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| 1 | Male obesity and subfertility, is it really about increased adiposity?显示文摘在繁殖的人的过重和肥胖的流行全球正在增加,与 > 70% 人 >作为在一些西方的国家超重或肥胖分类的 18 年。男肥胖与男 subfertility 被联系,损害性荷尔蒙,减少精子计数,增加氧化精子 DNA 损坏并且改变精子的 epigenetic 地位。精子的这些变化由于肥胖工作,进一步在人与损害胚胎开发,减少的实时出生率和增加的流产率被联系。动物模型建议了这些不利繁殖效果能被传给后代;在概念建议那人的健康可以影响他们的孩子的健康。除了更高的脂肪过多,男肥胖与 comorbidities 被联系,包括新陈代谢的症候群,血胆脂醇过多, hyperleptinemia 和一个支持 inflammatory 州,独立地与男 subfertility 被连接了的所有。一起拿,这些调查结果建议生育力上的男肥胖的效果是可能的 multifactorial 与也影响精子的联系 comorbidities,怀孕和随后的孩子健康。 | Nicole O McPherson | 2015 | Asian Journal of Andrology2015，17，3： | 10 |
| 2 | Role of retinoids in the prevention and treatment of colorectal cancer显示文摘Vitamin A and its derivatives, retinoids, have been widely studied for their use as cancer chemotherapeutic agents. With respect to colorectal cancer(CRC), several critical mutations dysregulate pathways implicated in progression and metastasis, resulting in aberrant Wnt/β-catenin signaling, gain-of-function mutations in K-ras and phosphatidylinositol-3-kinase/Akt, cyclooxygenase-2 over-expression, reduction of peroxisome proliferatoractivated receptor γ activation, and loss of p53 function. Dysregulation leads to increased cellular proliferation and invasion and decreased cell-cell interaction and differentiation. Retinoids affect these pathways by various mechanisms, many involving retinoic acid receptors(RAR). RAR bind to all-trans-retinoic acid(ATRA) to induce the transcription of genes responsible for cellular differentiation. Although most research concerning the chemotherapeutic efficacy of retinoids focuses on the ability of ATRA to decrease cancer cell proliferation, increase differentiation, or promote apoptosis; as CRC progresses, RAR expression is often lost, rendering treatment of CRCs with ATRA ineffective. Our laboratory focuses on the ability of dietary vitamin A to decrease CRC cell proliferation and invasion via RAR-independent pathways. This review discusses our research and others concerning the ability of retinoids to ameliorate the defective signaling pathways listed above and decrease tumor cell proliferation and invasion through both RAR-dependent and RAR-independent mechanisms. | Catherine C Applegate Michelle A Lane | 2015 | World Journal of Gastrointestinal Oncology2015，7，10： | 2 |
| 3 | Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer显示文摘 | David K Gardner Michelle Lane John Stevens Terry Schlenker William B Schoolcraft | 2000 | Fertility and Sterility2000，，6： | 2 |
| 4 | Vitrificaion of mouse oocytes using a nylon loop 显示文摘 | Lane Michelle Gardner David K | 2001 | Molecular Rproduction and Development2001，58，： | 1 |
| 5 | Analysis of polycyclic aromatic hydrocarbons (PAHs) in environmental samples: a critical review of gas chromatographic (GC) methods显示文摘 | Dianne L. Poster Michele M. Schantz Lane C. Sander Stephen A. Wise | 2006 | Analytical and Bioanalytical Chemistry2006，，4： | 1 |
| 6 | Vitrification of mouse and human blastocysts using a novel cryoloop container-less technique显示文摘 | Michelle Lane William B Schoolcraft David K Gardner D Phil | 1999 | Fertility and Sterility1999，，6： | 1 |
| 7 | Effect of changes in weight-bearing exercise on lumber bone mass after age fifty显示文摘 | Michel BA Lane NE Bloch MA | 1991 | Ann Med1991，23，4： | 1 |
| 8 | STJD14111700000229显示文摘 | Jennifer N. Griffin Lengyel Eun Young Park Anna R. Brunson Daniel Pinali Michelle A. Lane | 2014 | Nutrition and Cancer2014，，8： | 1 |
| 9 | Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer显示文摘 | David K Gardner Michelle Lane John Stevens Terry Schlenker William B Schoolcraft | 2000 | Fertility and Sterility2000，，6： | 1 |
| 10 | Need to Knowledge (NtK)Model: an evidence-based framework for generating technological innovations withsocio-economic impacts显示文摘 | Jennifer L Flagg Joseph P Lane Michelle M | 2013 | Implementation science: IS2013，8，1： | 1 |
| 11 | The CryoLoop facilitates revitriication of embryos at four successive stages of development without impairing embryo growth 显示文摘 | Courtney B Sheehan Michelle Lane | 2006 | Hum Reprod2006，21，11： | 1 |
| 12 | Increased gonadotrophin stimulation does not improve IVFoutcomes in patients with predicted poor ovarian reserve显示文摘 | Lekamge DN Lane Michelle Gilchrist RB | 2008 | J Assist Reprod Genet2008，25，： | 1 |
| 13 | The risk of osteoarthritiswith running and aging : a 5-year longitudinal study 显示文摘 | Lane NE Michel B Bjorkengren A | 1993 | J Rheumatol1993，20，3： | 1 |
| 14 | Culture and transfer of human blastocysts increases implantation rates and reduces the need for multiple embryo transfers显示文摘 | David K. Gardner Pauline Vella Michelle Lane Lyla Wagley Terry Schlenker William B. Schoolcraft | 1998 | Fertility and Sterility1998，，1： | 1 |
| 15 | Oral Fluorescence Imaging Using 405-nm Excitation, Aiding the Discrimination of Cancers and Precancers by Identifying Changes in Collagen and Elastic Breakdown and Neovascularization in the Underlying Stroma显示文摘 | Pierre Lane Sylvia Lam Michele Follen Calum MacAulay | 2012 | Gender Medicine2012，，1： | 1 |
| 16 | Oocyte-secreted factors:regulators of cumulus cell function and oocyte quality显示文摘 | Robert B Gilchrist Michelle Lane | 2008 | Hum Reprod2008，14，2： | 1 |
| 17 | Increased hyaluronan concentration in the embryo transfer medium results in a significant increase in human embryo implantation rate显示文摘 | William Schoolcraft Michelle Lane John Stevens | 2002 | Fertility and Sterility2002，14，： | 1 |
| 18 | The risk of osteoarthritis with running and aging:a 5-year longitudinal study显示文摘 | Lane NE Michel B Bjorkengren A | 1993 | J Rheumatol1993，20，3： | 1 |
| 19 | Does obesity really matter? The impact of BMI on embryo quality and pregnancy outcomes after IVF in women aged ≤38?years显示文摘 | Deirdre L. Zander‐Fox Richard Henshaw Hamish Hamilton Michelle Lane | 2012 | Aust N Z J Obstet Gynaecol2012，，3： | 1 |
| 20 | Disruption of Bidirectional Oocyte-Cumulus Paracrine Signaling During In Vitro Maturation Reduces Subsequent Mouse Oocyte Developmental Competence显示文摘 | Christine X Yeo Robert B Gilchrist Michelle Lane | | 0，，5： | 1 |
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