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| 1 | A nutraceutical combination improves insulin sensitivity in patients with metabolic syndrome显示文摘AIM:To test the efficacy of a proprietary nutraceutical combination in reducing insulin resistance associated with the metabolic syndrome(MetS).METHODS:Sixty-four patients with MetS followed at a tertiary outpatient clinic were randomly assigned to receive either placebo or a proprietary nutraceutical combination(AP)consisting of berberine,policosanol and red yeast rice,in a prospective,double-blind,placebo-controlled study.Evaluations were performed at baseline and after 18 wk of treatment.The homeostasis model assessment of insulin resistance(HOMAIR)index was the primary outcome measure.Secondary endpoints included lipid panel,blood glucose and insulin fasting,after a standard mixed meal and after an oral glucose tolerance test(OGTT),ow-mediated dilation(FMD),and waist circumference.RESULTS:Fifty nine patients completed the study,2 withdrew because of adverse effects.After 18 wk there was a signif icant reduction in the HOMA-IR index in the AP group compared with placebo(ΔHOMA respectively-0.6 ± 1.2 vs 0.4 ± 1.9;P < 0.05).Total and low density lipoprotein cholesterol also significantly decreased in the treatment arm compared with placebo(Δlow density lipoprotein cholesterol-0.82 ± 0.68 vs-0.13 ± 0.55 mmol/L;P < 0.001),while triglycerides,high density lipoprotein cholesterol,and the OGTT were not affected.In addition,there were significant reductions in blood glucose and insulin after the standard mixed meal,as well as an increase in FMD(ΔFMD 1.9 ± 4.2 vs 0 ± 1.9 %;P < 0.05)and a significant reduction in arterial systolic blood pressure in the AP arm.CONCLUSION:This short-term study shows that AP has relevant beneficial effects on insulin resistance and many other components of MetS. | Flora Affuso Valentina Mercurio Antonio Ruvolo Concetta Pirozzi Filomena Micillo Guido Carlomagno Fabrizia Grieco Serafino Fazio | 2012 | World Journal of Cardiology2012，4，3： | 7 |
| 2 | Respiratoryinfectionsandasthma显示文摘 | BiancoA DcAuriaD | 2000 | Allergy2000，55，42： | 1 |
| 3 | Respiratory infections and asthma 显示文摘 | Micillo E Bianco A D'Auria D | 2000 | Allergy2000，61，： | 1 |
| 4 | Respiratory infection and asthma 显示文摘 | Micillo E Bianco A Auria D | 2000 | Allergy2000，55，6： | 1 |
| 5 | Longitudinal growth, sexual maturation and final height in patients with congenital hypothyroidism detected by neonatal screening显示文摘 | Salerno M Micillo M Di Maio S | 2001 | Eur J Endocrinol2001，145，4： | 1 |
| 6 | Respiratory infection and asthma显示文摘 | Micillo E Bianco A Auria D | 2000 | Allergy2000，55，61： | 1 |
| 7 | Respiratory infectionsand asthma显示文摘 | Micillo E Bianco A Auria D | 2000 | Allergy2000，55，61： | 1 |
| 8 | Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function: a randomized, double-blind, pla- cebo-controlled study 显示文摘 | Affuso F Ruvalo A Micillo F | 2010 | Nutr Metab Cardiovasc Dis2010，20，9： | 1 |
| 9 | Viruses and asthmatic syndro-mes显示文摘 | Micillo E Marcatili P Palmieri S | 1998 | Monaldi Arch Chest Dis1998，53，1： | 1 |
| 10 | Respiratory infections and asthma显示文摘 | Micillo E Bianco A Auria D | | 0，，： | 1 |
| 11 | Viruses and asthmatic syndromes显示文摘 | Micillo E Marcatili P Palmieri S | 1998 | Monaldi Arch Chest Dis1998，53，： | 1 |
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