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| 1 | Ampullary cancer of intestinal origin and duodenal cancer-A logical clinical and therapeutic subgroup in periampullary cancer显示文摘Periampullary cancers include pancreatic, ampullary, biliary and duodenal cancers. At presentation, the majority of periampullary tumours have grown to involve the pancreas, bile duct, ampulla and duodenum. This can result in difficulty in defining the primary site of origin in all but the smallest tumors due to anatomical proximity and architectural distortion. This has led to variation in the reported proportions of resected periampullary cancers. Pancreatic cancer is the most common cancer resected with a pancreaticoduodenectomy followed by ampullary(16%-50%), bile duct(5%-39%), and duodenal cancer(3%-17%). Patients with resected duodenal and ampullary cancers have a better reported median survival(29-47 mo and 22-54 mo) compared to pancreatic cancer(13-19 mo). The poorer survival with pancreatic cancer relates to differences in tumour characteristics such as a higher incidence of nodal, neural and vascular invasion. While small ampullary cancers can present early with biliary obstruction, pancreatic cancers need to reach a certain size before biliary obstruction ensues. This larger size at presentation contributes to a higher incidence of resection margin involvement in pancreatic cancer. Ampullary cancers can be subdivided into intestinal or pancreatobiliary subtype cancers with histomolecular staining. This avoids relying on histomorphology alone, as even some poorly differentiated cancers preserve the histomolecular profile of their mucosa of origin. Histomolecular profiling is superior to anatomic location in prognosticating survival. Ampullary cancers of intestinal subtype and duodenal cancers are similar in their intestinal origin and form a logical clinical and therapeutic subgroup of periampullary cancers. They respond to 5-FU based chemotherapeutic regimens such as capecitabine-oxaliplatin. Unlike pancreatic cancers, KRAS mutation occurs in only approximately a third of ampullary and duodenal cancers. Future clinical trials should group ampullary cancers of intestinal origin and duodenal cancers together given their similarities and their response to fluoropyrimidine therapy in combination with oxaliplatin. The addition of anti-epidermal growth factor receptor therapy in this group warrants study. | Manju D Chandrasegaram Anthony J Gill Jas Samra Tim Price John Chen Jonathan Fawcett Neil D Merrett | 2017 | World Journal of Gastrointestinal Oncology2017，9，10： | 4 |
| 2 | Carbon dioxide-concentrating mechanism and the development of extracellul carbonic anhydrase in the marine picoeukaryote Micromonas pus ilia显示文摘 | Iglesias-rodriguez M D Nimer N A Merrett M J | 1998 | New Phytologist1998，140，： | 1 |
| 3 | Carbon dioxide-concentrating mechamism and the development of extracellular carbonic anhydrase in the marine picoeukaryote Micromonas pus ilia显示文摘 | Igleslas-rodrguez M D Nimer N A Merrett M J | 1998 | New Phytol1998，140，： | 1 |
| 4 | Reaching training inrats with spinal cord injury promotes plasticity and task specificrecovery显示文摘 | Girgis J Merrett D Kirkland S | 2007 | Brain2007，130，11： | 1 |
| 5 | An improved method of calculation for steady uniform flow in prismatic main channel/floodplain sections 显示文摘 | Wormleaton P R Merrett D J | 1990 | J Hydr Res Delft The Netherlands1990，28，2： | 1 |
| 6 | Bicarbonate utilization by marine phytoplankton species 显示文摘 | Nimer N A Iglesias-Rodriguez M D Merrett M J | 2008 | J Phycol2008，33，4： | 1 |
| 7 | Scales of struggle: economic restructuring in the US Midwest显示文摘 | Cntrnp J R Merrett C D | 1998 | Annals of the Association of American Geog- raphers1998，88，3： | 1 |
| 8 | Reaching training in rats with spinal cord injury promotes plasticity and task spe- cific recovery 显示文摘 | Girgis J Merrett D Kirkland S | 2007 | Brain2007，130，11： | 1 |
| 9 | Reaching training in rats with spinal cord injury promotes plasticity and task specific recovery 显示文摘 | Girgis J Merrett D Kirkland S | 2007 | Brain2007，130，11： | 1 |
| 10 | Utilization of dissolved inorganic carbon (DIC) and the response of the marine flagellate Isochrysisgalbana to carbon or nitrogen stress 显示文摘 | Clark D R Merrett M J Flynn K J | 1999 | New Phytol1999，144，3： | 1 |
| 11 | Reaching training in rats with spinal cord injury promotes plasticity and task specific re- covery 显示文摘 | Girgis J Merrett D Kirkland S | 2007 | Brain2007，130，11： | 1 |
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