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| 1 | Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer显示文摘Colorectal cancer(CRC)is one of the most common cancer worldwide and results from the accumulation of mutations and epimutations in colonic mucosa cells ultimately leading to cell proliferation and metastasis.Unfortunately,CRC prognosis is still poor and the search of novel diagnostic and prognostic biomarkers is highly desired to prevent CRC-related deaths.The present article aims to summarize the most recent findings concerning the use of either genetic or epigenetic(mainly related to DNA methylation)biomarkers for CRC diagnosis,prognosis,and response to treatment.Recent large-scale DNA methylation studies suggest that CRC can be divided into several subtypes according to the frequency of DNA methylation and those of mutations in key CRC genes,and that this is reflected by different prognostic outcomes.Increasing evidence suggests that the analysis of DNA methylation in blood or fecal specimens could represent a valuable non-invasive diagnostic tool for CRC.Moreover,a broad spectrum of studies indicates that the inter-individual response to chemotherapeutic treatments depends on both epigenetic modifications and genetic mutations occurring in colorectal cancer cells,thereby opening the way for a personalized medicine.Overall,combining genetic and epigenetic data might represent the most promising tool for a proper diagnostic,prognostic and therapeutic approach. | Fabio Coppedè Angela Lopomo Roberto Spisni Lucia Migliore | 2014 | World Journal of Gastroenterology2014，20，4： | 29 |
| 2 | Primary hepatic carcinoid:A case report and literature review显示文摘Carcinoids are tumors derived from neuroendocrine cells and often produce functional peptide hormones.Approximately 54.5% arise in the gastrointestinal tract and frequently metastasize to the liver.Primary hepatic carcinoid tumors(PHCT) are extremely rare;only 95 cases have been reported.A 65-year-old man came to our attention due to occasional ultrasound findings in absence of clinical manifestations.His previous medical history,since 2003,included an echotomography of the dishomogeneous parenchymal area but no focal lesions.A computed tomography scan performed in 2005 showed an enhanced pseudonodular-like lesion of about 2 cm.Cholangio-magnetic resonance imaging identified the lesion as a possible cholangiocarcinoma.No positive findings were obtained with positron emission tomography.Histology suggested a secondary localization in the liver caused by a low-grade malignant neuroendocrine tumor.Immunohistochemistry was positive for anti chromogranin antibodies,Ki67 antibodies and synaptophysin.Octreoscan scintigraphy indicated intense activity in the lesion.Endoscopic investigations were performed to exclude the presence of extrahepatic neoplasms.Diagnosis of PHCT was established.The patient underwent left hepatectomy,followed by hormone therapy with sandostatine LAR.Two months after surgery he had a lymph nodal relapse along the celiac trunk and caudate lobe,which was histologically confirmed.The postoperative clinical course was uneventful,with a negative follow-up for hematochemical,clinical and radiological investigations at 18 mo post-surgery.Diagnosis of PHCT is based principally on the histopathological confi rmation of a carcinoid tumor and the exclusion of a non-hepatic primary tumor.Surgical resection is the recommended primary treatment for PHCT.Recurrence rate and survival rate in patients treated with resection were 18% and 74%,respectively. | Luigi Maria Fenoglio Sara Severini Domenico Ferrigno Giovanni Gollè Cristina Serraino Christian Bracco Elisabetta Castagna Chiara Brignone Fulvio Pomero Elena Migliore Ezio David Mauro Salizzoni | 2009 | World Journal of Gastroenterology2009，15，19： | 14 |
| 3 | Screening of unknown atrial fibrillation through handheld device in the elderly显示文摘Objective To estimate the prevalence of unknown atrial fibrillation(AF)in the elderly population of the Veneto Region,Italy.Methods 1820 patients aged≥65 years with no history of AF and not anticoagulated were enrolled in primary-care settings.They underwent an opportunistic electrocardiogram screening with a handheld device(My Diagnostick)designed to specifically detect AF.The electrocardiogram recordings were reviewed by the researchers,who confirmed the presence of AF.Results The device detected an arrhythmia in 143 patients,which was confirmed as AF in 101/143(70.6%),with an overall prevalence of AF of 5.5%(101/1820).Prevalence of unknown AF resulted in 3.6%in patients aged 65–74 years,and 7.5%in patients age 75 or older,and increased according to CHA2 DS2-VASc score:3.5%in patients with a score of 1 or 2,5.6%in patients with a score of 3,7.0%in patients with a score of 4,and 7.2%in patients with a score≥5.The detection rate was significantly higher in patients with mild symptoms compared to asymptomatic counterparts(24.1%vs.4.0%,P<0.0001).At multivariate analysis,congestive heart failure and age≥75 years-old were independent predictors for screen-detected AF.Conclusions An opportunistic screening with handheld device revealed an unexpectedly high prevalence of unknown AF in elderly patients with mild symptoms.Prevalence increased with age and CHA2DS2-VASc score. | Francesco Rivezzi Riccardo Vio Claudio Bilato Leopoldo Pagliani Giampaolo Pasquetto Salvatore Saccà Roberto Verlato Federico Migliore Sabino Iliceto Vito Bossone Emanuele Bertaglia | 2020 | Journal of Geriatric Cardiology2020，17，8： | 3 |
| 4 | Genetics, Cytogenetics, and Epigenetics of Colorectal Cancer显示文摘 | Lucia Migliore Francesca Migheli Roberto Spisni Fabio Coppedè Nathan A. Ellis | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 2 |
| 5 | Venous Lower-Limb Evaluation in Patients With Acute Pulmonary Embolism显示文摘 | Fulvio Pomero Chiara Brignone Cristina Serraino Sergio Panzone Christian Bracco Elena Migliore Paola Dalmasso Paolo Cavallo Perin Luigi Maria Fenoglio | 2011 | Southern Medical Journal2011，，6： | 2 |
| 6 | Phytotoxicity to and uptake of enrofloxacin in crop plants显示文摘 | Luciana Migliore Salvatore Cozzolino Maurizio Fiori | 2003 | Chemosphere2003，，7： | 2 |
| 7 | Hormetic effect(s) of tetracyclines as environmental contaminant on Zea mays显示文摘 | Luciana Migliore Feliciana Godeas Stefania Paola De Filippis Paolo Mantovi Davide Barchi Cecilia Testa Nicolino Rubattu Gianfranco Brambilla | 2009 | Environmental Pollution2009，，1： | 2 |
| 8 | 基于确定性压缩感知采样策略的阵列失效单元远场诊断方法显示文摘在采用压缩感知的阵列失效单元诊断方法中,结构化随机采样策略的运用对测量矩阵性能造成不利影响。针对这一问题,该文提出一种基于确定性压缩感知采样策略的阵列失效单元远场诊断方法。首先在失效单元个数满足稀疏性的前提下构造差异性阵列并将其激励作为稀疏向量,其次利用所提方法构造确定性部分傅里叶矩阵(DPFM)作为测量矩阵,最后采用l1范数最小化算法对稀疏向量进行重构,从而实现对失效单元的高概率精确诊断。理论分析和仿真实验表明,所提方法有效消除了采样位置的随机分布特性对测量矩阵性能造成的不利影响,简化了采样过程,提高了诊断成功概率。 | 李玮 邓维波 杨强 MIGLIORE Marco Donald | 2018 | 电子与信息学报2018，40，11： | 2 |
| 9 | Soft stall control for variable speed stall regulated wind turbines显示文摘 | Muljadi E Pierce K Migliore P | 2000 | Journal of Wind Engineering and Industrial Aerodynamics2000，85，3： | 1 |
| 10 | Postoperative pain in neurosurgery: a pilot study in brain surgery 显示文摘 | De Benedittis G Lorenzetti A Migliore M | 1996 | Neurosurgery1996，38，3： | 1 |
| 11 | Microperimetry of localized retinal nerve fiber layer defects显示文摘 | Orzalesi N Miglior S Lonati C | 1998 | Vision Res1998，38，5： | 1 |
| 12 | Rates of inbreeding and genetic diversity in Canadian Holstein and Jersey cattle显示文摘 | K. Stachowicz M. Sargolzaei F. Miglior F.S. Schenkel | 2011 | Journal of Dairy Science2011，，10： | 1 |
| 13 | Assessment of sperm DNA integrity in workers exposed to styrene 显示文摘 | MIGLIORE L NACCARATI A ZANELLO A | 2002 | Hum Reprod2002，17，11： | 1 |
| 14 | Effectiveness and utility of hyaluronic acid in osteoarthritis显示文摘 | Migliore A Procopio S | 2015 | Clin Cases Miner Bone Metab2015，12，1： | 1 |
| 15 | The Capacity of Wireless Networks:Information-Theoretic and Physical Limits显示文摘 | FRANCESCHETTI M MIGLIORE M D MINERO P | 2009 | IEEE Transactions on Information Theory2009，55，8： | 1 |
| 16 | Environmental-induced oxidative stress in neurodegenerative disorders and aging显示文摘 | Migliore L Copped F | 2009 | Mutat Res2009，674，12： | 1 |
| 17 | Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE) 显示文摘 | Raaschou-Nielsen 0 Andersen ZJ Beelen R Samoli E Stafoggia M Weinmayr G Hoffmann B Fischer P Nieuwenhuijsen MJ Brunekreef B Xun WW Katsouyanni K Dimakopoulou K Sommar J Forsberg B Modig L Oudin A Oftedal B Schwarze PE Nafstad p De Faire U Pedersen NL Ostenson CG Fratiglioni L Penell J Korek M Pershagen G Eriksen KT Serensen M Tjenneland A Ellermann T Eeftens M Peeters PH Meliefste K Wang M Bueno-de-Mesquita B Key TJ de Hoogh K Concin H Nagel G Yilier A Grioni S Krogh y Tsai MY Ricceri F Sacerdote C Galassi C Migliore E Ranzi A Cesaroni G Badaloni C Forastiere F Tamayo I Amiano P Dorronsoro M Trichopoulou A Bamia C Yineis p Hoek G | 2013 | Lancet Oncol2013，14，9： | 1 |
| 18 | Oxidative damage and cytogenetic analysis in leukocytes of Parkinsons disease patients 显示文摘 | Petrozzi L Lucetti C | 2002 | Neurology2002，58，12： | 1 |
| 19 | Cytogenetic and oxidative damage induced in human lymphocytes by platinum, rhodium and palladium compounds 显示文摘 | Migliore L Frenzilli G Nesti C | 2002 | Mutagenesis2002，17，： | 1 |
| 20 | Phytotoxieity to and uptake of enrofloxacin in crop plants 显示文摘 | Migliore L Cozzolino S Fiori M | 2003 | Chemosphere2003，52，7： | 1 |
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