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| 1 | Antihydatic and immunomodulatory effects of Punica granatum peel aqueous extract in a murine model of echinococcosis显示文摘Objective:To investigate the effect of pomegranate peel aqueous extract(PGE) on the development of secondary experimental echinococcosis and on the viability of Echinococcux granulosus protoscoleces,and the immunomodulatory properties of PGE.Methods:Swiss mice were inoculated intraperitoneally with viable protoscoleces.Then,PGE was orally administered daily during cystic echinococcosis development.Cyst development and hepatic damage were macroscopically and histologically analyzed.The production of nitric oxide and TNF-α was assessed in plasma and the hepatic expression of iNOS.TNF-α,NF-κB and CD68 was examined.Moreover,protoscoleces were cultured and treated with different concentrations of PGE.Results:It was observed that in vitro treatment of protoscoleces caused a significant decrease in viability in a PGE-dose-dependent manner.In vivo,after treatment of cystic echinococcosis infected mice with PGE,a significant decrease in nitric oxide levels(P<0.000 1)and TNF-α levels(P<0.001) was observed.This decline was strongly related to the inhibition of cyst development(rate of hydatid cyst growth inhibition=63.08%) and a decrease in CD68 expression in both the pericystic layer of hepatic hydatid cysts and liver tissue(P<0.000 1).A significant diminution of iNOS,TNF-α and NF-κB expression was also observed in liver tissue of treated mice(P<0.000 1).Conclusions:Our results indicate an antihydatic scolicidal effect and immunomodulatory properties of PGE,suggesting its potential therapeutic role against Echinococcuss granulosus infection. | Moussa Labsi Lila Khelifi Dalila Mezioug Imene Soufli Chafia Touil-Boukoffa | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，3： | 5 |
| 2 | In Vitro Study of Nitric Oxide Metabolites Effects on Human Hydatid of Echinococcus granulosus显示文摘 | Razika Zeghir-Bouteldja Manel Amri Saliha Aitaissa Samia Bouaziz Dalila Mezioug Chafia Touil-Boukoffa Claudio Genchi | 2009 | Journal of Parasitology Research2009，，： | 1 |
| 3 | Antihydatic and immunomodulatory effects of Algerian propolis ethanolic extract:In vitro and in vivo study显示文摘Objective: To evaluate the in vitro and in vivo effect of the Algerian propolis ethanolic extract(EEP) against Echinococcus granulosus(E. granulosus) infection. Methods: In vitro scolicidal activity of EEP was investigated on the protoscolices of hydatid cyst. This in vitro study was conducted by using an in vivo assay. BALB/c mice were inoculated with E. granulosus and treated with propolis for three months. Hydatid cysts development was assessed. Nitric oxide(NO), tumor necrosis factor alpha(TNF-α) production and inducible NO synthase, NF-κB, and TNF-α spleen expression were estimated by Griess method and immunofluorescence respectively.Results: Our study revealed that EEP has a high scolicidal activity against E. granulosus. Oral administration of EEP decreased TNF-α, NF-κB and inducible NO synthase expression in the spleen tissues in the CE+EEP group, in comparison with the CE group. Concomitantly, EEP treatment caused an important systemic decrease in NO and TNF-α levels. These findings are associated with the reduction of CE development. Conclusions: This is the first report demonstrating with interest the antihydatic and immunomodulatory effects of the Algerian EEP, suggesting its therapeutic potential for the hydatid disease treatment. | Nahla Deghbar Dalila Mezioug Touri Kahina Yacine-Miloud Medjdoub Chafia Touil-Boukoffa | 2019 | Asian Pacific Journal of Tropical Medicine2019，12，3： | 1 |
| 4 | Involvement of IL-IOand IL-4 in evasion strategies of Echinococcus granulosusto host immune response显示文摘 | Amri M Mezioug D Touil Boukoffa C | 2009 | Eur Cytokine Netw2009，20，2： | 1 |
| 5 | Involvement of IL-10 and IL-4 in evasion strategies of Echinococcus granulosus to host immune response显示文摘 | Amri M Mezioug D Touil-Boukoffa C | 2009 | Eur Cytokine Netw2009，20，2： | 1 |
| 6 | Involvement of IL-10 and IL-4 in evasion strategies of Echinococcus granulosus to host immune response显示文摘 | Amri M Mezioug D Touil-Boukoffa C | 2009 | Eur Cytokine Netw2009，20，2： | 1 |
| 7 | Involvement of IL-10 and IL-4 in evasion strategies of Echinococcus granulosus to host im- mune response显示文摘 | Amri M Mezioug D Touil-Boukoffa C | 2009 | Eur Cytokine Netw2009，20，2： | 1 |
| 8 | Cytokine profile in human hydatidosis: possible role in the immunosurveillance of patients infected with Echinococcus granulosus 显示文摘 | Mezioug D Touil-Boukoffa C | 2009 | Parasite2009，16，1： | 1 |
| 9 | Involvement of IL-10 andIL-4 in evasion strategies of Echinococcusgranulosus to host im-mune response 显示文摘 | Amri M Mezioug D Touil-Boukoffa C | 2009 | Eur Cytokine Netw2009，20，2： | 1 |
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