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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | TNFα and reactive oxygen species in necrotic cell death显示文摘 | Michael J Morgan You-Sun Kim Zheng-gang Liu | 2008 | Cell Research2008，18，3： | 13 |
| 3 | New frontiers for the materials genome initiative显示文摘The Materials Genome Initiative(MGI)advanced a new paradigm for materials discovery and design,namely that the pace of new materials deployment could be accelerated through complementary efforts in theory,computation,and experiment.Along with numerous successes,new challenges are inviting researchers to refocus the efforts and approaches that were originally inspired by the MGI.In May 2017,the National Science Foundation sponsored the workshop“Advancing and Accelerating Materials Innovation Through the Synergistic Interaction among Computation,Experiment,and Theory:Opening New Frontiers”to review accomplishments that emerged from investments in science and infrastructure under the MGI,identify scientific opportunities in this new environment,examine how to effectively utilize new materials innovation infrastructure,and discuss challenges in achieving accelerated materials research through the seamless integration of experiment,computation,and theory.This article summarizes key findings from the workshop and provides perspectives that aim to guide the direction of future materials research and its translation into societal impacts. | Juan J.de Pablo Nicholas E.Jackson Michael A.Webb Long-Qing Chen Joel E.Moore Dane Morgan Ryan Jacobs Tresa Pollock Darrell G.Schlom Eric S.Toberer James Analytis Ismaila Dabo Dean M.DeLongchamp Gregory A.Fiete Gregory M.Grason Geoffroy Hautier Yifei Mo Krishna Rajan Evan J.Reed Efrain Rodriguez Vladan Stevanovic Jin Suntivich Katsuyo Thornton Ji-Cheng Zhao | 2019 | npj Computational Materials2019，，1： | 7 |
| 4 | Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies显示文摘In the past century, there have been many attempts to treat cancer with low levels of electric and magnetic fields. We have developed noninvasive biofeedback examination devices and techniques and discovered that patients with the same tumor type exhibit biofeedback responses to the same, precise frequencies. Intrabuccal administration of 27.12 MHz radiofrequency(RF) electromagnetic fields(EMF), which are amplitude-modulated at tumor-specific frequencies, results in long-term objective responses in patients with cancer and is not associated with any significant adverse effects. Intrabuccal administration allows for therapeutic delivery of very low and safe levels of EMF throughout the body as exemplified by responses observed in the femur, liver, adrenal glands, and lungs. In vitro studies have demonstrated that tumor-specific frequencies identified in patients with various forms of cancer are capable of blocking the growth of tumor cells in a tissue- and tumor-specific fashion. Current experimental evidence suggests that tumor-specific modulation frequencies regulate the expression of genes involved in migration and invasion and disrupt the mitotic spindle. This novel targeted treatment approach is emerging as an appealing therapeutic option for patients with advanced cancer given its excellent tolerability. Dissection of the molecular mechanisms accounting for the anti-cancer effects of tumor-specific modulation frequencies is likely to lead to the discovery of novel pathways in cancer. | Jacquelyn W.Zimmerman Hugo Jimenez Michael J.Pennison Ivan Brezovich Desiree Morgan Albert Mudry Frederico P.Costa Alexandre Barbault Boris Pasche | 2013 | Chinese Journal of Cancer2013，32，11： | 3 |
| 5 | Preoperative Nutritional Status Is an Important Predictor of Survival in Patients Undergoing Surgery for Renal Cell Carcinoma显示文摘 | Todd M. Morgan Dominic Tang Kelly L. Stratton Daniel A. Barocas Christopher B. Anderson Justin R. Gregg Sam S. Chang Michael S. Cookson S. Duke Herrell Joseph A. Smith Peter E. Clark | 2011 | European Urology2011，，6： | 2 |
| 6 | Study to Determine Adequate Margins in Radiotherapy Planning for Esophageal Carcinoma by Detailing Patterns of Recurrence After Definitive Chemoradiotherapy显示文摘 | Michael R. Button Carys A. Morgan Elizabeth S. Croydon S. Ashley Roberts Thomas D.L. Crosby | 2009 | International Journal of Radiation Oncology, Biology, Physics2009，，3： | 2 |
| 7 | Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice显示文摘基因表示能被调制 DNA 建筑学的染色质修饰词,抄写因素和蛋白质调整。在后者之中,在钩抄写因素作为能激活或镇压的 multifaceted 管理者出现了宽广 A/T-rich 基因网络。因此,在钩基因的改变能影响引起全球房间机能障碍的多重基因的抄写。这里,我们报导那指向了老鼠 AKNA 的删除,一个假想在钩状的抄写因素,敏化老鼠到导致病原体的发炎并且引起突然的新生的死亡。与野类型的同窝出生的人相比, AKNA 击倒老鼠显得弱,没能繁荣,大多数到出生后的白天死了 10。全身的发炎,主要在肺,被提高的白血球渗入和牙槽的破坏伴随。Cytologic, immunohistochemical 和分子的分析揭示了 CD11b + 是的 Gr1 + neutrophils 象嗜中性特定的 chemoattracting 因素的主要织物渗透者, neutrophilic 小粒蛋白质, cathelin 相关的抗菌剂肽和 S100A8/9, interleukin-1β并且 interferon-γ作为 proinflammatory 调停人,和矩阵 metalloprotease 9 作为牙槽的损坏的一个嘴巧的解朊的扳机。AKNA 击倒骨头髓在野类型的接受者移植复制了严重导致病原体的反应并且在尖锐发炎证实了 neutrophils 的参与。而且,倡导者 / 记者实验证明 AKNA 能充当一个基因抑压者。我们的结果支持协调小径特定的基因规定功能 modulating 的概念煽动性的回答的紧张,作为尖锐发炎的突出的调停人揭示 neutrophils 并且建议位于被触发尖锐、潜在地致命的有免疫力的反应下面的机制。 | WenbinMa BlancaOrtiz-Quintero RobertoRangel Morgan RMcKeller SaraHerrera-Rodriguez Eliseo FCastillo Kimberly SSchluns MaryHall HuiyuanZhang Woong-KyungSuh HitoshiOkada Tak WMak YangZhou Michael RBlackburn HectorMartinez-Valdez | 2011 | Cell Research2011，21，11： | 2 |
| 8 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 9 | Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2显示文摘 | Yong Zhao Joshua F. Ransom Ankang Li Vasanth Vedantham Morgan von Drehle Alecia N. Muth Takatoshi Tsuchihashi Michael T. McManus Robert J. Schwartz Deepak Srivastava | 2007 | Cell2007，，2： | 2 |
| 10 | Design and implementation of an intelligent grinding assistant system 显示文摘 | Morgan Michael N Cai Rui | 2007 | Abrasive Technology2007，1，1： | 1 |
| 11 | Expression of Engrailed-2 (EN2) protein in bladder cancer and its potential utility as a urinary diagnostic biomarker显示文摘 | Richard Morgan Richard T. Bryan Saqib Javed Francesca Launchbury Maurice P. Zeegers K.K. Cheng Nicholas D. James D. Michael A. Wallace Carolyn D. Hurst Douglas G. Ward Margaret A. Knowles Hardev Pandha | 2013 | European Journal of Cancer2013，，9： | 1 |
| 12 | Urinary engrailed‐2 (EN2) levels predict tumour volume in men undergoing radical prostatectomy for prostate cancer显示文摘 | Hardev Pandha Karen D. Sorensen Thorsten F. Orntoft Stephen Langley Soren Hoyer Michael Borre Richard Morgan | 2012 | BJU International2012，，6： | 1 |
| 13 | Anxiety reduction following exercise and meditation显示文摘 | Michael S. Bahrke William P. Morgan | 1978 | Cognitive Therapy and Research1978，，4： | 1 |
| 14 | Temporal price dispersion: Evidence from an online consumer electronics market显示文摘 | Michael R. Baye John Morgan Patrick Scholten | 2004 | Journal of Interactive Marketing2004，，4： | 1 |
| 15 | Role of cardiac magnetic resonance imaging in the diagnosis and management of COVID-19 related myocarditis: Clinical and imaging considerations显示文摘There is a growing evidence of cardiovascular complications in coronavirusdisease 2019 (COVID-19) patients. As evidence accumulated of COVID-19 mediatedinflammatory effects on the myocardium, substantial attention has beendirected towards cardiovascular imaging modalities that facilitate this diagnosis.Cardiac magnetic resonance imaging (CMRI) is the gold standard for thedetection of structural and functional myocardial alterations and its role inidentifying patients with COVID-19 mediated cardiac injury is growing. Despiteits utility in the diagnosis of myocardial injury in this population, CMRI’s impacton patient management is still evolving. This review provides a framework for theuse of CMRI in diagnosis and management of COVID-19 patients from theperspective of a cardiologist. We review the role of CMRI in the management ofboth the acutely and remotely COVID-19 infected patient. We discuss patientselection for this imaging modality;T1, T2, and late gadolinium enhancementimaging techniques;and previously described CMRI findings in other cardiomyopathieswith potential implications in COVID-19 recovered patients. | Lavannya Atri Michael Morgan Sean Harrell Wael AlJaroudi Adam E Berman | 2021 | World Journal of Radiology2021，13，9： | 1 |
| 16 | Hypertension,Age,and Location predict rupture of small intracranial aneurysms显示文摘 | BRUAN V N MICHAEL L D THOMAS MORGAN | 2005 | Neurosurgery2005，57，4： | 1 |
| 17 | Photocatalytic activities of N-doped nano-titanias and titanium nitride显示文摘 | Zhice Zhang Josephine B.M. Goodall David J. Morgan Sonal Brown Robin J.H. Clark Jonathan C. Knowles Nicola J. Mordan Julian R.G. Evans Albert F. Carley Michael Bowker Jawwad A. Darr | 2009 | Journal of the European Ceramic Society2009，，11： | 1 |
| 18 | The LONG-term beth status improvement seen after lung volume reduction surgey显示文摘 | Obey IF Michael DL Morgan | 2003 | Europe Cardiothoracic Surg2003，24，： | 1 |
| 19 | Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists显示文摘 | Wei Wang Pratik Devasthale Dennis Farrelly Liqun Gu Thomas Harrity Michael Cap Cuixia Chu Lori Kunselman Nathan Morgan Randy Ponticiello Rachel Zebo Litao Zhang Kenneth Locke Jonathan Lippy Kevin O’Malley Vinayak Hosagrahara Lisa Zhang Pathanjali Kadiyala | 2008 | Bioorganic & Medicinal Chemistry Letters2008，，6： | 1 |
| 20 | Telaprevir Versus Boceprevir in Chronic Hepatitis C: A Meta-Analysis of Data From Phase II and III Trials显示文摘 | Mugdha Sitole Matthew Silva Linda Spooner Morgan K. Comee Michael Malloy | 2013 | Clinical Therapeutics2013，，2： | 1 |
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