis of verbena and clitoria ternatea F3'5'H genes in transgenic verbena显示文摘 | Junichi Togami Mihoko Tamura | 2006 | Plant Biotechnology2006，23，4： | 1 |
| 11 | 显示文摘 | SUN Y MIHOKO N NAKASHIMA | 2002 | Biomed Chromatogr2002，16，： | 1 |
| 12 | Liquid chromatography–tandem mass spectrometric method for the determination of salivary 25-hydroxyvitamin D3: a noninvasive tool for the assessment of vitamin D status显示文摘 | Tatsuya Higashi Yujin Shibayama Mihoko Fuji Kazutake Shimada | 2008 | Analytical and Bioanalytical Chemistry2008，，1： | 1 |
| 13 | Effects of a soy protein diet on exercise-induced muscle protein catabolism in rats显示文摘 | Takeshi Nikawa Madoka Ikemoto Takashi Sakai Mihoko Kano Takako Kitano Tsukasa Kawahara Shigetada Teshima Kazuhito Rokutan Kyoichi Kishi | 2002 | Nutrition2002，，6： | 1 |
| 14 | Two patterns of β-amyloid precursor protein (APP) immunoreactivity in cases of blunt head injury显示文摘 | Takahito Hayashi Kazutoshi Ago Mihoko Ago Mamoru Ogata | 2009 | Legal Medicine2009，，： | 1 |
| 15 | Effects of spilled oil on microbial communities in a tidal flat显示文摘 | YOKO Katayama TETSE Oura MIHOKO Iizuka | 2003 | Marine Pollution Bulletin2003，，47： | 1 |
| 16 | Right and left ventriculax activation sequence in patients with heart failure and right buncue branch block:a detailed electroanatomie mapping system显示文摘 | Cecilia F Mihoko K Raimondo M | 2005 | J Cardiovasc Electrophysiol2005，16，： | 1 |
| 17 | Blue flower color devel- opment by anthocyanins: From chemical structure to cell physiology显示文摘 | Kumi Y Mihoko M Tadao K | 2009 | Natural Product Reports2009，26，： | 1 |
| 18 | Acute toxicity,accumulation and excretion of organophosphorous insecticides and their oxidation products in killifish显示文摘 | Taizo T Mihoko K Hiroyuki H | 1997 | Chemosphere1997，35，5： | 1 |
| 19 | Production of ubiquinone in Escherichia coli by expression of various genes responsible for ubiquinone biosynthesis 显示文摘 | Zhu Xufen Yuasa Mihoko Okada Kazunori | 1995 | Journal of Fermentation and Bioengineering1995，79，5： | 1 |
| 20 | Distribution of prolylhydroxyproline and its metabolites after oral administration in rats显示文摘 | Tomoaki K Patricia Naomi N Mihoko K | 2012 | Biological & Pharmaceutical Bulletin2012，35，3： | 1 |
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