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| 1 | Transient expression and insertional mutagenesis of Puccinia triticina using biolistics显示文摘 | CRAIG A W LES J S GUUS B CLARKE G RICHARD C S MERLE E JOHN P F | 2005 | Functional & Integrative Genomics2005，12，： | 1 |
| 2 | Approximations for the Exchange Potential in Electron Scattering 显示文摘 | MERLE E R DONALD G T | 1975 | J Chem Phys1975，63，： | 1 |
| 3 | Detection and quantification by real-time RT-PCR of hepatitis A virus from inoculated tap waters, salad vegetables, and soft fruits: characterization of the method performances显示文摘 | DUBOIS E HENNECHART C MERLE G | 2007 | Int J Food Microbiol2007，117，2： | 1 |
| 4 | Electropolyme- rized carbonic anhydrase immobilization for carbon diox- ide capture 显示文摘 | Merle G Fradette S Madore E | 2014 | Langmuir2014，30，23： | 1 |
| 5 | 显示文摘 | Van de Ven E Chairuna A Merle G | 2013 | J Power Sources2013，222，15： | 1 |
| 6 | The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation 显示文摘 | Merle U Fein E Gehrke S G | 2007 | Endocrinology2007，148，： | 1 |
| 7 | Detection and quantification by real-time RT-PCR of hepatitis A virus from inoculated tap waters, salad vegetables, and soft fruits : characterization of the method performances 显示文摘 | Dubis E Hennechart C Merle G | 2007 | Int J Food Microbiol2007，117，2： | 1 |
| 8 | Detection and quantification by real-time RT-PCR of hepatitis A virus from inoculated tap waters, salad vegetables, and soft fruits: characterization of the method performances 显示文摘 | Dubois E Hennechart C Merle G | 2007 | Int J Food Microbiol2007，117，2： | 1 |
| 9 | Detection and quantification by real-time RT-PCR of hepatitis A virus from inoculated tap waters, salad vegetables, and soft fruits: characterization of the method performances显示文摘 | Dubois E Hennechart C Merle G | 2007 | Int J Food Microbiol2007，117，2： | 1 |
| 10 | Phosphorus,potassium,chloride and fungicide effects on wheat yield and leaf rust severity显示文摘 | Daniel W S George V G Merle G E | 2000 | Journal of Plant Nutrition2000，23，9： | 1 |
| 11 | Ionic liquid doped polybenzimidazole membranes for high temperature proton exchange membrane fuel cell applications 显示文摘 | van de Ven E Chairuna A Merle G | 2013 | JPower Sources2013，222，15： | 1 |
| 12 | Approximations for the exchange potential in electron scattering 显示文摘 | Merle E Rily Donald G Truhlar | 1975 | J Chem Phys1975，63，： | 1 |
| 13 | The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation显示文摘 | MERLE U FEIN E GEHRKE S G | 2007 | Endocrinology2007，148，6： | 1 |
| 14 | Diversity of enterovirus sequences detected in oysters by RT-heminested PCR显示文摘 | DUBOIS E MERLE G ROQUIER C | 2004 | Int J Food Microbiol2004，92，1： | 1 |
| 15 | Ionic liquid doped polybenzimidazole membranes for HTPEMFC applic- ations显示文摘 | van de Ven E Chairuna A Merle G | 2013 | J Power Sources2013，222，： | 1 |
| 16 | Ionic liquid doped poly- benzimidazole membranes for high temperature proton exchange membrane fuel cell applications显示文摘 | Van de Ven E Chairuna A Merle G | 2013 | J Power Sources2013，222，15： | 1 |
| 17 | Pharmacological characterizationof synthetic cannabinoid MAM-2201:radioligand binding and abuse-related effects显示文摘OBJECTIVE Over 30% of all new psychoactive substances identified by the UN Office on Drugs and Crime in 2016 were synthetic cannabinoids.The recent emergence of MAM-2201 on the illicit market is troubling because this drug has no precedent in either the scientific or patent literature,and appears to be a novel compound developed specifically as a 'graymarket' drug of abuse bystructurally combining the known synthetic cannabinoids JWH-122 and AM-2201.There is currently no published information regarding the pharmacology of MAM-2201.METHODS The present studies characterized cannabinoid-like effects of MAM-2201 in vitro(interactions with cannabinoid type 1 receptors[CB1 Rs]) and in vivo(in mice and rats).RESULTS In a radioligand binding assay using [3 H]CP55,940 in HEK cell membranes transfected with the CB1 R,MAM-2201(K i=5.4 nmol·L^(-1)),had higher binding affinity than WIN 55,212-2(K i=80 nmol·L^(-1)),and D9-THC(K i=8.3 nmol·L^(-1)).The E max values for MAM-2201 and WIN 55,212-2 in an assay of agonist inhibition of forskolin-stimulated c AMP were 85%(EC50=0.45 nmol·L^(-1)) and 95%,respectively,as compared with the D9-THC E max of 74%.In mice,MAM-2201(0.003-1.0 mg·kg^(-1),IP) produced dose-dependent cannabimimetic effects which were both more potent and more effective than those of D9-THC.MAM-2201 and D9-THC dose-dependently produced hypothermia:ED50=0.287 and 25.4 mg·kg^(-1),analgesia:ED50=0.125 and 29.4 mg·kg^(-1),and catalepsy:ED50=0.301 and18.9 mg·kg^(-1) in adult male CD1 mice.Importantly,MAM-2201 also elicited convulsant effects at a dose of 1.0 mg·kg^(-1) in 8/8 murine subjects.In rats,MAM-2201 produced dose-dependent D9-THC-like interoceptive effects in subjects trained to discriminate 3.0 mg·kg^(-1)(IP) D9-THC from saline.CONCLUSION MAM-2201 binds CB1 Rs with high affinity and agonist efficacy,and functions as a potent cannabinoid agonist in vivo across several complementary measures of cannabinoid activity in two rodent species. | William E FANTEGROSSI Aaron JANOWSKY Amy J ESHLEMAN Lauren N RUSSELL Saki FUKUDA Jyoti GOGOI Cassandra PRIOLEAU Ambuja S BALE Srihari R TELLA Merle G PAULE Takato HIRANITA | 2017 | 中国药理学与毒理学杂志2017，31，10： | 0 |
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